Citation Impact
Citing Papers
Complement and microglia mediate early synapse loss in Alzheimer mouse models
2016 StandoutScience
Correction of Sickle Cell Disease in Transgenic Mouse Models by Gene Therapy
2001 Science
Treatment of Sickle Cell Anemia Mouse Model with iPS Cells Generated from Autologous Skin
2007 Science
RNA-Guided Human Genome Engineering via Cas9
2013 StandoutScience
Ferroptosis regulation by the NGLY1/NFE2L1 pathway
2022 StandoutNobel
The glial cell response is an essential component of hypoxia-induced erythropoiesis in mice
2009
The promise and challenge of therapeutic genome editing
2020 StandoutNatureNobel
Hypoxia-Inducible Factors in Physiology and Medicine
2012 StandoutNobel
Beta-globin locus activation regions: conservation of organization, structure, and function.
1990
Early Growth Response Protein 1 (Egr-1): Prototype of a Zinc-finger Family of Transcription Factors
1995
Hemoglobin disorders and endothelial cell interactions
2009
Locus control regions of mammalian β-globin gene clusters: combining phylogenetic analyses and experimental results to gain functional insights
1997
CRISPR/Cas9 β-globin gene targeting in human haematopoietic stem cells
2016 Nature
Pulmonary Hypertension as a Risk Factor for Death in Patients with Sickle Cell Disease
2004
Anti-inflammatory therapy ameliorates leukocyte adhesion and microvascular flow abnormalities in transgenic sickle mice
2004
Hematopoietic stem cell gene transfer for the treatment of hemoglobin disorders
2009
Failure of blood-island formation and vasculogenesis in Flk-1-deficient mice
1995 StandoutNature
Ultrasensitive fluorescent proteins for imaging neuronal activity
2013 StandoutNature
[45] Production of transgenic mice
1993
Imaging Neuronal Subsets in Transgenic Mice Expressing Multiple Spectral Variants of GFP
2000 Standout
The Oncogenic Cysteine-rich LIM domain protein Rbtn2 is essential for erythroid development
1994 StandoutNobel
Lethal α–thalassaemia created by gene targeting in mice and its genetic rescue
1995
Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis
2011 StandoutNature
p53-dependent transcription can exhibit both on/off and graded response after genotoxic stress
2004
Sickle cell anemia is associated with reduced nitric oxide bioactivity in peripheral conduit and resistance vessels
2003
Methylation of a CTCF-dependent boundary controls imprinted expression of the Igf2 gene
2000 StandoutNature
Rescue of erythroid development in gene targeted GATA–1− mouse embryonic stem cells
1992
2 The regulation of human globin gene expression
1993
The β-Globin LCR Is Not Necessary for an Open Chromatin Structure or Developmentally Regulated Transcription of the Native Mouse β-Globin Locus
1998
Erythroid transcription factor NF-E2 is a haematopoietic-specific basic–leucine zipper protein
1993 Nature
Critical role of endothelial cell activation in hypoxia-induced vasoocclusion in transgenic sickle mice
2005
Outcome of Sickle Cell Anemia
2005
Hydroxyurea induces the eNOS-cGMP pathway in endothelial cells
2006
To be or not to be active: the stochastic nature of enhancer action
2000
A long noncoding RNA maintains active chromatin to coordinate homeotic gene expression
2011 StandoutNature
A locus control region adjacent to the human red and green visual pigment genes
1992
Dysregulated Arginine Metabolism, Hemolysis-Associated Pulmonary Hypertension, and Mortality in Sickle Cell Disease
2005
A 5′ element of the chicken β-globin domain serves as an insulator in human erythroid cells and protects against position effect in Drosophila
1993
A locus control region in the T cell receptor α/δ locus
1994
Effects of Iron Supplementation and Depletion on Hypoxic Pulmonary Hypertension
2009 StandoutNobel
Sickle-cell disease
2010 Standout
Regulation of β-globin gene expression: straightening out the locus
1996
A position-effect assay for boundaries of higher order chromosomal domains
1991
Coinjection strategy for visual identification of transgenic mice
1991
Long Human–Mouse Sequence Alignments Reveal Novel Regulatory Elements: A Reason to Sequence the Mouse Genome
1997
Repeat-induced gene silencing in mammals
1998
The PtdIns(3,4)P2 phosphatase INPP4A is a suppressor of excitotoxic neuronal death
2010 StandoutNatureNobel
Cloning of cDNA for the major DNA-binding protein of the erythroid lineage through expression in mammalian cells
1989 Nature
Intergenic transcription and transinduction of the human β-globin locus
1997
Klotho converts canonical FGF receptor into a specific receptor for FGF23
2006 StandoutNature
Polycythemia vera and other primary polycythemias
2005
Cell-free hemoglobin limits nitric oxide bioavailability in sickle-cell disease
2002
A clonogenic common myeloid progenitor that gives rise to all myeloid lineages
2000 StandoutNature
Pulmonary Complications of Sickle Cell Disease
2008
Oxygen Sensing, Homeostasis, and Disease
2011 StandoutNobel
CTCF mediates methylation-sensitive enhancer-blocking activity at the H19/Igf2 locus
2000 StandoutNature
Pulmonary hypertension in patients with sickle cell disease: a longitudinal study
2006
Sickle cell disease and the kidney
2008
Allelic inactivation regulates olfactory receptor gene expression
1994 StandoutNobel
Coagulation activation and inflammation in sickle cell disease-associated pulmonary hypertension
2007
Developmental regulation of human fetal-to-adult globin gene switching in transgenic mice
1990 Nature
A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera
2005 StandoutNature
Sickle cell vaso-occlusion: multistep and multicellular paradigm
2002
Arginine Therapy
2003
Digoxin inhibits development of hypoxic pulmonary hypertension in mice
2012 StandoutNobel
High blood pressure in transgenic mice carrying the rat angiotensinogen gene.
1992
Chromatin interaction mechanism of transcriptional control invivo
1998
Endothelial cell NADPH oxidase mediates the cerebral microvascular dysfunction in sickle cell transgenic mice
2005
2016
The human AQP4 gene: definition of the locus encoding two water channel polypeptides in brain.
1996 StandoutNobel
Functional Analysis of the Human Adenosine Deaminase Gene Thymic Regulatory Region and Its Ability To Generate Position-Independent Transgene Expression
1992
Protein Engineering: Modified Hemoglobin as a Blood Substitute
1992
In Vitro Development of Primitive and Definitive Erythrocytes from Different Precursors
1996 StandoutScienceNobel
Efficient gene transfer into rhesus repopulating hematopoietic stem cells using a simian immunodeficiency virus–based lentiviral vector system
2004
In vivo selection of genetically modified erythroblastic progenitors leads to long-term correction of β-thalassemia
2008
Stochasticity in gene expression: from theories to phenotypes
2005 Standout
Enhancers increase the probability but not the level of gene expression.
1995
The Locus Control Region Is Necessary for Gene Expression in the Human β-Globin Locus but Not the Maintenance of an Open Chromatin Structure in Erythroid Cells
1998
Nanoscopy in a Living Mouse Brain
2012 StandoutScienceNobel
Derepression of mouse beta-major-globin gene transcription during erythroid differentiation.
1991
In situ hybridization reveals co-expression of embryonic and adult α globin genes in the earliest murine erythrocyte progenitors
1992
Overexpression of angiotensin AT 1 receptor transgene in the mouse myocardium produces a lethal phenotype associated with myocyte hyperplasia and heart block
1997 StandoutNobel
Pulmonary Arterial Hypertension
2006
Extreme hydrops fetalis and cardiovascular abnormalities in mice lacking a functional Adrenomedullin gene
2001 StandoutNobel
Cell-free hemoglobin limits nitric oxide bioavailability in sickle-cell disease
2002
Endothelial cell expression of tissue factor in sickle mice is augmented by hypoxia/reoxygenation and inhibited by lovastatin
2004
Reactivation of silenced, virally transduced genes by inhibitors of histone deacetylase
1997
Divergent Nitric Oxide Bioavailability in Men and Women With Sickle Cell Disease
2003
Synthetic Cyclic Oligosaccharides
1998 StandoutNobel
NRF2, a member of the NFE2 family of transcription factors, is not essential for murine erythropoiesis, growth, and development
1996
Cyclodextrin-Based Catenanes and Rotaxanes
1998 StandoutNobel
Hypoxia. 5. Hypoxia and hematopoiesis
2011
Illegitimate Cre-dependent chromosome rearrangements in transgenic mouse spermatids
2000 StandoutNobel
Human globin locus activation region (LAR): role in temporal control
1990
Hypertension, cardiac hypertrophy, and sudden death in mice lacking natriuretic peptide receptor A
1997 StandoutNobel
Stochastic Gene Expression in a Single Cell
2002 StandoutScience
Inactivation of the human beta-globin gene by targeted insertion into the beta-globin locus control region.
1992
A Common Human β Globin Splicing Mutation Modeled in Mice
1998 StandoutNobel
Functional analysis of the human adenosine deaminase gene thymic regulatory region and its ability to generate position-independent transgene expression.
1992
Transcriptional regulation of fetal to adult hemoglobin switching: new therapeutic opportunities
2011
Live-cell imaging of dendritic spines by STED microscopy
2008 StandoutNobel
Site-specific gene correction of a point mutation in human iPS cells derived from an adult patient with sickle cell disease
2011
Targeted deletion of 5'HS2 of the murine beta-globin LCR reveals that it is not essential for proper regulation of the beta-globin locus.
1995
Primary role for adherent leukocytes in sickle cell vascular occlusion: A new paradigm
2002
Lethal thalassemia after insertional disruption of the mouse major adult beta-globin gene.
1993 StandoutNobel
Subcellular colocalization of the cellular and scrapie prion proteins in caveolae-like membranous domains
1996 StandoutNobel
In vivo hematopoietic stem cell modification by mRNA delivery
2023 StandoutScienceNobel
Genetic control of blood pressure and the angiotensinogen locus.
1995 StandoutNobel
A mouse model for beta 0-thalassemia.
1995 StandoutNobel
Genetic treatment of a molecular disorder: gene therapy approaches to sickle cell disease
2016
In Vivo Transfer of GPI-Linked Complement Restriction Factors from Erythrocytes to the Endothelium
1995 Science
Genetic Decreases in Atrial Natriuretic Peptide and Salt-Sensitive Hypertension
1995 StandoutScienceNobel
Nitric oxide prevents axonal degeneration by inducing HIF-1–dependent expression of erythropoietin
2011 StandoutNobel
Deletion and Replacement of the Mouse Adult β-Globin Genes by a “Plug and Socket” Repeated Targeting Strategy
1994 StandoutNobel
Regulated Expression of Globin Chains and the Erythroid Transcription Factor GATA-1 during Erythropoiesis in the Developing Mouse
1990
Chemical Chaperones Reduce ER Stress and Restore Glucose Homeostasis in a Mouse Model of Type 2 Diabetes
2006 StandoutScience
A DNA insulator prevents repression of a targeted X-linked transgene but not its random or imprinted X inactivation
2006 StandoutNobel
Developmental regulation of human gamma- and beta-globin genes in the absence of the locus control region
1994
Sickle cell disease of transgenic SAD mice
1994
Conservation of the primary structure, organization, and function of the human and mouse beta-globin locus-activating regions.
1990
High-level, erythroid-specific expression of the human alpha-globin gene in transgenic mice and the production of human hemoglobin in murine erythrocytes.
1989
Deletion and replacement of the mouse adult beta-globin genes by a "plug and socket" repeated targeting strategy.
1994 StandoutNobel
Conservation of sequence and structure flanking the mouse and human β-globin loci: The β-globin genes are embedded within an array of odorant receptor genes
1999 StandoutNobel
L-4F, an Apolipoprotein A-1 Mimetic, Dramatically Improves Vasodilation in Hypercholesterolemia and Sickle Cell Disease
2003
Molecular phenotyping for analyzing subtle genetic effects in mice: Application to an angiotensinogen gene titration
2002 StandoutNobel
A deletion of the human beta-globin locus activation region causes a major alteration in chromatin structure and replication across the entire beta-globin locus.
1990
Works of Thomas M. Ryan being referenced
Human gamma- to beta-globin gene switching in transgenic mice.
1990
Nitric Oxide-dependent Generation of Reactive Species in Sickle Cell Disease
2003
A Recombinant Human Hemoglobin with Anti-sickling Properties Greater than Fetal Hemoglobin
2004
Stochastic, stage-specific mechanisms account for the variegation of a human globin transgene
1998
Oxygen radical inhibition of nitric oxide-dependent vascular function in sickle cell disease
2001
High-level erythroid expression of human alpha-globin genes in transgenic mice.
1989
Human Sickle Hemoglobin in Transgenic Mice
1990 Science
Correction of a mouse model of sickle cell disease: lentiviral/antisickling β-globin gene transduction of unmobilized, purified hematopoietic stem cells
2003
A single erythroid-specific DNase I super-hypersensitive site activates high levels of human beta-globin gene expression in transgenic mice.
1989
Correction of sickle cell disease by homologous recombination in embryonic stem cells
2006
Human beta-globin locus control region: analysis of the 5' DNase I hypersensitive site HS 2 in transgenic mice.
1991
Mouse model of human beta zero thalassemia: targeted deletion of the mouse beta maj- and beta min-globin genes in embryonic stem cells.
1995
Mouse model of congenital polycythemia: Homologous replacement of murine gene by mutant human erythropoietin receptor gene
2001
DNase I super-hypersensitive sites direct high level erythroid expression of human alpha-, beta- and beta s- globin genes in transgenic mice.
1989
Knockout-Transgenic Mouse Model of Sickle Cell Disease
1997 Science
Synthesis of Functional Human Hemoglobin in Transgenic Mice
1989 Science