Citation Impact
Citing Papers
An O -fucose site in the ligand binding domain inhibits Notch activation
2003
Fat Metabolism Links Germline Stem Cells and Longevity in C. elegans
2008 StandoutScienceNobel
An EGFR/Ebi/Sno Pathway Promotes Delta Expression by Inactivating Su(H)/SMRTER Repression during Inductive Notch Signaling
2002
Murine leukemia provirus‐mediated activation of the Notch1 gene leads to induction of HES‐1 in a mouse T lymphoma cell line, DL‐3
1999 StandoutNobel
Synergy between Suppressor of Hairless and Notch in Regulation of Enhancer of split mγ and mδ Expression
1997
Notch signalling controls pancreatic cell differentiation
1999 StandoutNatureNobel
Lack of requirement for Presenilin1 in Notch1 signaling
1999
Down-regulation of Delta by proteolytic processing
2002
Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain
1998 StandoutNature
Epstein-Barr virus immortalization: Notch2 interacts with CBF1 and blocks differentiation
1997
The Notch 3 intracellular domain represses Notch 1-mediated activation through Hairy/Enhancer of split (HES) promoters
1999
Functional Interaction between SEL-10, an F-box Protein, and the Nuclear Form of Activated Notch1 Receptor
2001 StandoutNobel
Groucho is required for Drosophila neurogenesis, segmentation, and sex determination and interacts directly with hairy-related bHLH proteins
1994
The WRPW Motif of the Hairy-Related Basic Helix-Loop-Helix Repressor Proteins Acts as a 4-Amino-Acid Transcription Repression and Protein-Protein Interaction Domain
1996
Lethal of Scute requires overexpression of Daughterless to elicit ectopic neuronal development during embryogenesis in Drosophila
1997
The neurogenic suppressor of hairless DNA-binding protein mediates the transcriptional activation of the enhancer of split complex genes triggered by Notch signaling.
1995
Engineered receptors for soluble cellular communication and disease sensing
2024 StandoutNatureNobel
The Notch signalling pathway is required for Enhancer of split bHLH protein expression during neurogenesis in the Drosophila embryo
1994
Genes of the Enhancer of split and achaete-scute complexes are required for a regulatory loop between Notch and Delta during lateral signalling in Drosophila
1996
The Human Homolog of Rat Jagged1Expressed by Marrow Stroma Inhibits Differentiation of 32D Cells through Interaction with Notch1
1998
The suppressor of hairless protein participates in notch receptor signaling
1994
Intracellular Cleavage of Notch Leads to a Heterodimeric Receptor on the Plasma Membrane
1997
LIN-12/Notch signaling: lessons from worms and flies
1998
Notch and neurogenesis
1998
Nuclear Notch1 signaling and the regulation of dendritic development
2000
Nicastrin Functions as a γ-Secretase-Substrate Receptor
2005 StandoutNobel
Topology of the human and mouse m6A RNA methylomes revealed by m6A-seq
2012 StandoutNature
Roles of the ankyrin repeats and C-terminal region of the mouse Notch1 intracellular region
1998 StandoutNobel
Physical Principles of Membrane Shape Regulation by the Glycocalyx
2019 StandoutNobel
Alagille syndrome is caused by mutations in human Jagged1, which encodes a ligand for Notch1
1997
An Activated Form of Notch Influences the Choice between CD4 and CD8 T Cell Lineages
1996
Jagged: A mammalian ligand that activates notch1
1995
Neurogenic genes and vertebrate neurogenesis
1996
High-Resolution Mapping Reveals a Conserved, Widespread, Dynamic mRNA Methylation Program in Yeast Meiosis
2013 StandoutNobel
Mutations in erupted, the Drosophila Ortholog of Mammalian Tumor Susceptibility Gene 101, Elicit Non-Cell-Autonomous Overgrowth
2005
Oncogenic Forms of NOTCH1 Lacking Either the Primary Binding Site for RBP-Jκ or Nuclear Localization Sequences Retain the Ability to Associate with RBP-Jκ and Activate Transcription
1997
Notch Receptors, Partners and Regulators: From Conserved Domains to Powerful Functions
1998
The Notch Ligands, Jagged and Delta, Are Sequentially Processed by α-Secretase and Presenilin/γ-Secretase and Release Signaling Fragments
2003
Mouse Jagged1 Physically Interacts with Notch2 and Other Notch Receptors
1999
Osteoblastic cells regulate the haematopoietic stem cell niche
2003 StandoutNature
Inactivation of Conserved C. elegans Genes Engages Pathogen- and Xenobiotic-Associated Defenses
2012 StandoutNobel
A conserved face of the Jagged/Serrate DSL domain is involved in Notch trans-activation and cis-inhibition
2008
Cell Surface Presenilin-1 Participates in the γ-Secretase-like Proteolysis of Notch
1999
Regulation of expression of Vg and establishment of the dorsoventral compartment boundary in the wing imaginal disc by Suppressor of Hairless
2005
Control of Daughter Cell Fates during Asymmetric Division: Interaction of Numb and Notch
1996
Regulated portals of entry into the cell
2003 StandoutNature
Genetic mosaic with dual binary transcriptional systems in Drosophila
2006
The Dorsoventral Regulatory Gene Cassette spätzle/Toll/cactus Controls the Potent Antifungal Response in Drosophila Adults
1996 StandoutNobel
Kuz and TACE can activate Notch independent of ligand
2008
Notch Signaling – Constantly on the Move
2007
A common enzyme connects Notch signaling and Alzheimer's disease
2000
The Ins and Outs of Notch Signaling
1997
A Novel Proteolytic Cleavage Involved in Notch Signaling
2000 Standout
Presenilin is required for activity and nuclear access of Notch in Drosophila
1999 Nature
Molecular characterization of the Notch homologue from the Australian sheep blowfly, Lucilia cuprina
1998
The Conserved C2 Domain Protein Lethal (2) Giant Discs Regulates Protein Trafficking in Drosophila
2006
Requirement for Dynamin during Notch Signaling inDrosophilaNeurogenesis
1997
Microfibrillar Proteins MAGP-1 and MAGP-2 Induce Notch1 Extracellular Domain Dissociation and Receptor Activation
2006
Design of biologically active binary protein 2D materials
2021 StandoutNatureNobel
Structural basis for autoinhibition of Notch
2007
Synthetic Par polarity induces cytoskeleton asymmetry in unpolarized mammalian cells
2023 StandoutNobel
Notchic-ER chimeras display hormone-dependent transformation, nuclear accumulation, phosphorylation and CBF1 activation
2000
Functional Interaction between the Mouse Notch1 Intracellular Region and Histone Acetyltransferases PCAF and GCN5
2000 StandoutNobel
Indirect evidence for Delta-dependent intracellular processing of Notch in Drosophila embryos
1998
A human homologue of the Drosophila Toll protein signals activation of adaptive immunity
1997 StandoutNature
Embryonic lethality in mice homozygous for a processing-deficient allele of Notch1
2000 Nature
Requirements for Presenilin-Dependent Cleavage of Notch and Other Transmembrane Proteins
2000
Taking dendritic cells into medicine
2007 StandoutNatureNobel
OSM-11 Facilitates LIN-12 Notch Signaling during Caenorhabditis elegans Vulval Development
2008
Notch in vertebrates
1997
γ-Secretase-mediated proteolysis in cell-surface-receptor signalling
2002
Structure/function studies of lin-12/Notch proteins
1994
The many facets of Notch ligands
2008
Characterization of the Drosophila cactus locus and analysis of interactions between cactus and dorsal proteins
1992
Notch activation stimulates transient and selective binding of Su(H)/CSL to target enhancers
2007
The Notch amino terminus regulates protein levels and Delta-induced clustering of Drosophila Notch receptors
2004
Ectodomain Shedding and Intramembrane Cleavage of Mammalian Notch Proteins Are Not Regulated through Oligomerization
2004
A comprehensive compilation and alignment of histones and histone genes
1989
Human deltex is a conserved regulator of Notch signalling
1998
Instruction of Distinct CD4 T Helper Cell Fates by Different Notch Ligands on Antigen-Presenting Cells
2004 StandoutNobel
The disintegrin/metalloprotease ADAM 10 is essential for Notch signalling but not for alpha-secretase activity in fibroblasts
2002
A zebrafish homologue of the Drosophila neurogenic gene Notch and its pattern of transcription during early embryogenesis
1993
N6-methyladenosine-dependent regulation of messenger RNA stability
2013 StandoutNature
CED-1 Is a Transmembrane Receptor that Mediates Cell Corpse Engulfment in C. elegans
2001 StandoutNobel
Kuzbanian Controls Proteolytic Processing of Notch and Mediates Lateral Inhibition during Drosophila and Vertebrate Neurogenesis
1997
Notch is required for wingless signaling in the epidermis of Drosophila
1994
Correlating Notch Signaling with Thymocyte Maturation
1998
Notch1 Expression in Early Lymphopoiesis Influences B versus T Lineage Determination
1999 Standout
When cell biology meets development: endocytic regulation of signaling pathways
2002
The Canonical Notch Signaling Pathway: Unfolding the Activation Mechanism
2009 Standout
CRISPR-Mediated Modular RNA-Guided Regulation of Transcription in Eukaryotes
2013 StandoutNobel
Involvement of Notch-1 in mammalian retinal neurogenesis: association of Notch-1 activity with both immature and terminally differentiated cells
1995
Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche
2009 StandoutNature
Identification of High-Molecular-Weight Proteins with Multiple EGF-like Motifs by Motif-Trap Screening
1998
Roles for Proteolysis and Trafficking in Notch Maturation and Signal Transduction
1998
Neurogenic phenotypes and altered Notch processing in Drosophila Presenilin mutants
1999 Nature
Expression of the Notch 3 intracellular domain in mouse central nervous system progenitor cells is lethal and leads to disturbed neural tube development
1996
Rumi Is a CAP10 Domain Glycosyltransferase that Modifies Notch and Is Required for Notch Signaling
2008
The origin of the ankyrin repeat region in Notch intracellular domains is critical for regulation of HES promoter activity
2001
Physical interaction between a novel domain of the receptor Notch and the transcription factor RBP-Jκ/Su(H)
1995 StandoutNobel
Histone and histone gene compilation and alignment update
1991
Crystal Structures of a Complexed and Peptide-Free Membrane Protein–Binding Domain: Molecular Basis of Peptide Recognition by PDZ
1996 StandoutNobel
The Notch pathway: democracy and aristocracy in the selection of cell fate
1996
Notch receptor cleavage depends on but is not directly executed by presenilins
2002 StandoutNobel
Alterations in Notch signaling in neoplastic lesions of the human cervix.
1995
A mammalian oocyte-specific linker histone gene H1oo: homology with the genes for the oocyte-specific cleavage stage histone (cs-H1) of sea urchin and the B4/H1M histone of the frog
2001
Roles of the RAM and ANK domains in signaling by the C. elegans GLP-1 receptor.
1996
Suppressor of hairless directly activates transcription of enhancer of split complex genes in response to Notch receptor activity.
1995
Notch1 is essential for postimplantation development in mice.
1994
Drosophila Inducer of MEiosis 4 (IME4) is required for Notch signaling during oogenesis
2011
Transcriptional regulation of Notch and Delta: requirement for neuroblast segregation in Drosophila
1997
Transient and restricted expression during mouse embryogenesis of Dll1, a murine gene closely related to Drosophila Delta
1995
Growth Suppression of Pre-T Acute Lymphoblastic Leukemia Cells by Inhibition of Notch Signaling
2003
Circadian oscillations in period gene mRNA levels are transcriptionally regulated.
1992 StandoutNobel
Signal transduction by activated mNotch: importance of proteolytic processing and its regulation by the extracellular domain.
1996
Constitutive Activation of Toll-Mediated Antifungal Defense in Serpin-Deficient Drosophila
1999 StandoutScienceNobel
Nuclear Access and Action of Notch In Vivo
1998
The Drosophila Numb protein inhibits signaling of the Notch receptor during cell-cell interaction in sensory organ lineage.
1996
Cis-interactions between Delta and Notch modulate neurogenic signalling in Drosophila
1998
canoe encodes a novel protein containing a GLGF/DHR motif and functions with Notch and scabrous in common developmental pathways in Drosophila.
1995
The adhesion force of Notch with Delta and the rate of Notch signaling
2004
Notch as a Mediator of Cell Fate Determination in Hematopoiesis: Evidence and Speculation
1999
SUP-17, a Caenorhabditis elegans ADAM protein related to Drosophila KUZBANIAN, and its role in LIN-12/NOTCH signalling
1997
Subcellular localization of Suppressor of Hairless in Drosophila sense organ cells during Notch signalling
1996
Leukemia-Associated Mutations within the NOTCH1 Heterodimerization Domain Fall into at Least Two Distinct Mechanistic Classes
2006
Ligand endocytosis drives receptor dissociation and activation in the Notch pathway
2000
Suppressor of Hairless, the Drosophila homologue of RBP-J.KAPPA., transactivates the neurogenic gene E(spl)m8.
1995 StandoutNobel
Notch regulates wingless expression and is not required for reception of the paracrine wingless signal during wing margin neurogenesis in Drosophila
1995
The molecular logic of Notch signaling – a structural and biochemical perspective
2008
The histone fold: evolutionary questions.
1995 StandoutNobel
Exclusive development of T cell neoplasms in mice transplanted with bone marrow expressing activated Notch alleles.
1996 Nobel
Transduction of Notch2 in feline leukemia virus-induced thymic lymphoma
1996
Neoplastic Transformation by Truncated Alleles of Human NOTCH1/TAN1 and NOTCH2
1997 Nobel
Frequent provirus insertional mutagenesis of Notch1 in thymomas of MMTVD/myc transgenic mice suggests a collaboration of c-myc and Notch1 for oncogenesis.
1996
Binding of F-spondin to amyloid-β precursor protein: A candidate amyloid-β precursor protein ligand that modulates amyloid-β precursor protein cleavage
2004 StandoutNobel
Conservation of the biochemical mechanisms of signal transduction among mammalian Notch family members
2001 StandoutNobel
A Ligand-Induced Extracellular Cleavage Regulates γ-Secretase-like Proteolytic Activation of Notch1
2000
Inhibition of granulocytic differentiation by mNotch1
1996
The Taxonomy of Developmental Control in Caenorhabditis elegans
1998 StandoutScienceNobel
Deltex acts as a positive regulator of Notch signaling through interactions with the Notch ankyrin repeats
1995
Neural Science
2000 StandoutNobel
The Notch ligand Jagged1 is required for inner ear sensory development
2001
Lateral inhibition mediated by the Drosophila neurogenic gene delta is enhanced by proneural proteins.
1994
The roles of receptor and ligand endocytosis in regulating Notch signaling
2005
Calcium Depletion Dissociates and Activates Heterodimeric Notch Receptors
2000
The Notch ligand Delta1 is sequentially cleaved by an ADAM protease and γ-secretase
2003
DSL ligand endocytosis physically dissociates Notch1 heterodimers before activating proteolysis can occur
2007
A human homologue of the Drosophila developmental gene, Notch, is expressed in CD34+ hematopoietic precursors
1994
Genetic Analysis of Caenorhabditis elegans glp-1 Mutants Suggests Receptor Interaction or Competition
2003
Feedback regulation is central to Delta-Notch signalling required for Drosophila wing vein morphogenesis
1997
Msx2-interacting nuclear target protein (Mint) deficiency reveals negative regulation of early thymocyte differentiation by Notch/RBP-J signaling
2007 StandoutNobel
Toll-related receptors and the control of antimicrobial peptide expression inDrosophila
2000 StandoutNobel
Characterization of somatic cell nuclear reprogramming by oocytes in which a linker histone is required for pluripotency gene reactivation
2010 StandoutNobel
NOTCH AND PRESENILIN : Regulated Intramembrane Proteolysis Links Development and Degeneration
2003
Suppressor of Hairless-independent events in Notch signaling imply novel pathway elements
1997
Evidence for Physical and Functional Association Between EMB-5 and LIN-12 in Caenorhabditis elegans
1996 Science
Activated Notch Inhibits Myogenic Activity of the MADS-Box Transcription Factor Myocyte Enhancer Factor 2C
1999
Light-arousal and circadian photoreception circuits intersect at the large PDF cells of the Drosophila brain
2008 StandoutNobel
Ventralization of the Drosophila embryo by deletion of extracellular leucine-rich repeats in the Toll protein.
1995
Notch Signaling
1995 Science
Notch signaling: control of cell communication and cell fate
2004
Truncated Mammalian Notch1 Activates CBF1/RBPJk-Repressed Genes by a Mechanism Resembling That of Epstein-Barr Virus EBNA2
1996
The Abruptex domain of Notch regulates negative interactions between Notch, its ligands and Fringe
2000
RBP-L, a Transcription Factor Related to RBP-Jκ
1997 StandoutNobel
Notch Inhibition of E47 Supports the Existence of a Novel Signaling Pathway
1998
Mutually exclusive interaction of the CCAAT-binding factor and of a displacement protein with overlapping sequences of a histone gene promoter
1987
Conservation of neurogenic genes and mechanisms
1999
Notch Signaling: Cell Fate Control and Signal Integration in Development
1999 StandoutScience
The Notch1 receptor is cleaved constitutively by a furin-like convertase
1998
The Caenorhabditis elegans IMPAS gene, imp-2, is essential for development and is functionally distinct from related presenilins
2004 StandoutNobel
Disulfide cross-linking in crude embryonic lysates reveals three complexes of the Drosophila morphogen dorsal and its inhibitor cactus.
1994 StandoutNobel
Cell proliferation control by Notch signaling in Drosophila development
1998
Complex Proteolytic Processing Acts on Delta, a Transmembrane Ligand for Notch, duringDrosophilaDevelopment
1998
Notch1 is required for the coordinate segmentation of somites
1995
An activated Notch suppresses neurogenesis and myogenesis but not gliogenesis in mammalian cells
1994 StandoutNobel
The intracellular domain of mouse Notch: a constitutively activated repressor of myogenesis directed at the basic helix-loop-helix region of MyoD
1994
THE LIN-12/Notch SIGNALING PATHWAY AND ITS REGULATION
1997
Delta is a ventral to dorsal signal complementary to Serrate, another Notch ligand, in Drosophila wing formation.
1996
Activation of the kinase Pelle by Tube in the dorsoventral signal transduction pathway of Drosophila embryo
1994 StandoutNatureNobel
Dominant-negative mutation in the β2 and β6 proteasome subunit genes affect alternative cell fate decisions in the Drosophila sense organ lineage
1999
SKIP, a CBF1-Associated Protein, Interacts with the Ankyrin Repeat Domain of NotchIC To Facilitate NotchIC Function
2000
Recombination signal sequence-binding protein Jκ alters mesodermal cell fate decisions by suppressing cardiomyogenesis
2003 StandoutNobel
Binding of Delta1, Jagged1, and Jagged2 to Notch2 Rapidly Induces Cleavage, Nuclear Translocation, and Hyperphosphorylation of Notch2
2000
Sara endosomes and the asymmetric division of intestinal stem cells
2014
Serrate expression can functionally replace Delta activity during neuroblast segregation in the Drosophila embryo
1995
Works of Toby Lieber being referenced
Single amino acid substitutions in EGF-like elements of notch and delta modify drosophila development and affect cell adhesion in vitro
1992
The Abruptex Mutations of Notch Disrupt the Establishment of Proneural Clusters in Drosophila
1999
Ligand-induced cleavage and regulation of nuclear entry of Notch in Drosophila melanogaster embryos
1998
Furin cleavage is not a requirement for Drosophila Notch function
2002
kuzbanian-mediated cleavage of Drosophila Notch
2002
Analysis of histone gene expression in adult tissues of the sea urchins Strongylocentrotus purpuratus and Lytechinus pictus: tissue-specific expression of sperm histone genes.
1986
Antineurogenic phenotypes induced by truncated Notch proteins indicate a role in signal transduction and may point to a novel function for Notch in nuclei.
1993
The nucleotide sequence of the gene encoding the sperm specific histone subtype H2B-1 from the sea urchinStrongylocentrotus purpuratus
1986
Sea urchin (Lytechinus pictus) late-stage histone H3 and H4 genes: Characterization and mapping of a clustered but nontandemly linked multigene family
1982
Analysis of Histone Gene Expression in Adult Tissues of the Sea Urchins Strongylocentrotus purpuratus and Lytechinus pictus: Tissue-Specific Expression of Sperm Histone Genes
1986
A histone H1 protein in sea urchins is encoded by a poly(A)+ mRNA.
1988