Standout Papers
- Region-specific regulation of the actin multi-gene family in early amphibian embryos (1984)
- Transcription of muscle-specific actin genes in early xenopus development: Nuclear transplantation and cell dissociation (1984)
- Upstream sequences required for tissue-specific activation of the cardiac actin gene in Xenopus laevis embryos. (1986)
- All components required for the eventual activation of muscle-specific actin genes are localized in the subequatorial region of an uncleaved amphibian egg. (1985)
- Cell type-specific activation of actin genes in the early amphibian embryo (1984)
- Embryonic induction and muscle gene activation (1989)
- Actin genes in Xenopus and their developmental control (1985)
Citation Impact
Citing Papers
Induction of human neuronal cells by defined transcription factors
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1995 StandoutNatureNobel
A family of muscle gene promoter element (CArG) binding activities in Xenopus embryos: CArG/SRE discrimination and distribution during myogenesis
1991
A truncated activin receptor inhibits mesoderm induction and formation of axial structures in Xenopus embryos
1992 Nature
A community effect in animal development
1988 StandoutNatureNobel
Xenopus Mad Proteins Transduce Distinct Subsets of Signals for the TGFβ Superfamily
1996
Role for the p53 homologue p73 in E2F-1-induced apoptosis
2000 StandoutNatureNobel
The ‘CC.Ar.GG’ box
1988
The Fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegans
1997 StandoutNatureNobel
A maternal mRNA localized to the vegetal hemisphere in xenopus eggs codes for a growth factor related to TGF-β
1987
Studies with a Xenopus BMP receptor suggest that ventral mesoderm-inducing signals override dorsal signals in vivo
1994
Diffusible factors in vertebrate embryonic induction
1992
Eomesodermin, a Key Early Gene in Xenopus Mesoderm Differentiation
1996 StandoutNobel
Activins are expressed early in Xenopus embryogenesis and can induce axial mesoderm and anterior structures
1990
A Xenopus mRNA related to Drosophila twist is expressed in response to induction in the mesoderm and the neural crest
1989 StandoutNobel
The generation of diversity and pattern in animal development
1992 StandoutNobel
Inducing factors in Xenopus early embryos
1994
Ectopic mesoderm formation in Xenopus embryos caused by widespread expression of a Brachyury homologue
1992 Nature
Activation of muscle genes without myogenesis by ectopic expression of MyoD in frog embryo cells
1990 StandoutNatureNobel
Two Myogenin-related Genes Are Differentially Expressed inXenopus laevis Myogenesis and Differ in Their Ability to Transactivate Muscle Structural Genes
2002
A stress response pathway regulates DNA damage through β2-adrenoreceptors and β-arrestin-1
2011 StandoutNatureNobel
Mix.1, a homeobox mRNA inducible by mesoderm inducers, is expressed mostly in the presumptive endodermal cells of Xenopus embryos
1989
The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14
1993 StandoutNobel
Ubiquitous MyoD transcription at the midblastula transition precedes induction-dependent MyoD expression in presumptive mesoderm of X. laevis
1991
Activin signalling and response to a morphogen gradient
1994 StandoutNatureNobel
The regulation of E2F by pRB-family proteins
1998 Standout
Synergistic induction of mesoderm by FGF and TGF-β and the identification of an mRNA coding for FGF in the early xenopus embryo
1987
The mRNA encoding elongation factor 1-α (EF-1α) is a major transcript at the midblastula transition in Xenopus
1989
Caenorhabditis elegans has scores of homoeobox-containing genes
1989 StandoutNatureNobel
Capter 16 Nuclear Transplantation in Xenopus
1991 StandoutNobel
A mechanistic link between an inherited and an acquird cardiac arrthytmia: HERG encodes the IKr potassium channel
1995 Standout
C. elegans unc-4 gene encodes a homeodomain protein that determines the pattern of synaptic input to specific motor neurons
1992 StandoutNatureNobel
Multiple intercellular signalling systems control the development of the Caenorhabditis elegans vulva
1991 StandoutNatureNobel
DNA demethylation is necessary for the epigenetic reprogramming of somatic cell nuclei
2004 StandoutNobel
The entire mesodermal mantle behaves as Spemann's organizer in dorsoanterior enhanced Xenopus laevis embryos
1988
A bovine homolog to the human myogenic determination factor myf-5: sequence conservation and 3′ processing of transcripts
1990
A common E2F-1 and p73 pathway mediates cell death induced by TCR activation
2000 StandoutNatureNobel
Do the poly(A) tail and 3′ untranslated region control mRNA translation?
1990
Injected Wnt RNA induces a complete body axis in Xenopus embryos
1991
Eomesodermin is required for mouse trophoblast development and mesoderm formation
2000 StandoutNatureNobel
Responses of embryonic xenopus cells to activin and FGF are separated by multiple dose thresholds and correspond to distinct axes of the mesoderm
1992
Microinjection of synthetic Xhox-1A homeobox mRNA disrupts somite formation in developing Xenopus embryos
1988
Nuclear reprogramming to a pluripotent state by three approaches
2010 StandoutNatureNobel
Non-hydrophobic extracytoplasmic determinant of stop transfer in the prion protein
1990 StandoutNatureNobel
A conserved retinoic acid response element required for early expression of the homeobox gene Hoxb-1
1994 StandoutNatureNobel
Nuclear Reprogramming in Cells
2008 StandoutScienceNobel
Muscle gene activation in Xenopus requires intercellular communication during gastrula as well as blastula stages
1992 StandoutNobel
Retinoic acid perturbs the expression of Xhox.lab genes and alters mesodermal determination in Xenopus laevis.
1991
Xenopusoocytes reactivate muscle gene transcription in transplanted somatic nuclei independently of myogenic factors
2009 StandoutNobel
Activation of muscle-specific actin genes in xenopus development by an induction between animal and vegetal cells of a blastula
1985 StandoutNobel
Slow emergence of a multithreshold response to activin requires cell-contact-dependent sharpening but not prepattern
1994
Two distinct Xenopus genes with homology to MyoD1 are expressed before somite formation in early embryogenesis.
1990
Upstream regions of the human cardiac actin gene that modulate its transcription in muscle cells: presence of an evolutionarily conserved repeated motif.
1986
Detecting conserved regulatory elements with the model genome of the Japanese puffer fish, Fugu rubripes.
1995 StandoutNobel
CArG boxes in the human cardiac alpha-actin gene are core binding sites for positive trans-acting regulatory factors.
1987
Duplicated CArG Box Domains Have Positive and Mutually Dependent Regulatory Roles in Expression of the Human α-Cardiac Actin Gene
1987
Mesoderm Induction in Amphibians: the Role of TGF-β2-Like Factors
1988 Science
The CArG promoter sequence is necessary for muscle-specific transcription of the cardiac actin gene in Xenopus embryos.
1989 StandoutNobel
Slow emergence of a multithreshold response to activin requires cell-contact-dependent sharpening but not prepattern
1994
Multiple 5'-flanking regions of the human alpha-skeletal actin gene synergistically modulate muscle-specific expression.
1987
Expression of intermediate filament proteins during development of Xenopus laevis: II. Identification and molecular characterization of desmin
1989
Expression of intermediate filament proteins during development of Xenopus laevis: I.cDNA clones encoding different forms of vimentin
1989
Bix1, a direct target of Xenopus T-box genes, causes formation of ventral mesoderm and endoderm
1998
Muscle-specific expression of the cardiac alpha-actin gene requires MyoD1, CArG-box binding factor, and Sp1.
1990
Two-level regulation of cardiac actin gene transcription: muscle-specific modulating factors can accumulate before gene activation.
1986
A homeobox-containing marker of posterior neural differentiation shows the importance of predetermination in neural induction
1987 StandoutNobel
The future of cloning
1999 StandoutNatureNobel
Tissue-specific expression of actin genes injected into Xenopus embryos
1986
Plasticity of the Differentiated State
1985 Science
The induction of anterior and posterior neural genes in Xenopus laevis
1990 StandoutNobel
Nuclear reprogramming and stem cell creation
2003 StandoutNobel
Cross-Binding of Factors to Functionally Different Promoter Elements in c-fos and Skeletal Actin Genes
1989
The DNA-binding protein E12 co-operates with XMyoD in the activation of muscle-specific gene expression in Xenopus embryos.
1992 StandoutNobel
Expression of a novel FGF in theXenopusembryo. A new candidate inducing factor for mesoderm formation and anteroposterior specification
1992
Stability of RNA in developing Xenopus embryos and identification of a destabilizing sequence in TFIIIA messenger RNA
1988
An experimental system for analyzing response to a morphogen gradient.
1996 StandoutNobel
The initiation of new gene transcription duringXenopusgastrulation requires immediately preceding protein synthesis
1987 StandoutNobel
Inductive effects of fibroblast growth factor and lithium ion on Xenopus blastula ectoderm
1988
Functional gap junctions are not required for muscle gene activation by induction in Xenopus embryos.
1987 StandoutNobel
Controlling mRNA lifespan
1988 StandoutNatureNobel
Loss of competence in amphibian induction can take place in single nondividing cells.
1989 StandoutNobel
Cell interactions and the control of gene activity during early development of Xenopus laevis
1986
Xenopus embryos contain a somite-specific, MyoD-like protein that binds to a promoter site required for muscle actin expression.
1991 StandoutNobel
Expression of the Tcp-1 locus of the mouse during early embryogenesis
1985
XIF3, a Xenopus peripherin gene, requires an inductive signal for enhanced expression in anterior neural tissue
1989 StandoutNobel
From Nuclear Transfer to Nuclear Reprogramming: The Reversal of Cell Differentiation
2006 StandoutNobel
Upstream Regions of the Human Cardiac Actin Gene That Modulate Its Transcription in Muscle Cells: Presence of an Evolutionarily Conserved Repeated Motif
1986
Nuclear Transplantation in Eggs and Oocytes
1986 StandoutNobel
Mesodermal Patterning by a Gradient of the Vertebrate Homeobox Gene goosecoid
1994 Science
The Xenopus T-box gene, Antipodean, encodes a vegetally localised maternal mRNA and can trigger mesoderm formation
1996 StandoutNobel
Protein synthesis and messenger RNA levels along the animal–vegetal axis during early Xenopus development
1986
Unusual Topogenic Sequence Directs Prion Protein Biogenesis
1990 StandoutScienceNobel
Localized expression of a Xenopus POU gene depends on cell-autonomous transcriptional activation and induction-dependent inactivation
1992
Secretion and mesoderm-inducing activity of the TGF-beta-related domain of Xenopus Vg1.
1993
Localization of specific mRNAs in Xenopus embryos by whole-mount in situ hybridization
1990
Transcripts of α-cardiac and α-skeletal actins are early markers for myogenesis in the mouse embryo
1988
Body-Wall Muscle Formation in Caenorhabditis elegans Embryos that Lack the MyoD Homolog hlh-1
1992 StandoutScienceNobel
Mesoderm induction and mesoderm-inducing factors in early amphibian development
1989
Muscle gene activation by induction and the nonrequirement for cell division
1986 StandoutNobel
Cytoplasmic localization and chordamesoderm induction in the frog embryo
1985
Bix4is activated directly by VegT and mediates endoderm formation inXenopusdevelopment
1999
Mesoderm induction in Xenopus laevis: a quantitative study using a cell lineage label and tissue-specific antibodies
1985
Developmental expression of a neurofilament-M and two vimentin-like genes in Xenopus laevis
1988
Expression of the myogenic gene MRF4 during Xenopus development
1992
Identification of a myocyte nuclear factor that binds to the muscle-specific enhancer of the mouse muscle creatine kinase gene.
1989
Localization of specific mRNA sequences in Xenopus laevis embryos by in situ hybridization
1986
Developmental regulation of a gastrula-specific gene injected into fertilized Xenopus eggs.
1985
Mesoderm induction in Xenopus laevis. responding cells must be in contact for mesoderm formation but suppression of epidermal differentiation can occur in single cells
1988
A role for cytoplasmic determinants in mesoderm patterning: cell-autonomous activation of the goosecoid and Xwnt-8 genes along the dorsoventral axis of early Xenopus embryos
1994 StandoutNobel
MyoD expression in the forming somites is an early response to mesoderm induction in Xenopus embryos.
1989 StandoutNobel
Embryonic induction - molecular prospects
1987 StandoutNobel
Two-Level Regulation of Cardiac Actin Gene Transcription: Muscle-Specific Modulating Factors Can Accumulate before Gene Activation
1986
Interaction of Nuclear Proteins with Muscle-Specific Regulatory Sequences of the Human Cardiac α-Actin Promoter
1988
Development of the ectoderm in Xenopus: Tissue specification and the role of cell association and division
1986
Identification of Two Nuclear Factor-Binding Domains on the Chicken Cardiac Actin Promoter: Implications for Regulation of the Gene
1989
Effects of truncated activin and FGF receptors and of follistatin on the inducing activities of BVg1 and activin: does activin play a role in mesoderm induction?
1994
Embryonic expression and nuclear localization of Xenopus homeobox (Xhox) gene products.
1986
Bone morphogenetic protein 4: a ventralizing factor in early Xenopus development
1992
The Xenopus MyoD gene: an unlocalised maternal mRNA predates lineage- restricted expression in the early embryo
1990
Activin-mediated mesoderm induction requires FGF
1994
Gastrulation movements provide an early marker of mesoderm induction in Xenopus laevis
1987
Xenopus Myf-5 marks early muscle cells and can activate muscle genes ectopically in early embryos
1991 StandoutNobel
[25] The use of xenopus oocytes for the expression of cloned genes
1983 StandoutNobel
Graded changes in dose of a Xenopus activin A homologue elicit stepwise transitions in embryonic cell fate
1990 Nature
Expression of genes encoding the transcription factor SRF during early development of Xenopus laevis: identification of a CArG box-binding activity as SRF.
1991
Multiple 5′-Flanking Regions of the Human α-Skeletal Actin Gene Synergistically Modulate Muscle-Specific Expression
1987
Epidermal keratin gene expressed in embryos of Xenopus laevis.
1985
Cross-binding of factors to functionally different promoter elements in c-fos and skeletal actin genes.
1989
Construction of defined polytopic integral transmembrane proteins. The role of signal and stop transfer sequence permutations.
1988
Expression ofXenopusN-CAM RNA in ectoderm is an early response to neural induction
1987
Repression of c- fos Transcription and an Altered Genetic Program in Senescent Human Fibroblasts
1990 Science
Xenopus endo B is a keratin preferentially expressed in the embryonic notochord.
1988
Regional specification within the mesoderm of early embryos ofXenopus laevis
1987
From intestine to muscle: Nuclear reprogramming through defective cloned embryos
2002 StandoutNobel
Morphogen gradient interpretation
2001 StandoutNatureNobel
Works of Tim Mohun being referenced
Muscle differentiation
1992
Temporal and tissue-specific expression of the proto-oncogene c-fos during development in Xenopus laevis
1989
Myogenesis in Xenopus laevis
1994
A third striated muscle actin gene is expressed during early development in the amphibian Xenopus laevis
1988
Embryonic induction and muscle gene activation
1989 StandoutNobel
Cell type-specific activation of actin genes in the early amphibian embryo
1984 StandoutNatureNobel
The secretion of proteinsin vitrofromXenopusoocytes and their accessory cells: a biochemical and morphological study
1981
An amphibian cytoskeletal-type actin gene is expressed exclusively in muscle tissue
1987
Molecular characterization of Xenopus laevis DP proteins.
1994
Muscle-specific (CArG) and serum-responsive (SRE) promoter elements are functionally interchangeable inXenopusembryos and mouse fibroblasts
1989
Upstream sequences required for tissue-specific activation of the cardiac actin gene in Xenopus laevis embryos.
1986 StandoutNobel
The Influence of Topology and Glycosylation on the Fate of Heterologous Secretory Proteins Made in Xenopus Oocytes
1981
Xenopus cytoskeletal actin and human c-fos gene promoters share a conserved protein-binding site.
1987
Actin genes in Xenopus and their developmental control
1985 StandoutNobel
Transcription of muscle-specific actin genes in early xenopus development: Nuclear transplantation and cell dissociation
1984 StandoutNobel
All components required for the eventual activation of muscle-specific actin genes are localized in the subequatorial region of an uncleaved amphibian egg.
1985 StandoutNobel
Differential expression of two skeletal muscle beta-tropomyosin mRNAs during Xenopus laevis development.
1999