Citation Impact
Citing Papers
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Stopped-flow Fluorescence Studies of Inhibitor Binding to Tyrosinase from Streptomyces antibioticus
2004
Structural and Folding Dynamic Properties of the T70N Variant of Human Lysozyme
2003
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Cu(I)-dependent Biogenesis of the Galactose Oxidase Redox Cofactor
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1999 StandoutNobel
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2009
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2005
Structural Basis of Transcription: Role of the Trigger Loop in Substrate Specificity and Catalysis
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1997
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2009
The Highly Cooperative Folding of Small Naturally Occurring Proteins Is Likely the Result of Natural Selection
2007 StandoutNobel
Comparative modeling of the latent form of a plant catechol oxidase using a molluskan hemocyanin structure
2002
Molecular mechanisms of theprotein serine/threonine phosphatases
1996
The role of cholesterol on the activity and stability of neurotensin receptor 1
2012
Structure of rhodopsin and the metarhodopsin I photointermediate
2005
Making and Breaking Nucleic Acids: Two-Mg2+-Ion Catalysis and Substrate Specificity
2006
Chemoselective small molecules that covalently modify one lysine in a non-enzyme protein in plasma
2009
High-resolution crystal structure of human protease-activated receptor 1
2012 StandoutNatureNobel
Peptide ligation and its application to protein engineering
1999
Di-iron—carboxylate proteins
1995
Transthyretin amyloidosis: a tale of weak interactions
2001
Protein aggregation in disease: a role for folding intermediates forming specific multimeric interactions
2002
Tyrosinase and ocular diseases: Some novel thoughts on the molecular basis of oculocutaneous albinism type 1
2007
Crystallographic Evidence That the Dinuclear Copper Center of Tyrosinase Is Flexible during Catalysis
2006
The road to fully programmable protein catalysis
2022 StandoutNatureNobel
A competition assay to identify amyloidogenesis inhibitors by monitoring the fluorescence emitted by the covalent attachment of a stilbene derivative to transthyretin
2010
X-ray structure of the Escherichia coli periplasmic 5'-nucleotidase containing a dimetal catalytic site.
1999
Principles for designing ideal protein structures
2012 StandoutNatureNobel
Fungal tyrosinases: new prospects in molecular characteristics, bioengineering and biotechnological applications
2006
Identification, function and structure of the mycobacterial sulfotransferase that initiates sulfolipid-1 biosynthesis
2004 StandoutNobel
Synthesis and biological investigations of dopaminergic partial agonists preferentially recognizing the D4 receptor subtype
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Contribution of Hydrophobic Interactions to Protein Stability
2011
Gelsolin amyloidosis: genetics, biochemistry, pathology and possible strategies for therapeutic intervention
2012
The Structure of T. aquaticus DNA Polymerase III Is Distinct from Eukaryotic Replicative DNA Polymerases
2006 StandoutNobel
Modulation of Protein Splicing of the Saccharomyces cerevisiae Vacuolar Membrane ATPase Intein
1998
Structure of an aromatic-ring-hydroxylating dioxygenase – naphthalene 1,2-dioxygenase
1998
Ligand-specific regulation of the extracellular surface of a G-protein-coupled receptor
2010 StandoutNatureNobel
Structure of the human M2 muscarinic acetylcholine receptor bound to an antagonist
2012 StandoutNatureNobel
Structure-based design of kinetic stabilizers that ameliorate the transthyretin amyloidoses
2010
Molecular Basis of the Bohr Effect in Arthropod Hemocyanin
2008
Metal Ion Site Engineering Indicates a Global Toggle Switch Model for Seven-transmembrane Receptor Activation
2006
Characterization of the monophenolase activity of tyrosinase on betaxanthins: the tyramine-betaxanthin/dopamine-betaxanthin pair
2005
A comparative analysis of 23 structures of the amyloidogenic protein transthyretin
2000
Switch between tyrosinase and catecholoxidase activity of scorpion hemocyanin by allosteric effectors
2008
The structure and function of G-protein-coupled receptors
2009 StandoutNatureNobel
First Structures of an Active Bacterial Tyrosinase Reveal Copper Plasticity
2010
Evaluation of the Pichia pastoris expression system for the production of GPCRs for structural analysis
2011
A Novel o-Aminophenol Oxidase Responsible for Formation of the Phenoxazinone Chromophore of Grixazone
2005
X-ray structures of a novel acid phosphatase from Escherichia blattae and its complex with the transition-state analog molybdate
2000
Plant Polyphenols: Chemical Properties, Biological Activities, and Synthesis
2011 Standout
Purification, characterization and molecular cloning of tyrosinase from the cephalopod mollusk, Illex argentinus
2003
Nucleoside triphosphate-binding proteins: different scaffolds to achieve phosphoryl transfer
1999
Phosphoesterase domains associated with DNA polymerases of diverse origins
1998
Crystal structure of the µ-opioid receptor bound to a morphinan antagonist
2012 StandoutNatureNobel
Oxygen Binding, Activation, and Reduction to Water by Copper Proteins
2001
The Amyloid State of Proteins in Human Diseases
2012 Standout
Structure of the human histamine H1 receptor complex with doxepin
2011 Nature
The Transthyretin Amyloidoses: From Delineating the Molecular Mechanism of Aggregation Linked to Pathology to a Regulatory-Agency-Approved Drug
2012
Structure of a β1-adrenergic G-protein-coupled receptor
2008 StandoutNatureNobel
The human and mouse repertoire of the adhesion family of G-protein-coupled receptors
2004
Hemocyanin conformational changes associated with SDS-induced phenol oxidase activation
2007
Structural basis for the protective role of sulfite against transthyretin amyloid formation
2006
Structure-based design of non-natural amino-acid inhibitors of amyloid fibril formation
2011 StandoutNatureNobel
Benzoxazoles as Transthyretin Amyloid Fibril Inhibitors: Synthesis, Evaluation, and Mechanism of Action
2003
Mechanistic Insight into the Activity of Tyrosinase from Variable‐Temperature Studies in an Aqueous/Organic Solvent
2005
The Role of Internal Water Molecules in the Structure and Function of the Rhodopsin Family of G Protein‐Coupled Receptors
2006
The chemical repertoire of natural ribozymes
2002 StandoutNatureNobel
Crystal Structure of Agaricus bisporus Mushroom Tyrosinase: Identity of the Tetramer Subunits and Interaction with Tropolone
2011
Three-dimensional structure of the catalytic subunit of protein serine/threonine phosphatase-1
1995 StandoutNature
Design, synthesis, and evaluation of oxazole transthyretin amyloidogenesis inhibitors
2005
Hydroxylated Polychlorinated Biphenyls Selectively Bind Transthyretin in Blood and Inhibit Amyloidogenesis: Rationalizing Rodent PCB Toxicity
2004
Tyrosinase maturation through the mammalian secretory pathway: bringing color to life
2006
Structural Mechanism of SDS-Induced Enzyme Activity of Scorpion Hemocyanin Revealed by Electron Cryomicroscopy
2009
Molecular Mechanisms of Amyloidosis
2003 Standout
Kinetic characterisation of the reaction mechanism of mushroom tyrosinase on tyramine/dopamine and l-tyrosine methyl esther/l-dopa methyl esther
2002
A Substructure Combination Strategy To Create Potent and Selective Transthyretin Kinetic Stabilizers That Prevent Amyloidogenesis and Cytotoxicity
2009
GPCRdb: an information system for G protein-coupled receptors
2015
Toward high-resolution prediction and design of transmembrane helical protein structures
2007 StandoutNobel
Quantitative exploration of the molecular origin of the activation of GTPase
2013 StandoutNobel
Protein folding: progress made and promises ahead
2000
A Cas9–guide RNA complex preorganized for target DNA recognition
2015 StandoutScienceNobel
De NovoDesign of Helical Bundles as Models for Understanding Protein Folding and Function
2000
Geometric and Electronic Structure/Function Correlations in Non-Heme Iron Enzymes
1999 Standout
Structure/function correlations among coupled binuclear copper proteins through spectroscopic and reactivity studies of NspF
2012
Potent and Selective Structure-Based Dibenzofuran Inhibitors of Transthyretin Amyloidogenesis: Kinetic Stabilization of the Native State
2005
Inhibition of Bacteriophage λ Protein Phosphatase by Organic and Oxoanion Inhibitors
2001
Structure of soybean lipoxygenase L3 and a comparison with its L1 isoenzyme
1997
Crystal structure of the precursor of galactose oxidase: An unusual self-processing enzyme
2001
Pathogenesis, diagnosis and treatment of systemic amyloidosis
2001
Copper Active Sites in Biology
2014 Standout
Peroxidation of polyunsaturated fatty acids by lipoxygenases drives ferroptosis
2016 Standout
Crystal structure of Manduca sexta prophenoloxidase provides insights into the mechanism of type 3 copper enzymes
2009
Cholesterol increases kinetic, energetic, and mechanical stability of the human β2-adrenergic receptor
2012 StandoutNobel
Chemical Glycobiology
2001 StandoutScienceNobel
Structural and Functional Aspects of Metal Sites in Biology
1996 Standout
Tafamidis, a potent and selective transthyretin kinetic stabilizer that inhibits the amyloid cascade
2012
Identification of a Subunit Interface in Transthyretin Amyloid Fibrils: Evidence for Self-Assembly from Oligomeric Building Blocks
2001
Processing of crayfish hemocyanin subunits into phenoloxidase
2004
The Role of Protein Crystallography in Defining the Mechanisms of Biogenesis and Catalysis in Copper Amine Oxidase
2012
Diflunisal Analogues Stabilize the Native State of Transthyretin. Potent Inhibition of Amyloidogenesis
2003
Semisynthesis of Proteins by Expressed Protein Ligation
2003
Defining the Catalytic Metal Ion Interactions in the Tetrahymena Ribozyme Reaction
2001
Mechanistic Studies on the Reactions of Molybdenum(VI), Tungsten(VI), Vanadium(V), and Arsenic(V) Tetraoxo Anions with the FeIIFeIII Form of Purple Acid Phosphatase from Porcine Uteri (Uteroferrin)
1996
Synthesis and Characterization of Potent Bivalent Amyloidosis Inhibitors That Bind Prior to Transthyretin Tetramerization
2003
The cell-adhesion G protein-coupled receptor BAI3 is a high-affinity receptor for C1q-like proteins
2011 StandoutNobel
Genistein, a natural product from soy, is a potent inhibitor of transthyretin amyloidosis
2005
Aureusidin Synthase: A Polyphenol Oxidase Homolog Responsible for Flower Coloration
2000 Science
High thermodynamic stability of parametrically designed helical bundles
2014 StandoutScienceNobel
Contribution of hydrogen bonds to protein stability
2014
Direct observation of kinetic traps associated with structural transformations leading to multiple pathways of S-layer assembly
2012 StandoutNobel
The Chemistry and Biochemistry of Vanadium and the Biological Activities Exerted by Vanadium Compounds
2004 Standout
Structure-based discovery of β 2 -adrenergic receptor ligands
2009 StandoutNobel
(+)-Larreatricin hydroxylase, an enantio-specific polyphenol oxidase from the creosote bush ( Larrea tridentata )
2003
Enzymatic Mechanisms of Phosphate and Sulfate Transfer
2006
A New Strategy for Identification of N-Glycosylated Proteins and Unambiguous Assignment of Their Glycosylation Sites Using HILIC Enrichment and Partial Deglycosylation
2004
Computational Modeling Approaches to Structure−Function Analysis of G Protein-Coupled Receptors
2005
Toward Optimization of the Linker Substructure Common to Transthyretin Amyloidogenesis Inhibitors Using Biochemical and Structural Studies
2008
Toward Optimization of the Second Aryl Substructure Common to Transthyretin Amyloidogenesis Inhibitors Using Biochemical and Structural Studies
2009
Aromatic Sulfonyl Fluorides Covalently Kinetically Stabilize Transthyretin to Prevent Amyloidogenesis while Affording a Fluorescent Conjugate
2013 StandoutNobel
The Combinatorial Synthesis of Bicyclic Privileged Structures or Privileged Substructures
2003 Standout
A chemical approach to unraveling the biological function of the glycosylphosphatidylinositol anchor
2007 StandoutNobel
Prevention of Transthyretin Amyloid Disease by Changing Protein Misfolding Energetics
2003 Science
MOLECULAR MECHANISM OF 7TM RECEPTOR ACTIVATION—A GLOBAL TOGGLE SWITCH MODEL
2006
Mechanism of inhibition of bovine F 1 -ATPase by resveratrol and related polyphenols
2007 Nobel
Membrane Protein Structure: Prediction versus Reality
2007
Electrostatic Basis for Enzyme Catalysis
2006 StandoutNobel
Designed amyloid fibers as materials for selective carbon dioxide capture
2013 StandoutNobel
Prediction of membrane protein structures with complex topologies using limited constraints
2009 StandoutNobel
Synthetic Models for Heme−Copper Oxidases
2004
Pathway to Synthesis and Processing of Mycolic Acids in Mycobacterium tuberculosis
2005
Post-Translational His-Cys Cross-Linkage Formation in Tyrosinase Induced by Copper(II)−Peroxo Species
2011
A Stilbene That Binds Selectively to Transthyretin in Cells and Remains Dark until It Undergoes a Chemoselective Reaction To Create a Bright Blue Fluorescent Conjugate
2010
Autoproteolysis in nucleoporin biogenesis
1999 StandoutNobel
Native State Kinetic Stabilization as a Strategy To Ameliorate Protein Misfolding Diseases: A Focus on the Transthyretin Amyloidoses
2005
Protein aggregation in disease: a role for folding intermediates forming specific multimeric interactions
2002
Biochemical and Structural Evaluation of Highly Selective 2-Arylbenzoxazole-Based Transthyretin Amyloidogenesis Inhibitors
2007
Update 1 of: Computational Modeling Approaches to Structure–Function Analysis of G Protein-Coupled Receptors
2011
The Pathway by Which the Tetrameric Protein Transthyretin Dissociates
2005
PapA1 and PapA2 are acyltransferases essential for the biosynthesis of theMycobacterium tuberculosisvirulence factor Sulfolipid-1
2007 StandoutNobel
Binuclear Metallohydrolases
1996
Mechanisms of signaling and related enzymes
1997
Bisaryloxime Ethers as Potent Inhibitors of Transthyretin Amyloid Fibril Formation
2005 StandoutNobel
Structural Basis for Double-Stranded RNA Processing by Dicer
2006 StandoutScienceNobel
Mechanistic Studies on Synthetic Fe−S-Based Clusters and Their Relevance to the Action of Nitrogenases
2005 StandoutNobel
Cu-Catalyzed Azide−Alkyne Cycloaddition
2008 StandoutNobel
Reaction Coordinate of a Functional Model of Tyrosinase: Spectroscopic and Computational Characterization
2009
Mechanisms of signaling and related enzymes
1997
Characterization of a cytosolic phosphatase from pea plumules having significant protein tyrosine phosphatase activity
1998
Evaluating the binding selectivity of transthyretin amyloid fibril inhibitors in blood plasma
2001
Trapping of palindromic ligands within native transthyretin prevents amyloid formation
2010
Chemical Glycoproteomics
2016 StandoutNobel
Geometric and electronic structure differences between the type 3 copper sites of the multicopper oxidases and hemocyanin/tyrosinase
2009
Crystal structure of delta9 stearoyl-acyl carrier protein desaturase from castor seed and its relationship to other di-iron proteins.
1996
Selective Structure-Based Virtual Screening for Full and Partial Agonists of the β2 Adrenergic Receptor
2008
Works of Thomas Klabunde being referenced
Drug Design Strategies for Targeting G-Protein-Coupled Receptors
2002
GPCR Antitarget Modeling: Pharmacophore Models for Biogenic Amine Binding GPCRs to Avoid GPCR‐Mediated Side Effects
2005
Crystal Structure of a Purple Acid Phosphatase Containing a Dinuclear Fe(III)-Zn(II) Active Site
1995 Science
The Amino Acid Sequence of the Red Kidney Bean Fe(III)‐Zn(II) Purple Acid Phosphatase
1994
Structural relationship between the mammalian Fe(III)‐Fe(II) and the Fe(III)‐Zn(II) plant purple acid phosphatases
1995
Rational design of potent human transthyretin amyloid disease inhibitors.
2000
Crystal structure of a plant catechol oxidase containing a dicopper center
1998
The oligosaccharides of the Fe(III)‐Zn(II) purple acid phosphatase of the red kidney bean
1994
Mechanism of Fe(III) – Zn(II) Purple Acid Phosphatase Based on Crystal Structures
1996
Computational Approaches Towards the Rational Design of Drug-like Compound Libraries
2001
Crystal Structure of Lyme Disease Variable Surface Antigen VlsE of Borrelia burgdorferi
2002
Crystal structure of GyrA intein from Mycobacterium xenopi reveals structural basis of protein splicing
1998
Crystal structure of the secreted form of antigen 85C reveals potential targets for mycobacterial drugs and vaccines.
2000
Virtual Screening of Biogenic Amine-Binding G-Protein Coupled Receptors: Comparative Evaluation of Protein- and Ligand-Based Virtual Screening Protocols
2005
Two‐Metal Ion Catalysis in Enzymatic Acyl‐ and Phosphoryl‐Transfer Reactions
1996 Nobel
Sequence-Derived Three-Dimensional Pharmacophore Models for G-Protein-Coupled Receptors and Their Application in Virtual Screening
2009
Structure-Based Design of N-Phenyl Phenoxazine Transthyretin Amyloid Fibril Inhibitors
2000
Identification of Nonpeptidic Urotensin II Receptor Antagonists by Virtual Screening Based on a Pharmacophore Model Derived from Structure−Activity Relationships and Nuclear Magnetic Resonance Studies on Urotensin II
2002
Structure-based Drug Discovery Using GPCR Homology Modeling: Successful Virtual Screening for Antagonists of the Alpha1A Adrenergic Receptor
2005
Inhibiting transthyretin conformational changes that lead to amyloid fibril formation
1998
Acyl Ureas as Human Liver Glycogen Phosphorylase Inhibitors for the Treatment of Type 2 Diabetes
2005