Citation Impact
Citing Papers
Targeted gene evolution in Escherichia coli using a highly error-prone DNA polymerase I
2003
Expanded therapeutic potential in activity space of next-generation 5-nitroimidazole antimicrobials with broad structural diversity
2013 StandoutNobel
Protein interaction networks revealed by proteome coevolution
2019 StandoutScienceNobel
Bridging the gaps in design methodologies by evolutionary optimization of the stability and proficiency of designed Kemp eliminase KE59
2012 StandoutNobel
Removing T-cell epitopes with computational protein design
2014 StandoutNobel
GEMME: A Simple and Fast Global Epistatic Model Predicting Mutational Effects
2019
Thermodynamic prediction of protein neutrality
2005 StandoutNobel
Evolution of new nonantibody proteins via iterative somatic hypermutation
2004 StandoutNobel
A possible mechanism for exonuclease 1-independent eukaryotic mismatch repair
2009 StandoutNobel
Protein stability promotes evolvability
2006 StandoutNobel
Intense Neutral Drifts Yield Robust and Evolvable Consensus Proteins
2008
Saccharomyces cerevisiae MutLα Is a Mismatch Repair Endonuclease
2007 StandoutNobel
De novo design of modular and tunable protein biosensors
2021 StandoutNatureNobel
De novo design of allosterically switchable protein assemblies
2024 StandoutNatureNobel
Novel imidazole substituted 6-methylidene-penems as broad-spectrum β-lactamase inhibitors
2004
Mutagenesis of amino acid residues in the SHV-1 β-lactamase: the premier role of Gly238Ser in penicillin and cephalosporin resistance
2001
Origin and impact of plasmid-mediated extended-spectrum beta-lactamases
1994
Engineering and characterization of a superfolder green fluorescent protein
2005 Standout
extradenticle, a regulator of homeotic gene activity, is a homolog of the homeobox-containing human proto-oncogene pbx1
1993 StandoutNobel
Combinatorial and computational challenges for biocatalyst design
2001 StandoutNatureNobel
Crystal structure of the human β2 adrenergic G-protein-coupled receptor
2007 StandoutNatureNobel
Robustness–epistasis link shapes the fitness landscape of a randomly drifting protein
2006 Nature
Expression and Purification of the Saccharomyces cerevisiae α-Factor Receptor (Ste2p), a 7-Transmembrane-segment G Protein-coupled Receptor
1997
The Hox-1.3 homeo box protein is a sequence-specific DNA-binding phosphoprotein.
1989
Components and Dynamics of DNA Replication Complexes in S. cerevisiae: Redistribution of MCM Proteins and Cdc45p during S Phase
1997
CRISPR-Cas9 Circular Permutants as Programmable Scaffolds for Genome Modification
2019 StandoutNobel
When Checkpoints Fail
1997 StandoutNobel
Structure-guided SCHEMA recombination of distantly related β-lactamases
2006 StandoutNobel
Evolution of an Antibiotic Resistance Enzyme Constrained by Stability and Activity Trade-offs
2002
“Break Copy” Duplication: A Model for Chromosome Fragment Formation in Saccharomyces cerevisiae
1997
Protein building blocks preserved by recombination
2002 StandoutNobel
Telomere Dysfunction Increases Mutation Rate and Genomic Instability
2001 StandoutNobel
Library analysis of SCHEMA‐guided protein recombination
2003 StandoutNobel
Sister chromatids are preferred over homologs as substrates for recombinational repair in Saccharomyces cerevisiae.
1992 StandoutNobel
Predicting and interpreting large-scale mutagenesis data using analyses of protein stability and conservation
2022
Predicting the emergence of antibiotic resistance by directed evolution and structural analysis.
2001
Acyl-intermediate Structures of the Extended-spectrum Class A β-Lactamase, Toho-1, in Complex with Cefotaxime, Cephalothin, and Benzylpenicillin
2002
The coming of age of de novo protein design
2016 StandoutNatureNobel
Role of Ser-237 in the substrate specificity of the carbapenem-hydrolyzing class A β-lactamase Sme-1
1999
MX2 is an interferon-induced inhibitor of HIV-1 infection
2013 StandoutNatureNobel
Inhibitor-resistant TEM -lactamases: phenotypic, genetic and biochemical characteristics
1999
Kemp elimination catalysts by computational enzyme design
2008 StandoutNatureNobel
Ultrahigh Resolution Structure of a Class A β-Lactamase: On the Mechanism and Specificity of the Extended-spectrum SHV-2 Enzyme
2003
Protein binding specificity versus promiscuity
2010
Mutation effects predicted from sequence co-variation
2017
Computational Design of Calmodulin Mutants with up to 900-Fold Increase in Binding Specificity
2008
Site-saturation Mutagenesis of Tyr-105 Reveals Its Importance in Substrate Stabilization and Discrimination in TEM-1 β-Lactamase
2004
Crystal structure of Escherichia coli TEM1 β‐lactamase at 1.8 Å resolution
1993
The Cdt1 protein is required to license DNA for replication in fission yeast
2000 StandoutNatureNobel
Extreme Genetic Fragility of the HIV-1 Capsid
2013
Rapid evolution of a protein in vitro by DNA shuffling
1994 Nature
Emerging role of homo- and heterodimerization in G-protein-coupled receptor biosynthesis and maturation
2005
Hydrolysis of Third-generation Cephalosporins by Class C β-Lactamases
2004
Site-directed Mutagenesis of Glutamate 166 in Two β-Lactamases
1997
β-Lactamase inhibitors: evolving compounds for evolving resistance targets
2004
Evolution and epidemiology of extended-spectrum β-lactamases (ESBLs) and ESBL-producing microorganisms
2001
General Method for Sequence-independent Site-directed Chimeragenesis
2003 StandoutNobel
The binary protein-protein interaction landscape of Escherichia coli
2014
Missense meanderings in sequence space: a biophysical view of protein evolution
2005
The molecular architecture of protein–protein binding sites
2007
Repurposing CRISPR as an RNA-Guided Platform for Sequence-Specific Control of Gene Expression
2013 StandoutNobel
Kinetic role of early intermediates in protein folding
1997
beta-Lactamases in laboratory and clinical resistance
1995
PCNA function in the activation and strand direction of MutLα endonuclease in mismatch repair
2010 StandoutNobel
Purification and characterization of proteins that bind to yeast ARSs.
1988
Amino Acid Substitutions at Ambler Position Gly238 in the SHV-1 β-Lactamase: Exploring Sequence Requirements for Resistance to Penicillins and Cephalosporins
2002
The structural and energetic basis for high selectivity in a high-affinity protein-protein interaction
2010 StandoutNobel
Search and Discovery Strategies for Biotechnology: the Paradigm Shift
2000
23S rRNA base pair 2057–2611 determines ketolide susceptibility and fitness cost of the macrolide resistance mutation 2058A→G
2005 StandoutNobel
Checkpoints: Controls That Ensure the Order of Cell Cycle Events
1989 StandoutScienceNobel
Computational method to reduce the search space for directed protein evolution
2001 StandoutNobel
IMP-12, a New Plasmid-Encoded Metallo-β-Lactamase from a Pseudomonas putida Clinical Isolate
2003
In the light of directed evolution: Pathways of adaptive protein evolution
2009 StandoutNobel
Resistance to β-Lactamase Inhibitor Protein Does Not Parallel Resistance to Clavulanic Acid in TEM β-Lactamase Mutants
2002
RNA Polymerase II Initiation Factor Interactions and Transcription Start Site Selection
1994 StandoutScienceNobel
Global Protein−Protein Interaction Network in the Human Pathogen Mycobacterium tuberculosis H37Rv
2010
Bacterial Resistance to β-Lactam Antibiotics: Compelling Opportunism, Compelling Opportunity
2005 Standout
Advances, Interactions, and Future Developments in the CNS, Phenix, and Rosetta Structural Biology Software Systems
2013 StandoutNobel
Growing Group of Extended-Spectrum β-Lactamases: the CTX-M Enzymes
2003
Directed evolution of a thermostable esterase
1998 StandoutNobel
The Structure of a Thermophilic Kinase Shapes Fitness upon Random Circular Permutation
2016
A possible role for the yeast TATA-element-binding protein in DNA replication.
1993
PMS2 endonuclease activity has distinct biological functions and is essential for genome maintenance
2010 StandoutNobel
Darwinian Evolution Can Follow Only Very Few Mutational Paths to Fitter Proteins
2006 Science
Pathway correcting DNA replication errors in Saccharomyces cerevisiae.
1993
Three Decades of β-Lactamase Inhibitors
2010 Standout
Molecular breeding: The natural approach to protein design
2001
Yeast chromosome replication and segregation
1988
A family of thermostable fungal cellulases created by structure-guided recombination
2009 StandoutNobel
Switchable Reporter Enzymes Based on Mutually Exclusive Domain Interactions Allow Antibody Detection Directly in Solution
2013
A structural view of evolutionary divergence
1999 StandoutNobel
Optical measurement of synaptic glutamate spillover and reuptake by linker optimized glutamate-sensitive fluorescent reporters
2008 StandoutNobel
An Engineered Disulfide Bond between Residues 69 and 238 in Extended-Spectrum β-Lactamase Toho-1 Reduces Its Activity toward Third-Generation Cephalosporins
2004
Enzyme Redesign
2001
A functional classification scheme for beta-lactamases and its correlation with molecular structure
1995 Standout
Mutant TEM β-Lactamase Producing Resistance to Ceftazidime, Ampicillins, and β-Lactamase Inhibitors
2002
On the conservative nature of intragenic recombination
2005 StandoutNobel
Flexible Gates: Dynamic Topologies and Functions for FG Nucleoporins in Nucleocytoplasmic Transport
2009
NanoLuc Complementation Reporter Optimized for Accurate Measurement of Protein Interactions in Cells
2015
Ultrasensitive magnetic biosensor for homogeneous immunoassay
2000 StandoutNobel
How β-Lactamases Have Driven Pharmaceutical Drug Discovery
1998
The Fluorescent Toolbox for Assessing Protein Location and Function
2006 StandoutScienceNobel
Structural insight into TRPV5 channel function and modulation
2019 StandoutNobel
Design of a hyperstable 60-subunit protein icosahedron
2016 StandoutNatureNobel
Extrahelical (CAG)/(CTG) triplet repeat elements support proliferating cell nuclear antigen loading and MutLα endonuclease activation
2013 StandoutNobel
Identification and purification of a factor that binds to the Mlu I cell cycle box of yeast DNA replication genes.
1991 StandoutNobel
Integrating Genetic Approaches into the Discovery of Anticancer Drugs
1997 StandoutScienceNobel
Dynamic Control of Chiral Space in a Catalytic Asymmetric Reaction Using a Molecular Motor
2011 StandoutScienceNobel
Extended-Spectrum β-Lactamases in the 21st Century: Characterization, Epidemiology, and Detection of This Important Resistance Threat
2001 Standout
Using deep mutational scanning to benchmark variant effect predictors and identify disease mutations
2020
Accurate proteome-wide missense variant effect prediction with AlphaMissense
2023 StandoutScienceNobel
De novo design of protein logic gates
2020 StandoutScienceNobel
Metabolic labeling enables selective photocrosslinking of O-GlcNAc-modified proteins to their binding partners
2012 StandoutNobel
Limited internal friction in the rate-limiting step of a two-state protein folding reaction
1998 StandoutNobel
Engineering of protease variants exhibiting high catalytic activity and exquisite substrate selectivity
2005
Works of Timothy Palzkill being referenced
The protein network of bacterial motility
2007
Fine Mapping of the Sequence Requirements for Binding of β-Lactamase Inhibitory Protein (BLIP) to TEM-1 β-Lactamase Using a Genetic Screen for BLIP Function
2009
Deep Sequencing of Systematic Combinatorial Libraries Reveals β-Lactamase Sequence Constraints at High Resolution
2012
Contributions of Aspartate 49 and Phenylalanine 142 Residues of a Tight Binding Inhibitory Protein of β-Lactamases
1999
Evolution of antibiotic resistance: several different amino acid substitutions in an active site loop alter the substrate profile of β‐lactamase
1994
Mapping protein–ligand interactions using whole genome phage display libraries
1998
Analysis of a circular derivative of Saccharomyces cerevisiae chromosome III: a physical map and identification and location of ARS elements.
1991
Analysis of the Context Dependent Sequence Requirements of Active Site Residues in the Metallo-β-lactamase IMP-1
2004
Identification of residues critical for metallo‐β‐lactamase function by codon randomization and selection
2001
The Role of Residue 238 of TEM-1 β-Lactamase in the Hydrolysis of Extended-spectrum Antibiotics
1998
A broad-spectrum peptide inhibitor of -lactamase identified using phage display and peptide arrays
2003
Cephalosporin Substrate Specificity Determinants of TEM-1 β-Lactamase
1997
The Binary Protein Interactome of Treponema pallidum – The Syphilis Spirochete
2008
Thermodynamic Investigation of the Role of Contact Residues of β-Lactamase-inhibitory Protein for Binding to TEM-1 β-Lactamase
2007
How Structural and Physicochemical Determinants Shape Sequence Constraints in a Functional Enzyme
2015
Dissecting the Protein-Protein Interface between β-Lactamase Inhibitory Protein and Class A β-Lactamases
2004
Co-Crystal Structures of PKG Iβ (92–227) with cGMP and cAMP Reveal the Molecular Details of Cyclic-Nucleotide Binding
2011
Identification of Residues in β-Lactamase Critical for Binding β-Lactamase Inhibitory Protein
1999
Probing β‐lactamase structure and function using random replacement mutagenesis
1992
Penicillin-derived inhibitors that simultaneously target both metallo- and serine-β-lactamases
2004
Determinants of Binding Affinity and Specificity for the Interaction of TEM-1 and SME-1 β-Lactamase with β-Lactamase Inhibitory Protein
2003
Selection and Characterization of Amino Acid Substitutions at Residues 237-240 of TEM-1 β-Lactamase with Altered Substrate Specificity for Aztreonam and Ceftazidime
1996
A yeast replication origin consists of multiple copies of a small conserved sequence
1988
β-Lactamases: protein evolution in real time
1998
The rate-limiting step in the folding of thecis-Pro167Thr mutant of TEM-1 β-lactamase is thetranstocisisomerization of a non-proline peptide bond
1996
Using peptide arrays to define nuclear carrier binding sites on nucleoporins
2006
Amino Acid Sequence Determinants of β-Lactamase Structure and Activity
1996
Structure–function analysis of α-helix H4 using PSE-4 as a model enzyme representative of class A β-lactamases
2000
Evaluation of penicillin-based inhibitors of the class A and B β-lactamases from Bacillus anthracis
2003
DNA sequence analysis ofARSelements from chromosome III ofSaccharomyces cerevisiae: identification of a new conserved sequence
1986
Identification of amino acid substitutions that alter the substrate specificity of TEM-1 beta-lactamase
1992
Roles of Amino Acids 161 to 179 in the PSE-4 Ω Loop in Substrate Specificity and in Resistance to Ceftazidime
1998
A natural polymorphism in β-lactamase is a global suppressor
1997
Outbreak of ceftazidime resistance due to a novel extended-spectrum beta-lactamase in isolates from cancer patients
1992
New variant of TEM-10 beta-lactamase gene produced by a clinical isolate of proteus mirabilis
1995
Binding Properties of a Peptide Derived from β-Lactamase Inhibitory Protein
2001
Characterization of a PSE-4 Mutant with Different Properties in Relation to Penicillanic Acid Sulfones: Importance of Residues 216 to 218 in Class A β-Lactamases
1998
A secondary drug resistance mutation of TEM-1 β-lactamase that suppresses misfolding and aggregation
2000
Systematic mutagenesis of the yeast mating pheromone receptor third intracellular loop.
1994
Systematic mutagenesis of the active site omega loop of TEM-1 beta-lactamase
1996
Amino Acid Sequence Requirements at Residues 69 and 238 for the SME-1 β-Lactamase To Confer Resistance to β-Lactam Antibiotics
2003
Characterization of TEM-1 beta-lactamase mutants from positions 238 to 241 with increased catalytic efficiency for ceftazidime.
1994