Citation Impact
Citing Papers
Loss of cryptochrome reduces cancer risk in p53 mutant mice
2009 StandoutNobel
Expression of the HPV16 E7 gene generates proliferation in stratified squamous cell cultures which is independent of endogenous p53 levels.
1992
Basal cell carcinomas: attack of the hedgehog
2008 Standout
Hallmarks of Cancer: The Next Generation
2011 Standout
Sequence-specific DNA binding by p53: identification of target sites and lack of binding to p53 - MDM2 complexes.
1993
Human papillomavirus 16 E6 expression disrupts the p53-mediated cellular response to DNA damage.
1993
Mdm2 promotes the rapid degradation of p53
1997 StandoutNature
Regulation of p53 stability by Mdm2
1997 StandoutNature
Cellular responses of HPV-positive cancer cells to genotoxic anti-cancer agents: Repression ofE6/E7-oncogene expression and induction of apoptosis
1996
Are tumours immortal?
1992
WAF1, a potential mediator of p53 tumor suppression
1993 Standout
Role for the p53 homologue p73 in E2F-1-induced apoptosis
2000 StandoutNatureNobel
p53 in growth control and neoplasia
1996
Functional regulation of p73 and p63: development and cancer
2003
Papillomavirus infections — a major cause of human cancers
1996 StandoutNobel
Immortalization and Transformation of Human Cells by Human Papillomavirus
1994
Specific repression of TATA-mediated but not initiator-mediated transcription by wild-type p53
1993 Nature
p53, the Cellular Gatekeeper for Growth and Division
1997 Standout
The Genetics of Sun Sensitivity in Humans
2004
Human papillomavirus DNA sequences in esophagus squamous cell carcinoma
1994
The ubiquitin-proteasome proteolytic pathway
1994 StandoutNobel
The HPV-16 E6 and E6-AP complex functions as a ubiquitin-protein ligase in the ubiquitination of p53
1993 Standout
Proliferation, cell cycle and apoptosis in cancer
2001 StandoutNature
Expression of RB and p53 proteins in HPV‐positive and HPV‐negative cervical carcinoma cell lines
1991
Ubiquitin-mediated Processing of NF-κB Transcriptional Activator Precursor p105
1995 StandoutNobel
Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours
1996 StandoutNature
Mutant conformation of p53
1992
The Hallmarks of Cancer
2000 Standout
The predominant mRNA class in HPV16‐infected genital neoplasias does not encode the e6 or the E7 protein
1993
The role of the E6-p53 interaction in the molecular pathogenesis of HPV
1999
Human papillomavirus 16 E6 oncoprotein binds to interferon regulatory factor-3 and inhibits its transcriptional activity
1998
Skin Cancers after Organ Transplantation
2003 Standout
COMMENTARY: p53 Tumor suppressor gene: from the basic research laboratory to the clinic—an abridged historical perspective
1996
Papillomaviruses and cancer: from basic studies to clinical application
2002 StandoutNobel
Cooperative tumorigenic effects of germline mutations in Rb and p53
1994
Specific interaction between HPV-16 E1–E4 and cytokeratins results in collapse of the epithelial cell intermediate filament network
1991 Nature
Complete reconstitution of conjugation and subsequent degradation of the tumor suppressor protein p53 by purified components of the ubiquitin proteolytic system
1994 StandoutNobel
Identification of differentially expressed genes in HPV-positive and HPV-negative oropharyngeal squamous cell carcinomas
2006
Human Papillomavirus and Survival of Patients with Oropharyngeal Cancer
2010 Standout
Viruses and tumours – an update
2004
p53 Deficiency Rescues the Adverse Effects of Telomere Loss and Cooperates with Telomere Dysfunction to Accelerate Carcinogenesis
1999 StandoutNobel
Molecular Pathogenesis of Cancer of the Cervix and Its Causation by Specific Human Papillomavirus Types
1994 StandoutNobel
Analysis of p53 status in tonsillar carcinomas associated with human papillomavirus
1994
Disrupted dichotomous intracellular control of human papillomavirus infection in cancer of the cervix
1994 StandoutNobel
The DNA damage response: putting checkpoints in perspective
2000 StandoutNature
Short Dysfunctional Telomeres Impair Tumorigenesis in the INK4aΔ2/3 Cancer-Prone Mouse
1999 StandoutNobel
On the mechanisms of biocompatibility
2008 Standout
Human papillomavirus type 16 and 18 gene expression in cervical neoplasias
1992
p53-dependent apoptosis modulates the cytotoxicity of anticancer agents
1993 Standout
Role of a p53 polymorphism in the development of human papilloma-virus-associated cancer
1998 Nature
Phylogenetic Classification of Human Papillomaviruses: Correlation With Clinical Manifestations
1992
Cooperative effect of antisense-Rb and antisense-p53 oligomers on the extension of life span in human diploid fibroblasts, TIG-1
1991
Human papillomavirus type 16 (HPV 16) gene expression and DNA replication in cervical neoplasia: Analysis by in situ hybridization
1992
Epidemiologic Classification of Human Papillomavirus Types Associated with Cervical Cancer
2003 Standout
Restoration of p53 expression sensitizes human papillomavirus type 16 immortalized human keratinocytes to CD95-mediated apoptosis
2002 StandoutNobel
The tumore suppressor p53
1993
Cellular transformation by papilomavirus oncorproteins
1993
The cancer genome
2009 StandoutNature
The Role of E6AP in the Regulation of p53 Protein Levels in Human Papillomavirus (HPV)-positive and HPV-negative Cells
1998
Expression of vaccinia recombinant HPV 16 L1 and L2 ORF proteins in epithelial cells is sufficient for assembly of HPV virion-like particles
1991
Specific loss of apoptotic but not cell-cycle arrest function in a human tumor derived p53 mutant.
1996
Identification of a minimal transforming domain of p53: negative dominance through abrogation of sequence-specific DNA binding.
1992
Human papillomavirus type 16 E6 increases the degradation rate of p53 in human keratinocytes
1992
Circadian clock disruption improves the efficacy of chemotherapy through p73-mediated apoptosis
2011 StandoutNobel
Complete switch from Mdm2 to human papillomavirus E6-mediated degradation of p53 in cervical cancer cells
2001 StandoutNobel
Myc-mediated apoptosis is blocked by ectopic expression of Bcl-2.
1993
New Approaches to Immunotherapy for HPV Associated Cancers
2011
Telomerase extends the lifespan of virus-transformed human cells without net telomere lengthening
1999 StandoutNobel
Crystal Structure of a p53 Tumor Suppressor-DNA Complex: Understanding Tumorigenic Mutations
1994 StandoutScience
Group-specific differentiation between high- and low-risk human papillomavirus genotypes by general primer-mediated PCR and two cocktails of oligonucleotide probes
1995
Mechanisms of DNA Excision Repair
1994 StandoutScienceNobel
Myc-mediated apoptosis requires wild-type p53 in a manner independent of cell cycle arrest and the ability of p53 to induce p21waf1/cip1.
1994
Growth arrest by induction of p53 in DNA damaged keratinocytes is bypassed by human papillomavirus 16 E7.
1994
Cancer Cell Cycles
1996 StandoutScience
Cell Cycle Control and Cancer
1994 StandoutScienceNobel
Mapping epitopes and antigenicity by site-directed masking
2006 StandoutNobel
Reversible repression of papillomavirus oncogene expression in cervical carcinoma cells: consequences for the phenotype and E6-p53 and E7-pRB interactions
1994
Regulation of p53 Function and Stability by Phosphorylation
1999
Characterization of the human papillomavirus E2 protein: evidence of trans-activation and trans-repression in cervical keratinocytes.
1994
The mdm-2 oncogene can overcome wild-type p53 suppression of transformed cell growth.
1993
Stimulation-dependent I kappa B alpha phosphorylation marks the NF-kappa B inhibitor for degradation via the ubiquitin-proteasome pathway.
1995 StandoutNobel
mdm2 expression is induced by wild type p53 activity.
1993
A comparison of the biological activities of wild‐type and mutant p53
1993
Antioxidant-induced changes of the AP-1 transcription complex are paralleled by a selective suppression of human papillomavirus transcription
1997 StandoutNobel
Unique potential of 4-1BB agonist antibody to promote durable regression of HPV + tumors when combined with an E6/E7 peptide vaccine
2015 StandoutNobel
Multiple Functions of Human Papillomavirus Type 16 E6 Contribute to the Immortalization of Mammary Epithelial Cells
1999
Specific Association of Human Telomerase Activity with Immortal Cells and Cancer
1994 StandoutScience
Proteolytic Cleavage of Human p53 by Calpain: a Potential Regulator of Protein Stability
1997
Oncogenic mutations of the p53 tumor suppressor: the demons of the guardian of the genome.
2000
A strategy of exon shuffling for making large peptide repertoires displayed on filamentous bacteriophage.
1996 StandoutNobel
Deregulated transcription factor E2F-1 expression leads to S-phase entry and p53-mediated apoptosis.
1994 StandoutNobel
Wild-type p53 mediates apoptosis by E1A, which is inhibited by E1B.
1993
A cellular protein mediates association of p53 with the E6 oncoprotein of human papillomavirus types 16 or 18.
1991
Degradation of the tumor suppressor protein p53 by the ubiquitin-mediated proteolytic system requires a novel species of ubiquitin-carrier protein, E2
1994 StandoutNobel
Basal and human papillomavirus E6 oncoprotein-induced degradation of Myc proteins by the ubiquitin pathway
1998 StandoutNobel
Protein kinase mutants of human ATR increase sensitivity to UV and ionizing radiation and abrogate cell cycle checkpoint control
1998
The Ubiquitin-Proteasome Proteolytic Pathway: Destruction for the Sake of Construction
2002 StandoutNobel
c-Abl Regulates p53 Levels under Normal and Stress Conditions by Preventing Its Nuclear Export and Ubiquitination
2001 StandoutNobel
Cloning and expression of the cDNA for E6-AP, a protein that mediates the interaction of the human papillomavirus E6 oncoprotein with p53.
1993
Control of Angiogenesis in Fibroblasts by p53 Regulation of Thrombospondin-1
1994 StandoutScience
THE UBIQUITIN SYSTEM
1998 StandoutNobel
The WT1 gene product stabilizes p53 and inhibits p53-mediated apoptosis.
1995
Mechanisms and Genes of Cellular Suicide
1995 StandoutScience
Reversible phosphorylation controls the activity of cyclosome-associated cyclin-ubiquitin ligase.
1995 StandoutNobel
Works of Timothy Crook being referenced
Lymphoproliferative response to fusion proteins of human papillomaviruses in patients with cervical intraepithelial neoplasia
1989
A late complication following the insertion of hydrogel breast implants
2006
Detection of novel splicing patterns in a HPV16-containing keratinocyte cell line
1990
E7 proteins from oncogenic human papillomavirus types transactivate p73: role in cervical intraepithelial neoplasia
2002
Relationship Between p53 Codon 72 Polymorphism and Susceptibility to Sunburn and Skin Cancer
2002
Human papillomavirus E6 proteins bind p53 in vivo and abrogate p53-mediated repression of transcription.
1992
Properties of p53 mutations detected in primary and secondary cervical cancers suggest mechanisms of metastasis and involvement of environmental carcinogens.
1992
Status of c-myc, p53 and retinoblastoma genes in human papillomavirus positive and negative squamous cell carcinomas of the anus.
1991
p53 is frequently mutated in Burkitt's lymphoma cell lines.
1991
p53 point mutation in HPV negative human cervical carcinoma cell lines.
1991
Modulation of immortalizing properties of human papillomavirus type 16 E7 by p53 expression
1991