Citation Impact
Citing Papers
SuFEx-enabled, agnostic discovery of covalent inhibitors of human neutrophil elastase
2019 StandoutNobel
Molecular Analysis of Commensal Host-Microbial Relationships in the Intestine
2001 StandoutScience
De novo design of transmembrane β barrels
2021 StandoutScienceNobel
Conformational Switch of Syntaxin-1 Controls Synaptic Vesicle Fusion
2008 StandoutScienceNobel
Gating the Selectivity Filter in ClC Chloride Channels
2003 StandoutScienceNobel
Diversity oriented clicking delivers β-substituted alkenyl sulfonyl fluorides as covalent human neutrophil elastase inhibitors
2022 StandoutNobel
Purification and Characterization of Recombinant Cystic Fibrosis Transmembrane Conductance Regulator from Chinese Hamster Ovary and Insect Cells
1995
Developmental Differences of Cystic Fibrosis Transmembrane Conductance Regulator Functional Expression in Isolated Rat Fetal Distal Airway Epithelial Cells
1994
Extensive posttranscriptional deletion of the coding sequences for part of nucleotide-binding fold 1 in respiratory epithelial mRNA transcripts of the cystic fibrosis transmembrane conductance regulator gene is not associated with the clinical manifestations of cystic fibrosis.
1992
Altered chloride ion channel kinetics associated with the ΔF508 cystic fibrosis mutation
1991 Nature
Characterization of the oligosaccharide structures associated with the cystic fibrosis transmembrane conductance regulator
2000
Genetic Influences on Cystic Fibrosis Lung Disease Severity
2013
Influenza virus M2 protein has ion channel activity
1992
cAMP stimulates bicarbonate secretion across normal, but not cystic fibrosis airway epithelia.
1992
Localization of cystic fibrosis transmembrane conductance regulator in chloride secretory epithelia.
1992
ABC-ATPases, adaptable energy generators fuelling transmembrane movement of a variety of molecules in organisms from bacteria to humans
1999
Synergy-Based Small-Molecule Screen Using a Human Lung Epithelial Cell Line Yields ΔF508-CFTR Correctors That Augment VX-809 Maximal Efficacy
2014
Understanding how cystic fibrosis mutations disrupt CFTR function: From single molecules to animal models
2014
Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Potentiator VX-770 (Ivacaftor) Opens the Defective Channel Gate of Mutant CFTR in a Phosphorylation-dependent but ATP-independent Manner
2012
Generation and characterization of a ΔF508 cystic fibrosis mouse model
1995 StandoutNobel
Nucleotide signalling during inflammation
2014 StandoutNature
Effects of the ?F508 mutation on the structure, function, and folding of the first nucleotide-binding domain of CFTR
1993
Cystic Fibrosis Transmembrane Conductance Regulator Is Required for Protein Kinase A Activation of an Outwardly Rectified Anion Channel Purified from Bovine Tracheal Epithelia
1995
Differential and Simultaneous Adenosine Di- and Triphosphate Binding by MutS
2003 StandoutNobel
Hydrolytically Deficient MutS E694A Is Defective in the MutL-dependent Activation of MutH and in the Mismatch-dependent Assembly of the MutS · MutL · Heteroduplex Complex
2003 StandoutNobel
Chloride channels, Golgi pH and cystic fibrosis
1992
The C. elegans Cell Corpse Engulfment Gene ced-7 Encodes a Protein Similar to ABC Transporters
1998 StandoutNobel
Activation by Extracellular Nucleotides of Chloride Secretion in the Airway Epithelia of Patients with Cystic Fibrosis
1991
The Degradation of Apolipoprotein B100 Is Mediated by the Ubiquitin-proteasome Pathway and Involves Heat Shock Protein 70
1997 StandoutNobel
Sequence and structural homology among membrane-associated domains of CFTR and certain transporter proteins
1993
In vivo transfer of the human cystic fibrosis transmembrane conductance regulator gene to the airway epithelium
1992
Defective regulation of outwardly rectifying Cl− channels by protein kinase A corrected by insertion of CFTR
1992 Nature
Phosphorylation of the R domain by cAMP-dependent protein kinase regulates the CFTR chloride channel
1991
Proteasome- and p53-dependent Masking of Signal Transducer and Activator of Transcription (STAT) Factors
1997 StandoutNobel
Syntaxin 1A is expressed in airway epithelial cells, where it modulates CFTR Cl– currents
2000
Neutrophil elastase in respiratory epithelial lining fluid of individuals with cystic fibrosis induces interleukin-8 gene expression in a human bronchial epithelial cell line.
1992
Processing of mutant cystic fibrosis transmembrane conductance regulator is temperature-sensitive
1992 Nature
Multiple physiological functions for multidrug transporter P-glycoprotein?
2000
Nucleoside triphosphates are required to open the CFTR chloride channel
1991
Identification of the Cystic Fibrosis Transmembrane Conductance Regulator Domains That Are Important for Interactions with ROMK2
2000
Function of the R Domain in the Cystic Fibrosis Transmembrane Conductance Regulator Chloride Channel
1997
Identification and regulation of the cystic fibrosis transmembrane conductance regulator-generated chloride channel.
1991
Activation of endogenous deltaF508 cystic fibrosis transmembrane conductance regulator by phosphodiesterase inhibition.
1996
Molecular mechanisms of CFTR chloride channel dysfunction in cystic fibrosis
1993
Degradation of 3-Hydroxy-3-methylglutaryl-CoA Reductase in Endoplasmic Reticulum Membranes Is Accelerated as a Result of Increased Susceptibility to Proteolysis
1996 StandoutNobel
Sec6l-mediated transfer of a membrane protein from the endoplasmic reticulum to the proteasome for destruction
1996 StandoutNature
Mucus clearance as a primary innate defense mechanism for mammalian airways
2002
Inactivation of the murine cftr gene abolishes cAMP-mediated but not Ca2+-mediated secretagogue-induced volume decrease in small-intestinal crypts
1993 StandoutNobel
Regulation of CFTR chloride channels by syntaxin and Munc18 isoforms
1997 Nature
Mislocalization of ΔF508 CFTR in cystic fibrosis sweat gland
1992
Salmonella typhi uses CFTR to enter intestinal epithelial cells
1998 StandoutNatureNobel
Expression of the human cystic fibrosis transmembrane conductance regulator gene in the mouse lung afterin vivointratracheal plasmid-mediated gene transfer
1992
Localization of cystic fibrosis transmembrane conductance regulator mRNA in the human gastrointestinal tract by in situ hybridization.
1994
In vivo cell-specific expression of the cystic fibrosis transmembrane conductance regulator
1991 Nature
Cystic fibrosis genetics: from molecular understanding to clinical application
2014 Standout
CFTR expression is regulated during both the cycle of the seminiferous epithelium and the oestrous cycle of rodents
1993
Overcoming Hysteresis to Attain Reversible Equilibrium Folding for Outer Membrane Phospholipase A in Phospholipid Bilayers
2011
Correlation of sweat chloride concentration with classes of the cystic fibrosis transmembrane conductance regulator gene mutations
1995
Correction of Both NBD1 Energetics and Domain Interface Is Required to Restore ΔF508 CFTR Folding and Function
2012
Cystic fibrosis transmembrane conductance regulator splice variants are not conserved and fail to produce chloride channels
1993
A Mutation in the Cystic Fibrosis Transmembrane Conductance Regulator Generates a Novel Internalization Sequence and Enhances Endocytic Rates
2003
CFTR and outward rectifying chloride channels are distinct proteins with a regulatory relationship
1993 Nature
Activation of ion transport pathways by changes in cell volume
1991
A constitutively open potassium channel formed by KCNQ1 and KCNE3
2000 StandoutNature
Interaction between Cystic Fibrosis Transmembrane Conductance Regulator and Outwardly Rectified Chloride Channels
1995
Cystic fibrosis: molecular biology and therapeutic implications
1992 StandoutScience
SWELL1, a Plasma Membrane Protein, Is an Essential Component of Volume-Regulated Anion Channel
2014 StandoutNobel
A Naturally Occurring Sequence Variation That Creates a YY1 Element Is Associated with Increased Cystic Fibrosis Transmembrane Conductance Regulator Gene Expression
2000
Multiple proteolytic systems, including the proteasome, contribute to CFTR processing
1995
Mucin Granule Intraluminal Organization in Living Mucous/Goblet Cells
2005 StandoutNobel
Submucosal glands are the predominant site of CFTR expression in the human bronchus
1992
Golgi Localization of Carbohydrate Sulfotransferases Is a Determinant of L-selectin Ligand Biosynthesis
2003 StandoutNobel
twine, a cdc25 homolog that functions in the male and female germline of drosophila
1992 StandoutNobel
CFTR: Development of high- affinity antibodies and localization in sweat gland
1991
Mechanism-based corrector combination restores ΔF508-CFTR folding and function
2013
Molecular genetics of cell death in the nematode Caenorhabditis elegans
1992
The Nature of Small-Airway Obstruction in Chronic Obstructive Pulmonary Disease
2004 Standout
CFTR Cl- channel and CFTR-associated ATP channel: distinct pores regulated by common gates
1998
A mouse model for the delta F508 allele of cystic fibrosis.
1995 StandoutNobel
In Vivo Nasal Potential Difference: Techniques and Protocols for Assessing Efficacy of Gene Transfer in Cystic Fibrosis
1995
Degradation of a Mutant Secretory Protein, α1-Antitrypsin Z, in the Endoplasmic Reticulum Requires Proteasome Activity
1996 StandoutNobel
A Novel Mutation in the Cystic Fibrosis Gene in Patients with Pulmonary Disease but Normal Sweat Chloride Concentrations
1994
Correction of the ion transport defect in cystic fibrosis transgenic mice by gene therapy
1993 StandoutNatureNobel
Phosphorylation-regulated CI− channel in CHO cells stably expressing the cystic fibrosis gene
1991 Nature
LRRC8 Proteins Form Volume-Regulated Anion Channels that Sense Ionic Strength
2016 StandoutNobel
C. elegans cell survival gene ced-9 encodes a functional homolog of the mammalian proto-oncogene bcl-2
1994 StandoutNobel
Nuclear Import of Influenza Virus RNA Can Be Mediated by Viral Nucleoprotein and Transport Factors Required for Protein Import
1995 StandoutNobel
Stimulation of CFTR activity by its phosphorylated R domain
1997 Nature
Differential Localization of the Cystic Fibrosis Transmembrane Conductance Regulator in Normal and Cystic Fibrosis Airway Epithelium
1992
An Animal Model for Cystic Fibrosis Made by Gene Targeting
1992 StandoutScienceNobel
Regulation of Plasma Membrane Recycling by CFTR
1992 Science
Chloride Conductance Expressed by ΔF508 and Other Mutant CFTRs In Xenopus Oocytes
1991 Science
The common variant of cystic fibrosis transmembrane conductance regulator is recognized by hsp70 and degraded in a pre-Golgi nonlysosomal compartment.
1993
Voltage-dependent block of the cystic fibrosis transmembrane conductance regulator Cl- channel by two closely related arylaminobenzoates.
1993
CFTR activation: additive effects of stimulatory and inhibitory phosphorylation sites in the R domain
1997
Expression cloning of an ATP receptor from mouse neuroblastoma cells.
1993 StandoutNobel
Abnormal localization of cystic fibrosis transmembrane conductance regulator in primary cultures of cystic fibrosis airway epithelia.
1992
Effect of ATP-sensitive K+ channel regulators on cystic fibrosis transmembrane conductance regulator chloride currents.
1992
Relationship of a non-cystic fibrosis transmembrane conductance regulator-mediated chloride conductance to organ-level disease in Cftr(-/-) mice.
1994
Defective Epithelial Chloride Transport in a Gene-Targeted Mouse Model of Cystic Fibrosis
1992 StandoutScienceNobel
Biochemical characterization of the cystic fibrosis transmembrane conductance regulator in normal and cystic fibrosis epithelial cells.
1992
The delta F508 mutation decreases the stability of cystic fibrosis transmembrane conductance regulator in the plasma membrane. Determination of functional half-lives on transfected cells.
1993
Demonstration That CFTR Is a Chloride Channel by Alteration of Its Anion Selectivity
1991 Science
Enhanced Myocardial Function in Transgenic Mice Overexpressing the β 2 -Adrenergic Receptor
1994 StandoutScienceNobel
Potentiator ivacaftor abrogates pharmacological correction of ΔF508 CFTR in cystic fibrosis
2014
Vx-770 potentiates CFTR function by promoting decoupling between the gating cycle and ATP hydrolysis cycle
2013
Swelling-induced and depolarization-induced C1-channels in normal and cystic fibrosis epithelial cells
1991
Cystic Fibrosis Gene Mutation in Two Sisters with Mild Disease and Normal Sweat Electrolyte Levels
1991
Bacterial Biofilms: A Common Cause of Persistent Infections
1999 StandoutScience
Molecular Structure and Physiological Function of Chloride Channels
2002
Conformational maturation of CFTR but not its mutant counterpart (delta F508) occurs in the endoplasmic reticulum and requires ATP.
1994
The cystic fibrosis transmembrane conductance regulator is a dual ATP and chloride channel.
1994
Regulation of the cystic fibrosis transmembrane conductance regulator Cl- channel by negative charge in the R domain.
1993
Cystic ibrosis: Molecular Biology and Therapeutic Implications
1992 Science
Mouse VAP33 is associated with the endoplasmic reticulum and microtubules
2000 StandoutNobel
The multidrug resistance and cystic fibrosis genes have complementary patterns of epithelial expression.
1992
Cl- channel activity in Xenopus oocytes expressing the cystic fibrosis gene.
1991
Extracellular UTP stimulates electrogenic bicarbonate secretion across CFTR knockout gallbladder epithelium
2000
Secretin Promotes Osmotic Water Transport in Rat Cholangiocytes by Increasing Aquaporin-1 Water Channels in Plasma Membrane
1997 StandoutNobel
Stoichiometry of recombinant cystic fibrosis transmembrane conductance regulator in epithelial cells and its functional reconstitution into cells in vitro.
1994
Potential of preventing Pseudomonas aeruginosa lung infections in cystic fibrosis patients: Experimental studies in animals
1996
The silent codon change I507‐ATC→ATT contributes to the severity of the ΔF508 CFTR channel dysfunction
2013
Pathophysiology of Gene-Targeted Mouse Models for Cystic Fibrosis
1999
Control of CFTR Channel Gating by Phosphorylation and Nucleotide Hydrolysis
1999
Mutational analysis of the yeast a-factor transporter STE6, a member of the ATP binding cassette (ABC) protein superfamily.
1991
Failure of the Cystic Fibrosis Transmembrane Conductance Regulator to Conduct ATP
1996 Science
Correlation between Genotype and Phenotype in Patients with Cystic Fibrosis
1993
Controlling Allosteric Networks in Proteins
2016
A Panel of TrpB Biocatalysts Derived from Tryptophan Synthase through the Transfer of Mutations that Mimic Allosteric Activation
2016 StandoutNobel
Mechanical Bonds and Topological Effects in Radical Dimer Stabilization
2014 StandoutNobel
Mucus clearance as a primary innate defense mechanism for mammalian airways
2002
Participation of the endoplasmic reticulum chaperone calnexin (p88, IP90) in the biogenesis of the cystic fibrosis transmembrane conductance regulator.
1994
Cystic Fibrosis Heterozygote Resistance to Cholera Toxin in the Cystic Fibrosis Mouse Model
1994 Science
Genetic Variation and Clinical Heterogeneity in Cystic Fibrosis
2011
Modulation of disease severity in cystic fibrosis transmembrane conductance regulator deficient mice by a secondary genetic factor
1996
Characterization of the cystic fibrosis transmembrane conductance regulator in a colonocyte cell line.
1992
Regulation of Cl- channels in normal and cystic fibrosis airway epithelial cells by extracellular ATP.
1992
Channelling our thoughts
1991 Nature
Immunocytochemical localization of the cystic fibrosis gene product CFTR.
1991
Maturation and function of cystic fibrosis transmembrane conductance regulator variants bearing mutations in putative nucleotide-binding domains 1 and 2.
1991
Lung Infections Associated with Cystic Fibrosis
2002 Standout
A C-terminal motif found in the β 2 -adrenergic receptor, P2Y1 receptor and cystic fibrosis transmembrane conductance regulator determines binding to the Na + /H + exchanger regulatory factor family of PDZ proteins
1998 StandoutNobel
THE UBIQUITIN SYSTEM
1998 StandoutNobel
Altered ubiquitination and stability of aquaporin-1 in hypertonic stress
2001 StandoutNobel
Impaired cell volume regulation in intestinal crypt epithelia of cystic fibrosis mice.
1995 StandoutNobel
Role of membrane trafficking in plasma membrane solute transport
1994
Structural flexibility of the Gαs α-helical domain in the β 2 -adrenoceptor Gs complex
2011 StandoutNobel
Phenylalanine-508 mediates a cytoplasmic–membrane domain contact in the CFTR 3D structure crucial to assembly and channel function
2008
Genetic determination of exocrine pancreatic function in cystic fibrosis.
1992
Effect of Deleting the R Domain on CFTR-Generated Chloride Channels
1991 Science
ATP transduces signals from ASGM1, a glycolipid that functions as a bacterial receptor
2001 StandoutNobel
Tetrathiafulvalene-Calix[4]pyrroles: Synthesis, Anion Binding, and Electrochemical Properties
2006
Production and characterisation of monoclonal and polyclonal antibodies to different regions of the cystic fibrosis transmembrane conductance regulator (cftr): Detection of immunologically related proteins
1995
Activation of a heterologously expressed octopamine receptor coupled only to adenylyl cyclase produces all the features of presynaptic facilitation inAplysiasensory neurons
2000 StandoutNobel
cAMP-inducible chloride conductance in mouse fibroblast lines stably expressing the human cystic fibrosis transmembrane conductance regulator.
1991
Works of Tim Jensen being referenced
Purification and functional reconstitution of the cystic fibrosis transmembrane conductance regulator (CFTR)
1992
Regulatory Insertion Removal Restores Maturation, Stability and Function of ΔF508 CFTR
2010
The cystic fibrosis mutation (ΔF508) does not influence the chloride channel activity of CFTR
1993
Expression of the cystic fibrosis gene in non-epithelial invertebrate cells produces a regulated anion conductance
1991
Allosteric Modulation Balances Thermodynamic Stability and Restores Function of ΔF508 CFTR
2012
Correctors of ΔF508 CFTR restore global conformational maturation without thermally stabilizing the mutant protein
2012