Citation Impact
Citing Papers
Schizosacharomyces pombe RNA polymerase II at 3.6-Å resolution
2009 Nobel
The 2016 revision of the World Health Organization classification of lymphoid neoplasms
2016 Standout
MicroRNA genes are transcribed by RNA polymerase II
2004 Standout
Guidelines for the welfare and use of animals in cancer research
2010 Standout
Identification of a Small Interface between the Methyltransferase and RNA Polymerase of NS5 that is Essential for Zika Virus Replication
2018 StandoutNobel
Endothelial E-selectin inhibition improves acute myeloid leukaemia therapy by disrupting vascular niche-mediated chemoresistance
2020
The promise and challenge of therapeutic genome editing
2020 StandoutNatureNobel
Chromatin Reader Brd4 Functions in Ig Class Switching as a Repair Complex Adaptor of Nonhomologous End-Joining
2014 StandoutNobel
The General Transcription Machinery and General Cofactors
2006
The role of TFIIB-RNA polymerase II interaction in start site selection in yeast cells
2002
The ϕ29 DNA polymerase:protein‐primer structure suggests a model for the initiation to elongation transition
2006 StandoutNobel
Leukemic Stem Cells Evade Chemotherapy by Metabolic Adaptation to an Adipose Tissue Niche
2016
The mechanisms of Hedgehog signalling and its roles in development and disease
2013 Standout
Anti-apoptotic Mcl-1 is essential for the development and sustained growth of acute myeloid leukemia
2012
Regulation of interaction of the acetyltransferase region of p300 and the DNA‐binding domain of Sp1 on and through DNA binding
2000
The Role of Human TFIIB in Transcription Start Site Selection in Vitro and in Vivo
1999
Evidence That Transcription Factor IIB Is Required for a Post-assembly Step in Transcription Initiation
1999
RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia
2011 StandoutNature
Expanding the Biologist’s Toolkit with CRISPR-Cas9
2015 StandoutNobel
Visualizing polynucleotide polymerase machines at work
2006 StandoutNobel
Binding of TFIIB to RNA Polymerase II
2003
Hallmarks of aging: An expanding universe
2023 Standout
Structural basis of eukaryotic gene transcription
2004 StandoutNobel
The Hedgehog's tale: developing strategies for targeting cancer
2011
Influence of tumour micro-environment heterogeneity on therapeutic response
2013 StandoutNature
Cancer Epigenetics: From Mechanism to Therapy
2012 Standout
In vivo engineering of oncogenic chromosomal rearrangements with the CRISPR/Cas9 system
2014 Nature
Intermediates in formation and activity of the RNA polymerase II preinitiation complex: holoenzyme recruitment and a postrecruitment role for the TATA box and TFIIB
1999
Cancer stem cells revisited
2017 Standout
Acetyl Coenzyme A: A Central Metabolite and Second Messenger
2015
Two Functionally Distinct Forms of the RSC Nucleosome-Remodeling Complex, Containing Essential AT Hook, BAH, and Bromodomains
1999 StandoutNobel
RNA polymerase II–TFIIB structure and mechanism of transcription initiation
2009 Nature
Recruitment of RNA polymerase III to its target promoters
2002
The Role of Transcription Factor B in Transcription Initiation and Promoter Clearance in the Archaeon Sulfolobus acidocaldarius
2000
Structure and mechanism of the RNA polymerase II transcription machinery
2004
Stable RNA interference rules for silencing
2013
Cancer-associated IDH2 mutants drive an acute myeloid leukemia that is susceptible to Brd4 inhibition
2013
Unraveling the therapeutic potential of the Hedgehog pathway in cancer
2013 Standout
Tumour heterogeneity and cancer cell plasticity
2013 StandoutNature
The clinical impact of glycobiology: targeting selectins, Siglecs and mammalian glycans
2021 StandoutNobel
Targeting metastasis-initiating cells through the fatty acid receptor CD36
2016 Nature
Toolkit for evaluating genes required for proliferation and survival using tetracycline-regulated RNAi
2010
The Role of Chromatin during Transcription
2007 Standout
Mediator as a General Transcription Factor
2005 StandoutNobel
Control of apoptosis by the BCL-2 protein family: implications for physiology and therapy
2013 Standout
Modeling and predicting clinical efficacy for drugs targeting the tumor milieu
2012
Understanding the Intersections between Metabolism and Cancer Biology
2017 Standout
Structure of a (Cys3His) zinc ribbon, a ubiquitous motif in archaeal and eucaryal transcription
2000
CRISPR-Based Technologies for the Manipulation of Eukaryotic Genomes
2016 Standout
The PI3K Pathway in Human Disease
2017 Standout
Cornerstones of CRISPR–Cas in drug discovery and therapy
2016 StandoutNobel
A decade of exploring the cancer epigenome — biological and translational implications
2011 Standout
Cell of origin determines clinically relevant subtypes of MLL-rearranged AML
2012
CasX enzymes comprise a distinct family of RNA-guided genome editors
2019 StandoutNatureNobel
Dissecting the Regulatory Circuitry of a Eukaryotic Genome
1998 Standout
Distinct and predictive chromatin signatures of transcriptional promoters and enhancers in the human genome
2007 Standout
A Novel Subunit of Yeast RNA Polymerase III Interacts with the TFIIB-Related Domain of TFIIIB70
2000
MLL3 Is a Haploinsufficient 7q Tumor Suppressor in Acute Myeloid Leukemia
2014
Identification of microRNAs of the herpesvirus family
2005 StandoutNobel
An integrated approach to dissecting oncogene addiction implicates a Myb-coordinated self-renewal program as essential for leukemia maintenance
2011
Genome-editing revolution: My whirlwind year with CRISPR
2015 StandoutNatureNobel
Molecular Genetics of the RNA Polymerase II General Transcriptional Machinery
1998
Architecture of an RNA Polymerase II Transcription Pre-Initiation Complex
2013 StandoutScienceNobel
The Structure of a Transcribing T7 RNA Polymerase in Transition from Initiation to Elongation
2008 StandoutScienceNobel
Diffusion of nucleoside triphosphates and role of the entry site to the RNA polymerase II active center
2004 StandoutNobel
Acute Myeloid Leukemia
2015 Standout
The Organocatalytic Approach to Enantiopure 2H‐ and 3H‐Pyrroles: Inhibitors of the Hedgehog Signaling Pathway
2016 StandoutNobel
The ProTide Prodrug Technology: From the Concept to the Clinic
2017
Conservation of Glutamine-Rich Transactivation Function between Yeast and Humans
2000
Histone Acetyltransferases
2001 Standout
The new frontier of genome engineering with CRISPR-Cas9
2014 StandoutScienceNobel
Genomic Engineering and the Future of Medicine
2015 StandoutNobel
Core Promoter-Dependent TFIIB Conformation and a Role for TFIIB Conformation in Transcription Start Site Selection
2002
Spermidine in health and disease
2018 StandoutScience
Metabolic reprogramming and cancer progression
2020 StandoutScience
Cancer Genome Landscapes
2013 StandoutScience
Complete, 12-subunit RNA polymerase II at 4.1-Å resolution: Implications for the initiation of transcription
2003 StandoutNobel
Peripheral T‐cell and NK ‐cell lymphomas and their mimics; taking a step forward – report on the lymphoma workshop of the XVI th meeting of the European Association for Haematopathology and the Society for Hematopathology
2013
The RNA Polymerase II Core Promoter
2003
Structural Basis of Transcription: An RNA Polymerase II-TFIIB Cocrystal at 4.5 Angstroms
2004 StandoutScienceNobel
SPT20/ADA5 Encodes a Novel Protein Functionally Related to the TATA-Binding Protein and Important for Transcription in Saccharomyces cerevisiae
1996
Quantitative Characterization of Domain Motions in Molecular Machines
2017 StandoutNobel
Swift Is a Novel BRCT Domain Coactivator of Smad2 in Transforming Growth Factor β Signaling
2001 StandoutNobel
A cluster of cooperating tumor-suppressor gene candidates in chromosomal deletions
2012
Phase 2 trial of CPX-351, a fixed 5:1 molar ratio of cytarabine/daunorubicin, vs cytarabine/daunorubicin in older adults with untreated AML
2014
The zinc ribbon domains of the general transcription factors TFIIB and Brf: conserved functional surfaces but different roles in transcription initiation
2000
Works of Timothy S. Pardee being referenced
A Phase I Study of the First-in-Class Antimitochondrial Metabolism Agent, CPI-613, in Patients with Advanced Hematologic Malignancies
2014
Flt3-ITD alters chemotherapy response in vitro and in vivo in a p53-dependent manner
2011
Improving nucleoside analogs via lipid conjugation: Is fatter any better?
2016
Mouse models of human AML accurately predict chemotherapy response
2009
The Glutamine-Rich Activation Domains of Human Sp1 Do Not Stimulate Transcription in Saccharomyces cerevisiae
1995
Subcutaneous panniculitis-like T cell lymphoma with mesenteric involvement
2012
The N-terminal Region of Yeast TFIIB Contains Two Adjacent Functional Domains Involved in Stable RNA Polymerase II Binding and Transcription Start Site Selection
1998
Mutational Analysis of the D1/E1 Core Helices and the Conserved N-Terminal Region of Yeast Transcription Factor IIB (TFIIB): Identification of an N-terminal Mutant That Stabilizes TATA-Binding Protein-TFIIB-DNA Complexes
1997