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Citing Papers
AMP-activated protein kinase (AMPK) action in skeletal muscle via direct phosphorylation of PGC-1α
2007 Standout
Modulation of immune cell reactivity with cis -binding Siglec agonists
2021 StandoutNobel
Regulation of alternative splicing by a transcriptional enhancer through RNA pol II elongation
2002 StandoutNobel
IMF-κB and Rel: Participants in a Multiform Transcriptional Regulatory System
1993
Alterations in Lipoprotein Metabolism in Peroxisome Proliferator-activated Receptor α-deficient Mice
1997
Genetic variability of the AIDS virus: Nucleotide sequence analysis of two isolates from African patients
1986 StandoutNobel
Expression of the SV40 promoter in fission yeast: Identification and characterization of an AP-1-like factor
1988 StandoutNobel
EGL-10 Regulates G Protein Signaling in the C. elegans Nervous System and Shares a Conserved Domain with Many Mammalian Proteins
1996 StandoutNobel
PPARγ knockdown by engineered transcription factors: exogenous PPARγ2 but not PPARγ1 reactivates adipogenesis
2002
AMPK: guardian of metabolism and mitochondrial homeostasis
2017 Standout
The Fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegans
1997 StandoutNatureNobel
Transcription-independent functions of MYC: regulation of translation and DNA replication
2008
A Dominant Negative Human Peroxisome Proliferator-Activated Receptor (PPAR)α Is a Constitutive Transcriptional Corepressor and Inhibits Signaling through All PPAR Isoforms
2005
Release of chromatin protein HMGB1 by necrotic cells triggers inflammation
2002 StandoutNature
The AMPK signalling pathway coordinates cell growth, autophagy and metabolism
2011 Standout
Xenopus peroxisome proliferator activated receptors: Genomic organization, response element recognition, heterodimer formation with retinoid X receptor and activation by fatty acids
1993
A Human Gene Encoding a Putative Basic Helix–Loop–Helix Phosphoprotein Whose mRNA Increases Rapidly in Cycloheximide-Treated Blood Mononuclear Cells
1994
Synthesis and secretion of hepatic apolipoprotein B-containing lipoproteins
1994
Adora2b-elicited Per2 stabilization promotes a HIF-dependent metabolic switch crucial for myocardial adaptation to ischemia
2012
Interferon-γ-induced Regulation of Peroxisome Proliferator-activated Receptor γ and STATs in Adipocytes
2001
Gene Model 129 (Gm129) Encodes a Novel Transcriptional Repressor That Modulates Circadian Gene Expression
2014 StandoutNobel
Regulated Production of a Peroxisome Proliferator-activated Receptor-γ Ligand during an Early Phase of Adipocyte Differentiation in 3T3-L1 Adipocytes
2004
Magnesium Replacement Improves the Metabolic Profile in Obese and Pre-Diabetic Patients with Mild-to-Moderate Chronic Kidney Disease: A 3-Month, Randomised, Double-Blind, Placebo-Controlled Study
2017 Standout
Cellular survival: a play in three Akts
1999 Standout
Activation of transcription factor IIIC by the adenovirus E1A protein
1988
Diabetic KKAy mice exhibit increased hepatic PPARγ1 gene expression and develop hepatic steatosis upon chronic treatment with antidiabetic thiazolidinediones
2001
Polarity and Specific Sequence Requirements of Peroxisome Proliferator-activated Receptor (PPAR)/Retinoid X Receptor Heterodimer Binding to DNA
1997
PPARgamma agonists in the treatment of type II diabetes: is increased fatness commensurate with long-term efficacy?
2003
Cloning, Characterization, and Phylogenetic Analysis of Siglec-9, a New Member of the CD33-related Group of Siglecs
2000
The T/E1A-binding domain of the retinoblastoma product can interact selectively with a sequence-specific DNA-binding protein
1991 StandoutNobel
Central Role for Phosphatidylinositide 3-Kinase in the Repression of Glucose-6-phosphatase Gene Transcription by Insulin
1998
PPARs and the complex journey to obesity
2004
Phosphorylation of Serine 256 by Protein Kinase B Disrupts Transactivation by FKHR and Mediates Effects of Insulin on Insulin-like Growth Factor-binding Protein-1 Promoter Activity through a Conserved Insulin Response Sequence
1999
PPARγ: A Critical Determinant of Body Fat Distribution in Humans and Mice
2005
AICAR inhibits adipocyte differentiation in 3T3L1 and restores metabolic alterations in diet-induced obesity mice model
2006
Cooperativity mutants of the γδ resolvase identify an essential interdimer interaction
1990 StandoutNobel
Protein Kinase B/Akt Mediates Effects of Insulin on Hepatic Insulin-like Growth Factor-binding Protein-1 Gene Expression through a Conserved Insulin Response Sequence
1998
Two -acting regulatory sequences in the peroxisome proliferator-responsive enhancer region of rat acyl-CoA oxidase gene
1991
The Nuclear Receptors Peroxisome Proliferator-activated Receptor α and Rev-erbα Mediate the Species-specific Regulation of Apolipoprotein A-I Expression by Fibrates
1998
Delayed catabolism of apoB-48 lipoproteins due to decreased heparan sulfate proteoglycan production in diabetic mice
2000
Mode of Action of Peroxisome Proliferators as Hypolipidemic Drugs.
1995
Mechanisms linking obesity to insulin resistance and type 2 diabetes
2006 StandoutNature
A Dominant Negative Peroxisome Proliferator-activated Receptor-γ Knock-in Mouse Exhibits Features of the Metabolic Syndrome
2005
Dual roles of a multiprotein complex from S. cerevisiae in transcription and DNA repair
1993 StandoutNobel
PPARγ signaling and metabolism: the good, the bad and the future
2013 Standout
Fatty acyl-CoA thioesters are ligands of hepatic nuclear factor-4α
1998 Nature
Biochemical Analysis of the Canonical Model for the Mammalian Circadian Clock
2011 StandoutNobel
Mechanisms of fatty acid-induced inhibition of glucose uptake.
1994 Standout
Biochemistry and molecular cell biology of diabetic complications
2001 StandoutNature
Retinoids increase human apo C-III expression at the transcriptional level via the retinoid X receptor. Contribution to the hypertriglyceridemic action of retinoids.
1998
A futile metabolic cycle activated in adipocytes by antidiabetic agents
2002
Hypertension and abnormal fat distribution but not insulin resistance in mice with P465L PPARγ
2004
Integrase-mediated spacer acquisition during CRISPR–Cas adaptive immunity
2015 StandoutNatureNobel
Rapid genetic analysis of families with polycystic kidney disease 1 by means of a microsatellite marker
1991 StandoutNobel
The role of autophagy during the early neonatal starvation period
2004 StandoutNatureNobel
Injection of the cAMP-responsive element into the nucleus of Aplysia sensory neurons blocks long-term facilitation
1990 StandoutNatureNobel
TRIP6 transcriptional co-activator is a novel substrate of AMP-activated protein kinase
2006
Genetics of Type 2 diabetes
2005
A Multicomponent Insulin Response Sequence Mediates a Strong Repression of Mouse Glucose-6-phosphatase Gene Transcription by Insulin
1997
Regulation by HIV Rev depends upon recognition of splice sites
1989 StandoutNobel
Liver Peroxisome Proliferator-activated Receptor γ Contributes to Hepatic Steatosis, Triglyceride Clearance, and Regulation of Body Fat Mass
2003
Adenovirus E1A proteins can dissociate heteromeric complexes involving the E2F transcription factor: A novel mechanism for E1A trans-activation
1990
A single element in the phosphoenolpyruvate carboxykinase gene mediates thiazolidinedione action specifically in adipocytes
2001
Cyclin A and the retinoblastoma gene product complex with a common transcription factor
1991 StandoutNatureNobel
The Anti-diabetic Drugs Rosiglitazone and Metformin Stimulate AMP-activated Protein Kinase through Distinct Signaling Pathways
2002
Local Supercoil-Stabilized DNA Structure
1991
Fibrates Increase Human REV-ERBα Expression in Liver via a Novel Peroxisome Proliferator-Activated Receptor Response Element
1999
Posttranslational Modifications of PPAR‐γ: Fine‐tuning the Metabolic Master Regulator
2009
Study of a new PPARγ2 promoter polymorphism and haplotype analysis in a French population
2005
Roles of PPARs in health and disease
2000 StandoutNature
Adenovirus-2 E1A products repress enhancer-induced stimulation of transcription
1984 Nature
Dual modulation of cell survival and cell death by β 2 -adrenergic signaling in adult mouse cardiac myocytes
2001 StandoutNobel
Degradation of nuclear oncoproteins by the ubiquitin system in vitro.
1991 StandoutNobel
Different Functional Domains of the Adenovirus E1A Gene are Involved in Regulation of Host Cell Cycle Products
1987 StandoutNobel
Fibrosis, not cell size, delineates β-myosin heavy chain reexpression during cardiac hypertrophy and normal aging in vivo
2006 StandoutNobel
Minireview: The AMP-Activated Protein Kinase Cascade: The Key Sensor of Cellular Energy Status
2003
Identification of separate domains in the adenovirus E1A gene for immortalization activity and the activation of virus early genes.
1986
Hypertriglyceridemia as a Result of Human apo CII Gene Expression in Transgenic Mice
1990 Science
Two functions encoded by adenovirus early region 1A are responsible for the activation and repression of the DNA-binding protein gene.
1985
HNF-3A, a hepatocyte-enriched transcription factor of novel structure is regulated transcriptionally.
1990
Lytic and transforming functions of individual products of the adenovirus E1A gene
1986 StandoutNobel
Genome organization and transactivation of the human immunodeficiency virus type 2
1987 StandoutNatureNobel
Adenovirus E1a proteins repress transcription from the SV40 early promoter
1985
Region E3 of human adenoviruses; differences between the oncogenic adenovirus-3 and the non-oncogenic adenovirus-2
1986
DAF-16 recruits the CREB-binding protein coactivator complex to the insulin-like growth factor binding protein 1 promoter in HepG2 cells
2000 StandoutNobel
Apolipoprotein B mRNA-editing protein induces hepatocellular carcinoma and dysplasia in transgenic animals.
1995 StandoutNobel
Identification of factors that interact with the E1A-inducible adenovirus E3 promoter.
1987
An adenovirus type 2 glycoprotein blocks cell surface expression of human histocompatibility class I antigens
1985
Mechanisms of DNA Excision Repair
1994 StandoutScienceNobel
The release of growth arrest by microinjection of adenovirus E1A DNA.
1985
The AMP-activated protein kinase cascade – a unifying system for energy control
2003
Impaired insulin secretion and glucose intolerance in synaptotagmin-7 null mutant mice
2008 StandoutNobel
Uses for JNK: the Many and Varied Substrates of the c-Jun N-Terminal Kinases
2006
Different functional domains of the adenovirus E1A gene are involved in regulation of host cell cycle products.
1987 StandoutNobel
AMP-activated protein kinase activates transcription of the UCP3 and HKII genes in rat skeletal muscle
2002
Repression of the Immunoglobulin Heavy Chain Enhancer by the Adenovirus-2 E1A Products
1985 Science
Adenoviruses of subgenera B, C, D, and E modulate cell-surface expression of major histocompatibility complex class I antigens.
1986 StandoutNobel
Adenovirus E1A coding sequences that enable ras and pmt oncogenes to transform cultured primary cells.
1986
PPARs and Lipid Ligands in Inflammation and Metabolism
2011
Tyrosine Agonists Reverse the Molecular Defects Associated with Dominant-Negative Mutations in Human Peroxisome Proliferator-Activated Receptor γ
2003
Glucocorticoids Enhance Stability of Human Growth Hormone mRNA
1987 StandoutNobel
Fibrates Suppress Fibrinogen Gene Expression in Rodents Via Activation of the Peroxisome Proliferator-Activated Receptor-
1999
Peroxisome Proliferator-Activated Receptors: Nuclear Control of Metabolism*
1999 Standout
A short sequence in the COOH-terminus makes an adenovirus membrane glycoprotein a resident of the endoplasmic reticulum
1987 StandoutNobel
Yeast RAD3 protein binds directly to both SSL2 and SSL1 proteins: implications for the structure and function of transcription/repair factor b.
1994 StandoutNobel
Recent progress in understanding apolipoprotein B.
1990
Abundant class of human DNA polymorphisms which can be typed using the polymerase chain reaction.
1989 Standout
Promotion of direct reprogramming by transformation-deficient Myc
2010 StandoutNobel
Functional domains of adenovirus type 5 E1a proteins
1987
The lack of chromosomal protein Hmg1 does not disrupt cell growth but causes lethal hypoglycaemia in newborn mice
1999
The directly repeated RG(G/T)TCA motifs of the rat and mouse cellular retinol-binding protein II genes are promiscuous binding sites for RAR, RXR, HNF-4, and ARP-1 homo- and heterodimers.
1994
Adenovirus E1A Coding Sequences That Enable ras and pmt Oncogenes To Transform Cultured Primary Cells
1986
Regulation of the Ets-Related Transcription Factor Elf-1 by Binding to the Retinoblastoma Protein
1993 StandoutScienceNobel
Inhibitors of the proteasome pathway interfere with induction of nitric oxide synthase in macrophages by blocking activation of transcription factor NF-kappa B.
1996 StandoutNobel
Identification of Separate Domains in the Adenovirus E1A Gene for Immortalization Activity and the Activation of Virus Early Genes
1986
Hypoxia-inducible factor 1 is required for remote ischemic preconditioning of the heart
2013 StandoutNobel
RXR Agonists Activate PPARα-Inducible Genes, Lower Triglycerides, and Raise HDL Levels In Vivo
1998
Glucocorticoids enhance stability of human growth hormone mRNA.
1987 StandoutNobel
Clinical Guidelines on the Identification, Evaluation, and Treatment of Overweight and Obesity in Adults--The Evidence Report. National Institutes of Health.
1998 Standout
Individual adenovirus type 5 early region 1A gene products elicit distinct alterations of cellular morphology and gene expression
1985
ERCC2: cDNA cloning and molecular characterization of a human nucleotide excision repair gene with high homology to yeast RAD3.
1990
The location of cis-acting regulatory sequences in the human T cell lymphotropic virus type III (HTLV-III/LAV) long terminal repeat
1985
The Dawn of the SPPARMs?
2002
JNK1 controls mast cell degranulation and IL-1β production in inflammatory arthritis
2010 StandoutNobel
Transcriptional regulation of human apolipoprotein genes ApoB, ApoCIII, and ApoAII by members of the steroid hormone receptor superfamily HNF-4, ARP-1, EAR-2, and EAR-3.
1992
Rapid turnover of adenovirus E1A is determined through a co-translational mechanism that requires an aminoterminal domain.
1988
Identification of a cellular transcription factor involved in E1A trans-activation
1986
Works of Todd Leff being referenced
Transcriptional regulation of the apoC-III gene by insulin in diabetic mice: correlation with changes in plasma triglyceride levels.
1994
Hypolipidemic activity of select fibrates correlates to changes in hepatic apolipoprotein C-III expression: a potential physiologic basis for their mode of action.
1995
A novel compound that elevates high density lipoprotein and activates the peroxisome proliferator activated receptor
1998
PER2 Controls Lipid Metabolism by Direct Regulation of PPARγ
2010
Common genetic variation in the promoter of the human apo CIII gene abolishes regulation by insulin and may contribute to hypertriglyceridemia.
1995
c-Myc Does Not Require Max for Transcriptional Activity in PC-12 Cells
1994
AMP-activated Protein Kinase Regulates HNF4α Transcriptional Activity by Inhibiting Dimer Formation and Decreasing Protein Stability
2003
Regulation of Transcription by AMP-activated Protein Kinase
2001
Sequence-specific activation of transcription by adenovirus EIa products is observed in HeLa cells but not in 293 cells
1986
PPARG F388L, a Transactivation-Deficient Mutant, in Familial Partial Lipodystrophy
2002
Human apolipoprotein CIII gene expression is regulated by positive and negative cis-acting elements and tissue-specific protein factors.
1988
A Novel Potent Antagonist of Peroxisome Proliferator-Activated Receptor γ Blocks Adipocyte Differentiation But Does Not Revert the Phenotype of Terminally Differentiated Adipocytes
2001
c-Jun N-Terminal Kinase Phosphorylates Peroxisome Proliferator-Activated Receptor-γ1 and Negatively Regulates Its Transcriptional Activity
1999
Troglitazone, an antidiabetic agent, inhibits cholesterol biosynthesis through a mechanism independent of peroxisome proliferator-activated receptor-gamma.
1999
Nuclear factors AF-1 and C/EBP bind to the human ApoB gene promoter and modulate its transcriptional activity in hepatic cells.
1990
Differential activation of peroxisome proliferator-activated receptor-gamma by troglitazone and rosiglitazone.
2000
Transcriptional analysis of the adenovirus-5 EIII promoter: absence of sequence specificity for stimulation by EIa gene products
1985
Individual products of the adenovirus 12S and 13S EIa mRNAs stimulate viral EIIa and EIII expression at the transcriptional level.
1984
The human apolipoprotein C-II gene sequence contains a novel chromosome 19-specific minisatellite in its third intron.
1987
A Regulatory Element in the ApoCIII Promoter That Directs Hepatic Specific Transcription Binds to Proteins in Expressing and Nonexpressing Cell Types
1989
Cell type-specific expression of the human apoB gene is controlled by two cis-acting regulatory regions.
1988
AMP-activated protein kinase regulates gene expression by direct phosphorylation of nuclear proteins
2003
Far upstream sequences are required for efficient transcription from the adenovirus-2 E1A transcription unit
1983