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Citing Papers
A Novel Functional Human Eukaryotic Translation Initiation Factor 4G
1998
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Generation of Pluripotent Stem Cells from Adult Mouse Liver and Stomach Cells
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Characterization of a canine homolog of hepatitis C virus
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Translation Initiation Factor eIF4G-1 Binds to eIF3 through the eIF3e Subunit
2006
Circularization of mRNA by Eukaryotic Translation Initiation Factors
1998
Rotavirus RNA-binding protein NSP3 interacts with eIF4GI and evicts the poly(A) binding protein from eIF4F
1998
Phosphorylation of the eIF4E‐binding protein PHAS‐I after exposure of PC12 cells to EGF and NGF
1996
Mutually Cooperative Binding of Eukaryotic Translation Initiation Factor (eIF) 3 and eIF4A to Human eIF4G-1
2000
Internal translation initiation of picornaviruses and hepatitis C virus
2009
Defining the proteolytic landscape during enterovirus infection
2020 StandoutNobel
Human Eukaryotic Initiation Factor 4G (eIF4G) Protein Binds to eIF3c, -d, and -e to Promote mRNA Recruitment to the Ribosome
2013
The Human Homologue of the Yeast Prt1 Protein Is an Integral Part of the Eukaryotic Initiation Factor 3 Complex and Interacts with p170
1997
Mechanism of autoproteolysis at the NS2–NS3 junction of the hepatitis C virus polyprotein
1998
A new translational regulator with homology to eukaryotic translation initiation factor 4G
1997
Binding activities of a repertoire of single immunoglobulin variable domains secreted from Escherichia coli
1989 StandoutNatureNobel
Effect of mRNA Cap Structure on eIF-4E Phosphorylation and Cap Binding Analyses Using Ser209-Mutated eIF-4Es
1998
Differential Cleavage of eIF4GI and eIF4GII in Mammalian Cells
2006
Structural Basis for the Substrate Specificity of Tobacco Etch Virus Protease
2002
Functional Overlap between eIF4G Isoforms in Saccharomyces cerevisiae
2010 StandoutNobel
Cell cycle regulation of hepatitis C virus internal ribosomal entry site–directed translation
2000
eIF4E activity is regulated at multiple levels
1999
Translation initiation: structures, mechanisms and evolution
2004
RNA-binding activity of translation initiation factor eIF4G1 from Saccharomyces cerevisiae
2003
Identification of the residues in human CD4 critical for the binding of HIV
1989 StandoutNobel
Structural Characterization of the Human Eukaryotic Initiation Factor 3 Protein Complex by Mass Spectrometry
2007 StandoutNobel
Expression of poliovirus 2Apro in mammalian cells: effects on translation
1995
Internal Initiation of Translation Directed by the 5′-Untranslated Region of the mRNA for eIF4G, a Factor Involved in the Picornavirus-induced Switch from Cap-dependent to Internal Initiation
1996
Involvement of Stress-activated Protein Kinase and p38/RK Mitogen-activated Protein Kinase Signaling Pathways in the Enhanced Phosphorylation of Initiation Factor 4E in NIH 3T3 Cells
1997
eIF4G Dramatically Enhances the Binding of eIF4E to the mRNA 5′-Cap Structure
1997
Viral proteins containing the purine NTP-binding sequence pattern
1989
Purification of tetrahymena telomerase and cloning of genes encoding the two protein components of the enzyme
1995 StandoutNobel
Intact Eukaryotic Initiation Factor 4G Is Required for Hepatitis A Virus Internal Initiation of Translation
1997
Enteroviruses: Classification, diseases they cause, and approaches to development of antiviral drugs
2017
pH-dependent Conformational Flexibility of the SARS-CoV Main Proteinase (Mpro) Dimer: Molecular Dynamics Simulations and Multiple X-ray Structure Analyses
2005
Mammalian microRNAs predominantly act to decrease target mRNA levels
2010 StandoutNature
Cleavage site analysis in picornaviral polyproteins: Discovering cellular targets by neural networks
1996
Gene-Specific Regulation by General Translation Factors
2002
Translation initiation factor eIF-4gamma is encoded by an amplified gene and induces an immune response in squamous cell lung carcinoma
1997
Viral and cellular mRNA capping: Past and prospects
2000
‘Ribozoomin’ – Translation Initiation from the Perspective of the Ribosome-bound Eukaryotic Initiation Factors (eIFs)
2012
Purification of two picornaviral 2A proteinases: Interaction with eIF-4.gamma. and influence on the in vitro translation
1993
Engineering Considerations for the Application of Extremophiles in Biotechnology
1991
Essential role of NAT1/p97/DAP5 in embryonic differentiation and the retinoic acid pathway
2000 StandoutNobel
Internal ribosome entry sites in eukaryotic mRNA molecules
2001
Interaction of Translation Initiation Factor eIF4G with eIF4A in the Yeast Saccharomyces cerevisiae
1999
Starting at the Beginning, Middle, and End: Translation Initiation in Eukaryotes
1997
Multiple Isoforms of Eukaryotic Protein Synthesis Initiation Factor 4E in Caenorhabditis elegans Can Distinguish between Mono- and Trimethylated mRNA Cap Structures
1998
Interaction of polyadenylate-binding protein with the eIF4G homologue PAIP enhances translation
1998 Nature
Transport Selectivity of Nuclear Pores, Phase Separation, and Membraneless Organelles
2015
The picornaviral 3C proteinases: Cysteine nucleophiles in serine proteinase folds
1995
CD4: Collaborator in immune recognition and HIV infection
1990 StandoutNobel
A Serpin Shapes the Extracellular Environment to Prevent Influenza A Virus Maturation
2015 StandoutNobel
Conservation and diversity in the structure of translation initiaton factor eIF3 from humans and yeast
1996
Characterization of cDNAs Encoding the p44 and p35 Subunits of Human Translation Initiation Factor eIF3
1998
Protein synthesis initiation factor 4G
1999
Translation Eukaryotic Initiation Factor 4G Recognizes a Specific Structural Element within the Internal Ribosome Entry Site of Encephalomyocarditis Virus RNA
1998
Inactivation of eIF2B and Phosphorylation of PHAS-I in Heat-shocked Rat Hepatoma Cells
1997
Ribosome Loading onto the mRNA Cap Is Driven by Conformational Coupling between eIF4G and eIF4E
2003
Structure of mammalian eIF3 in the context of the 43S preinitiation complex
2015 StandoutNatureNobel
The Crystal Structure of Hepatitis C Virus NS3 Proteinase Reveals a Trypsin-like Fold and a Structural Zinc Binding Site
1996
The roles of individual eukaryotic translation initiation factors in ribosomal scanning and initiation codon selection
2002
Cooperative modulation by eIF4G of eIF4E-binding to the mRNA 5' cap in yeast involves a site partially shared by p20
1998
Starting the protein synthesis machine: eukaryotic translation initiation
2003
Identification of partners of TIF34, a component of the yeast eIF3 complex, required for cell proliferation and translation initiation
1997
An Antibody Fragment from a Phage Display Library Competes for Ligand Binding to the Low Density Lipoprotein Receptor Family and Inhibits Rhinovirus Infection
1995 StandoutNobel
Complex Formation by All Five Homologues of Mammalian Translation Initiation Factor 3 Subunits from Yeast Saccharomyces cerevisiae
1998
The proteolytic cleavage of eukaryotic initiation factor (eIF) 4G is prevented by eIF4E binding protein (PHAS-I; 4E-BP1) in the reticulocyte lysate
1997
A novel inhibitor of cap-dependent translation initiation in yeast: p20 competes with eIF4G for binding to eIF4E
1997
IRP-1 Binding to Ferritin mRNA Prevents the Recruitment of the Small Ribosomal Subunit by the Cap-Binding Complex eIF4F
1998
Foot-and-mouth disease virus infection induces proteolytic cleavage of PTB, eIF3a,b, and PABP RNA-binding proteins
2007
Insulin signalling and the regulation of glucose and lipid metabolism
2001 StandoutNature
Picornaviruses and nuclear functions: targeting a cellular compartment distinct from the replication site of a positive-strand RNA virus
2015
Conservation and Diversity of Eukaryotic Translation Initiation Factor eIF3
1997
eIF3: a versatile scaffold for translation initiation complexes
2006
Conserved bipartite motifs in yeast eIF5 and eIF2Bepsilon , GTPase-activating and GDP-GTP exchange factors in translation initiation, mediate binding to their common substrate eIF2
1999
The catalysis of the SARS 3C‐like protease is under extensive regulation by its extra domain
2006
The Saccharomyces cerevisiae HCR1 Gene Encoding a Homologue of the p35 Subunit of Human Translation Initiation Factor 3 (eIF3) Is a High Copy Suppressor of a Temperature-sensitive Mutation in the Rpg1p Subunit of Yeast eIF3
1999
Cryo-EM Visualization of a Viral Internal Ribosome Entry Site Bound to Human Ribosomes
2004 StandoutNobel
A newly identified N-terminal amino acid sequence of human eIF4G binds poly(A)-binding protein and functions in poly(A)-dependent translation
1998
Contribution of Trans-splicing, 5′ -Leader Length, Cap-Poly(A) Synergism, and Initiation Factors to Nematode Translation in an Ascaris suum Embryo Cell-free System
2004
A Fresh Look at iPS Cells
2009 StandoutNobel
eIF4G Functionally Differs from eIFiso4G in Promoting Internal Initiation, Cap-independent Translation, and Translation of Structured mRNAs
2001
Signalling through either the p38 or ERK mitogen‐activated protein (MAP) kinase pathway is obligatory for phorbol ester and T cell receptor complex (TCR‐CD3)‐stimulated phosphorylation of initiation factor (eIF) 4E in Jurkat T cells
1997
Translational control by CPEB: a means to the end
2001
p97/DAP5 is a ribosome‐associated factor that facilitates protein synthesis and cell proliferation by modulating the synthesis of cell cycle proteins
2006
Translational activation of the lck proto-oncogene
1988 StandoutNatureNobel
Initiation of Protein Synthesis in Eukaryotic Cells
1996
Crystal Structure of the Hepatitis C Virus NS3 Protease Domain Complexed with a Synthetic NS4A Cofactor Peptide
1996 StandoutNobel
Characterization of eIF3k
2003
Functional Characterization of the Internal Ribosome Entry Site of eIF4G mRNA
1998
The Predominant eIF4G-Specific Cleavage Activity in Poliovirus-Infected HeLa Cells Is Distinct from 2A Protease
1998
Translational control in stress and apoptosis
2005
Molecular interaction between human tumor marker protein p150, the largest subunit of eIF3, and intermediate filament protein K7
2001
The role of the 5′ untranslated region of an mRNA in translation regulation during development
1999
Global Brain Ischemia and Reperfusion: Modifications in Eukaryotic Initiation Factors Associated with Inhibition of Translation Initiation
1996
Global quantification of mammalian gene expression control
2011 StandoutNature
A Reevaluation of the Cap-binding Protein, eIF4E, as a Rate-limiting Factor for Initiation of Translation in Reticulocyte Lysate
1996
Structural and functional similarities between the central eukaryotic initiation factor (eIF)4A-binding domain of mammalian eIF4G and the eIF4A-binding domain of yeast eIF4G
2001
Molecular mechanisms of translational control
2004
Changes in integrity and association of eukaryotic protein synthesis initiation factors during apoptosis
2000
Translation Initiation Factors eIF-iso4G and eIF-4B Interact with the Poly(A)-binding Protein and Increase Its RNA Binding Activity
1997
Direct Cleavage of eIF4G by Poliovirus 2A Protease Is Inefficientin Vitro
1998
unr, a cellular cytoplasmic RNA-binding protein with five cold-shock domains, is required for internal initiation of translation of human rhinovirus RNA
1999
The Homeoprotein Nanog Is Required for Maintenance of Pluripotency in Mouse Epiblast and ES Cells
2003 StandoutNobel
Structure of translation factor elF4E bound to m7GDP and interaction with 4E-binding protein
1997
The j-Subunit of Human Translation Initiation Factor eIF3 Is Required for the Stable Binding of eIF3 and Its Subcomplexes to 40 S Ribosomal Subunits in Vitro
2004 StandoutNobel
Structure of the Mammalian Ribosomal 43S Preinitiation Complex Bound to the Scanning Factor DHX29
2013 StandoutNobel
A Transient, Neuron-Wide Form of CREB-Mediated Long-Term Facilitation Can Be Stabilized at Specific Synapses by Local Protein Synthesis
1999 StandoutNobel
Structure of the 80S Ribosome from Saccharomyces cerevisiae—tRNA-Ribosome and Subunit-Subunit Interactions
2001 StandoutNobel
Eukaryotic Translation Initiation Factor 4G Is Targeted for Proteolytic Cleavage by Caspase 3 during Inhibition of Translation in Apoptotic Cells
1998
The TOR (target of rapamycin) signal transduction pathway regulates the stability of translation initiation factor eIF4G in the yeast Saccharomyces cerevisiae
1998
A Novel Form of DAP5 Protein Accumulates in Apoptotic Cells as a Result of Caspase Cleavage and Internal Ribosome Entry Site-Mediated Translation
2000
cis- and trans-cleavage activities of poliovirus 2A protease expressed in Escherichia coli
1991
New insights into internal ribosome entry site elements relevant for viral gene expression
2008
Molecular Mechanism of Scanning and Start Codon Selection in Eukaryotes
2011
Naturally Occurring Dicistronic Cricket Paralysis Virus RNA Is Regulated by Two Internal Ribosome Entry Sites
2000
Improving Protein Expression, Stability, and Function with ProteinMPNN
2024 StandoutNobel
eIF4G and CBP80 Share a Common Origin and Similar Domain Organization: Implications for the Structure and Function of eIF4G
2005
Site-directed mutagenesis suggests close functional relationship between a human rhinovirus 3C cysteine protease and cellular trypsin-like serine proteases.
1990
eIF4 Initiation Factors: Effectors of mRNA Recruitment to Ribosomes and Regulators of Translation
1999 Standout
Hijacking the translation apparatus by RNA viruses
2002
Human Eukaryotic Translation Initiation Factor 4G (eIF4G) Possesses Two Separate and Independent Binding Sites for eIF4A
1997
eIF3d is an mRNA cap-binding protein that is required for specialized translation initiation
2016 StandoutNatureNobel
Cleavage of p220 by Purified Poliovirus 2Apro in Cell-Free Systems: Effects on Translation of Capped and Uncapped mRNAs
1997
Envelope structure of Semliki Forest virus reconstructed from cryo-electron micrographs
1986 StandoutNatureNobel
The hepatitis C virus NS3 serine proteinase and NS4A cofactor: establishment of a cell-free trans-processing assay.
1995 StandoutNobel
Phosphorylation of the Cap-Binding Protein Eukaryotic Translation Initiation Factor 4E by Protein Kinase Mnk1 In Vivo
1999
Enteroviral proteases: structure, host interactions and pathogenicity
2016
Rapamycin blocks the phosphorylation of 4E-BP1 and inhibits cap-dependent initiation of translation.
1996
Rapamycin and Wortmannin Enhance Replication of a Defective Encephalomyocarditis Virus
1998
Dengue Virus Utilizes a Novel Strategy for Translation Initiation When Cap-Dependent Translation Is Inhibited
2006
Seven Post-synthetic Covalent Reactions in Tandem Leading to Enzyme-like Complexity within Metal–Organic Framework Crystals
2016 StandoutNobel
Multiple molecular pathways for fitness recovery of an RNA virus debilitated by operation of Muller’s ratchet 1 1Edited by J. Karn
1999
Structural integrity of the PCI domain of eIF3a/TIF32 is required for mRNA recruitment to the 43S pre-initiation complexes
2014
A Region Rich in Aspartic Acid, Arginine, Tyrosine, and Glycine (DRYG) Mediates Eukaryotic Initiation Factor 4B (eIF4B) Self-Association and Interaction with eIF3
1996
Amino acid sequence of the human protein synthesis initiation factor eIF-4 gamma
1992
A Highly Divergent Picornavirus in a Marine Mammal
2007
Molecular Biology and Pathogenesis of Viral Myocarditis
2008
DAP-5, a Novel Homolog of Eukaryotic Translation Initiation Factor 4G Isolated as a Putative Modulator of Gamma Interferon-Induced Programmed Cell Death
1997
Transient Expression of Cellular Polypyrimidine-Tract Binding Protein Stimulates Cap-Independent Translation Directed by Both Picornaviral and Flaviviral Internal Ribosome Entry Sites In Vivo
2000
Viral cysteine proteases are homologous to the trypsin-like family of serine proteases: structural and functional implications.
1988
Thiouracil Cross-Linking Mass Spectrometry: a Cell-Based Method To Identify Host Factors Involved in Viral Amplification
2013
Proteolysis of human eukaryotic translation initiation factor eIF4GII, but not eIF4GI, coincides with the shutoff of host protein synthesis after poliovirus infection
1998
Canonical Eukaryotic Initiation Factors Determine Initiation of Translation by Internal Ribosomal Entry
1996
The Molecular Mechanics of Eukaryotic Translation
2004
Cleavage of Poly(A)-Binding Protein by Poliovirus 3C Protease Inhibits Host Cell Translation: a Novel Mechanism for Host Translation Shutoff
2004
Heat Shock Increases the Association of Binding Protein-1 with Initiation Factor 4E
1997
Molecular mechanisms of translation initiation in eukaryotes
2001
Eukaryotic Initiation Factor 4GII (eIF4GII), but Not eIF4GI, Cleavage Correlates with Inhibition of Host Cell Protein Synthesis after Human Rhinovirus Infection
1999
A novel translational repressor mRNA is edited extensively in livers containing tumors caused by the transgene expression of the apoB mRNA-editing enzyme.
1997 StandoutNobel
N-Terminomics TAILS Identifies Host Cell Substrates of Poliovirus and Coxsackievirus B3 3C Proteinases That Modulate Virus Infection
2018
Effects of Intercistronic Length on the Efficiency of Reinitiation by Eucaryotic Ribosomes
1987
The C-terminal domain of eukaryotic protein synthesis initiation factor (eIF) 4G is sufficient to support cap-independent translation in the absence of eIF4E.
1996
The Yeast Eukaryotic Initiation Factor 4G (eIF4G) HEAT Domain Interacts with eIF1 and eIF5 and Is Involved in Stringent AUG Selection
2003
Identification of a Translation Initiation Factor 3 (eIF3) Core Complex, Conserved in Yeast and Mammals, That Interacts with eIF5
1998
Identification in the Ancient Protist Giardia lamblia of Two Eukaryotic Translation Initiation Factor 4E Homologues with Distinctive Functions
2005
Increased Replicative Fitness Can Lead to Decreased Drug Sensitivity of Hepatitis C Virus
2014 StandoutNobel
Functional Dissection of Eukaryotic Initiation Factor 4F: the 4A Subunit and the Central Domain of the 4G Subunit Are Sufficient To Mediate Internal Entry of 43S Preinitiation Complexes
1996
RNA-protein interactions in regulation of picornavirus RNA translation
1996
A segment of the 5' nontranslated region of encephalomyocarditis virus RNA directs internal entry of ribosomes during in vitro translation
1988
Association of the yeast poly(A) tail binding protein with translation initiation factor eIF-4G.
1996
Mechanism of entry of human rhinovirus 2 into HeLa cells
1987
The Ubiquitin-Proteasome Proteolytic Pathway: Destruction for the Sake of Construction
2002 StandoutNobel
Functional reconstitution of human eukaryotic translation initiation factor 3 (eIF3)
2011 StandoutNobel
A Genomic Perspective on Protein Families
1997 StandoutScience
Enzyme engineering reaches the boiling point
1998 StandoutNobel
Structural Basis of Transcription: RNA Polymerase II at 2.8 Ångstrom Resolution
2001 StandoutScienceNobel
Structure of a human common cold virus and functional relationship to other picornaviruses
1985 Nature
Stimulation of Protein Synthesis, Eukaryotic Translation Initiation Factor 4E Phosphorylation, and PHAS-I Phosphorylation by Insulin Requires Insulin Receptor Substrate 1 and Phosphatidylinositol 3-Kinase
1996
Mass spectrometry reveals modularity and a complete subunit interaction map of the eukaryotic translation factor eIF3
2008 StandoutNobel
Identification of four conserved motifs among the RNA-dependent polymerase encoding elements.
1989
eIF4G--A Multipurpose Ribosome Adapter?
1997 Science
Role of maturation cleavage in infectivity of picornaviruses: activation of an infectosome
1993
Cap-Independent Translation Is Required for Starvation-Induced Differentiation in Yeast
2007 StandoutScienceNobel
Liquid phase condensation in cell physiology and disease
2017 StandoutScience
Coordinated assembly of human translation initiation complexes by the hepatitis C virus internal ribosome entry site RNA
2004 StandoutNobel
Evidence that the N-terminal domain of nonstructural protein NS3 from yellow fever virus is a serine protease responsible for site-specific cleavages in the viral polyprotein.
1990 StandoutNobel
Structure of the catalytic domain of the hepatitis C virus NS2-3 protease
2006 StandoutNatureNobel
ATP-sensitive potassium channel (K ATP )–dependent regulation of cardiotropic viral infections
2011 StandoutNobel
Works of Tim Skern being referenced
Specific Cleavage of the Nuclear Pore Complex Protein Nup62 by a Viral Protease
2010
Substrate requirements of a human rhinoviral 2A proteinase
1991
Polypeptide 2A of human rhinovirus type 2: Identification as a protease and characterization by mutational analysis
1989
Equine rhinovirus serotypes 1 and 2: relationship to each other and to aphthoviruses and cardioviruses
1996
The 2A Proteinase of Human Rhinovirus Is a Zinc Containing Enzyme
1994
Mapping of Functional Domains in Eukaryotic Protein Synthesis Initiation Factor 4G (eIF4G) with Picornaviral Proteases
1995
Foot-and-Mouth Disease Virus Leader Proteinase
2001
Low cost apparatus for primer-directed DNA amplification using Thermus aquaticus-DNA polymerase
1989
2A Proteinases of Coxsackie- and Rhinovirus Cleave Peptides Derived from eIF-4γ via a Common Recognition Motif
1994
Proteolytically Active 2A Proteinase of Human Rhinovirus 2 Is Toxic forSaccharomyces cerevisiaebut Does Not Cleave the Homologues of eIF-4γin Vivoorin Vitro
1996
Characterization of the active site thiol group of rhinovirus 2A proteinase
2000
The structures of picornaviral proteinases
1999
Human rhinovirus serotype 2: In vitro synthesis of an infectious RNA
1989
elF4G and its proteolytic cleavage products: effect on initiation of protein synthesis from capped, uncapped, and IRES-containing mRNAs.
1997
Mapping the cleavage site in protein synthesis initiation factor eIF-4 gamma of the 2A proteases from human Coxsackievirus and rhinovirus.
1993
Picornavirus 2A Proteinase-Mediated Stimulation of Internal Initiation of Translation Is Dependent on Enzymatic Activity and the Cleavage Products of Cellular Proteins
1995
Cleavage specificity on synthetic peptide substrates of human rhinovirus 2 proteinase 2A.
1992
Cleavage of Eukaryotic Translation Initiation Factor 4GII within Foot-and-Mouth Disease Virus-Infected Cells: Identification of the L-Protease Cleavage Site In Vitro
2004
Human rhinovirus 2: complete nucleotide sequence and proteolytic processing signals in the capsid protein region
1985
Proteinase trapping: screening for viral proteinase mutants by alpha complementation.
1991
Differential Targeting of Nuclear Pore Complex Proteins in Poliovirus-Infected Cells
2007
Relationship of human rhinovirus strain 2 and poliovirus as indicated by comparison of the polymerase gene regions
1984
An Antiviral Peptide Inhibitor That Is Active against Picornavirus 2A Proteinases but Not Cellular Caspases
2006
The eIF4G-eIF4E complex is the target for direct cleavage by the rhinovirus 2A proteinase
1996
Foot-and-mouth disease virus Lb proteinase can stimulate rhinovirus and enterovirus IRES-driven translation and cleave several proteins of cellular and viral origin
1995
Evolutionary relationships within the human rhinovirus genus: comparison of serotypes 89, 2, and 14.
1987
A Neutralizing Epitope on Human Rhinovirus Type 2 Includes Amino Acid Residues between 153 and 164 of Virus Capsid Protein VP2
1987