Standout Papers
Citation Impact
Citing Papers
Why highly expressed proteins evolve slowly
2005 StandoutNobel
Protein Misfolding, Amyloid Formation, and Human Disease: A Summary of Progress Over the Last Decade
2017 Standout
Long-Lived C. elegans daf-2 Mutants Are Resistant to Bacterial Pathogens
2003 StandoutScienceNobel
Small assemblies of unmodified amyloid β-protein are the proximate neurotoxin in Alzheimer’s disease
2004
Clusterin Binds to Aβ1–42 Oligomers with High Affinity and Interferes with Peptide Aggregation by Inhibiting Primary and Secondary Nucleation
2016
The Ca2+ activated SK3 channel is expressed in microglia in the rat striatum and contributes to microglia-mediated neurotoxicity in vitro
2010
Structural Classification of Toxic Amyloid Oligomers
2008
The HIV-1 Nef Protein and Phagocyte NADPH Oxidase Activation
2002
Alzheimer's disease: synaptic dysfunction and Aβ
2009
Conformational Differences between Two Amyloid β Oligomers of Similar Size and Dissimilar Toxicity
2012
Heterogeneity of Microglial Activation in the Innate Immune Response in the Brain
2009
Amyloid β-Protein Assembly and Alzheimer Disease
2008
Impaired synaptic plasticity and learning in aged amyloid precursor protein transgenic mice
1999
Microglial response to N-methyl-D-aspartate-mediated excitotoxicity in the immature rat brain
1996
Lipids revert inert Aβ amyloid fibrils to neurotoxic protofibrils that affect learning in mice
2007
Microglial cell population dynamics in the injured adult central nervous system
2005
Inflammatory processes in amyotrophic lateral sclerosis
2002
Neuroprotection of microglial conditioned medium on 6‐hydroxydopamine‐induced neuronal death: role of transforming growth factor beta‐2
2009
Targeting small Aβ oligomers: the solution to an Alzheimer's disease conundrum?
2001
The 'Arctic' APP mutation (E693G) causes Alzheimer's disease by enhanced Aβ protofibril formation
2001
Complement 5a controls motility of murine microglial cells in vitro via activation of an inhibitory G-protein and the rearrangement of the actin cytoskeleton
1996
Pathway Complexity of Prion Protein Assembly into Amyloid
2002 Nobel
Copper Binding to the Amyloid-β (Aβ) Peptide Associated with Alzheimer's Disease
2004
TGF-β1 promotes microglial amyloid-β clearance and reduces plaque burden in transgenic mice
2001
Presenilins are essential for regulating neurotransmitter release
2009 StandoutNatureNobel
Microglia in the Aging Brain
2006
The Highly Cooperative Folding of Small Naturally Occurring Proteins Is Likely the Result of Natural Selection
2007 StandoutNobel
Dimeric Amyloid β Protein Rapidly Accumulates in Lipid Rafts followed by Apolipoprotein E and Phosphorylated Tau Accumulation in the Tg2576 Mouse Model of Alzheimer's Disease
2004
Review: Immunoglobulin Light Chain Amyloidosis—The Archetype of Structural and Pathogenic Variability
2000
The amyloid cascade hypothesis for Alzheimer's disease: an appraisal for the development of therapeutics
2011 Standout
Spatial relationship between synapse loss and β‐amyloid deposition in Tg2576 mice
2006
Chemotaxis and accumulation of nerve growth factor by microglia and macrophages
1995
Temporal Profile of Amyloid-β (Aβ) Oligomerization in an in Vivo Model of Alzheimer Disease
2005
In Vitro Characterization of Conditions for Amyloid-β Peptide Oligomerization and Fibrillogenesis
2003
Inherent toxicity of aggregates implies a common mechanism for protein misfolding diseases
2002 StandoutNature
Cerebrovascular transport of Alzheimer's amyloidβ and apolipoproteins J and E: Possible anti-amyloidogenic role of the blood-brain barrier
1996
The Multifaceted Profile of Activated Microglia
2009
Deciphering the Molecular Basis of Memory Failure in Alzheimer's Disease
2004
Synaptic Targeting by Alzheimer's-Related Amyloid β Oligomers
2004
Aβ Oligomers Induce Neuronal Oxidative Stress through an N-Methyl-D-aspartate Receptor-dependent Mechanism That Is Blocked by the Alzheimer Drug Memantine
2007
Microglia-mediated neurotoxicity: uncovering the molecular mechanisms
2006 Standout
Screening for Inhibitors of Tau Polymerization
2005
CD22 blockade restores homeostatic microglial phagocytosis in ageing brains
2019 StandoutNatureNobel
A new amyloid β variant favoring oligomerization in Alzheimer's‐type dementia
2008
Natural Oligomers of the Alzheimer Amyloid-β Protein Induce Reversible Synapse Loss by Modulating an NMDA-Type Glutamate Receptor-Dependent Signaling Pathway
2007
Quantitative Measurement of Changes in Amyloid-β(40) in the Rat Brain and Cerebrospinal Fluid following Treatment with the γ-Secretase Inhibitor LY-411575 [N2-[(2 S)-2-(3,5-Difluorophenyl)-2-hydroxyethanoyl]-N1-[(7 S)-5-methyl-6-oxo-6,7-dihydro-5 H-dibenzo[b,d]azepin-7-yl]-l-alaninamide]
2005
Amyloid Oligomers Exacerbate Tau Pathology in a Mouse Model of Tauopathy
2012 Standout
Evidence of fibril-like β-sheet structures in a neurotoxic amyloid intermediate of Alzheimer's β-amyloid
2007
Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid β-peptide
2007 Standout
Amyloid β-Protein Fibrillogenesis
1999
Scavenger receptors in neurobiology and neuropathology: Their role on microglia and other cells of the nervous system
2002
Vasoactive intestinal peptide protects against β‐amyloid‐induced neurodegeneration by inhibiting microglia activation at multiple levels
2008
Protein aggregation and aggregate toxicity: new insights into protein folding, misfolding diseases and biological evolution
2003
Pathogenic protein seeding in alzheimer disease and other neurodegenerative disorders
2011
β-Amyloid-Stimulated Microglia Induce Neuron Death via Synergistic Stimulation of Tumor Necrosis Factor α and NMDA Receptors
2005
The Nonfibrillar Amyloid β‐Peptide Induces Apoptotic Neuronal Cell Death
1999
Multiple Assembly Pathways Underlie Amyloid-β Fibril Polymorphisms
2005
Cytokines and Chemokines as Mediators of Protection and Injury in the Central Nervous System Assessed in Transgenic Mice
2002
Understanding the tumor immune microenvironment (TIME) for effective therapy
2018 Standout
Fasting, Circadian Rhythms, and Time-Restricted Feeding in Healthy Lifespan
2016
Prevention of Alzheimer's Disease Pathology by Cannabinoids: Neuroprotection Mediated by Blockade of Microglial Activation
2005
Clusterin Has Chaperone-like Activity Similar to That of Small Heat Shock Proteins
1999 Standout
PGH2‐derived levuglandin adducts increase the neurotoxicity of amyloid β1–42
2006
Cytokines Associated with Amyloid Plaques in Alzheimer's Disease Brain Stimulate Human Glial and Neuronal Cell Cultures to Secrete Early Complement Proteins, But Not C1-Inhibitor
1999
Amyloidogenic role of cytokine TGF-β1 in transgenic mice and in Alzheimer's disease
1997 Nature
Probing the Initial Stage of Aggregation of the Aβ10-35-protein: Assessing the Propensity for Peptide Dimerization
2004
Contribution of two conserved glycine residues to fibrillogenesis of the 106–126 prion protein fragment. Evidence that a soluble variant of the 106–126 peptide is neurotoxic
2003
Cellular prion protein mediates impairment of synaptic plasticity by amyloid-β oligomers
2009 Nature
Probing the origins, diagnosis and treatment of amyloid diseases using antibodies
2004
Amyloids: Not Only Pathological Agents but Also Ordered Nanomaterials
2008
Soluble Amyloid β Peptide Concentration as a Predictor of Synaptic Change in Alzheimer's Disease
1999
Familial Alzheimer disease associated with A713T mutation in APP
2004
Genetic ablation of Dicer in adult forebrain neurons results in abnormal tau hyperphosphorylation and neurodegeneration
2010
Microglia and inflammatory mechanisms in the clearance of amyloid β peptide
2002
Enhanced Toxicity and Cellular Binding of a Modified Amyloid β Peptide with a Methionine to Valine Substitution
2004
Review: Modulating Factors in Amyloid-β Fibril Formation
2000
Mechanisms of Microglia-Mediated Neurotoxicity in a New Model of the Stroke Penumbra
2008
Unfolding the role of protein misfolding in neurodegenerative diseases
2003
Amyloid-β protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory
2008 Standout
Naturally secreted oligomers of amyloid β protein potently inhibit hippocampal long-term potentiation in vivo
2002 StandoutNature
Appearance of Sodium Dodecyl Sulfate-Stable Amyloid β-Protein (Aβ) Dimer in the Cortex During Aging
1999
Amyloid β-Protein Dimers Rapidly Form Stable Synaptotoxic Protofibrils
2010
Phenolic anti-inflammatory antioxidant reversal of Aβ-induced cognitive deficits and neuropathology
2001
Structural Differences in Aβ Amyloid Protofibrils and Fibrils Mapped by Hydrogen Exchange – Mass Spectrometry with On-line Proteolytic Fragmentation
2006
Monoclonal antibodies that target pathological assemblies of Aβ
2006
Biology of Amyloid: Structure, Function, and Regulation
2010
Gelsolin amyloidosis: genetics, biochemistry, pathology and possible strategies for therapeutic intervention
2012
Possible involvement of increase in spinal fibronectin following peripheral nerve injury in upregulation of microglial P2X4, a key molecule for mechanical allodynia
2006
Presenilins and APP in Neuritic and Synaptic Plasticity: Implications for the Pathogenesis of Alzheimer's Disease
2002
Only amyloidogenic intermediates of transthyretin induce apoptosis
2002
β-Amyloid-Mediated Inhibition of NMDA Receptor-Dependent Long-Term Potentiation Induction Involves Activation of Microglia and Stimulation of Inducible Nitric Oxide Synthase and Superoxide
2004
Globular amyloid β‐peptide1−42 oligomer − a homogenous and stable neuropathological protein in Alzheimer's disease
2005
Review: Alzheimer's Amyloid β-Peptide-Associated Free Radical Oxidative Stress and Neurotoxicity
2000
Apolipoprotein E4 Potentiates Amyloid β Peptide-induced Lysosomal Leakage and Apoptosis in Neuronal Cells
2002
Protein aggregation and neurodegenerative disease
2004 Standout
β-Amyloid Is Different in Normal Aging and in Alzheimer Disease
2005
A de novo designed helix-turn-helix peptide forms nontoxic amyloid fibrils.
2000
Curcumin Inhibits Formation of Amyloid β Oligomers and Fibrils, Binds Plaques, and Reduces Amyloid in Vivo
2004 Standout
Residues 17–20 and 30–35 of beta‐amyloid play critical roles in aggregation
2003
Bacterial Inclusion Bodies Contain Amyloid-Like Structure
2008
Structural and kinetic features of amyloid β-protein fibrillogenesis
1998
Expression of human apolipoprotein E reduces amyloid-β deposition in a mouse model of Alzheimer's disease
1999
C1q, the recognition subcomponent of the classical pathway of complement, drives microglial activation
2008
Fibril specific, conformation dependent antibodies recognize a generic epitope common to amyloid fibrils and fibrillar oligomers that is absent in prefibrillar oligomers
2007
α-Synuclein Oligomers: an Amyloid Pore?
2012
Protein aggregation diseases: pathogenicity and therapeutic perspectives
2010
Certain Inhibitors of Synthetic Amyloid β-Peptide (Aβ) Fibrillogenesis Block Oligomerization of Natural Aβ and Thereby Rescue Long-Term Potentiation
2005
Current progress in beta-amyloid immunotherapy
2004
Amyloid β-Protein Toxicity and the Pathogenesis of Alzheimer Disease
2008
Complement Component C1q Modulates the Phagocytosis of Aβ by Microglia
2000
The Ca2+-Activated K+ChannelKCNN4/KCa3.1 Contributes to Microglia Activation and Nitric Oxide-Dependent Neurodegeneration
2007
Copper-Zinc Superoxide Dismutase (SOD1) Is Released by Microglial Cells and Confers Neuroprotection against 6-OHDA Neurotoxicity
2012 Standout
Ibuprofen effects on Alzheimer pathology and open field activity in APPsw transgenic mice
2001
Glial degeneration and reactive gliosis in alpha-synucleinopathies: the emerging concept of primary gliodegeneration
2006
Amyloid pores from pathogenic mutations
2002 Nature
Alzheimer's disease
2006 Standout
Aβ Oligomer-Induced Aberrations in Synapse Composition, Shape, and Density Provide a Molecular Basis for Loss of Connectivity in Alzheimer's Disease
2007
Non-coding RNAs in human disease
2011 Standout
Role of high mobility group protein-1 (HMG1) in amyloid-β homeostasis
2003
Neprilysin-sensitive Synapse-associated Amyloid-β Peptide Oligomers Impair Neuronal Plasticity and Cognitive Function
2006
APP Processing and Synaptic Function
2003
Aβ42 Neurotoxicity Is Mediated by Ongoing Nucleated Polymerization Process Rather than by Discrete Aβ42 Species
2010
Toxic oligomers and islet beta cell death: guilty by association or convicted by circumstantial evidence?
2010
Roles of amyloid precursor protein and its fragments in regulating neural activity, plasticity and memory
2003
l-Serine-mediated release of apolipoprotein E and lipids from microglial cells
2004
A dual-Ca2+-sensor model for neurotransmitter release in a central synapse
2007 StandoutNatureNobel
The microglial sensome revealed by direct RNA sequencing
2013
Neuroglial activation repertoire in the injured brain: graded response, molecular mechanisms and cues to physiological function
1999
Review: Amyloidogenesis—Unquestioned Answers and Unanswered Questions
2000
Inhibition of Aβ fibril formation and Aβ-induced cytotoxicity by senile plaque-associated proteins
2000
Presence of Sodium Dodecyl Sulfate-Stable Amyloid β-Protein Dimers in the Hippocampus CA1 Not Exhibiting Neurofibrillary Tangle Formation
1999
Role of toll-like receptor signalling in A uptake and clearance
2006
The Amyloid State of Proteins in Human Diseases
2012 Standout
Antiamyloidogenic and Neuroprotective Functions of Cathepsin B: Implications for Alzheimer's Disease
2006
Dendritic Function of Tau Mediates Amyloid-β Toxicity in Alzheimer's Disease Mouse Models
2010
Age-related microglial activation in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced dopaminergic neurodegeneration in C57BL/6 mice
2003
Non-fibrillar oligomeric species of the amyloid ABri peptide, implicated in familial British dementia, are more potent at inducing apoptotic cell death than protofibrils or mature fibrils11Edited by J. Karn
2001
Amyloid β-Protein Fibrillogenesis
1997
The inflammatory response system of brain: implications for therapy of Alzheimer and other neurodegenerative diseases
1995
The Transthyretin Amyloidoses: From Delineating the Molecular Mechanism of Aggregation Linked to Pathology to a Regulatory-Agency-Approved Drug
2012
Oligomeric and Fibrillar Species of Amyloid-β Peptides Differentially Affect Neuronal Viability
2002 Standout
Structure-based design of non-natural amino-acid inhibitors of amyloid fibril formation
2011 StandoutNatureNobel
Amyloid-β forms fibrils by nucleated conformational conversion of oligomers
2011
Microglia Kv1.3 Channels Contribute to Their Ability to Kill Neurons
2005
Polyglutamine aggregation behavior in vitro supports a recruitment mechanism of cytotoxicity
2001
Dietary Restriction in Drosophila: Delayed Aging or Experimental Artefact?
2007
Evolution and Functions of Long Noncoding RNAs
2009 Standout
The toxic Aβ oligomer and Alzheimer's disease: an emperor in need of clothes
2012 Standout
Solution structures of micelle-bound amyloid β-(1-40) and β-(1-42) peptides of Alzheimer’s disease 1 1Edited by P. E. Wright
1999
System Xc−and Apolipoprotein E Expressed by Microglia Have Opposite Effects on the Neurotoxicity of Amyloid-β Peptide 1–40
2006
Neurotoxicity of Alzheimer's disease Aβ peptides is induced by small changes in the Aβ42 to Aβ40 ratio
2010
Docosahexaenoic Acid Protects from Dendritic Pathology in an Alzheimer's Disease Mouse Model
2004
Small Molecule Inhibitors of Aggregation Indicate That Amyloid β Oligomerization and Fibrillization Pathways Are Independent and Distinct
2007
Aβ Oligomers Cause Localized Ca 2+ Elevation, Missorting of Endogenous Tau into Dendrites, Tau Phosphorylation, and Destruction of Microtubules and Spines
2010
Antibodies against β‐amyloid reduce aβ oligomers, glycogen synthase kinase‐3β activation and τ phosphorylation in vivo and in vitro
2005
Long noncoding RNAs: functional surprises from the RNA world
2009 Standout
P2X7 receptor modulation of β-amyloid- and LPS-induced cytokine secretion from human macrophages and microglia
2003
Microglial apolipoprotein E and astroglial apolipoprotein J expression in vitro: opposite effects of lipopolysaccharide
2003
Pathways towards and away from Alzheimer's disease
2004 StandoutNature
Molecular Mechanisms of Amyloidosis
2003 Standout
A novelβ‐sheet breaker, RS‐0406, reverses amyloidβ‐induced cytotoxicity and impairment of long‐term potentiationin vitro
2002
Elucidation of Primary Structure Elements Controlling Early Amyloid β-Protein Oligomerization
2003
Alzheimer's disease-type neuronal tau hyperphosphorylation induced by Aβ oligomers
2007
Photoconductance and inverse photoconductance in films of functionalized metal nanoparticles
2009 StandoutNatureNobel
Reciprocal Interactions Between Microglia and Neurons: From Survival to Neuropathology
2002
Non-coding RNAs and new opportunities for the private sector
2009
Amyloid fibrils
2008
Translating cell biology into therapeutic advances in Alzheimer's disease
1999 Nature
Transthyretin suppresses the toxicity of oligomers formed by misfolded proteins in vitro
2013
Amyloid-β/Fyn–Induced Synaptic, Network, and Cognitive Impairments Depend on Tau Levels in Multiple Mouse Models of Alzheimer's Disease
2011
Effects of secreted oligomers of amyloid β‐protein on hippocampal synaptic plasticity: a potent role for trimers
2006
Ion mobility–mass spectrometry reveals a conformational conversion from random assembly to β-sheet in amyloid fibril formation
2010
Soluble amyloid precursor protein (APP) regulates transthyretin and Klotho gene expression without rescuing the essential function of APP
2010 StandoutNobel
The Interplay of Catalysis and Toxicity by Amyloid Intermediates on Lipid Bilayers: Insights from Type II Diabetes
2009
Protofibrillar Intermediates of Amyloid β-Protein Induce Acute Electrophysiological Changes and Progressive Neurotoxicity in Cortical Neurons
1999
Protofibrillar intermediates of amyloid beta-protein induce acute electrophysiological changes and progressive neurotoxicity in cortical neurons.
1999
Prediction of the structure of symmetrical protein assemblies
2007 StandoutNobel
Alzheimer's disease-affected brain: Presence of oligomeric Aβ ligands (ADDLs) suggests a molecular basis for reversible memory loss
2003
Exogenous Induction of Cerebral ß-Amyloidogenesis Is Governed by Agent and Host
2006 Science
Permeabilization of Lipid Bilayers Is a Common Conformation-dependent Activity of Soluble Amyloid Oligomers in Protein Misfolding Diseases
2004
Alzheimer Disease: Mechanistic Understanding Predicts Novel Therapies
2004
Place cell firing correlates with memory deficits and amyloid plaque burden in Tg2576 Alzheimer mouse model
2008 StandoutNobel
The Amyloid Hypothesis of Alzheimer's Disease: Progress and Problems on the Road to Therapeutics
2002 StandoutScience
PROTOFIBRILS , PORES , FIBRILS, AND NEURODEGENERATION : Separating the Responsible Protein Aggregates from The Innocent Bystanders
2003
Mechanism of Nucleated Conformational Conversion of Aβ42
2015
Molecular mechanisms used by chaperones to reduce the toxicity of aberrant protein oligomers
2012
Rapid Tyrosine Phosphorylation of Neuronal Proteins Including Tau and Focal Adhesion Kinase in Response to Amyloid-β Peptide Exposure: Involvement of Src Family Protein Kinases
2002
3D structure of Alzheimer's amyloid-β(1–42) fibrils
2005 Standout
Use-Dependent Effects of Amyloidogenic Fragments of β-Amyloid Precursor Protein on Synaptic Plasticity in Rat HippocampusIn Vivo
2001
Spherical aggregates of β-amyloid (amylospheroid) show high neurotoxicity and activate tau protein kinase I/glycogen synthase kinase-3β
2003
Spatial distribution of calcium channels and cytosolic calcium transients in growth cones and cell bodies of sympathetic neurons.
1988 StandoutNobel
Synergistic dopaminergic neurotoxicity of MPTP and inflammogen lipopolysaccharide: relevance to the etiology of Parkinson's disease
2003
Self-Assembly of Aβ1-42into Globular Neurotoxins
2003
Copper Homeostasis and Neurodegenerative Disorders (Alzheimer's, Prion, and Parkinson's Diseases and Amyotrophic Lateral Sclerosis)
2006 Standout
DAF-16 Target Genes That Control C. elegans Life-Span and Metabolism
2003 StandoutScienceNobel
Localized Surface Plasmon Resonance Spectroscopy and Sensing
2006 Standout
Oligomeric amyloid β associates with postsynaptic densities and correlates with excitatory synapse loss near senile plaques
2009
Isoform-specific effect of apolipoprotein E on cell survival and beta-amyloid-induced toxicity in rat hippocampal pyramidal neuronal cultures.
1998
The Genetics of Aging
2001 StandoutNobel
Characterization of Chemical Exchange between Soluble and Aggregated States of β-Amyloid by Solution-State NMR upon Variation of Salt Conditions
2005
Spermidine in health and disease
2018 StandoutScience
Alzheimer's Disease: Genes, Proteins, and Therapy
2001 Standout
Immunotherapy for Alzheimer's disease
2004
A monoclonal antibody against synthetic Aβ dimer assemblies neutralizes brain‐derived synaptic plasticity‐disrupting Aβ
2011
The 5HT2 receptor defines a family of structurally distinct but functionally conserved serotonin receptors.
1990 StandoutNobel
How chronic inflammation can affect the brain and support the development of Alzheimer's disease in old age: the role of microglia and astrocytes
2004
Alzheimer's Disease Is a Synaptic Failure
2002 StandoutScience
Cystatin C reduces thein vitroformation of soluble Aβ1‐42 oligomers and protofibrils
2006
Small Molecule Microarrays Enable the Discovery of Compounds That Bind the Alzheimer’s Aβ Peptide and Reduce its Cytotoxicity
2010
Prolactin: Structure, Function, and Regulation of Secretion
2000 Standout
Alzheimer's Disease: Molecular Understanding Predicts Amyloid-Based Therapeutics
2003
Complement C1q Is Dramatically Up-Regulated in Brain Microglia in Response to Transient Global Cerebral Ischemia
2000
Partial peripheral nerve injury leads to activation of astroglia and microglia which parallels the development of allodynic behavior
1998
Rat brain serotonin receptors in Xenopus oocytes are coupled by intracellular calcium to endogenous channels.
1987 StandoutNobel
Plaque-independent disruption of neural circuits in Alzheimer’s disease mouse models
1999
Amyloid precursor protein (APP) traffics from the cell surface via endosomes for amyloid β (Aβ) production in the trans -Golgi network
2012 StandoutNobel
Proteases and Proteolysis in Alzheimer Disease: A Multifactorial View on the Disease Process
2010
High-Level Neuronal Expression of Aβ1–42in Wild-Type Human Amyloid Protein Precursor Transgenic Mice: Synaptotoxicity without Plaque Formation
2000 Standout
N-Methylated Peptide Inhibitors of β-Amyloid Aggregation and Toxicity. Optimization of the Inhibitor Structure
2006
Inositol Stereoisomers Stabilize an Oligomeric Aggregate of Alzheimer Amyloid β Peptide and Inhibit Aβ-induced Toxicity
2000
Common structure and toxic function of amyloid oligomers implies a common mechanism of pathogenesis
2006
Acceleration of oligomerization, not fibrillization, is a shared property of both α-synuclein mutations linked to early-onset Parkinson's disease: Implications for pathogenesis and therapy
2000
Synergistic Dopaminergic Neurotoxicity of the Pesticide Rotenone and Inflammogen Lipopolysaccharide: Relevance to the Etiology of Parkinson's Disease
2003
Chemotherapy triggers HIF-1–dependent glutathione synthesis and copper chelation that induces the breast cancer stem cell phenotype
2015 StandoutNobel
Imaging Distinct Conformational States of Amyloid-β Fibrils in Alzheimer’s Disease Using Novel Luminescent Probes
2007
Common Structure of Soluble Amyloid Oligomers Implies Common Mechanism of Pathogenesis
2003 StandoutScience
Grafting of cultured microglial cells into the lesioned spinal cord of adult rats enhances neurite outgrowth
1997
The Development of Amyloid β Protein Deposits in the Aged Brain
2006
The Relationship between Aβ and Memory in the Tg2576 Mouse Model of Alzheimer's Disease
2002
Peroxynitrite generated by inducible nitric oxide synthase and NADPH oxidase mediates microglial toxicity to oligodendrocytes
2005
Self-catalyzed growth of S layers via an amorphous-to-crystalline transition limited by folding kinetics
2010 StandoutNobel
Transforming Growth Factor-β1-Mediated Neuroprotection against Excitotoxic Injury in Vivo
2003
Self-Assembly of β-Amyloid 42 Is Retarded by Small Molecular Ligands at the Stage of Structural Intermediates
2000 StandoutNobel
Extending Healthy Life Span—From Yeast to Humans
2010 StandoutScience
Amyloid β-protein (Aβ) assembly: Aβ40 and Aβ42 oligomerize through distinct pathways
2002
Amyloid β42Activates a G-Protein-Coupled Chemoattractant Receptor, FPR-Like-1
2001
Molecular basis for amyloid-β polymorphism
2011
Physiology of Microglia
2011 Standout
Oxidative stress in neurodegeneration: cause or consequence?
2004 Standout
Works of Todd E. Morgan being referenced
Scavenger receptor mRNAs in rat brain microglia are induced by kainic acid lesioning and by cytokines
1997
Short-term calorie and protein restriction provide partial protection from chemotoxicity but do not delay glioma progression
2013
TGF-β1 mRNA Increases in Macrophage/Microglial Cells of the Hippocampus in Response to Deafferentation and Kainic Acid-Induced Neurodegeneration
1993
C1qB and clusterin mRNA increase in association with neurodegeneration in sporadic amyotrophic lateral sclerosis
1999
Astrocytes and Microglia Respond to Estrogen with Increased apoE mRNAin Vivoandin Vitro
1997
Macrosialin increases during normal brain aging are attenuated by caloric restriction
2005
Age-changes in gene expression in primary mixed glia cultures from young vs. old rat cerebral cortex are modified by interactions with neurons
2011
TGF‐β1 is an organizer of responses to neurodgeneration
1993
Transforming growth factor β1 and fibronectin messenger RNA in rat brain: Responses to injury and cell-type localization
1993
Expression of a noncoding RNA is elevated in Alzheimer's disease and drives rapid feed-forward regulation of β-secretase
2008
The mosaic of brain glial hyperactivity during normal ageing and its attenuation by food restriction
1999
Complement C1qB and C4 mRNAs responses to lesioning in rat brain
1992
Pituitary lactotrope expresses transforming growth factor β (TGFβ) type II receptor mRNA and protein and contains 125I-TGFβ1 binding sites
1996
Age-Related Activation of Microglia and Astrocytes: In Vitro Studies Show Persistent Phenotypes of Aging, Increased Proliferation, and Resistance to Down-Regulation
1998
Caloric restriction attenuates Aβ-deposition in Alzheimer transgenic models
2004
Kainic Acid and Decorticating Lesions Stimulate the Synthesis of C1q Protein in Adult Rat Brain
1997
Fasting-Mimicking Diet Reduces HO-1 to Promote T Cell-Mediated Tumor Cytotoxicity
2016
Clusterin (apoJ) Alters the Aggregation of Amyloid β-Peptide (Aβ1-42) and Forms Slowly Sedimenting Aβ Complexes That Cause Oxidative Stress
1995
Vaccination with soluble Aβ oligomers generates toxicity‐neutralizing antibodies
2001
Joint Genome-Wide Profiling of miRNA and mRNA Expression in Alzheimer's Disease Cortex Reveals Altered miRNA Regulation
2010
Selective expression of clusterin (SGP-2) and complement C1qB and C4 during responses to neurotoxinsin vivo andin vitro
1994
Diffusible, nonfibrillar ligands derived from Aβ 1–42 are potent central nervous system neurotoxins
1998 Standout
Peroxynitrite Mediates Neurotoxicity of Amyloid β-Peptide1–42- and Lipopolysaccharide-Activated Microglia
2002
Transcription supports age-related increases of GFAP gene expression in the male rat brain
1996
Peroxynitrite mediates neurotoxicity of amyloid beta-peptide1-42- and lipopolysaccharide-activated microglia.
2002