Citation Impact
Citing Papers
Integrative genomic and functional analyses reveal neuronal subtype differentiation bias in human embryonic stem cell lines
2007 StandoutNobel
Multiplex Genome Engineering Using CRISPR/Cas Systems
2013 StandoutScience
RNAi in Budding Yeast
2009 Science
C3PO, an Endoribonuclease That Promotes RNAi by Facilitating RISC Activation
2009 Science
The Arabidopsis double-stranded RNA-binding protein HYL1 plays a role in microRNA-mediated gene regulation
2004
A Distinct Small RNA Pathway Silences Selfish Genetic Elements in the Germline
2006 Science
Functional Genomic Analysis of RNA Interference in C. elegans
2005 StandoutScienceNobel
TRBP, a regulator of cellular PKR and HIV‐1 virus expression, interacts with Dicer and functions in RNA silencing
2005
A Programmable Dual-RNA–Guided DNA Endonuclease in Adaptive Bacterial Immunity
2012 StandoutScienceNobel
MicroRNAs Regulate Brain Morphogenesis in Zebrafish
2005 Science
Transposition-Driven Genomic Heterogeneity in the Drosophila Brain
2013 StandoutScienceNobel
Distinct Populations of Primary and Secondary Effectors During RNAi in C. elegans
2006 StandoutScienceNobel
RNA Interference Directs Innate Immunity Against Viruses in Adult Drosophila
2006 Science
Deletion of Human tarbp2 Reveals Cellular MicroRNA Targets and Cell-Cycle Function of TRBP
2014
Characterization of the TRBP domain required for Dicer interaction and function in RNA interference
2009
Two novel PIWI families: roles in inter-genomic conflicts in bacteria and Mediator-dependent modulation of transcription in eukaryotes
2013
DNA-Damage-Induced Nuclear Export of Precursor MicroRNAs Is Regulated by the ATM-AKT Pathway
2013
Structure of Aquifex aeolicus Argonaute Highlights Conformational Flexibility of the PAZ Domain as a Potential Regulator of RNA-induced Silencing Complex Function
2006
MicroRNA Biogenesis: Drosha Can't Cut It without a Partner
2005
Autoinhibition of Human Dicer by Its Internal Helicase Domain
2008 StandoutNobel
Recapitulation of Short RNA-Directed Translational Gene Silencing In Vitro
2006
Differential roles of human Dicer-binding proteins TRBP and PACT in small RNA processing
2013 StandoutNobel
Normal microRNA Maturation and Germ-Line Stem Cell Maintenance Requires Loquacious, a Double-Stranded RNA-Binding Domain Protein
2005
Structure of the TRPA1 ion channel suggests regulatory mechanisms
2015 StandoutNatureNobel
RNA Helicase A Interacts with RISC in Human Cells and Functions in RISC Loading
2007
Regulation of microRNA function in animals
2018 Standout
A human, ATP-independent, RISC assembly machine fueled by pre-miRNA
2005
Genome-wide identification of targets of the drosha–pasha/DGCR8 complex
2009 StandoutNobel
Dicer is dispensable for asymmetric RISC loading in mammals
2011
RDE-4 preferentially binds long dsRNA and its dimerization is necessary for cleavage of dsRNA to siRNA
2006
Human Argonaute2 Mediates RNA Cleavage Targeted by miRNAs and siRNAs
2004 Standout
Sorting of Drosophila Small Silencing RNAs
2007
Structural insights into RNA processing by the human RISC-loading complex
2009 StandoutNobel
Alternative Processing of Primary microRNA Transcripts by Drosha Generates 5′ End Variation of Mature microRNA
2009
Recognition of the pre-miRNA structure by Drosophila Dicer-1
2011
Hierarchical Rules for Argonaute Loading in Drosophila
2009
A conserved motif in Argonaute-interacting proteins mediates functional interactions through the Argonaute PIWI domain
2007
Regulation of microRNA biogenesis
2014 Standout
Human ADAR1 Prevents Endogenous RNA from Triggering Translational Shutdown
2018 StandoutNobel
Specific association of Piwi with rasiRNAs derived from retrotransposon and heterochromatic regions in the Drosophila genome
2006
Drosophila microRNAs Are Sorted into Functionally Distinct Argonaute Complexes after Production by Dicer-1
2007
Passenger-Strand Cleavage Facilitates Assembly of siRNA into Ago2-Containing RNAi Enzyme Complexes
2005
Identification of small RNA pathway genes using patterns of phylogenetic conservation and divergence
2012 StandoutNatureNobel
nhl-2 Modulates MicroRNA Activity in Caenorhabditis elegans
2009 StandoutNobel
Precursor MicroRNA-Programmed Silencing Complex Assembly Pathways in Mammals
2012
Two distinct mechanisms generate endogenous siRNAs from bidirectional transcription in Drosophila melanogaster
2008
Substrate-Specific Kinetics of Dicer-Catalyzed RNA Processing
2010 StandoutNobel
Origins and Mechanisms of miRNAs and siRNAs
2009 Standout
New CRISPR–Cas systems from uncultivated microbes
2016 StandoutNatureNobel
R2D2 Leads the Silencing Trigger to mRNA's Death Star
2003
MicroRNAs: small RNAs with a big role in gene regulation
2004 Standout
RISC is a 5′ phosphomonoester-producing RNA endonuclease
2004
TRBP alters human precursor microRNA processing in vitro
2012 StandoutNobel
Small silencing RNAs: an expanding universe
2009 Standout
Slicer function of Drosophila Argonautes and its involvement in RISC formation
2005
A Dicer-2-Dependent 80S Complex Cleaves Targeted mRNAs during RNAi in Drosophila
2004
Sumoylation of Human Argonaute 2 at Lysine-402 Regulates Its Stability
2014
Hsc70/Hsp90 Chaperone Machinery Mediates ATP-Dependent RISC Loading of Small RNA Duplexes
2010
CRISPR RNA maturation by trans-encoded small RNA and host factor RNase III
2011 StandoutNatureNobel
Structural determinants of miRNAs for RISC loading and slicer-independent unwinding
2009
MicroRNA biogenesis: coordinated cropping and dicing
2005 Standout
MicroRNAs: Target Recognition and Regulatory Functions
2009 Standout
The Human DiGeorge Syndrome Critical Region Gene 8 and Its D. melanogaster Homolog Are Required for miRNA Biogenesis
2004
Posttranscriptional Crossregulation between Drosha and DGCR8
2009
A three-dimensional view of the molecular machinery of RNA interference
2008 StandoutNatureNobel
Homeostatic control of Argonaute stability by microRNA availability
2013
The Drosophila RNA Methyltransferase, DmHen1, Modifies Germline piRNAs and Single-Stranded siRNAs in RISC
2007
Natural Selection Drives Extremely Rapid Evolution in Antiviral RNAi Genes
2006
RNase III enzymes and the initiation of gene silencing
2004
microRNAs associated with the different human Argonaute proteins
2012
Structural features of small RNA precursors determine Argonaute loading in Caenorhabditis elegans
2007
Structural Foundations of RNA Silencing by Argonaute
2017
Crystal structure of a PIWI protein suggests mechanisms for siRNA recognition and slicer activity
2004
Molecular Basis for Target RNA Recognition and Cleavage by Human RISC
2007
Sorting of Drosophila small silencing RNAs partitions microRNA* strands into the RNA interference pathway
2009
Analysis of the C. elegans Argonaute Family Reveals that Distinct Argonautes Act Sequentially during RNAi
2006 StandoutNobel
Distinct Roles for Drosophila Dicer-1 and Dicer-2 in the siRNA/miRNA Silencing Pathways
2004
Argonaute proteins: functional insights and emerging roles
2013
Sequence-Specific Inhibition of Small RNA Function
2004 StandoutNobel
The HHpred interactive server for protein homology detection and structure prediction
2005 Standout
Making RISC
2010
A genome-wide transgenic RNAi library for conditional gene inactivation in Drosophila
2007 StandoutNature
Human RISC Couples MicroRNA Biogenesis and Posttranscriptional Gene Silencing
2005
Trans-splicing in C. elegans generates the negative RNAi regulator ERI-6/7
2008 StandoutNatureNobel
microRNA-Directed Phasing during Trans-Acting siRNA Biogenesis in Plants
2005 Standout
Dicer Partner Proteins Tune the Length of Mature miRNAs in Flies and Mammals
2012
Argonaute proteins: key players in RNA silencing
2007
Phosphorylation of the Human MicroRNA-Generating Complex Mediates MAPK/Erk Signaling
2009
Conversion of pre-RISC to holo-RISC by Ago2 during assembly of RNAi complexes
2006
Human Argonaute 2 Has Diverse Reaction Pathways on Target RNAs
2015
Functional Anatomy of the Drosophila MicroRNA-generating Enzyme
2007
Antiviral immunity in drosophila
2009
The MicroRNA miR-1 Regulates a MEF-2-Dependent Retrograde Signal at Neuromuscular Junctions
2008 StandoutNobel
Argonaute: a scaffold for the function of short regulatory RNAs
2006
RISC Assembly Defects in the Drosophila RNAi Mutant armitage
2004
Assembly and function of RNA silencing complexes
2005
A comprehensive survey of 3′ animal miRNA modification events and a possible role for 3′ adenylation in modulating miRNA targeting effectiveness
2010
The DExD/H-box helicase Dicer-2 mediates the induction of antiviral activity in drosophila
2008 StandoutNobel
Small RNA-Mediated Quiescence of Transposable Elements in Animals
2010
TRBP recruits the Dicer complex to Ago2 for microRNA processing and gene silencing
2005 StandoutNature
Characterization of DGCR8/Pasha, the essential cofactor for Drosha in primary miRNA processing
2006
Processing of Pre-microRNAs by the Dicer-1–Loquacious Complex in Drosophila Cells
2005
Versatile microRNA biogenesis in animals and their viruses
2014
Gene silencing mechanisms mediated by Aubergine–piRNA complexes in Drosophila male gonad
2007
Structure of yeast Argonaute with guide RNA
2012 Nature
Improved protein structure prediction using potentials from deep learning
2020 StandoutNatureNobel
The RISC subunit Tudor-SN binds to hyper-edited double-stranded RNA and promotes its cleavage
2005
Sorting of Small RNAs into Arabidopsis Argonaute Complexes Is Directed by the 5′ Terminal Nucleotide
2008
Processing of primary microRNAs by the Microprocessor complex
2004 StandoutNature
The Nuclear dsRNA Binding Protein HYL1 Is Required for MicroRNA Accumulation and Plant Development, but Not Posttranscriptional Transgene Silencing
2004
MicroRNA therapeutics: towards a new era for the management of cancer and other diseases
2017 Standout
RNA interference in protozoan parasites
2004
Structural basis for 5′-end-specific recognition of guide RNA by the A. fulgidus Piwi protein
2005 Nature
Specialization and evolution of endogenous small RNA pathways
2007
mRNA degradation by miRNAs and GW182 requires both CCR4:NOT deadenylase and DCP1:DCP2 decapping complexes
2006
Ars2 Regulates Both miRNA- and siRNA- Dependent Silencing and Suppresses RNA Virus Infection in Drosophila
2009
Decay of mRNAs targeted by RISC requires XRN1, the Ski complex, and the exosome
2005
Small RNAs as Guardians of the Genome
2009
The molecular architecture of human Dicer
2012
Importin 8 Is a Gene Silencing Factor that Targets Argonaute Proteins to Distinct mRNAs
2009
Evolution of Animal and Plant Dicers: Early Parallel Duplications and Recurrent Adaptation of Antiviral RNA Binding in Plants
2012
Highly Complementary Target RNAs Promote Release of Guide RNAs from Human Argonaute2
2013
Overexpression of Exportin 5 enhances RNA interference mediated by short hairpin RNAs and microRNAs
2004
ATP-dependent human RISC assembly pathways
2009
MicroRNA expression profiles classify human cancers
2005 StandoutNatureNobel
Structure of C3PO and mechanism of human RISC activation
2011
Distinct Mechanisms for MicroRNA Strand Selection by Drosophila Argonautes
2009
Essential and overlapping functions for mammalian Argonautes in microRNA silencing
2009
Human TRBP and PACT Directly Interact with Each Other and Associate with Dicer to Facilitate the Production of Small Interfering RNA
2007
Dicer-2 and R2D2 coordinately bind siRNA to promote assembly of the siRISC complexes
2006
Structural basis for overhang-specific small interfering RNA recognition by the PAZ domain
2004 Nature
Dicer-1, but not Loquacious, is critical for assembly of miRNA-induced silencing complexes
2007
dsRNA Binding Properties of RDE-4 and TRBP Reflect Their Distinct Roles in RNAi
2008
Mechanisms of gene silencing by double-stranded RNA
2004 StandoutNature
Dicer-1 and R3D1-L catalyze microRNA maturation in Drosophila
2005
miRNAs on the move: miRNA biogenesis and the RNAi machinery
2004
A crucial role for GW182 and the DCP1:DCP2 decapping complex in miRNA-mediated gene silencing
2005
The Drosha-DGCR8 complex in primary microRNA processing
2004 Standout
Biogenesis of small RNAs in animals
2009 Standout
Structures of the first and second double‐stranded RNA‐binding domains of human TAR RNA‐binding protein
2010
The functions of animal microRNAs
2004 StandoutNatureNobel
Distinct roles for Argonaute proteins in small RNA-directed RNA cleavage pathways
2004
Dual Role for Argonautes in MicroRNA Processing and Posttranscriptional Regulation of MicroRNA Expression
2007
Perspective: machines for RNAi
2005
Molecular mechanisms that funnel RNA precursors into endogenous small-interfering RNA and microRNA biogenesis pathways in Drosophila
2010
Argonaute Proteins: Mediators of RNA Silencing
2007
Single Processing Center Models for Human Dicer and Bacterial RNase III
2004
Multiple sensors ensure guide strand selection in human RNAi pathways
2013 StandoutNobel
The role of PACT in the RNA silencing pathway
2006
The Mechanism of RNase III Action: How Dicer Dices
2007
An endogenous small interfering RNA pathway in Drosophila
2008 Nature
Biochemical mechanisms of the RNA-induced silencing complex
2007
The contributions of dsRNA structure to Dicer specificity and efficiency
2005
Characterization of the interactions between mammalian PAZ PIWI domain proteins and Dicer
2004
A Cas9–guide RNA complex preorganized for target DNA recognition
2015 StandoutScienceNobel
An antiviral role for the RNA interference machinery in Caenorhabditis elegans
2005
Tudor domain ERI-5 tethers an RNA-dependent RNA polymerase to DCR-1 to potentiate endo-RNAi
2011 Nobel
Structural and biochemical insights into the dicing mechanism of mouse Dicer: A conserved lysine is critical for dsRNA cleavage
2008
ATP-independent diffusion of double-stranded RNA binding proteins
2012 StandoutNobel
A bacterial Argonaute with noncanonical guide RNA specificity
2016 StandoutNobel
Characterization of Dicer-deficient murine embryonic stem cells
2005
Recognition of siRNA Asymmetry by TAR RNA Binding Protein
2010
In vitro reconstitution of the human RISC-loading complex
2008 StandoutNobel
RNAi-mediated immunity provides strong protection against the negative-strand RNA vesicular stomatitis virus in Drosophila
2010 StandoutNobel
Structural basis for microRNA targeting
2014 Science
Cellular cofactors affecting hepatitis C virus infection and replication
2007 StandoutNobel
RNAi is an antiviral immune response against a dsRNA virus in Drosophila melanogaster
2006
Small RNAs: Classification, Biogenesis, and Function
2005
A Protein Sensor for siRNA Asymmetry
2004 Science
Structural Basis for Double-Stranded RNA Processing by Dicer
2006 StandoutScienceNobel
Virus Counterdefense: Diverse Strategies for Evading the RNA-Silencing Immunity
2006
The neuronal microRNA system
2006
The growing catalog of small RNAs and their association with distinct Argonaute/Piwi family members
2008
Structural basis for gating charge movement in the voltage sensor of a sodium channel
2011 StandoutNobel
Works of Tim Rand being referenced
R2D2, a Bridge Between the Initiation and Effector Steps of the Drosophila RNAi Pathway
2003 Science
The let-7/LIN-41 Pathway Regulates Reprogramming to Human Induced Pluripotent Stem Cells by Controlling Expression of Prodifferentiation Genes
2013 Nobel
Argonaute2 Cleaves the Anti-Guide Strand of siRNA during RISC Activation
2005
Biochemical identification of Argonaute 2 as the sole protein required for RNA-induced silencing complex activity
2004