Standout Papers
- antiSMASH: rapid identification, annotation and analysis of secondary metabolite biosynthesis gene clusters in bacterial and fungal genome sequences (2011)
- antiSMASH 3.0—a comprehensive resource for the genome mining of biosynthetic gene clusters (2015)
- antiSMASH 7.0: new and improved predictions for detection, regulation, chemical structures and visualisation (2023)
- antiSMASH 5.0: updates to the secondary metabolite genome mining pipeline (2019)
- antiSMASH 6.0: improving cluster detection and comparison capabilities (2021)
Citation Impact
Citing Papers
Directed evolution of the tryptophan synthase β-subunit for stand-alone function recapitulates allosteric activation
2015 StandoutNobel
A microbial factory for defensive kahalalides in a tripartite marine symbiosis
2019 Science
Comprehensive computational design of ordered peptide macrocycles
2017 StandoutScienceNobel
Diversity and evolution of secondary metabolism in the marine actinomycete genus Salinispora
2014
Assembly of long error-prone reads using de Bruijn graphs
2016
Computational Stabilization of a Non‐Heme Iron Enzyme Enables Efficient Evolution of New Function
2024 StandoutNobel
Genetic manipulation of Patescibacteria provides mechanistic insights into microbial dark matter and the epibiotic lifestyle
2023 StandoutNobel
Expansive discovery of chemically diverse structured macrocyclic oligoamides
2024 StandoutScienceNobel
Integrative genomic mining for enzyme function to enable engineering of a non-natural biosynthetic pathway
2015 StandoutNobel
ColabFold: making protein folding accessible to all
2022 Standout
Inhibition of CRISPR-Cas9 ribonucleoprotein complex assembly by anti-CRISPR AcrIIC2
2019 StandoutNobel
Antibiotics: past, present and future
2019 Standout
The promise and challenge of therapeutic genome editing
2020 StandoutNatureNobel
Genome-Wide Prediction of Metabolic Enzymes, Pathways, and Gene Clusters in Plants
2017
Mapping the Limits of Substrate Specificity of the Adenylation Domain of TycA
2009
The MetaCyc database of metabolic pathways and enzymes and the BioCyc collection of pathway/genome databases
2015 Standout
Identification and characterization of new family members in the tautomerase superfamily: Analysis and implications
2014
Precision microbiome reconstitution restores bile acid mediated resistance to Clostridium difficile
2014 StandoutNature
Antibiotic resistance: a rundown of a global crisis
2018 Standout
Genome-Editing Technologies: Principles and Applications
2016
CRISPR-Cas Systems and the Paradox of Self-Targeting Spacers
2020
Unlocking the trove of metabolic treasures: activating silent biosynthetic gene clusters in bacteria and fungi
2019
The ClusPro web server for protein–protein docking
2017 Standout
O-Pair Search with MetaMorpheus for O-glycopeptide characterization
2020 StandoutNobel
Discovery of microbial natural products by activation of silent biosynthetic gene clusters
2015
Combinatorial biosynthesis of reduced polyketides
2005
Natural‐Product Sugar Biosynthesis and Enzymatic Glycodiversification
2008
Therapeutic strategies to combat antibiotic resistance
2014
Calling All Hosts: Bacterial Communication In Situ
2017
Biosynthetic Pathway Connects Cryptic Ribosomally Synthesized Posttranslationally Modified Peptide Genes with Pyrroloquinoline Alkaloids
2016
Chemical warfare between leafcutter ant symbionts and a co-evolved pathogen
2018
The Science of Antibiotic Discovery
2020 Standout
A Branched Biosynthetic Pathway Is Involved in Production of Roquefortine and Related Compounds in Penicillium chrysogenum
2013
Genomic basis for natural product biosynthetic diversity in the actinomycetes
2009
γ-Butyrolactones: Streptomyces signalling molecules regulating antibiotic production and differentiation
2006
Diet–microbiota interactions as moderators of human metabolism
2016 StandoutNature
Novel soil bacteria possess diverse genes for secondary metabolite biosynthesis
2018 Nature
Insights into Secondary Metabolism from a Global Analysis of Prokaryotic Biosynthetic Gene Clusters
2014
Understanding the mechanisms and drivers of antimicrobial resistance
2015 Standout
Revealing the human mucinome
2022 StandoutNobel
Human commensals producing a novel antibiotic impair pathogen colonization
2016 Nature
Refactoring the Cryptic Streptophenazine Biosynthetic Gene Cluster Unites Phenazine, Polyketide, and Nonribosomal Peptide Biochemistry
2019
Bacterial CRISPR: accomplishments and prospects
2015
Discovery of MRSA active antibiotics using primary sequence from the human microbiome
2016
A thermostable Cas9 with increased lifetime in human plasma
2017 StandoutNobel
Assembly of long, error-prone reads using repeat graphs
2019 Standout
Intervene: a tool for intersection and visualization of multiple gene or genomic region sets
2017
Chemistry of Class 1 CRISPR-Cas effectors: Binding, editing, and regulation
2020 StandoutNobel
A Systematic Analysis of Biosynthetic Gene Clusters in the Human Microbiome Reveals a Common Family of Antibiotics
2014
Next Generation Prokaryotic Engineering: The CRISPR-Cas Toolkit
2016
The role of antibiotics and antibiotic resistance in nature
2009
Characterization and Repurposing of Type I and Type II CRISPR–Cas Systems in Bacteria
2018
Engineering synthetic recursive pathways to generate non-natural small molecules
2012
Microbial secondary metabolites and their impacts on insect symbioses
2014
Asymmetric Total Synthesis of Indole Alkaloids Containing an Indoline Spiroaminal Framework
2015 StandoutNobel
The MetaCyc database of metabolic pathways and enzymes and the BioCyc collection of Pathway/Genome Databases
2013
The host-encoded RNase E endonuclease as the crRNA maturation enzyme in a CRISPR–Cas subtype III-Bv system
2018
Molecular engineering approaches to peptide, polyketide and other antibiotics
2006
The Biosynthetic Logic of Polyketide Diversity
2009 Standout
Gut microbiota in human metabolic health and disease
2020 Standout
Trends in peptide drug discovery
2021
Natural product diversity associated with the nematode symbionts Photorhabdus and Xenorhabdus
2017
Protein structure predictions to atomic accuracy with AlphaFold
2022 StandoutNobel
Pfam: The protein families database in 2021
2020 Standout
The old nuclear star cluster in the Milky Way: dynamics, mass, statistical parallax, and black hole mass
2014 StandoutNobel
Something old, something new: revisiting natural products in antibiotic drug discovery
2014
Ribosomal Synthesis of N-Methyl Peptides
2008 StandoutNobel
Avenolide, a Streptomyces hormone controlling antibiotic production in Streptomyces avermitilis
2011 StandoutNobel
Drug Discovery and Natural Products: End of an Era or an Endless Frontier?
2009 StandoutScience
Tridecaptin M, a New Variant Discovered in Mud Bacterium, Shows Activity against Colistin- and Extremely Drug-Resistant Enterobacteriaceae
2019
Silencing cryptic specialized metabolism in Streptomyces by the nucleoid-associated protein Lsr2
2019
Engineering enzymes for noncanonical amino acid synthesis
2018 StandoutNobel
The PRIDE database resources in 2022: a hub for mass spectrometry-based proteomics evidences
2021 Standout
Antibiotics and Bacterial Resistance in the 21st Century
2014 Standout
Small molecules from the human microbiota
2015 Science
Biosynthesis of natural products containing β-amino acids
2014
Efficient Genome Editing of a Facultative Thermophile Using Mesophilic spCas9
2017
Biosynthesis of methyl-proline containing griselimycins, natural products with anti-tuberculosis activity
2017
CRISPR-Cas: biology, mechanisms and relevance
2016 StandoutNobel
Microbial metabolites: 45 years of wandering, wondering and discovering
2011 StandoutNobel
Genome-minimized Streptomyces host for the heterologous expression of secondary metabolism
2010 StandoutNobel
Hydrogenases
2014 Standout
Natural product discovery: past, present, and future
2016
Enzyme Promiscuity: A Mechanistic and Evolutionary Perspective
2010 Standout
Unlocking Reactivity of TrpB: A General Biocatalytic Platform for Synthesis of Tryptophan Analogues
2017 StandoutNobel
Formicamycins, antibacterial polyketides produced by Streptomyces formicae isolated from African Tetraponera plant-ants
2017
Galaxy masses
2014
Evolutionary-scale prediction of atomic-level protein structure with a language model
2023 StandoutScience
Culture-independent discovery of natural products from soil metagenomes
2015
MGnify: the microbiome analysis resource in 2020
2019
Biosynthesis of the Iron-Guanylylpyridinol Cofactor of [Fe]-Hydrogenase in Methanogenic Archaea as Elucidated by Stable-Isotope Labeling
2012
Catalytic Asymmetric Synthesis of Unprotected β2-Amino Acids
2021 StandoutNobel
Harnessing the biocatalytic potential of iron- and α-ketoglutarate-dependent dioxygenases in natural product total synthesis
2020
Reactive Oxygen Species (ROS)-Based Nanomedicine
2019 Standout
Chemomimetic Biocatalysis: Exploiting the Synthetic Potential of Cofactor-Dependent Enzymes To Create New Catalysts
2015 StandoutNobel
Recombinational DNA Repair of Damaged Replication Forks inEscherichia coli: Questions
2001
Engineering of temperature- and light-switchable Cas9 variants
2013 StandoutNobel
Editing the microbiome the CRISPR way
2019
Chemoenzymatic elaboration of monosaccharides using engineered cytochrome P450 BM3 demethylases
2009 StandoutNobel
Synthetic and Therapeutic Applications of Ammonia-lyases and Aminomutases
2017
Origins and Evolution of Antibiotic Resistance
2010 Standout
Targeted gene knock-in by homology-directed genome editing using Cas9 ribonucleoprotein and AAV donor delivery
2017 StandoutNobel
PubChem in 2021: new data content and improved web interfaces
2020 Standout
Non-ribosomal Propeptide Precursor in Nocardicin A Biosynthesis Predicted from Adenylation Domain Specificity Dependent on the MbtH Family Protein NocI
2013
Accurate proteome-wide missense variant effect prediction with AlphaMissense
2023 StandoutScienceNobel
Molecular Mechanisms of Mammalian DNA Repair and the DNA Damage Checkpoints
2004 StandoutNobel
A RaPID way to discover nonstandard macrocyclic peptide modulators of drug targets
2017
Works of Tilmann Weber being referenced
Phylogenetic analysis of condensation domains in NRPS sheds light on their functional evolution
2007
CRISPy-web: An online resource to design sgRNAs for CRISPR applications
2016
Genome‐scale metabolic representation of Amycolatopsis balhimycina
2012
antiSMASH 2.0—a versatile platform for genome mining of secondary metabolite producers
2013
Characterization of the ‘pristinamycin supercluster’ of Streptomyces pristinaespiralis
2010
antiSMASH: rapid identification, annotation and analysis of secondary metabolite biosynthesis gene clusters in bacterial and fungal genome sequences
2011 Standout
antiSMASH 3.0—a comprehensive resource for the genome mining of biosynthetic gene clusters
2015 Standout
Exploiting the genetic potential of polyketide producing streptomycetes
2003
NRPSpredictor2—a web server for predicting NRPS adenylation domain specificity
2011
antiSMASH 4.0—improvements in chemistry prediction and gene cluster boundary identification
2017
Metabolic engineering of antibiotic factories: new tools for antibiotic production in actinomycetes
2014
Reprogramming Acyl Carrier Protein Interactions of an Acyl-CoA Promiscuous trans-Acyltransferase
2014
Comparative analysis and insights into the evolution of gene clusters for glycopeptide antibiotic biosynthesis
2005
Module Extension of a Non‐Ribosomal Peptide Synthetase of the Glycopeptide Antibiotic Balhimycin Produced by Amycolatopsis balhimycina
2008
The kirromycin gene cluster of Streptomyces collinus Tü 365 codes for an aspartate-α-decarboxylase, KirD, which is involved in the biosynthesis of the precursor β-alanine
2009
Molecular Analysis of the Kirromycin Biosynthetic Gene Cluster Revealed β-Alanine as Precursor of the Pyridone Moiety
2008
In silico tools for the analysis of antibiotic biosynthetic pathways
2014
Draft genome sequence of Talaromyces islandicus (“Penicillium islandicum”) WF-38-12, a neglected mold with significant biotechnological potential
2015
CLUSEAN: A computer-based framework for the automated analysis of bacterial secondary metabolite biosynthetic gene clusters
2009
Improved Lanthipeptide Detection and Prediction for antiSMASH
2014
Transcriptional and Mutational Analyses of theStreptomyces lividans recXGene and Its Interference with RecA Activity
2000
CRISPR-Cas9 Based Engineering of Actinomycetal Genomes
2015
Identification and activation of novel biosynthetic gene clusters by genome mining in the kirromycin producer Streptomyces collinus Tü 365
2015
The evolution of genome mining in microbes – a review
2016
The cyclochlorotine mycotoxin is produced by the nonribosomal peptide synthetase CctN in Talaromyces islandicus (‘ Penicillium islandicum ’)
2016
antiSMASH 5.0: updates to the secondary metabolite genome mining pipeline
2019 Standout