Citation Impact
Citing Papers
Fetal Hemoglobin, Sickling, and Sickle Cell Disease
1990
The Molecular Genetics of Human Hemoglobin
1984
Rapamycin Inhibits the Generation of Graft-Versus-Host Disease- and Graft-Versus-Leukemia-Causing T Cells by Interfering with the Production of Th1 or Th1 Cytotoxic Cytokines
1998
The N-terminal Domain of a Glycolipid-anchored Prion Protein Is Essential for Its Endocytosis via Clathrin-coated Pits
1995
Phage-assisted evolution of an adenine base editor with improved Cas domain compatibility and activity
2020 StandoutNobel
Locus control regions of mammalian β-globin gene clusters: combining phylogenetic analyses and experimental results to gain functional insights
1997
Looping versus linking: toward a model for long-distance gene activation
1999
Pathogenesis and Treatment of Sickle Cell Disease
1997
Targeted Disruption of Results in a Complete Lack of Bone Formation owing to Maturational Arrest of Osteoblasts
1997 Standout
Chromatin Unfolds
1996
Epigenetics in human disease and prospects for epigenetic therapy
2004 StandoutNature
The β-Thalassemias
1999 Standout
Cleavage of poly(ADP-ribose) polymerase by a proteinase with properties like ICE
1994 StandoutNature
Effect of Hydroxyurea on the Frequency of Painful Crises in Sickle Cell Anemia
1995 Standout
Acute graft-vs-host disease
2001
Cytolytic pathways in haematopoietic stem-cell transplantation
2002
Fetal Hemoglobin in Sickle Cell Anemia: Determinants of Response to Hydroxyurea
1997
Hematopoiesis: An Evolving Paradigm for Stem Cell Biology
2008 Standout
The molecular basis of blood coagulation
1988 Standout
Extracellular Proteins Organize the Mechanosensory Channel Complex in C. elegans Touch Receptor Neurons
2004 StandoutNobel
Cell Death
2004 Standout
Crystal structure of the nucleosome core particle at 2.8 Å resolution
1997 StandoutNature
Transcriptional control of erythropoiesis: emerging mechanisms and principles
2007
NOVEL TREATMENT OPTIONS IN THE SEVERE β‐GLOBIN DISORDERS
1995
Erythroid transcription factor NF-E2 is a haematopoietic-specific basic–leucine zipper protein
1993 Nature
Graft-versus-host disease
2009 Standout
Investigational drugs in sickle cell anemia
2009
Simple Combinations of Lineage-Determining Transcription Factors Prime cis-Regulatory Elements Required for Macrophage and B Cell Identities
2010 Standout
Gene Silencing in Cancer in Association with Promoter Hypermethylation
2003 Standout
Prevention of a First Stroke by Transfusions in Children with Sickle Cell Anemia and Abnormal Results on Transcranial Doppler Ultrasonography
1998 Standout
Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals
2003 Standout
DNA Methylation Inhibitors in the Treatment of Leukemias, Myelodysplastic Syndromes and Hemoglobinopathies: Clinical Results and Possible Mechanisms of Action
2000
Selective Neuronal Targeting in Prion Disease
1997 StandoutNobel
TROY, a Newly Identified Member of the Tumor Necrosis Factor Receptor Superfamily, Exhibits a Homology with Edar and Is Expressed in Embryonic Skin and Hair Follicles
2000
Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis
1995 StandoutNature
Levels of Fetal Hemoglobin Necessary for Treatment of Sickle Cell Disease
1988
Sickle-cell disease
2010 Standout
Hematopoietic Stem-Cell Transplantation
2006 Standout
Regulation of β-globin gene expression: straightening out the locus
1996
Hemophilia B (factor IXSeattle 2) due to a single nucleotide deletion in the gene for factor IX.
1987
Cytotoxic lymphocytes require granzyme B for the rapid induction of DNA fragmentation and apoptosis in allogeneic target cells
1994
Identification of the haemoglobin scavenger receptor
2001 StandoutNature
Impaired Immunity and Enhanced Resistance to Endotoxin in the Absence of Neutrophil Elastase and Cathepsin G
2000
Genomic and Epigenomic Landscapes of Adult De Novo Acute Myeloid Leukemia
2013 Standout
Immunobiology of acute graft-versus-host disease
2003
The Fas Death Factor
1995 StandoutScience
Disseminated Intravascular Coagulation
1999 Standout
A clonogenic common myeloid progenitor that gives rise to all myeloid lineages
2000 StandoutNature
Squamous Cell Carcinoma Antigen 2 Is a Novel Serpin That Inhibits the Chymotrypsin-like Proteinases Cathepsin G and Mast Cell Chymase
1997
Long-term hydroxyurea treatment in young sickle cell patients
1999
The TNF and TNF Receptor Superfamilies
2001 Standout
Treatment of Sickle Cell Anemia with Hydroxyurea and Erythropoietin
1990
Jak2 Is Essential for Signaling through a Variety of Cytokine Receptors
1998 Standout
Position-independent, high-level expression of the human β-globin gene in transgenic mice
1987 Standout
Pharmacologic Modulation of Fetal Hemoglobin
2001
Extended Therapy with Intravenous Arginine Butyrate in Patients with β-Hemoglobinopathies
1995
Identification of human granzyme B promoter regulatory elements interacting with activated T-cell-specific proteins: implication of Ikaros and CBF binding sites in promoter activation.
1995
Advances in thalassemia research
1984
Hydroxyurea induction of hemoglobin F production in sickle cell disease: relationship between cytotoxicity and F cell production
1986
mRNA surveillance by the Caenorhabditis elegans smg genes.
1993
Effects of 5-aza-2′-deoxycytidine on fetal hemoglobin levels, red cell adhesion, and hematopoietic differentiation in patients with sickle cell disease
2003
When cells stop making sense: effects of nonsense codons on RNA metabolism in vertebrate cells.
1995
Nonsense mutations inhibit splicing of MVM RNA in cis when they interrupt the reading frame of either exon of the final spliced product.
1992
Serpin Structure, Mechanism, and Function
2002 Standout
High-penetrance mouse model of acute promyelocytic leukemia with very low levels of PML-RARα expression
2003
A gene deletion ending within a complex array of repeated sequences 3' to the human beta-globin gene cluster.
1986 StandoutNobel
The Locus Control Region Is Necessary for Gene Expression in the Human β-Globin Locus but Not the Maintenance of an Open Chromatin Structure in Erythroid Cells
1998
Hydroxyurea: effects on hemoglobin F production in patients with sickle cell anemia [see comments]
1992
Nucleotide sequence of 16-kilobase pairs of DNA 5' to the human epsilon-globin gene.
1985 StandoutNobel
Is there a threshold level of fetal hemoglobin that ameliorates morbidity in sickle cell anemia?
1984
Apoptosis in the Pathogenesis and Treatment of Disease
1995 StandoutScience
Induction of fetal hemoglobin production in subjects with sickle cell anemia by oral sodium phenylbutyrate
1994
A ChineseGγ+(Aγδβ)0thalassemia deletion: comparison to other deletions in the human β-globin gene cluster and sequence analysis of the breakpoints
1985 StandoutNobel
On the induction of fetal hemoglobin by butyrates: in vivo and in vitro studies with sodium butyrate and comparison of combination treatments with 5-AzaC and AraC
1989
Illegitimate Cre-dependent chromosome rearrangements in transgenic mouse spermatids
2000 StandoutNobel
Prion Diseases and the BSE Crisis
1997 StandoutScienceNobel
Inactivation of the human beta-globin gene by targeted insertion into the beta-globin locus control region.
1992
Sustained induction of fetal hemoglobin by pulse butyrate therapy in sickle cell disease.
1999
The primacy of the gastrointestinal tract as a target organ of acute graft-versus-host disease: rationale for the use of cytokine shields in allogeneic bone marrow transplantation
2000
Prions
1998 StandoutNobel
Transcriptional regulation of fetal to adult hemoglobin switching: new therapeutic opportunities
2011
Beta-globin nonsense mutation: deficient accumulation of mRNA occurs despite normal cytoplasmic stability.
1992
Ribosome Components Are Associated with Sites of Transcription
2002 StandoutNobel
Immunobiology of Allogeneic Hematopoietic Stem Cell Transplantation
2006
Regulated expression of globin chains and the erythroid transcription factor GATA-1 during erythropoiesis in the developing mouse.
1990
RNA as a target of double-stranded RNA-mediated genetic interference in Caenorhabditis elegans
1998 StandoutNobel
Targeted deletion of 5'HS2 of the murine beta-globin LCR reveals that it is not essential for proper regulation of the beta-globin locus.
1995
Glycolipid-anchored proteins in neuroblastoma cells form detergent-resistant complexes without caveolin.
1995
Lethal thalassemia after insertional disruption of the mouse major adult beta-globin gene.
1993 StandoutNobel
Subcellular colocalization of the cellular and scrapie prion proteins in caveolae-like membranous domains
1996 StandoutNobel
Correction of a human beta S-globin gene by gene targeting.
1991 StandoutNobel
Locus control region-A gamma transgenic mice: a new model for studying the induction of fetal hemoglobin in the adult
1991
Histone H3K27ac separates active from poised enhancers and predicts developmental state
2010 Standout
Antigen-Specific Cytotoxicity by Invariant NKT Cells In Vivo Is CD95/CD178-Dependent and Is Correlated with Antigenic Potency
2010 StandoutNobel
Cell Survival Promoted by the Ras-MAPK Signaling Pathway by Transcription-Dependent and -Independent Mechanisms
1999 StandoutScience
Altering mice by homologous recombination using embryonic stem cells.
1994 StandoutNobel
The silent carrier allele: β thalassemia without a mutation in the β-globin gene or its immediate flanking regions
1984 StandoutNobel
Lymphocyte-Mediated Cytotoxicity
2002
An "in-out" strategy using gene targeting and FLP recombinase for the functional dissection of complex DNA regulatory elements: analysis of the beta-globin locus control region.
1993
Tissue-specific factors additively increase the probability of the all-or-none formation of a hypersensitive site.
1996
Nonsense mutations in the dihydrofolate reductase gene affect RNA processing.
1989
Changes in DNA Methylation in Neoplasia: Pathophysiology and Therapeutic Implications
2001
Conservation of the primary structure, organization, and function of the human and mouse beta-globin locus-activating regions.
1990
COOH-terminal sequence of the cellular prion protein directs subcellular trafficking and controls conversion into the scrapie isoform
1997 StandoutNobel
Conservation of sequence and structure flanking the mouse and human β-globin loci: The β-globin genes are embedded within an array of odorant receptor genes
1999 StandoutNobel
Mechanisms and Genes of Cellular Suicide
1995 StandoutScience
Induction of bcl-2 Expression by Phosphorylated CREB Proteins during B-Cell Activation and Rescue from Apoptosis
1996
B7 Expression on T Cells Down-Regulates Immune Responses through CTLA-4 Ligation via R-T Interactions
2004 StandoutNobel
Works of TJ Ley being referenced
Beta O-39 thalassemia gene: a premature termination codon causes beta- mRNA deficiency without affecting cytoplasmic beta-mRNA stability
1984
The pharmacology of hemoglobin switching: of mice and men
1991
Consensus AP-1 and CRE motifs upstream from the human cytotoxic serine protease B (CSP-B/CGL-1) gene synergize to activate transcription
1993
Hydroxyurea induction of hemoglobin F production in sickle cell disease: relationship between cytotoxicity and F cell production
1986
The role of granzyme B in murine models of acute graft-versus-host disease and graft rejection
1996
5-Azacytidine increases gamma-globin synthesis and reduces the proportion of dense cells in patients with sickle cell anemia
1983
Functional properties of the beta-globin locus control region in K562 erythroleukemia cells
1991
Function of normal and mutated gamma-globin gene promoters in electroporated K562 erythroleukemia cells
1990
Molecular cloning, chromosomal location, and tissue-specific expression of the murine cathepsin G gene
1993
5-Azacytidine increases gamma-globin synthesis and reduces the proportion of dense cells in patients with sickle cell anemia
1983
Advances in thalassemia research
1984