Citation Impact
Citing Papers
Partitioning of Lipid-Modified Monomeric GFPs into Membrane Microdomains of Live Cells
2002 StandoutScienceNobel
Properties regulating the nature of the plasmacytoid dendritic cell response to Toll-like receptor 9 activation
2006
Role of LBPA and Alix in Multivesicular Liposome Formation and Endosome Organization
2004 StandoutScienceNobel
Homotypic fusion of early endosomes: SNAREs do not determine fusion specificity
2006
An Activating Mutation of AKT2 and Human Hypoglycemia
2011 Science
SNARE Proteins: One to Fuse and Three to Keep the Nascent Fusion Pore Open
2012 StandoutScienceNobel
Keeping G Proteins at Bay: A Complex Between G Protein-Coupled Receptor Kinase 2 and Gßγ
2003 StandoutScienceNobel
LDL receptor and its family members serve as the cellular receptors for vesicular stomatitis virus
2013
Four-component protein nanocages designed by programmed symmetry breaking
2024 StandoutNatureNobel
Engineered receptors for soluble cellular communication and disease sensing
2024 StandoutNatureNobel
Inhibition of GLUT4 Translocation by Tbc1d1, a Rab GTPase-activating Protein Abundant in Skeletal Muscle, Is Partially Relieved by AMP-activated Protein Kinase Activation
2008
Activation of Store-Operated Ca2+ Current in Xenopus Oocytes Requires SNAP-25 but Not a Diffusible Messenger
1999 StandoutNobel
Protein Kinase A and G Protein-coupled Receptor Kinase Phosphorylation Mediates β-1 Adrenergic Receptor Endocytosis through Different Pathways
2003 StandoutNobel
The essential tyrosine of the internalization signal in lysosomal acid phosphatase is part of a β turn
1991
COPII-Coated Vesicle Formation Reconstituted with Purified Coat Proteins and Chemically Defined Liposomes
1998 StandoutNobel
Regulation of glucose transport by insulin: traffic control of GLUT4
2012
Lipid Rafts
2003
SNAREs are concentrated in cholesterol-dependent clusters that define docking and fusion sites for exocytosis
2001
AMPK: guardian of metabolism and mitochondrial homeostasis
2017 Standout
Crystal Structure of a pol α Family Replication DNA Polymerase from Bacteriophage RB69
1997 StandoutNobel
AKT/PKB Signaling: Navigating Downstream
2007 Standout
The mechanism of receptor‐mediated endocytosis
1991
Posttranslational regulation of Akt in human cancer
2014
CD22 blockade restores homeostatic microglial phagocytosis in ageing brains
2019 StandoutNatureNobel
Coupling of Coat Assembly and Vesicle Budding to Packaging of Putative Cargo Receptors
1999 StandoutNobel
Transferrin receptor internalization sequence YXRF implicates a tight turn as the structural recognition motif for endocytosis
1990
Endocytosis and signals for internalization
1991
Metabolic Reprogramming by the PI3K-Akt-mTOR Pathway in Cancer
2016
Growth Hormone Receptor Ubiquitination Coincides with Recruitment to Clathrin-coated Membrane Domains
2001
Emerging role for AS160/TBC1D4 and TBC1D1 in the regulation of GLUT4 traffic
2008
Transient receptor potential channelopathies
2010
The receptor DEC-205 expressed by dendritic cells and thymic epithelial cells is involved in antigen processing
1995 StandoutNatureNobel
Three-Dimensional Structure of an Evolutionarily Conserved N-Terminal Domain of Syntaxin 1A
1998 StandoutNobel
Rapid gating and anion permeability of an intracellular aquaporin
1999 StandoutNatureNobel
Metabolism of stromal and immune cells in health and disease
2014 Nature
The Arabidopsis det3 mutant reveals a central role for the vacuolar H+-ATPase in plant growth and development
1999
The biology and function of fibroblasts in cancer
2016 Standout
Molecular basis of human CD22 function and therapeutic targeting
2017
AMPK Protects Leukemia-Initiating Cells in Myeloid Leukemias from Metabolic Stress in the Bone Marrow
2015
A Functional Phosphatidylinositol 3,4,5-Trisphosphate/Phosphoinositide Binding Domain in the Clathrin Adaptor AP-2 α Subunit. IMPLICATIONS FOR THE ENDOCYTIC PATHWAY
1996
The role of lipid signaling in constitutive membrane traffic
1997
Intracellular Toll-like Receptors
2010 StandoutNobel
Differential Targeting of β-Adrenergic Receptor Subtypes and Adenylyl Cyclase to Cardiomyocyte Caveolae
2000
Saturation of the Endocytic Pathway for the Transferrin Receptor Does Not Affect the Endocytosis of the Epidermal Growth Factor Receptor
1997 StandoutNobel
Catabolic cancer-associated fibroblasts transfer energy and biomass to anabolic cancer cells, fueling tumor growth
2014
Reactive oxygen species (ROS) as pleiotropic physiological signalling agents
2020 Standout
Membrane protein sequestering by ionic protein–lipid interactions
2011 StandoutNatureNobel
Plasma Membrane Is the Site of Productive HIV-1 Particle Assembly
2006
Insulin-stimulated Phosphorylation of a Rab GTPase-activating Protein Regulates GLUT4 Translocation
2003
Design of biologically active binary protein 2D materials
2021 StandoutNatureNobel
The NPXY internalization signal of the LDL receptor adopts a reverse-turn conformation
1991
Intrinsic Immunity Shapes Viral Resistance of Stem Cells
2017 StandoutNobel
The complete nucleotide sequence of the left very early region of Escherichia coli bacteriophage PRD1 coding for the terminal protein and the DNA polymerase
1987
Rho GTPases and signaling networks
1997 Standout
Regulation of receptor-mediated endocytosis by phorbol esters
1991
Roles of lipid rafts in membrane transport
2001
Ribosome recycling by ribosome recycling factor (RRF) ? An important but overlooked step of protein biosynthesis
1996
Membrane Fusion
2003 StandoutNobel
MX2 is an interferon-induced inhibitor of HIV-1 infection
2013 StandoutNatureNobel
The structure and function of G-protein-coupled receptors
2009 StandoutNatureNobel
Metabolic Regulation of Neocortical Expansion in Development and Evolution
2020
The GLUT4 Glucose Transporter
2007
Structure of the TRPV1 ion channel determined by electron cryo-microscopy
2013 StandoutNatureNobel
Oncogenes induce the cancer-associated fibroblast phenotype: Metabolic symbiosis and “fibroblast addiction” are new therapeutic targets for drug discovery
2013
Redox regulation of protein kinases
2013
Synthetic cell surface receptors for delivery of therapeutics and probes
2012
Sar1p N-Terminal Helix Initiates Membrane Curvature and Completes the Fission of a COPII Vesicle
2005 StandoutNobel
Lipid rafts: contentious only from simplistic standpoints
2006
The role of mouse Akt2 in insulin-dependent suppression of adipocyte lipolysis in vivo
2015
A Role for 14-3-3 in Insulin-stimulated GLUT4 Translocation through Its Interaction with the RabGAP AS160
2006
Claudin-1 is a hepatitis C virus co-receptor required for a late step in entry
2007 StandoutNatureNobel
Direct observation of the nanoscale dynamics of membrane lipids in a living cell
2008 StandoutNatureNobel
Genome-Scale Identification of SARS-CoV-2 and Pan-coronavirus Host Factor Networks
2020 StandoutNobel
Distinct Saturable Pathways for the Endocytosis of Different Tyrosine Motifs
1998 StandoutNobel
Akt3 Deficiency in Macrophages Promotes Foam Cell Formation and Atherosclerosis in Mice
2012
AKT/PKB Signaling: Navigating the Network
2017 Standout
CED-1 Is a Transmembrane Receptor that Mediates Cell Corpse Engulfment in C. elegans
2001 StandoutNobel
Structural Determinants of Interaction of Tyrosine-based Sorting Signals with the Adaptor Medium Chains
1996
Glycocalyx Engineering with a Recycling Glycopolymer that Increases Cell Survival In Vivo
2015 StandoutNobel
The PI3K Pathway in Human Disease
2017 Standout
Rapid Activation of Akt2 Is Sufficient to Stimulate GLUT4 Translocation in 3T3-L1 Adipocytes
2008
Cellubrevin is a ubiquitous tetanus-toxin substrate homologous to a putative synaptic vesicle fusion protein
1993 StandoutNatureNobel
Lysosome-targeting chimaeras for degradation of extracellular proteins
2020 StandoutNatureNobel
Distinct endocytic pathways regulate TGF-β receptor signalling and turnover
2003
CLIP170-like tip1p Spatially Organizes Microtubular Dynamics in Fission Yeast
2000 StandoutNobel
Receptor Heterodimerization Modulates Endocytosis through Collaborative and Competitive Mechanisms
2019
Ribosome Structure and the Mechanism of Translation
2002 StandoutNobel
Syntaxin 7, a Novel Syntaxin Member Associated with the Early Endosomal Compartment
1998
Clathrin Box in G Protein-coupled Receptor Kinase 2
2001
The endocytic pathway: a mosaic of domains
2001
Insulin signalling mechanisms for triacylglycerol storage
2013
Selective Activation of Cognate SNAREpins by Sec1/Munc18 Proteins
2007 StandoutNobel
The Arp2/3 Activator WASH Controls the Fission of Endosomes through a Large Multiprotein Complex
2009
Regulatory interactions in the recognition of endocytic sorting signals by AP-2 complexes
1997
Sorting of membrane components from endosomes and subsequent recycling to the cell surface occurs by a bulk flow process.
1993
Serotonin-Mediated Endocytosis of apCAM: an Early Step of Learning-Related Synaptic Growth in Aplysia
1992 StandoutScienceNobel
Mammalian Autophagy: How Does It Work?
2016
The basolateral targeting signal in the cytoplasmic domain of glycoprotein G from vesicular stomatitis virus resembles a variety of intracellular targeting motifs related by primary sequence but having diverse targeting activities.
1994
Mechanisms of Insulin Action and Insulin Resistance
2018 Standout
Structure of the STRA6 receptor for retinol uptake
2016 StandoutScienceNobel
The State of Lipid Rafts: From Model Membranes to Cells
2003
Isoform-specific regulation of Akt by PDGF-induced reactive oxygen species
2011
Regulation of Receptor Fate by Ubiquitination of Activated β 2 -Adrenergic Receptor and β-Arrestin
2001 StandoutScienceNobel
Sequence requirements for the recognition of tyrosine-based endocytic signals by clathrin AP-2 complexes.
1996
Myocyte Adrenoceptor Signaling Pathways
2003 StandoutScienceNobel
Movement of internalized ligand–receptor complexes along a continuous endosomal reticulum
1990 Nature
A point mutation in the cytoplasmic domain of the transferrin receptor inhibits endocytosis
1990
Regulation of GPCRs by Endocytic Membrane Trafficking and Its Potential Implications
2007
Dynamics of putative raft-associated proteins at the cell surface
2004
The Rab GTPase-Activating Protein AS160 as a Common Regulator of Insulin- and G.ALPHA.q-Mediated Intracellular GLUT4 Vesicle Distribution
2009
Coordinate phosphorylation of multiple residues on single AKT1 and AKT2 molecules
2013
Human TKTL1 implies greater neurogenesis in frontal neocortex of modern humans than Neanderthals
2022 StandoutScienceNobel
An internal deletion in the cytoplasmic tail reverses the apical localization of human NGF receptor in transfected MDCK cells.
1991
A Synthetic Mimic of Human Fc Receptors: Defined Chemical Modification of Cell Surfaces Enables Efficient Endocytic Uptake of Human Immunoglobulin-G
2006
ADAPTORS FOR CLATHRIN COATS: Structure and Function
2004
ClC-5, the chloride channel mutated in Dent’s disease, colocalizes with the proton pump in endocytotically active kidney cells
1998
Selective Disruption of Early/Recycling Endosomes: Release of Disulfide-Linked Cargo Mediated by a N-Alkyl-3β-Cholesterylamine-Capped Peptide
2008
Characteristics of the tyrosine recognition signal for internalization of transmembrane surface glycoproteins.
1990
Protein targeting by tyrosine- and di-leucine-based signals: evidence for distinct saturable components.
1996
Anatomy and Dynamics of a Supramolecular Membrane Protein Cluster
2007 StandoutScienceNobel
Role of Dynactin in Endocytic Traffic: Effects of Dynamitin Overexpression and Colocalization with CLIP-170
1999
Fat Cell–Specific Ablation of Rictor in Mice Impairs Insulin-Regulated Fat Cell and Whole-Body Glucose and Lipid Metabolism
2010
Mechanisms of membrane deformation
2003
Rab10 associates with primary cilia and the exocyst complex in renal epithelial cells
2010
Fibroblast heterogeneity in the cancer wound
2014
Akt isoforms differentially regulate neutrophil functions
2010
Alteration of Stimulus-Specific Guard Cell Calcium Oscillations and Stomatal Closing in Arabidopsis det3 Mutant
2000 StandoutScienceNobel
Inhibition of Endosome Function in CHO Cells Bearing a Temperature-sensitive Defect in the Coatomer (COPI) Component ε-COP
1997
Bacteriophage PRD1 DNA polymerase: evolution of DNA polymerases.
1987
Hepatitis C Virus Entry Requires a Critical Postinternalization Step and Delivery to Early Endosomes via Clathrin-Coated Vesicles
2006
Synthetic Mimics of Small Mammalian Cell Surface Receptors
2004
Folate receptors targeted to clathrin-coated pits cannot regulate vitamin uptake.
1995
Cytokine Stimulation Promotes Glucose Uptake via Phosphatidylinositol-3 Kinase/Akt Regulation of Glut1 Activity and Trafficking
2007
Viral Capsid DNA Aptamer Conjugates as Multivalent Cell-Targeting Vehicles
2009
YTRF is the conserved internalization signal of the transferrin receptor, and a second YTRF signal at position 31-34 enhances endocytosis.
1993
The position of lysosomes within the cell determines their luminal pH
2016
The Role of PDE3B Phosphorylation in the Inhibition of Lipolysis by Insulin
2015
ß-Arrestin 2 Mediates Endocytosis of Type III TGF-ß Receptor and Down-Regulation of Its Signaling
2003 StandoutScienceNobel
Endothelial Akt1 mediates angiogenesis by phosphorylating multiple angiogenic substrates
2014
Transplanted LDL and mannose-6-phosphate receptor internalization signals promote high-efficiency endocytosis of the transferrin receptor.
1991
Protein-Lipid Interplay in Fusion and Fission of Biological Membranes
2003
A mutated transferrin receptor lacking asparagine-linked glycosylation sites shows reduced functionality and an association with binding immunoglobulin protein.
1991
Works of Timothy E. McGraw being referenced
Hyperinsulinemia leads to uncoupled insulin regulation of the GLUT4 glucose transporter and the FoxO1 transcription factor
2011
Metabolic Alterations in Lung Cancer–Associated Fibroblasts Correlated with Increased Glycolytic Metabolism of the Tumor
2013
Phosphorylation of TXNIP by AKT Mediates Acute Influx of Glucose in Response to Insulin
2017
Rab10, a Target of the AS160 Rab GAP, Is Required for Insulin-Stimulated Translocation of GLUT4 to the Adipocyte Plasma Membrane
2007
Endocytic recycling
2004
Isolation of a temperature‐sensitive variant Chinese hamster ovary cell line with a morphologically altered endocytic recycling compartment
1993
An Internalization Motif Is Created in the Cytoplasmic Domain of the Transferrin Receptor by Substitution of a Tyrosine at the First Position of a Predicted Tight Turn
1995
GLUT4 Distribution between the Plasma Membrane and the Intracellular Compartments Is Maintained by an Insulin-modulated Bipartite Dynamic Mechanism
2005
The Akt kinases: Isoform specificity in metabolism and cancer
2009
The Carboxyl Terminus of GLUT4 Contains a Serine-Leucine-Leucine Sequence That Functions as a Potent Internalization Motif in Chinese Hamster Ovary Cells
1996
Vesicular and Non-vesicular Sterol Transport in Living Cells
2002
GLUT4 is internalized by a cholesterol‐dependent nystatin‐sensitive mechanism inhibited by insulin
2006
Identification of an Insulin-responsive, Slow Endocytic Recycling Mechanism in Chinese Hamster Ovary Cells
1998
Bafilomycin A1 Treatment Retards Transferrin Receptor Recycling More than Bulk Membrane Recycling
1997
Biochemical and cellular properties of insulin receptor signalling
2017
AMPK-Dependent Degradation of TXNIP upon Energy Stress Leads to Enhanced Glucose Uptake via GLUT1
2013
Full intracellular retention of GLUT4 requires AS160 Rab GTPase activating protein
2005
Wortmannin-sensitive Trafficking Pathways in Chinese Hamster Ovary Cells
1996
The epithelial-specific adaptor AP1B mediates post-endocytic recycling to the basolateral membrane
2002
Establishment of a physical and genetic map for bacteriophage PRD1
1983
Insulin-modulated Akt subcellular localization determines Akt isoform-specific signaling
2009
Acute cholesterol depletion inhibits clathrin-coated pit budding
1999
Functional expression of the human transferrin receptor cDNA in Chinese hamster ovary cells deficient in endogenous transferrin receptor.
1987
Insulin Signaling Diverges into Akt-dependent and -independent Signals to Regulate the Recruitment/Docking and the Fusion of GLUT4 Vesicles to the Plasma Membrane
2006
Endosome acidification and receptor trafficking: bafilomycin A1 slows receptor externalization by a mechanism involving the receptor's internalization motif.
1993
GLUT4 Is Retained by an Intracellular Cycle of Vesicle Formation and Fusion with Endosomes
2003
GLUT4 Retention in Adipocytes Requires Two Intracellular Insulin-regulated Transport Steps
2002
A Di-Leucine Sequence and a Cluster of Acidic Amino Acids Are Required for Dynamic Retention in the Endosomal Recycling Compartment of Fibroblasts
2001
Iterative fractionation of recycling receptors from lysosomally destined ligands in an early sorting endosome.
1989
Insulin-regulated Release from the Endosomal Recycling Compartment Is Regulated by Budding of Specialized Vesicles
2001
Demonstration of insulin-responsive trafficking of GLUT4 and vpTR in fibroblasts
2000
Regulation of endocytic trafficking and acidification are independent of the cystic fibrosis transmembrane regulator.
1994
Insulin Stimulation of GLUT4 Exocytosis, but Not Its Inhibition of Endocytosis, Is Dependent on RabGAP AS160
2004
Human transferrin receptor internalization is partially dependent upon an aromatic amino acid on the cytoplasmic domain.
1990
Identification of a protein bound to the termini of bacteriophage PRD1 DNA
1983
Phorbol ester treatment increases the exocytic rate of the transferrin receptor recycling pathway independent of serine-24 phosphorylation.
1988
Molecular cloning of bacteriophage PRD1 genomic fragments
1983
Overexpression of MAP4 inhibits organelle motility and trafficking in vivo
1997
Molecular Mechanisms Controlling GLUT4 Intracellular Retention
2008
Distinct Akt phosphorylation states are required for insulin regulated Glut4 and Glut1-mediated glucose uptake
2017
Nucleotide sequence of the small double-stranded RNA segment of bacteriophage phi 6: novel mechanism of natural translational control
1986