Standout Papers
Citation Impact
Citing Papers
Anti-Markovnikov alkene oxidation by metal-oxo–mediated enzyme catalysis
2017 StandoutScienceNobel
Characterizing and explaining the impact of disease-associated mutations in proteins without known structures or structural homologs
2022 StandoutNobel
Directed Evolution Mimics Allosteric Activation by Stepwise Tuning of the Conformational Ensemble
2018 StandoutNobel
Exploiting conformational dynamics to modulate the function of designed proteins
2023 StandoutNobel
Conformational dynamics of a G-protein α subunit is tightly regulated by nucleotide binding
2016
Determinants of trafficking, conduction, and disease within a K+ channel revealed through multiparametric deep mutational scanning
2022
Protein oligomer modeling guided by predicted interchain contacts in CASP14
2021 StandoutNobel
Protein tertiary structure prediction and refinement using deep learning and Rosetta in CASP14
2021 StandoutNobel
Computational Stabilization of a Non‐Heme Iron Enzyme Enables Efficient Evolution of New Function
2024 StandoutNobel
Zero‐shot mutation effect prediction on protein stability and function using RoseTTAFold
2023 StandoutNobel
Modeling the expansion of virtual screening libraries
2023
Membrane curvature regulates the spatial distribution of bulky glycoproteins
2022 StandoutNobel
Computation and Functional Studies Provide a Model for the Structure of the Zinc Transporter hZIP4
2015 StandoutNobel
Expansive discovery of chemically diverse structured macrocyclic oligoamides
2024 StandoutScienceNobel
Computational design of soluble and functional membrane protein analogues
2024 StandoutNatureNobel
GPCR activation mechanisms across classes and macro/microscales
2021
The role of liquid–liquid phase separation in aggregation of the TDP-43 low-complexity domain
2019 Standout
De novo design of immunoglobulin-like domains
2022 StandoutNobel
Directed evolution improves the catalytic efficiency of TEV protease
2019
Substitutions at the cofactor phosphate-binding site of a clostridial alcohol dehydrogenase lead to unexpected changes in substrate specificity
2015
Cryo-EM structure of the activated GLP-1 receptor in complex with a G protein
2017 NatureNobel
Discovery of a regioselectivity switch in nitrating P450s guided by molecular dynamics simulations and Markov models
2016 StandoutNobel
Transforming Growth Factor-β Signaling in Immunity and Cancer
2019 Standout
ALS-Causing Mutations Significantly Perturb the Self-Assembly and Interaction with Nucleic Acid of the Intrinsically Disordered Prion-Like Domain of TDP-43
2016
AI in health and medicine
2022 Standout
The road to fully programmable protein catalysis
2022 StandoutNatureNobel
Structure of a Hallucinogen-Activated Gq-Coupled 5-HT2A Serotonin Receptor
2020
Molecular Dynamics Simulation for All
2018 Standout
A central hydrophobic E1 region controls the pH range of hepatitis C virus membrane fusion and susceptibility to fusion inhibitors
2019 StandoutNobel
CHARMM36m: an improved force field for folded and intrinsically disordered proteins
2016 Standout
The trRosetta server for fast and accurate protein structure prediction
2021 StandoutNobel
Computational design of G Protein-Coupled Receptor allosteric signal transductions
2019
Improved protein structure refinement guided by deep learning based accuracy estimation
2021 StandoutNobel
An Ancient Fingerprint Indicates the Common Ancestry of Rossmann-Fold Enzymes Utilizing Different Ribose-Based Cofactors
2016
Structure and dynamics of GPCR signaling complexes
2017 Nobel
Enzyme engineering: reaching the maximal catalytic efficiency peak
2017
Protein Phase Separation: A New Phase in Cell Biology
2018
Intrinsically disordered proteins in cellular signalling and regulation
2014 Standout
Improved protein structure prediction using potentials from deep learning
2020 StandoutNatureNobel
Protein design and variant prediction using autoregressive generative models
2021
The neural basis of psychedelic action
2022 Standout
Mutations in adenine-binding pockets enhance catalytic properties of NAD(P)H-dependent enzymes
2015 StandoutNobel
Membrane mimetic systems in CryoEM: keeping membrane proteins in their native environment
2019 StandoutNobel
Identification and optimization of a novel thermo- and solvent stable ketol-acid reductoisomerase for cell free isobutanol biosynthesis
2014
Engineering the cofactor specificity of an alcohol dehydrogenase via single mutations or insertions distal to the 2′-phosphate group of NADP(H)
2017
Synergy between intrinsically disordered domains and structured proteins amplifies membrane curvature sensing
2018
Uncovering rare NADH-preferring ketol-acid reductoisomerases
2014 StandoutNobel
Engineering a minimal G protein to facilitate crystallisation of G protein-coupled receptors in their active conformation
2016
De novo protein design by deep network hallucination
2021 StandoutNatureNobel
Simple yet functional phosphate-loop proteins
2018 StandoutNobel
A General Tool for Engineering the NAD/NADP Cofactor Preference of Oxidoreductases
2016 StandoutNobel
The SCOP database in 2020: expanded classification of representative family and superfamily domains of known protein structures
2019
Improving Protein Expression, Stability, and Function with ProteinMPNN
2024 StandoutNobel
Engineered Biosynthesis of β‐Alkyl Tryptophan Analogues
2018 StandoutNobel
Structure of the adenosine A2A receptor bound to an engineered G protein
2016 Nature
Structural basis of latent TGF-β1 presentation and activation by GARP on human regulatory T cells
2018 Science
Engineering enzymes for noncanonical amino acid synthesis
2018 StandoutNobel
A Panel of TrpB Biocatalysts Derived from Tryptophan Synthase through the Transfer of Mutations that Mimic Allosteric Activation
2016 StandoutNobel
Tryptophan Synthase Uses an Atypical Mechanism To Achieve Substrate Specificity
2016 StandoutNobel
Clinically Approved Ion Channel Inhibitors Close Gates for Hepatitis C Virus and Open Doors for Drug Repurposing in Infectious Viral Diseases
2016
Protein structure prediction using multiple deep neural networks in the 13th Critical Assessment of Protein Structure Prediction (CASP13)
2019 StandoutNobel
Improved Synthesis of 4-Cyanotryptophan and Other Tryptophan Analogues in Aqueous Solvent Using Variants of TrpB from Thermotoga maritima
2018 StandoutNobel
Artificial domain duplication replicates evolutionary history of ketol‐acid reductoisomerases
2015 StandoutNobel
The large intracellular loop of hZIP4 is an intrinsically disordered zinc binding domain
2015
Unlocking Reactivity of TrpB: A General Biocatalytic Platform for Synthesis of Tryptophan Analogues
2017 StandoutNobel
Classification of Intrinsically Disordered Regions and Proteins
2014 Standout
F‐domain valency determines outcome of signaling through the angiopoietin pathway
2021 StandoutNobel
Design and optimization of enzymatic activity in a de novo β‐barrel scaffold
2022 StandoutNobel
Cofactor specificity motifs and the induced fit mechanism in class I ketol-acid reductoisomerases
2015 StandoutNobel
Evolutionary-scale prediction of atomic-level protein structure with a language model
2023 StandoutScience
Engineering highly functional thermostable proteins using ancestral sequence reconstruction
2018
A Panel of TrpB Biocatalysts Derived from Tryptophan Synthase through the Transfer of Mutations that Mimic Allosteric Activation
2016 StandoutNobel
Engineering of Flexible Loops in Enzymes
2014
Multimerization of an Alcohol Dehydrogenase by Fusion to a Designed Self-Assembling Protein Results in Enhanced Bioelectrocatalytic Operational Stability
2019 StandoutNobel
Recent advances in engineering proteins for biocatalysis
2014
Accurate proteome-wide missense variant effect prediction with AlphaMissense
2023 StandoutScienceNobel
Works of Tilman Flock being referenced
Controlling entropy to tune the functions of intrinsically disordered regions
2014
Selectivity determinants of GPCR–G-protein binding
2017 Nature
Universal allosteric mechanism for Gα activation by GPCRs
2015 Nature
Structured and disordered facets of the GPCR fold
2014
Molecular Principles of Gene Fusion Mediated Rewiring of Protein Interaction Networks in Cancer
2016
Exploiting sequence and stability information for directing nanobody stability engineering
2017
An online resource for GPCR structure determination and analysis
2019
Visualization and analysis of non-covalent contacts using the Protein Contacts Atlas
2018
Molecular mechanism of modulating arrestin conformation by GPCR phosphorylation
2018
Probing Gαi1 protein activation at single–amino acid resolution
2015
General approach to reversing ketol-acid reductoisomerase cofactor dependence from NADPH to NADH
2013 StandoutNobel
Diverse activation pathways in class A GPCRs converge near the G-protein-coupling region
2016 Nature