Citation Impact
Citing Papers
Histone demethylase KDM6A directly senses oxygen to control chromatin and cell fate
2019 StandoutScienceNobel
Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles
2005 Standout
VEGF is an essential mediator of the neurogenic and behavioral actions of antidepressants
2007
Conserved N-terminal cysteine dioxygenases transduce responses to hypoxia in animals and plants
2019 StandoutScienceNobel
( R )-2-Hydroxyglutarate Is Sufficient to Promote Leukemogenesis and Its Effects Are Reversible
2013 StandoutScienceNobel
The Myeloma Drug Lenalidomide Promotes the Cereblon-Dependent Destruction of Ikaros Proteins
2013 StandoutScienceNobel
Predominant role of hypoxia-inducible transcription factor (Hif)-1alpha versus Hif-2alpha in regulation of the transcriptional response to hypoxia.
2003 StandoutNobel
Gene expression profiling in a renal cell carcinoma cell line: dissecting VHL and hypoxia-dependent pathways.
2003 StandoutNobel
Targeted Replacement of Hypoxia-Inducible Factor-1α by a Hypoxia-Inducible Factor-2α Knock-in Allele Promotes Tumor Growth
2005
The N-Terminal Transactivation Domain Confers Target Gene Specificity of Hypoxia-inducible Factors HIF-1α and HIF-2α
2007
Role of ETS Transcription Factors in the Hypoxia-Inducible Factor-2 Target Gene Selection
2006
Differential Gene Up-Regulation by Hypoxia-Inducible Factor-1α and Hypoxia-Inducible Factor-2α in HEK293T Cells
2005
Cancer and Altered Metabolism: Potential Importance of Hypoxia-Inducible Factor and 2-Oxoglutarate-Dependent Dioxygenases
2011 StandoutNobel
Hypoxia inducible factors regulate pluripotency and proliferation in human embryonic stem cells cultured at reduced oxygen tensions
2009
Differential Regulation of the Transcriptional Activities of Hypoxia-Inducible Factor 1 Alpha (HIF-1α) and HIF-2α in Stem Cells
2006
Acute postnatal ablation of Hif-2 α results in anemia
2007
Regulation of Angiogenesis by Oxygen and Metabolism
2009
Widespread, hypoxia‐inducible expression of HIF‐2α in distinct cell populations of different organs
2002 StandoutNobel
Up-regulation of hypoxia-inducible factor 2alpha in renal cell carcinoma associated with loss of Tsc-2 tumor suppressor gene.
2003
On-target efficacy of a HIF-2α antagonist in preclinical kidney cancer models
2016 StandoutNatureNobel
Hypoxia Increases Sirtuin 1 Expression in a Hypoxia-inducible Factor-dependent Manner
2011
Activation of the HIF pathway in cancer
2001
Differential activation and antagonistic function of HIF-α isoforms in macrophages are essential for NO homeostasis
2010
Abnormal Heart Development and Lung Remodeling in Mice Lacking the Hypoxia-Inducible Factor-Related Basic Helix-Loop-Helix PAS Protein NEPAS
2007
Target gene selectivity of hypoxia-inducible factor-α in renal cancer cells is conveyed by post-DNA-binding mechanisms
2007 StandoutNobel
Genome-wide Association of Hypoxia-inducible Factor (HIF)-1α and HIF-2α DNA Binding with Expression Profiling of Hypoxia-inducible Transcripts
2009 StandoutNobel
HIF-2α-Haploinsufficient Mice Have Blunted Retinal Neovascularization Due to Impaired Expression of a Proangiogenic Gene Battery
2008
Differential Roles of Hypoxia-Inducible Factor 1α (HIF-1α) and HIF-2α in Hypoxic Gene Regulation
2003
HIF Hydroxylase Pathways in Cardiovascular Physiology and Medicine
2015 StandoutNobel
HIF-2α, but not HIF-1α, promotes iron absorption in mice
2009
Endothelial deletion of hypoxia-inducible factor–2α (HIF-2α) alters vascular function and tumor angiogenesis
2009
Contrasting Properties of Hypoxia-Inducible Factor 1 (HIF-1) and HIF-2 in von Hippel-Lindau-Associated Renal Cell Carcinoma
2005 StandoutNobel
The angiopoietin‐2 gene of endothelial cells is up‐regulated in hypoxia by a HIF binding site located in its first intron and by the central factors GATA‐2 and Ets‐1
2008
Hypoxia-Inducible Factors and the Response to Hypoxic Stress
2010 Standout
HIF1α and HIF2α: sibling rivalry in hypoxic tumour growth and progression
2011
Hypoxia-Inducible Factors in Physiology and Medicine
2012 StandoutNobel
The hypoxia-inducible factor α pathway couples angiogenesis to osteogenesis during skeletal development
2007
Biology of hypoxia-inducible factor-2α in development and disease
2008
Hypoxia — a key regulatory factor in tumour growth
2002 Standout
HIF‐1α and HIF‐2α have divergent roles in colon cancer
2008
Heterozygous deficiency of hypoxia-inducible factor–2α protects mice against pulmonary hypertension and right ventricular dysfunction during prolonged hypoxia
2003
Genetics and Genomic Studies in Scleroderma (Systemic Sclerosis)
2008
Short-Term Effects of Nose-Only Cigarette Smoke Exposure on Glutathione Redox Homeostasis, Cytochrome P450 1A1/2 and Respiratory Enzyme Activities in Mice Tissues
2013 Standout
C. elegans EGL-9 and Mammalian Homologs Define a Family of Dioxygenases that Regulate HIF by Prolyl Hydroxylation
2001 StandoutNobel
Hypoxia-inducible Transcription Factor-2α in Endothelial Cells Regulates Tumor Neovascularization through Activation of Ephrin A1
2008
The contribution of VHL substrate binding and HIF1-α to the phenotype of VHL loss in renal cell carcinoma
2002
Hypoxia‐induced increase in the production of extracellular matrix proteins in systemic sclerosis
2007
Influence of Metabolism on Epigenetics and Disease
2013 StandoutNobel
Prolyl hydroxylase 3 (PHD3) is essential for hypoxic regulation of neutrophilic inflammation in humans and mice
2011 StandoutNobel
Human ADAR1 Prevents Endogenous RNA from Triggering Translational Shutdown
2018 StandoutNobel
Recruitment of HIF-1α and HIF-2α to common target genes is differentially regulated in neuroblastoma: HIF-2α promotes an aggressive phenotype
2006
Animal models of chronic obstructive pulmonary disease
2008
Effects of hypoxia on tumor metabolism
2007
Capillary Regeneration in Scleroderma: Stem Cell Therapy Reverses Phenotype?
2008
Prolonged Hypoxia Differentially Regulates Hypoxia-inducible Factor (HIF)-1α and HIF-2α Expression in Lung Epithelial Cells
2004
Eph/ephrin molecules—a hub for signaling and endocytosis
2010
Histone deacetylases induce angiogenesis by negative regulation of tumor suppressor genes
2001
HIF2α cooperates with RAS to promote lung tumorigenesis in mice
2009 StandoutNobel
Transformation by the (R)-enantiomer of 2-hydroxyglutarate linked to EGLN activation
2012 StandoutNatureNobel
Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources
2008 Standout
Hypoxia Inducible-Factor1α Regulates the Metabolic Shift of Pulmonary Hypertensive Endothelial Cells
2010
HIF-1α in Epidermis: Oxygen Sensing, Cutaneous Angiogenesis, Cancer, and Non-Cancer Disorders
2011
The biology of VEGF and its receptors
2003 Standout
A new role for the von Hippel-Lindau tumor suppressor protein: stimulation of mitochondrial oxidative phosphorylation complex biogenesis
2004
Scleroderma
2009 Standout
Inhibition of endogenous HIF inactivation induces angiogenesis in ischaemic skeletal muscles of mice
2004
The role of neurotrophic factors in adult hippocampal neurogenesis, antidepressant treatments and animal models of depressive-like behavior
2007
HIF-1 Inhibits Mitochondrial Biogenesis and Cellular Respiration in VHL-Deficient Renal Cell Carcinoma by Repression of C-MYC Activity
2007 StandoutNobel
Tumor Hypoxia and Malignant Progression
2004
Angiogenesis in health and disease
2003 Standout
The NOX Family of ROS-Generating NADPH Oxidases: Physiology and Pathophysiology
2007 Standout
Hypoxic Induction of the Regulator of G-Protein Signalling 4 Gene Is Mediated by the Hypoxia-Inducible Factor Pathway
2012
Role of myocardial hypoxia in the remodeling of the embryonic avian cardiac outflow tract
2003
Inhibition of cytochrome c oxidase subunit 4 precursor processing by the hypoxia mimic cobalt chloride
2006
Hypoxia and the extracellular matrix: drivers of tumour metastasis
2014 StandoutNobel
Molecular Mechanisms of Depression: Perspectives on New Treatment Strategies
2013 Standout
Hypoxia and Fetal Heart Development
2010
Reactive oxygen species (ROS) as pleiotropic physiological signalling agents
2020 Standout
von Hippel-Lindau disease
2003 Standout
Oxygen sensing and hypoxia signalling pathways in animals: the implications of physiology for cancer
2013 StandoutNobel
Epithelial hypoxia-inducible factor-1 is protective in murine experimental colitis
2004
Regulation of angiogenesis by hypoxia: role of the HIF system
2003 StandoutNobel
Proteomic changes in renal cancer and co‐ordinate demonstration of both the glycolytic and mitochondrial aspects of the Warburg effect
2003
The Lysyl Oxidases LOX and LOXL2 Are Necessary and Sufficient to Repress E-cadherin in Hypoxia
2009
Failure to prolyl hydroxylate hypoxia‐inducible factor α phenocopies VHL inactivation in vivo
2006 StandoutNobel
The Role of Hypoxia in Development of the Mammalian Embryo
2009
Depletion of PHD3 protects heart from ischemia/reperfusion injury by inhibiting cardiomyocyte apoptosis
2015
Gliogenesis and Glial Pathology in Depression
2007
Systemic sclerosis: a prototypic multisystem fibrotic disorder
2007 Standout
Ephrin-B2 controls VEGF-induced angiogenesis and lymphangiogenesis
2010 Nature
limma powers differential expression analyses for RNA-sequencing and microarray studies
2015 Standout
Dynamics of endothelial cell behavior in sprouting angiogenesis
2010
HIF-1 Regulates Cytochrome Oxidase Subunits to Optimize Efficiency of Respiration in Hypoxic Cells
2007 StandoutNobel
HIF-2α Promotes Hypoxic Cell Proliferation by Enhancing c-Myc Transcriptional Activity
2007
Basic and Therapeutic Aspects of Angiogenesis
2011 Standout
Allosteric inhibition of hypoxia inducible factor-2 with small molecules
2013
Hypoxia-responsive signaling regulates the apoptosis-dependent remodeling of the embryonic avian cardiac outflow tract
2004
VEGF links hippocampal activity with neurogenesis, learning and memory
2004
Chromatin as an oxygen sensor and active player in the hypoxia response
2011
Oxygen Sensing, Homeostasis, and Disease
2011 StandoutNobel
Inhibition of HIF is necessary for tumor suppression by the von Hippel-Lindau protein
2002 StandoutNobel
The Retinoblastoma Binding Protein RBP2 Is an H3K4 Demethylase
2007 StandoutNobel
Circulating endothelial progenitor cells in systemic sclerosis: association with disease severity
2008
Hypoxia Inducible Factor-1: Its Potential Role In Cerebral Ischemia
2012
Loss of pVHL is sufficient to cause HIF dysregulation in primary cells but does not promote tumor growth
2003
Molecular mechanisms and clinical applications of angiogenesis
2011 StandoutNature
Pten controls lung morphogenesis, bronchioalveolar stem cells, and onset of lung adenocarcinomas in mice
2007 StandoutNobel
ROS signalling in the biology of cancer
2017 Standout
Pyruvate Kinase M2 Is a PHD3-Stimulated Coactivator for Hypoxia-Inducible Factor 1
2011 StandoutNobel
FOXO3a Is Activated in Response to Hypoxic Stress and Inhibits HIF1-Induced Apoptosis via Regulation of CITED2
2007
Oxygen homeostasis
2009 StandoutNobel
Depression of Synaptic Transmission by Vascular Endothelial Growth Factor in Adult Rat Hippocampus and Evidence for Increased Efficacy after Chronic Seizures
2005
VEGF: once regarded as a specific angiogenic factor, now implicated in neuroprotection
2004
Life with Oxygen
2007 StandoutScienceNobel
The Von Hippel-Lindau Tumor Suppressor Gene and Kidney Cancer
2004 StandoutNobel
Antitumor activity and pharmacodynamic properties of PX-478, an inhibitor of hypoxia-inducible factor-1α
2004
Integration of Oxygen Signaling at the Consensus HRE
2005
Inhibition of mitochondrial respiration elevates oxygen concentration but leaves regulation of hypoxia-inducible factor (HIF) intact
2005
HIF2α inhibition promotes p53 pathway activity, tumor cell death, and radiation responses
2009
Constitutive expression of hypoxia-inducible factor-1alpha renders pancreatic cancer cells resistant to apoptosis induced by hypoxia and nutrient deprivation.
2001
Inhibiting Hypoxia-Inducible Factor 1 for Cancer Therapy
2006
The thioredoxin redox inhibitors 1-methylpropyl 2-imidazolyl disulfide and pleurotin inhibit hypoxia-induced factor 1alpha and vascular endothelial growth factor formation.
2003
Adaptive and Maladaptive Cardiorespiratory Responses to Continuous and Intermittent Hypoxia Mediated by Hypoxia-Inducible Factors 1 and 2
2012 StandoutNobel
EglN3 hydroxylase stabilizes BIM-EL linking VHL type 2C mutations to pheochromocytoma pathogenesis and chemotherapy resistance
2019 StandoutNobel
Hypoxic induction of an HIF-1α–dependent bFGF autocrine loop drives angiogenesis in human endothelial cells
2005
Cellular adaptation to hypoxia: O 2 ‐sensing protein hydroxylases, hypoxia‐inducible transcription factors, and O 2 ‐regulated gene expression
2002
Essential Role of Developmentally Activated Hypoxia-Inducible Factor 1α for Cardiac Morphogenesis and Function
2008
Regulation of E-cadherin Expression by VHL and Hypoxia-Inducible Factor
2006
Reactivation of Hepatic EPO Synthesis in Mice After PHD Loss
2010 StandoutScienceNobel
pVHL suppresses kinase activity of Akt in a proline-hydroxylation–dependent manner
2016 StandoutScienceNobel
Nitric Oxide Impairs Normoxic Degradation of HIF-1α by Inhibition of Prolyl Hydroxylases
2003
HIF-2α deletion promotes Kras-driven lung tumor development
2010
Antitumor activity and pharmacodynamic properties of PX-478, an inhibitor of hypoxia-inducible factor-1alpha.
2004
Hypoxia-Induced Pulmonary Vascular Remodeling
2006
Regulation of ventilatory sensitivity and carotid body proliferation in hypoxia by the PHD2/HIF‐2 pathway
2015 StandoutNobel
Constitutive activation of hypoxia-inducible genes related to overexpression of hypoxia-inducible factor-1alpha in clear cell renal carcinomas.
2001
Renal Cyst Development in Mice with Conditional Inactivation of the von Hippel-Lindau Tumor Suppressor
2006
Inhibition of hypoxia-inducible factor activity in endothelial cells disrupts embryonic cardiovascular development
2005
Bone Marrow-Derived Cells Do Not Incorporate Into the Adult Growing Vasculature
2003
Inactivation of the Arylhydrocarbon Receptor Nuclear Translocator (Arnt) Suppresses von Hippel-Lindau Disease-Associated Vascular Tumors in Mice
2005
Role ofVHLGene Mutation in Human Cancer
2004 StandoutNobel
The differential expression of VEGF, VEGFR-2, and GLUT-1 proteins in disease subtypes of systemic sclerosis
2005
Gene Profile of Electroconvulsive Seizures: Induction of Neurotrophic and Angiogenic Factors
2003
Inhibition of Hypoxia-Inducible Factor Prolyl Hydroxylase Domain Oxygen Sensors: Tricking the Body into Mounting Orchestrated Survival and Repair Responses
2013
Works of Till Acker being referenced
Prolyl Hydroxylases 2 and 3 Act in Gliomas as Protective Negative Feedback Regulators of Hypoxia-Inducible Factors
2009
Genetic evidence for a tumor suppressor role of HIF-2α
2005
Loss of PHD3 allows tumours to overcome hypoxic growth inhibition and sustain proliferation through EGFR
2014
Loss of HIF-2α and inhibition of VEGF impair fetal lung maturation, whereas treatment with VEGF prevents fatal respiratory distress in premature mice
2002
Cell type specific expression of vascular endothelial growth factor and angiopoietin-1 and -2 suggests an important role of astrocytes in cerebellar vascularization
2001
Protein kinase D2 is a novel regulator of glioblastoma growth and tumor formation
2011
Direct Stimulation of Adult Neural Stem Cells In Vitro and Neurogenesis In Vivo by Vascular Endothelial Growth Factor
2004
Up-regulation of hypoxia-inducible factors HIF-1α and HIF-2α under normoxic conditions in renal carcinoma cells by von Hippel-Lindau tumor suppressor gene loss of function
2000
Ephrin-B2 regulates VEGFR2 function in developmental and tumour angiogenesis
2010 Nature
Cell Type-Specific Expression of Neuropilins in an MCA-Occlusion Model in Mice Suggests a Potential Role in Post-Ischemic Brain Remodeling
2002
A role for hypoxia and hypoxia-inducible transcription factors in tumor physiology
2002
The good, the bad and the ugly in oxygen-sensing: ROS, cytochromes and prolyl-hydroxylases
2006
Cooperative Interaction of Hypoxia-inducible Factor-2α (HIF-2α) and Ets-1 in the Transcriptional Activation of Vascular Endothelial Growth Factor Receptor-2 (Flk-1)
2003
Role of hypoxia in tumor angiogenesis?molecular and cellular angiogenic crosstalk
2003
Participation of Bone Marrow-Derived Cells in Long-Term Repair Processes after Experimental Stroke
2003
Activation of c-Jun NH2-terminal kinase/stress-activated protein kinase (JNK/SAPK) is critical for hypoxia-induced apoptosis of human malignant melanoma.
2001
Uncontrolled Expression of Vascular Endothelial Growth Factor and Its Receptors Leads to Insufficient Skin Angiogenesis in Patients With Systemic Sclerosis
2004