Citation Impact
Citing Papers
Features, Evaluation and Treatment Coronavirus (COVID-19)
2020 Standout
QT interval prolongation related to psychoactive drug treatment: a comparison of monotherapy versus polytherapy
2005
Impact of sex and gender on COVID-19 outcomes in Europe
2020
The hERG potassium channel and hERG screening for drug-induced torsades de pointes
2008
Effect of tacrolimus on the gene expression of renin and endothelin in the rat kidney
2001
A human ether-á-go-go-related (hERG) ion channel atomistic model generated by long supercomputer molecular dynamics simulations and its use in predicting drug cardiotoxicity
2014 StandoutNobel
The association of serum testosterone levels and ventricular repolarization
2009
The influence of drug-like concepts on decision-making in medicinal chemistry
2007 Standout
Strategies to reduce the risk of drug‐induced QT interval prolongation: a pharmaceutical company perspective
2008
Lessons learned from the fate of AstraZeneca's drug pipeline: a five-dimensional framework
2014 Standout
Novel N-Linked Aminopiperidine Inhibitors of Bacterial Topoisomerase Type II with Reduced pKa: Antibacterial Agents with an Improved Safety Profile
2012
Renal Endothelin in FK506-Induced Nephrotoxicity in Spontaneously Hypertensive Rats
1998 StandoutNobel
The Generation R Study: design and cohort update 2010
2010 Standout
In silico search of putative adverse drug reaction related proteins as a potential tool for facilitating drug adverse effect prediction
2006
Epidemiology of symptomatic drug-induced long QT syndrome and torsade de pointes in Germany
2013
Computational Methods in Drug Discovery
2014
Biologic and oral disease-modifying antirheumatic drug monotherapy in rheumatoid arthritis
2013
A structure-based computational workflow to predict liability and binding modes of small molecules to hERG
2020 StandoutNobel
A quantitative assessment of hERG liability as a function of lipophilicity
2006
Sex and gender: modifiers of health, disease, and medicine
2020 Standout
IL-6 in Inflammation, Immunity, and Disease
2014 Standout
Relationships between preclinical cardiac electrophysiology, clinical QT interval prolongation and torsade de pointes for a broad range of drugs: evidence for a provisional safety margin in drug development
2003
Inhibition of nuclear factor-κB activation by pyrrolidine dithiocarbamate prevents chronic FK506 nephropathy
2003 StandoutNobel
Therapeutic implications of the gender-specific aspects of cardiovascular disease
2006
Microfluidic organs-on-chips
2014 Standout
In vitro pharmacologic testing using human induced pluripotent stem cell-derived cardiomyocytes
2009 StandoutNobel
Development and Comparison of hERG Blocker Classifiers: Assessment on Different Datasets Yields Markedly Different Results
2011
Running to stand still: adaptation and the response of plants to rapid climate change
2005 Standout
Estimating the Risk of Drug-Induced Proarrhythmia Using Human Induced Pluripotent Stem Cell–Derived Cardiomyocytes
2011
The ChEMBL database in 2017
2016 Standout
Indoles as therapeutics of interest in medicinal chemistry: Bird's eye view
2017 Standout
Rechanneling the cardiac proarrhythmia safety paradigm: A meeting report from the Cardiac Safety Research Consortium
2013
Toxicology for the twenty-first century
2009 StandoutNature
Assessing the proarrhythmic potential of drugs: Current status of models and surrogate parameters of torsades de pointes arrhythmias
2006
Reducing safety-related drug attrition: the use of in vitro pharmacological profiling
2012
An analysis of the attrition of drug candidates from four major pharmaceutical companies
2015 Standout
Male Circumcision in the United States for the Prevention of HIV Infection and other Adverse Health Outcomes: Report from a CDC Consultation
2010
Rings in Drugs
2014 Standout
Climate change and the permafrost carbon feedback
2015 StandoutNature
Engineering Adolescence
2014 Standout
A Study of the Hydration of the Alkali Metal Ions in Aqueous Solution
2011 Standout
Ion channels in toxicology
2010
pkCSM: Predicting Small-Molecule Pharmacokinetic and Toxicity Properties Using Graph-Based Signatures
2015 Standout
Fluorine and Fluorinated Motifs in the Design and Application of Bioisosteres for Drug Design
2018 Standout
Recent changes in treeline forest distribution and structure in interior Alaska
2003
In Silico Binary Classification QSAR Models Based on 4D-Fingerprints and MOE Descriptors for Prediction of hERG Blockage
2010
A critical assessment of modeling safety-related drug attrition
2013
The Medicinal Chemist’s Toolbox: An Analysis of Reactions Used in the Pursuit of Drug Candidates
2011 Standout
Novel N-Linked Aminopiperidine Inhibitors of Bacterial Topoisomerase Type II: Broad-Spectrum Antibacterial Agents with Reduced hERG Activity
2011
Sex and Gender Differences in Risk, Pathophysiology and Complications of Type 2 Diabetes Mellitus
2016 Standout
admetSAR: A Comprehensive Source and Free Tool for Assessment of Chemical ADMET Properties
2012 Standout
Molecular Docking and Structure-Based Drug Design Strategies
2015 Standout
Antimicrobial Resistance in Neisseria gonorrhoeae in the 21st Century: Past, Evolution, and Future
2014 Standout
Special Issue: KDIGO Clinical Practice Guideline for the Care of Kidney Transplant Recipients
2009 Standout
Future of ToxicologyMechanisms of Toxicity and Drug Safety: Where Do We Go from Here?
2006
Human kidney proximal tubule-on-a-chip for drug transport and nephrotoxicity assessment
2013 Standout
Computer Simulations of Structure–Activity Relationships for hERG Channel Blockers
2011
2015 ESC Guidelines for the management of patients with ventricular arrhythmias and the prevention of sudden cardiac death
2015 Standout
Model for long QT syndrome type 2 using human iPS cells demonstrates arrhythmogenic characteristics in cell culture
2011 StandoutNobel
Pharmacological and electrophysiological characterization of nine, single nucleotide polymorphisms of the hERG‐encoded potassium channel
2009
Molecular Docking: Shifting Paradigms in Drug Discovery
2019 Standout
Non-quinolone Inhibitors of Bacterial Type IIA Topoisomerases: A Feat of Bioisosterism
2013
Impact of ion class and time on oral drug molecular properties
2010
Male circumcision for prevention of heterosexual acquisition of HIV in men
2009 Standout
Oxadiazole isomers: all bioisosteres are not created equal
2012
Biomarker definitions and their applications
2018 Standout
Metal–Organic Frameworks in Biomedicine
2011 Standout
Shrinking ponds in subarctic Alaska based on 1950–2002 remotely sensed images
2006
A Multiscale Simulation System for the Prediction of Drug-Induced Cardiotoxicity
2011
Applications of Fluorine in Medicinal Chemistry
2015 Standout
Discovery of 4-{4-[(3R)-3-Methylmorpholin-4-yl]-6-[1-(methylsulfonyl)cyclopropyl]pyrimidin-2-yl}-1H-indole (AZ20): A Potent and Selective Inhibitor of ATR Protein Kinase with Monotherapy in Vivo Antitumor Activity
2013
Works of Tim Hammond being referenced
A preliminary poll of men circumcised in infancy or childhood
1999
Nonclinical proarrhythmia models: Predicting Torsades de Pointes
2005
A framework to assess the translation of safety pharmacology data to humans
2009
Pancreatic and nephrotoxicity of immunomodulator compounds
1995
Evidence for gender differences in electrophysiological properties of canine Purkinje fibres
2004
Methods of collecting and evaluating non-clinical cardiac electrophysiology data in the pharmaceutical industry: results of an international survey
2001
Safety and secondary pharmacology: Successes, threats, challenges and opportunities
2008
Sex differences in ventricular repolarization: from cardiac electrophysiology to Torsades de Pointes
2004
Correction of QT values to allow for increases in heart rate in conscious Beagle dogs in toxicology assessment
2005
An introduction to QT interval prolongation and non‐clinical approaches to assessing and reducing risk
2010
Optimisation and validation of a medium-throughput electrophysiology-based hERG assay using IonWorks™ HT
2006
A Rabbit Langendorff Heart Proarrhythmia Model: Predictive Value for Clinical Identification of Torsades de Pointes
2006
Spatial prediction of climatic state factor regions in Alaska
1996
FK506-Induced Endothelin Release by Cultured Rat Mesangial Cells
1995
AB0593 Subcutaneous methotrexate is more efficacious and better tolerated than oral methotrexate: The experience of a large group of patients in the rheumatology department of a district general hospital
2012
Impact and prevalence of safety pharmacology-related toxicities throughout the pharmaceutical life cycle
2010