Standout Papers
- Priming of protective T cell responses against virus-induced tumors in mice with human immune system components (2009)
- Targeting the nuclear antigen 1 of Epstein-Barr virus to the human endocytic receptor DEC-205 stimulates protective T-cell responses (2008)
- Inflammasomes in health and disease (2012)
- Distinct Polysaccharide Utilization Determines Interspecies Competition between Intestinal Prevotella spp. (2020)
- A flagellum-specific chaperone facilitates assembly of the core type III export apparatus of the bacterial flagellum (2017)
- NLRP6 Inflammasome Regulates Colonic Microbial Ecology and Risk for Colitis (2011)
- Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity (2012)
Citation Impact
Citing Papers
Noncanonical Inflammasome Activation by Intracellular LPS Independent of TLR4
2013 Science
The Application of Ecological Theory Toward an Understanding of the Human Microbiome
2012 Science
Improved cellular and humoral immune responses in vivo following targeting of HIV Gag to dendritic cells within human anti–human DEC205 monoclonal antibody
2010 StandoutNobel
Genome-wide CRISPR screens reveal a specific ligand for the glycan-binding immune checkpoint receptor Siglec-7
2021 StandoutNobel
Minimal "Self" Peptides That Inhibit Phagocytic Clearance and Enhance Delivery of Nanoparticles
2013 Science
Aberrant actin depolymerization triggers the pyrin inflammasome and autoinflammatory disease that is dependent on IL-18, not IL-1β
2015
Intestinal Microbiota Containing Barnesiella Species Cures Vancomycin-Resistant Enterococcus faecium Colonization
2013
Crystal Structure of NLRC4 Reveals Its Autoinhibition Mechanism
2013 Science
Mouse models of acute and chronic hepacivirus infection
2017 StandoutScienceNobel
Interactions Between Commensal Fungi and the C-Type Lectin Receptor Dectin-1 Influence Colitis
2012 Science
Cytoplasmic LPS Activates Caspase-11: Implications in TLR4-Independent Endotoxic Shock
2013 Science
The microbiota regulates type 2 immunity through RORγt + T cells
2015 StandoutScienceNobel
An enzymatic toolkit for selective proteolysis, detection, and visualization of mucin-domain glycoproteins
2020 StandoutNobel
Expansion of intestinal Prevotella copri correlates with enhanced susceptibility to arthritis
2013
A Functional Role for Nlrp6 in Intestinal Inflammation and Tumorigenesis
2011
In Vivo Role of Flt3 Ligand and Dendritic Cells in NK Cell Homeostasis
2010
Genetic manipulation of Patescibacteria provides mechanistic insights into microbial dark matter and the epibiotic lifestyle
2023 StandoutNobel
Knockdown of autophagy enhances the innate immune response in hepatitis C virus-infected hepatocytes
2010
A diet-induced animal model of non-alcoholic fatty liver disease and hepatocellular cancer
2016
Interleukin-18 and IL-18 Binding Protein
2013
Non-alcoholic fatty liver and the gut microbiota
2016
Platelet factor 4–induced T H 1-T reg polarization suppresses antitumor immunity
2024 StandoutScienceNobel
Deubiquitinases Regulate the Activity of Caspase-1 and Interleukin-1β Secretion via Assembly of the Inflammasome
2012
Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries
2018 Standout
Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries
2021 Standout
NLRP3 inflammasome blockade reduces liver inflammation and fibrosis in experimental NASH in mice
2017
Fatty acid–induced mitochondrial uncoupling elicits inflammasome-independent IL-1α and sterile vascular inflammation in atherosclerosis
2013
Diet, Metabolites, and “Western-Lifestyle” Inflammatory Diseases
2014
Autophagy in Viral Replication and Pathogenesis
2010
Contributions of metabolic dysregulation and inflammation to nonalcoholic steatohepatitis, hepatic fibrosis, and cancer
2013
Autophagy in infection, inflammation and immunity
2013 Standout
New concepts in the generation and functions of IgA
2012
IKKα negatively regulates ASC-dependent inflammasome activation
2014
Autophagy and Viruses: Adversaries or Allies?
2013 Standout
Intestinal Microbial Diversity during Early-Life Colonization Shapes Long-Term IgE Levels
2013
Administration of Akkermansia muciniphila Ameliorates Dextran Sulfate Sodium-Induced Ulcerative Colitis in Mice
2019
Mechanisms of NOD-like Receptor-Associated Inflammasome Activation
2013
Cancer nanomedicine: progress, challenges and opportunities
2016 Standout
Parameters for establishing humanized mouse models to study human immunity: Analysis of human hematopoietic stem cell engraftment in three immunodeficient strains of mice bearing the IL2rγnull mutation
2010
Enhancing immune responses by targeting antigen to DC
2009
Human Genetics Shape the Gut Microbiome
2014 Standout
Signals from the gut microbiota to distant organs in physiology and disease
2016
Functions of autophagy in normal and diseased liver
2013
Gut biogeography of the bacterial microbiota
2015 Standout
Critical Role for the DNA Sensor AIM2 in Stem Cell Proliferation and Cancer
2015
Structure of the Type VI Secretion System Contractile Sheath
2015 StandoutNobel
Host genetic variation impacts microbiome composition across human body sites
2015
Genome sequences of rare, uncultured bacteria obtained by differential coverage binning of multiple metagenomes
2013
Activation of Gpr109a, Receptor for Niacin and the Commensal Metabolite Butyrate, Suppresses Colonic Inflammation and Carcinogenesis
2014 Standout
Microbiota-Modulated Metabolites Shape the Intestinal Microenvironment by Regulating NLRP6 Inflammasome Signaling
2015
Activation and regulation of the inflammasomes
2013 Standout
Increased inflammasome related gene expression profile in PBMC may facilitate T helper 17 cell induction in multiple sclerosis
2014
Microtubule-driven spatial arrangement of mitochondria promotes activation of the NLRP3 inflammasome
2013
Changes in the Intestinal Microbiome and Alcoholic and Nonalcoholic Liver Diseases: Causes or Effects?
2016
Toll-like Receptors and Their Crosstalk with Other Innate Receptors in Infection and Immunity
2011 Standout
The transcription factor IRF1 and guanylate-binding proteins target activation of the AIM2 inflammasome by Francisella infection
2015
A human natural killer cell subset provides an innate source of IL-22 for mucosal immunity
2008 StandoutNature
An NLRP7-Containing Inflammasome Mediates Recognition of Microbial Lipopeptides in Human Macrophages
2012
NLRP6 negatively regulates innate immunity and host defence against bacterial pathogens
2012 Nature
Intestinal microbiota and nonalcoholic steatohepatitis
2017
Caspase-11 activation requires lysis of pathogen-containing vacuoles by IFN-induced GTPases
2014 Nature
Increased Expression and Activation of Absent in Melanoma 2 Inflammasome Components in Lymphocytic Infiltrates of Abdominal Aortic Aneurysms
2014
Effector functions of NLRs in the intestine: innate sensing, cell death, and disease
2012
The PYRIN Domain-only Protein POP1 Inhibits Inflammasome Assembly and Ameliorates Inflammatory Disease
2015
Unified Polymerization Mechanism for the Assembly of ASC-Dependent Inflammasomes
2014 Standout
Role of the Microbiota in Immunity and Inflammation
2014 Standout
The CD40-Autophagy Pathway Is Needed for Host Protection Despite IFN-Γ-Dependent Immunity and CD40 Induces Autophagy via Control of P21 Levels
2010
Mechanisms of NAFLD development and therapeutic strategies
2018 Standout
Mechanisms of inflammasome activation: recent advances and novel insights
2015
The Genome of Th17 Cell-Inducing Segmented Filamentous Bacteria Reveals Extensive Auxotrophy and Adaptations to the Intestinal Environment
2011
Viral interactions with macroautophagy: A double-edged sword
2010
The role of the gut microbiota in NAFLD
2016
Heterogeneity of the gut microbiome in mice: guidelines for optimizing experimental design
2015
Functional interactions between the gut microbiota and host metabolism
2012 StandoutNature
Regulation of inflammasome signaling
2012
Caspase Functions in Cell Death and Disease
2013 Standout
Omega-3 Fatty Acids Prevent Inflammation and Metabolic Disorder through Inhibition of NLRP3 Inflammasome Activation
2013
The Impact of the Gut Microbiota on Human Health: An Integrative View
2012 Standout
NLRC4-driven production of IL-1β discriminates between pathogenic and commensal bacteria and promotes host intestinal defense
2012
Enterochromaffin Cells Are Gut Chemosensors that Couple to Sensory Neural Pathways
2017 StandoutNobel
TRIF Licenses Caspase-11-Dependent NLRP3 Inflammasome Activation by Gram-Negative Bacteria
2012
Immunoglobulin A
2011
Progression of NAFLD to diabetes mellitus, cardiovascular disease or cirrhosis
2013
Dendritic Cells Prime Natural Killer Cells by trans-Presenting Interleukin 15
2007
The Beclin 1 network regulates autophagy and apoptosis
2011 Standout
Taking dendritic cells into medicine
2007 StandoutNatureNobel
Novel role of PKR in inflammasome activation and HMGB1 release
2012 Nature
NLRP6 Inflammasome Orchestrates the Colonic Host-Microbial Interface by Regulating Goblet Cell Mucus Secretion
2014
Inflammasomes: mechanism of assembly, regulation and signalling
2016 Standout
Autophagy in infection
2010
Innate Immune Function by Toll-like Receptors: Distinct Responses in Newborns and the Elderly
2012
Long-Term Expansion of Functional Mouse and Human Hepatocytes as 3D Organoids
2018 StandoutNobel
Inflammatory caspases are innate immune receptors for intracellular LPS
2014 StandoutNature
TRPM2 links oxidative stress to NLRP3 inflammasome activation
2013
Host Defense Pathways: Role of Redundancy and Compensation in Infectious Disease Phenotypes
2011
Gut microbiota, metabolites and host immunity
2016 Standout
Mechanisms and Functions of Inflammasomes
2014 Standout
Induction of human humoral immune responses in a novel HLA-DR-expressing transgenic NOD/Shi-scid/ cnull mouse
2012
Animal Models for Hepatitis C
2013
Inflammation-induced cancer: crosstalk between tumours, immune cells and microorganisms
2013 Standout
Repertoires of Autophagy in the Pathogenesis of Ocular Diseases
2015 Standout
Protective and pathogenic functions of macrophage subsets
2011 Standout
Newly described pattern recognition receptors team up against intracellular pathogens
2013
Humanized mice for immune system investigation: progress, promise and challenges
2012
Inflammasome-independent role of AIM2 in suppressing colon tumorigenesis via DNA-PK and Akt
2015
Non-transcriptional Priming and Deubiquitination Regulate NLRP3 Inflammasome Activation
2012
Intestinal microbiota: Shaping local and systemic immune responses
2011
The Inflammasome Puts Obesity in the Danger Zone
2012
Microbiota-mediated colonization resistance against intestinal pathogens
2013
Metagenomics and Personalized Medicine
2011
Inflammasomes: mechanism of action, role in disease, and therapeutics
2015 Standout
Inflammasome activation and function in liver disease
2015
Clinical relevance of tumour-associated macrophages
2022
Triggering of Inflammasome by Aggregated α–Synuclein, an Inflammatory Response in Synucleinopathies
2013
Two distinct RNase activities of CRISPR-C2c2 enable guide-RNA processing and RNA detection
2016 StandoutNatureNobel
TMEM41B Is a Pan-flavivirus Host Factor
2020 StandoutNobel
Inflammasomes and Metabolic Disorders: Old Genes in Modern Diseases
2014
Lessons from patient-derived xenografts for better in vitro modeling of human cancer
2014
Small RNAs are modified with N-glycans and displayed on the surface of living cells
2021 StandoutNobel
Genetic Loss of Murine Pyrin, the Familial Mediterranean Fever Protein, Increases Interleukin-1β Levels
2012
An Update on PYRIN Domain-Containing Pattern Recognition Receptors: From Immunity to Pathology
2013
The role of inflammation in depression: from evolutionary imperative to modern treatment target
2015 Standout
Humanized mice efficiently engrafted with fetal hepatoblasts and syngeneic immune cells develop human monocytes and NK cells
2016 StandoutNobel
The Human Cancer Antigen Mesothelin Is More Efficiently Presented to the Mouse Immune System when Targeted to the DEC‐205/CD205 Receptor on Dendritic Cells
2009 StandoutNobel
Development of Virus-Like Particle Technology from Small Highly Symmetric to Large Complex Virus-Like Particle Structures
2013 Standout
Liver Cancer: Connections with Obesity, Fatty Liver, and Cirrhosis
2015
Immunization with HIV Gag targeted to dendritic cells followed by recombinant New York vaccinia virus induces robust T-cell immunity in nonhuman primates
2011 StandoutNobel
Utility of Humanized BLT Mice for Analysis of Dengue Virus Infection and Antiviral Drug Testing
2013 StandoutNobel
Role of caspase-1 in regulation of triglyceride metabolism
2013
Caspase-12, but Not Caspase-11, Inhibits Obesity and Insulin Resistance
2015
Structure and assembly of the mouse ASC inflammasome by combined NMR spectroscopy and cryo-electron microscopy
2015
Flagellin-induced NLRC4 phosphorylation primes the inflammasome for activation by NAIP5
2015
Interactions Between the Microbiota and the Immune System
2012 StandoutScience
Flt3 permits survival during infection by rendering dendritic cells competent to activate NK cells
2010 StandoutNobel
Caspase-1 autoproteolysis is differentially required for NLRP1b and NLRP3 inflammasome function
2014
Membrane proteomics of phagosomes suggests a connection to autophagy
2008 StandoutNobel
Comparable T helper 1 (Th1) and CD8 T-cell immunity by targeting HIV gag p24 to CD8 dendritic cells within antibodies to Langerin, DEC205, and Clec9A
2011 StandoutNobel
Infectious diseases in humanized mice
2013
Interactions between Siglec-7/9 receptors and ligands influence NK cell–dependent tumor immunosurveillance
2014
Cryo-EM structure of the activated NAIP2-NLRC4 inflammasome reveals nucleated polymerization
2015 Science
Mechanism of NLRP3 inflammasome activation
2014
Toll-Like Receptor–Gut Microbiota Interactions: Perturb at Your Own Risk!
2011
Intracellular sensing of microbes and danger signals by the inflammasomes
2011
Lipotoxicity and the gut-liver axis in NASH pathogenesis
2017
Caspase‐4 mediates non‐canonical activation of the NLRP3 inflammasome in human myeloid cells
2015
Host-microbiota interactions in inflammatory bowel disease
2012
Dendritic cell maturation by innate lymphocytes
2005 StandoutNobel
Microbiota, Disease, and Back to Health: A Metastable Journey
2012
Guanylate binding proteins promote caspase-11–dependent pyroptosis in response to cytoplasmic LPS
2014
Precision glycocalyx editing as a strategy for cancer immunotherapy
2016 StandoutNobel
Generation of functional human T-cell subsets with HLA-restricted immune responses in HLA class I expressing NOD/SCID/IL2rγnullhumanized mice
2010
The severity of nonalcoholic fatty liver disease is associated with gut dysbiosis and shift in the metabolic function of the gut microbiota
2015
Nlrp6 regulates intestinal antiviral innate immunity
2015 Science
Expression of HLA Class II Molecules in Humanized NOD.Rag1KO.IL2RgcKO Mice Is Critical for Development and Function of Human T and B Cells
2011
Inflammasomes and Their Roles in Health and Disease
2012
Host-Gut Microbiota Metabolic Interactions
2012 StandoutScience
IL-15 trans-presentation promotes human NK cell development and differentiation in vivo
2008
IL-22 Deficiency Alters Colonic Microbiota To Be Transmissible and Colitogenic
2013
Cutting Edge: Nlrp10 Is Essential for Protective Antifungal Adaptive Immunity against Candida albicans
2012
NLRP1-Dependent Pyroptosis Leads to Acute Lung Injury and Morbidity in Mice
2012
Design of a hyperstable 60-subunit protein icosahedron
2016 StandoutNatureNobel
Recognition of Bacteria by Inflammasomes
2012
Characterization of Human Antiviral Adaptive Immune Responses during Hepatotropic Virus Infection in HLA-Transgenic Human Immune System Mice
2013 StandoutNobel
Mitophagy confers resistance to siderophore-mediated killing by Pseudomonas aeruginosa
2015 StandoutNobel
Development of human CD4+FoxP3+ regulatory T cells in human stem cell factor–, granulocyte-macrophage colony-stimulating factor–, and interleukin-3–expressing NOD-SCID IL2Rγnull humanized mice
2011 StandoutNobel
Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation
2009 StandoutScience
Innate lymphocyte and dendritic cell cross-talk: a key factor in the regulation of the immune response
2008
Reconfigurable asymmetric protein assemblies through implicit negative design
2022 StandoutScienceNobel
Therapeutic Modulation of Microbiota-Host Metabolic Interactions
2012
A Role for Gut Microbiota and the Metabolite‐Sensing Receptor GPR43 in a Murine Model of Gout
2015
Humanized mouse models of HIV infection.
2011
Structural and biochemical basis for induced self-propagation of NLRC4
2015 Science
Works of Till Strowig being referenced
Inflammation-induced tumorigenesis in the colon is regulated by caspase-1 and NLRC4
2010
Microbiota-induced activation of epithelial IL-6 signaling links inflammasome-driven inflammation with transmissible cancer
2013
Improving human hemato-lymphoid-system mice by cytokine knock-in gene replacement
2011
NLRP10 is a NOD-like receptor essential to initiate adaptive immunity by dendritic cells
2012 Nature
NLRP6 Inflammasome Regulates Colonic Microbial Ecology and Risk for Colitis
2011 Standout
Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity
2012 StandoutNature
Development and function of human innate immune cells in a humanized mouse model
2014
Inflammasomes: far beyond inflammation
2012
Matrix Protein 2 of Influenza A Virus Blocks Autophagosome Fusion with Lysosomes
2009
Tonsilar NK Cells Restrict B Cell Transformation by the Epstein-Barr Virus via IFN-γ
2008
Caspase-11 Activation in Response to Bacterial Secretion Systems that Access the Host Cytosol
2013
NK cell survival mediated through the regulatory synapse with human DCs requires IL-15Rα
2007
Inflammasomes in health and disease
2012 StandoutNature
Regulation of the Antimicrobial Response by NLR Proteins
2011
Transgenic expression of human signal regulatory protein alpha in Rag2−/−γc−/−mice improves engraftment of human hematopoietic cells in humanized mice
2011
Distinct roles of IL-12 and IL-15 in human natural killer cell activation by dendritic cells from secondary lymphoid organs
2004
Human Hemato-Lymphoid System Mice: Current Use and Future Potential for Medicine
2013
Caspase-11 stimulates rapid flagellin-independent pyroptosis in response to Legionella pneumophila
2013
Priming of protective T cell responses against virus-induced tumors in mice with human immune system components
2009 StandoutNobel
Human NK cells of mice with reconstituted human immune system components require preactivation to acquire functional competence
2010
Targeting the nuclear antigen 1 of Epstein-Barr virus to the human endocytic receptor DEC-205 stimulates protective T-cell responses
2008 StandoutNobel
CD56brightCD16− Killer Ig-Like Receptor− NK Cells Display Longer Telomeres and Acquire Features of CD56dim NK Cells upon Activation
2007