Citation Impact
Citing Papers
A polyketide synthase-peptide synthetase gene cluster from an uncultured bacterial symbiont of Paederus beetles
2002 Standout
Olefin Cyclopropanation via Carbene Transfer Catalyzed by Engineered Cytochrome P450 Enzymes
2012 StandoutScienceNobel
Antitumor polyketide biosynthesis by an uncultivated bacterial symbiont of the marine sponge Theonella swinhoei
2004 Standout
Global Strategy for the Diagnosis, Management, and Prevention of Chronic Obstructive Pulmonary Disease
2007 Standout
Metabolic engineering for drug discovery and development
2003
Recombinant organisms for production of industrial products
2010
Engineering a polyketide with a longer chain by insertion of an extra module into the erythromycin-producing polyketide synthase
2001
The evolving role of natural products in drug discovery
2005 Standout
Modular click chemistry libraries for functional screens using a diazotizing reagent
2019 StandoutNatureNobel
Organocatalytic cascade reactions as a new tool in total synthesis
2010 Standout
Natural products: A continuing source of novel drug leads
2013 Standout
Novel Mechanism for Dehalogenation and Glutathione Conjugation of Dihalogenated Anilines in Human Liver Microsomes: Evidence foripsoGlutathione Addition
2011
Polymorphism of human cytochrome P450 enzymes and its clinical impact
2009
The biology and management of non-small cell lung cancer
2018 StandoutNature
INTERACTIONS OF TWO MAJOR METABOLITES OF PRASUGREL, A THIENOPYRIDINE ANTIPLATELET AGENT, WITH THE CYTOCHROMES P450
2006
Efficacy of Varenicline, an α4β2 Nicotinic Acetylcholine Receptor Partial Agonist, vs Placebo or Sustained-Release Bupropion for Smoking Cessation<SUBTITLE>A Randomized Controlled Trial</SUBTITLE>
2006
Type I polyketide biosynthesis in bacteria (Part A — erythromycin biosynthesis) (1994 to 2000)
2001
Cytochrome P-450 Polymorphisms and Response to Clopidogrel
2008 Standout
Metabolism and Excretion of Anacetrapib, a Novel Inhibitor of the Cholesteryl Ester Transfer Protein, in Humans
2009
In-solution enrichment identifies peptide inhibitors of protein–protein interactions
2019
Modulation of epothilone analog production through media design
2002
Opportunities and challenges in phenotypic drug discovery: an industry perspective
2017
Inhibitors of BACE for treating Alzheimer's disease: a fragment-based drug discovery story
2013
Application of drug metabolising mutants of cytochrome P450 BM3 (CYP102A1) as biocatalysts for the generation of reactive metabolites
2007
Antituberculosis drugs: Ten years of research
2007
Inhibiting Bacterial Fatty Acid Synthesis
2006
Organocatalytic Enantioselective Decarboxylative Aldol Reaction of Malonic Acid Half Thioesters with Aldehydes
2013 StandoutNobel
Varenicline for Tobacco Dependence
2008
Comparison of random mutagenesis and semi-rational designed libraries for improved cytochrome P450 BM3-catalyzed hydroxylation of small alkanes
2012 StandoutNobel
Building-block selectivity of polyketide synthases
2003
Selective C H bond functionalization with engineered heme proteins: new tools to generate complexity
2018 StandoutNobel
Natural products to drugs: natural product-derived compounds in clinical trials
2008 Standout
Selective stalling of human translation through small-molecule engagement of the ribosome nascent chain
2017 StandoutNobel
Skipping in a Hybrid Polyketide Synthase
2002
Nanoscale synthesis and affinity ranking
2018 Nature
Asymmetric Organocatalytic Domino Reactions
2007 Standout
Anchor extension: a structure-guided approach to design cyclic peptides targeting enzyme active sites
2021 StandoutNobel
Recombinant protein expression in Escherichia coli: advances and challenges
2014 Standout
Drug repurposing: progress, challenges and recommendations
2018 Standout
Metabolic engineering and directed evolution for the production of pharmaceuticals
2000
Sequential assembly of the septal cell envelope prior to V snapping in Corynebacterium glutamicum
2019 StandoutNobel
Biosynthesis of the Angiogenesis Inhibitor Borrelidin by Streptomyces parvulus Tü4055
2004
Natural Product Hybrids as New Leads for Drug Discovery
2003 Standout
Manipulation and Analysis of Polyketide Synthases
2004
Biosynthesis and attachment of novel bacterial polyketide synthase starter units
2001
Polyketide biosynthesis: a millennium review
2001 Standout
The use of spirocyclic scaffolds in drug discovery
2014 Standout
Analysis of the biosynthetic gene cluster for the polyether antibiotic monensin in Streptomyces cinnamonensis and evidence for the role of monB and monC genes in oxidative cyclization
2003
A crevice adjoining the ribosome tunnel: Hints for cotranslational folding
2005 StandoutNobel
PROTAC targeted protein degraders: the past is prologue
2022 Standout
Complex reactions catalyzed by cytochrome P450 enzymes
2006
Larval Zebrafish Model for FDA-Approved Drug Repositioning for Tobacco Dependence Treatment
2014
Engineering specificity of starter unit selection by the erythromycin‐producing polyketide synthase
2002
The contentious nature of soil organic matter
2015 StandoutNature
DNA‐Templated Organic Synthesis: Nature's Strategy for Controlling Chemical Reactivity Applied to Synthetic Molecules
2004 Standout
Combinatorial biosynthesis of polyketides and nonribosomal peptides
2001
The Crystal Structure of Yeast Fatty Acid Synthase, a Cellular Machine with Eight Active Sites Working Together
2007 StandoutNobel
Pharmacokinetics, Metabolism, and Excretion of Anacetrapib, a Novel Inhibitor of the Cholesteryl Ester Transfer Protein, in Rats and Rhesus Monkeys
2009
Chain initiation on the soraphen-producing modular polyketide synthase from Sorangium cellulosum
2001
Oral Druggable Space beyond the Rule of 5: Insights from Drugs and Clinical Candidates
2014
The Biosynthetic Logic of Polyketide Diversity
2009 Standout
Pharmacological profile of the α4β2 nicotinic acetylcholine receptor partial agonist varenicline, an effective smoking cessation aid
2006
Global Strategy for the Diagnosis, Management, and Prevention of Chronic Obstructive Pulmonary Disease
2012 Standout
Prospects for Generating New Antibiotics
2002
The history of proprotein convertase subtilisin kexin-9 inhibitors and their role in the treatment of cardiovascular disease
2020
Data-Mining for Sulfur and Fluorine: An Evaluation of Pharmaceuticals To Reveal Opportunities for Drug Design and Discovery
2013 Standout
Total Synthesis of Borrelidin
2007 StandoutNobel
Fluorine and Fluorinated Motifs in the Design and Application of Bioisosteres for Drug Design
2018 Standout
Biological Activities of Hydrazone Derivatives
2007 Standout
A Survey of the Role of Noncovalent Sulfur Interactions in Drug Design
2015
Natural Products as Sources of New Drugs over the Nearly Four Decades from 01/1981 to 09/2019
2020 Standout
The Organocatalytic Approach to Enantiopure 2H‐ and 3H‐Pyrroles: Inhibitors of the Hedgehog Signaling Pathway
2016 StandoutNobel
Sponge-Associated Microorganisms: Evolution, Ecology, and Biotechnological Potential
2007 Standout
Next Generation of Fluorine-Containing Pharmaceuticals, Compounds Currently in Phase II–III Clinical Trials of Major Pharmaceutical Companies: New Structural Trends and Therapeutic Areas
2016 Standout
The Origin of Chalcogen-Bonding Interactions
2017 Standout
Formation and Cleavage of C–C Bonds by Enzymatic Oxidation–Reduction Reactions
2018
Cardiovascular Risk Reduction with Icosapent Ethyl for Hypertriglyceridemia
2018 Standout
Structure-Based Design of β-Site APP Cleaving Enzyme 1 (BACE1) Inhibitors for the Treatment of Alzheimer’s Disease
2013
Straightforward Synthesis of α,β-Unsaturated Thioesters via Ruthenium-Catalyzed Olefin Cross-Metathesis with Thioacrylate
2008 StandoutNobel
Pharmacogenetic testing among patients with mood and anxiety disorders is associated with decreased utilization and cost: A propensity-score matched study
2018 StandoutNobel
Engineered Bacterial Mimics of Human Drug Metabolizing Enzyme CYP2C9
2011 StandoutNobel
ETCM: an encyclopaedia of traditional Chinese medicine
2018 Standout
Natural product and natural product derived drugs in clinical trials
2014 Standout
Impact of Natural Products on Developing New Anti-Cancer Agents
2009 Standout
Hydrogen Bond Basicity Prediction for Medicinal Chemistry Design
2016
Natural Products as Sources of New Drugs from 1981 to 2014
2016 Standout
New Rapamycin Derivatives by Precursor‐Directed Biosynthesis
2004
A C 35 Carotenoid Biosynthetic Pathway
2003 StandoutNobel
Principles and Applications of Halogen Bonding in Medicinal Chemistry and Chemical Biology
2012 Standout
Sulfur(VI) Fluoride Exchange (SuFEx)-Enabled High-Throughput Medicinal Chemistry
2020 StandoutNobel
Works of Thomas N. O’Connell being referenced
METABOLISM AND DISPOSITION OF VARENICLINE, A SELECTIVE α4β2 ACETYLCHOLINE RECEPTOR PARTIAL AGONIST, IN VIVO AND IN VITRO
2005
CYP2C8- and CYP3A-Mediated C-Demethylation of (3-{[(4-tert-Butylbenzyl)-(pyridine-3-sulfonyl)-amino]-methyl}-phenoxy)-acetic Acid (CP-533,536), an EP2 Receptor-Selective Prostaglandin E2 Agonist: Characterization of Metabolites by High-Resolution Liquid Chromatography-Tandem Mass Spectrometry and Liquid Chromatography/Mass Spectrometry-Nuclear Magnetic Resonance
2008
Production of 6-Deoxy-13-cyclopropyl-Erythromycin B by Saccharopolyspora erythraea NRRL 18643.
1999
A Small-Molecule Anti-secretagogue of PCSK9 Targets the 80S Ribosome to Inhibit PCSK9 Protein Translation
2016
Novel Erythromycins from a Recombinant Saccharopolyspora erythraea Strain NRRL 2338 pIG1. I. Fermentation, Isolation and Biological Activity.
1998
Metabolism, Pharmacokinetics, and Excretion of a Cholesteryl Ester Transfer Protein Inhibitor, Torcetrapib, in Rats, Monkeys, and Mice: Characterization of Unusual and Novel Metabolites by High-Resolution Liquid Chromatography-Tandem Mass Spectrometry and 1H Nuclear Magnetic Resonance
2008
Synthesis and structure–activity relationships of thiotetronic acid analogues of thiolactomycin
2001
IDENTIFICATION OF A NOVEL GLUTATHIONE ADDUCT OF DICLOFENAC, 4′-HYDROXY-2′-GLUTATHION-DESCHLORO-DICLOFENAC, UPON INCUBATION WITH HUMAN LIVER MICROSOMES
2005
CHARACTERIZATION OF NOVEL DIHYDROTHIENOPYRIDINIUM AND THIENOPYRIDINIUM METABOLITES OF TICLOPIDINE IN VITRO: ROLE OF PEROXIDASES, CYTOCHROMES P450, AND MONOAMINE OXIDASES
2004
Integrating Intramolecular Hydrogen Bonding (IMHB) Considerations in Drug Discovery Using ΔlogP As a Tool
2013
Discovery and Optimization of a Novel Spiropyrrolidine Inhibitor of β-Secretase (BACE1) through Fragment-Based Drug Design
2012
Solution-Based Indirect Affinity Selection Mass Spectrometry—A General Tool For High-Throughput Screening Of Pharmaceutical Compound Libraries
2014