Citation Impact
Citing Papers
Neurotoxic protein expression reveals connections between the circadian clock and mating behavior in Drosophila
2006 StandoutNobel
p62/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-induced cell death
2005 Standout
CD8+ T cell concentration determines their efficiency in killing cognate antigen–expressing syngeneic mammalian cells in vitro and in mouse tissues
2010
Tumor Cell–Derived and Macrophage-Derived Cathepsin B Promotes Progression and Lung Metastasis of Mammary Cancer
2006
Genome-wide features of neuroendocrine regulation in Drosophila by the basic helix-loop-helix transcription factor DIMMED
2015 StandoutNobel
Schizophrenia risk from complex variation of complement component 4
2016 StandoutNature
Cellular Inclusion Bodies of Mutant Huntingtin Exon 1 Obscure Small Fibrillar Aggregate Species
2012 StandoutNobel
AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity
2009 StandoutNature
Modeling psychiatric disorders for developing effective treatments
2015
Signals from the lysosome: a control centre for cellular clearance and energy metabolism
2013 Standout
The Proteome of Primary Prostate Cancer
2015
Time course of early motor and neuropathological anomalies in a knock‐in mouse model of Huntington's disease with 140 CAG repeats
2003
The Ubiquitin Proteasome System in Neurodegenerative Diseases
2003 StandoutNobel
Cathepsin L Inactivates Human Trypsinogen, Whereas Cathepsin L-Deletion Reduces the Severity of Pancreatitis in Mice
2009
SARS and MERS: recent insights into emerging coronaviruses
2016 Standout
Secretory granule biogenesis: rafting to the SNARE
2001
MC4R Agonists: Structural Overview on Antiobesity Therapeutics
2018 StandoutNobel
Proteases Acting on Mutant Huntingtin Generate Cleaved Products that Differentially Build Up Cytoplasmic and Nuclear Inclusions
2002
The role of autophagy in neurodegenerative disease
2013 Standout
Huntington's disease
2007 Standout
Accessories to the Crime: Functions of Cells Recruited to the Tumor Microenvironment
2012 Standout
Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid β-peptide
2007 Standout
Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease
2004 Standout
Dramatic tissue-specific mutation length increases are an early molecular event in Huntington disease pathogenesis
2003
Imaging in the era of molecular oncology
2008 StandoutNature
Inclusion body formation reduces levels of mutant huntingtin and the risk of neuronal death
2004 StandoutNature
Nuclear Localization of a Non-caspase Truncation Product of Atrophin-1, with an Expanded Polyglutamine Repeat, Increases Cellular Toxicity
2003
Autophagy fights disease through cellular self-digestion
2008 StandoutNature
Trends in GPCR drug discovery: new agents, targets and indications
2017 Standout
Distinct roles for cysteine cathepsin genes in multistage tumorigenesis
2006
Cardiac autophagy is a maladaptive response to hemodynamic stress
2007 Standout
Dynamic imaging of protease activity with fluorescently quenched activity-based probes
2005
Inhibitors of Cathepsin B Improve Memory and Reduce β-Amyloid in Transgenic Alzheimer Disease Mice Expressing the Wild-type, but Not the Swedish Mutant, β-Secretase Site of the Amyloid Precursor Protein
2008
Mitochondria: More Than Just a Powerhouse
2006 Standout
Biological Functions of Autophagy Genes: A Disease Perspective
2019 Standout
Macrophage Diversity Enhances Tumor Progression and Metastasis
2010 Standout
Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice
2006 StandoutNature
Matrix Metalloproteinases Are Modifiers of Huntingtin Proteolysis and Toxicity in Huntington's Disease
2010
Protein aggregation and neurodegenerative disease
2004 Standout
Extracellular matrix structure
2015 Standout
Ebola virus entry requires the cholesterol transporter Niemann–Pick C1
2011 StandoutNature
The Perseus computational platform for comprehensive analysis of (prote)omics data
2016 Standout
Development by Self-Digestion
2004 Standout
Cathepsin cysteine proteases are effectors of invasive growth and angiogenesis during multistage tumorigenesis
2004
The nervous system and innate immunity: the neuropeptide connection
2005
Cysteine cathepsin proteases: regulators of cancer progression and therapeutic response
2015
The role of proopiomelanocortin (POMC) neurones in feeding behaviour
2007
A Cathepsin L Isoform that Is Devoid of a Signal Peptide Localizes to the Nucleus in S Phase and Processes the CDP/Cux Transcription Factor
2004
Copper-Zinc Superoxide Dismutase (SOD1) Is Released by Microglial Cells and Confers Neuroprotection against 6-OHDA Neurotoxicity
2012 Standout
Huntingtin Is Present in the Nucleus, Interacts with the Transcriptional Corepressor C-terminal Binding Protein, and Represses Transcription
2002
The Protein Architecture of Human Secretory Vesicles Reveals Differential Regulation of Signaling Molecule Secretion by Protein Kinases
2012
Polyglutamine Pathogenesis
2002
The Charcot–Marie–Tooth type 2A gene product, Mfn2, up-regulates fuel oxidation through expression of OXPHOS system
2005
The evolving tumor microenvironment: From cancer initiation to metastatic outgrowth
2023 Standout
Anti-Aβ Drug Screening Platform Using Human iPS Cell-Derived Neurons for the Treatment of Alzheimer's Disease
2011 StandoutNobel
The ubiquitin system: pathogenesis of human diseases and drug targeting
2004 StandoutNobel
Lessons from animal models of Huntington's disease
2002
Microenvironmental regulation of metastasis
2008 Standout
Antiamyloidogenic and Neuroprotective Functions of Cathepsin B: Implications for Alzheimer's Disease
2006
Mucin Granule Intraluminal Organization in Living Mucous/Goblet Cells
2005 StandoutNobel
Tumor metastasis: mechanistic insights and clinical challenges
2006 Standout
Autophagy in cell death: an innocent convict?
2005 Standout
Targeting programmed cell death in neurodegenerative diseases
2003
Microenvironmental regulation of tumor progression and metastasis
2013 Standout
The NALP3 inflammasome is involved in the innate immune response to amyloid-β
2008 Standout
Inflammasomes: mechanism of action, role in disease, and therapeutics
2015 Standout
Physiology, Signaling, and Pharmacology of Galanin Peptides and Receptors: Three Decades of Emerging Diversity
2014
Autophagy regulates the processing of amino terminal huntingtin fragments
2003
Parkinson's Disease
2003 Standout
Autophagy Is Activated for Cell Survival after Endoplasmic ReticulumStress
2006 Standout
An alternative metabolic pathway of amyloid precursor protein C‐terminal fragments via cathepsin B in a human neuroglioma model
2011
Caspase Cleavage of Mutant Huntingtin Precedes Neurodegeneration in Huntington's Disease
2002
Identification of a Broad-Spectrum Antiviral Small Molecule against Severe Acute Respiratory Syndrome Coronavirus and Ebola, Hendra, and Nipah Viruses by Using a Novel High-Throughput Screening Assay
2014
Cell–matrix interactions: focus on proteoglycan–proteinase interplay and pharmacological targeting in cancer
2014
Microglia Function in the Central Nervous System During Health and Neurodegeneration
2017 Standout
CD8+tumor-infiltrating lymphocytes at primary sites as a possible prognostic factor of cutaneous angiosarcoma
2013 StandoutNobel
Caspase 3-cleaved N-terminal fragments of wild-type and mutant huntingtin are present in normal and Huntington's disease brains, associate with membranes, and undergo calpain-dependent proteolysis
2001
Tau Suppression in a Neurodegenerative Mouse Model Improves Memory Function
2005 StandoutScience
Huntingtin forms toxic NH2-terminal fragment complexes that are promoted by the age-dependent decrease in proteasome activity
2003
Impaired Degradation of Mutant α-Synuclein by Chaperone-Mediated Autophagy
2004 StandoutScience
Extrahelical (CAG)/(CTG) triplet repeat elements support proliferating cell nuclear antigen loading and MutLα endonuclease activation
2013 StandoutNobel
Role of Hypothalamic Proopiomelanocortin Neuron Autophagy in the Control of Appetite and Leptin Response
2012
Autophagy in neurons: a review.
2002
Predominant Release of Lysosomal Enzymes by Newborn Rat Microglia After LPS Treatment Revealed by Proteomic Studies
2008
Differentiation of Effector CD4 T Cell Populations
2010 Standout
Sp1 and TAFII130 Transcriptional Activity Disrupted in Early Huntington's Disease
2002 Science
Works of Thomas Toneff being referenced
Major Role of Cathepsin L for Producing the Peptide Hormones ACTH, β-Endorphin, and α-MSH, Illustrated by Protease Gene Knockout and Expression
2008
Obliteration of α‐melanocyte‐stimulating hormone derived from POMC in pituitary and brains of PC2‐deficient mice
2003
Cathepsin L Expression Is Directed to Secretory Vesicles for Enkephalin Neuropeptide Biosynthesis and Secretion
2007
Differential activation of enkephalin, galanin, somatostatin, NPY, and VIP neuropeptide production by stimulators of protein kinases A and C in neuroendocrine chromaffin cells
2008
β‐Amyloid peptide in regulated secretory vesicles of chromaffin cells: evidence for multiple cysteine proteolytic activities in distinct pathways for β‐secretase activity in chromaffin vesicles
2002
Human iPSC Neurons Display Activity-Dependent Neurotransmitter Secretion: Aberrant Catecholamine Levels in Schizophrenia Neurons
2014
Molecular Cloning of Endopin 1, a Novel Serpin Localized to Neurosecretory Vesicles of Chromaffin Cells
1999
Cathepsin L participates in the production of neuropeptide Y in secretory vesicles, demonstrated by protease gene knockout and expression
2008
Arginine and Lysine Aminopeptidase Activities in Chromaffin Granules of Bovine Adrenal Medulla: Relevance to Prohormone Processing
1998
Beta-amyloid peptides undergo regulated co-secretion with neuropeptide and catecholamine neurotransmitters
2013
Inhibition of cathepsin B reduces β-amyloid production in regulated secretory vesicles of neuronal chromaffin cells: evidence for cathepsin B as a candidate β-secretase of Alzheimer's disease
2005
Brain Pyroglutamate Amyloid-β is Produced by Cathepsin B and is Reduced by the Cysteine Protease Inhibitor E64d, Representing a Potential Alzheimer's Disease Therapeutic
2014
Hemostatic factors in rabbit limb lymph: relationship to mechanisms regulating extravascular coagulation
1998
Evidence for Functional Localization of the Proenkephalin-Processing Enzyme, Prohormone Thiol Protease, to Secretory Vesicles of Chromaffin Cells*
1999
Cathepsin L in secretory vesicles functions as a prohormone-processing enzyme for production of the enkephalin peptide neurotransmitter
2003
Inhibition of cathepsin B reduces β-amyloid production in regulated secretory vesicles of neuronal chromaffin cells: evidence for cathepsin B as a candidate β-secretase of Alzheimer's disease
2005
Tissue-Specific Proteolysis of Huntingtin (htt) in Human Brain: Evidence of Enhanced Levels of N- and C-Terminal htt Fragments in Huntington's Disease Striatum
2001
Comparison of huntingtin proteolytic fragments in human lymphoblast cell lines and human brain
2002