Standout Papers

Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase 2005 2026 2012 2019 3.7k
  1. Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase (2005)
    Helen E. Bryant, Niklas Schultz et al. Nature
  2. DNA repair pathways as targets for cancer therapy (2008)
    Thomas Helleday, Eva Petermann et al. Nature reviews. Cancer
  3. Hydroxyurea-Stalled Replication Forks Become Progressively Inactivated and Require Two Different RAD51-Mediated Pathways for Restart and Repair (2010)
    Eva Petermann, Manuel Luís Orta et al. Molecular Cell
  4. The underlying mechanism for the PARP and BRCA synthetic lethality: Clearing up the misunderstandings (2011)
    Thomas Helleday Molecular Oncology
  5. Mechanisms underlying mutational signatures in human cancers (2014)
    Thomas Helleday, Saeed Eshtad et al. Nature Reviews Genetics
  6. The cell-cycle checkpoint kinase Chk1 is required for mammalian homologous recombination repair (2005)
    Claus Storgaard Sørensen, Lasse Tengbjerg Hansen et al. Nature Cell Biology

Immediate Impact

8 by Nobel laureates 51 from Science/Nature 168 standout
Sub-graph 1 of 18

Citing Papers

Transcription–replication conflicts underlie sensitivity to PARP inhibitors
2024 StandoutNature
RHOJ controls EMT-associated resistance to chemotherapy
2023 StandoutNature
15 intermediate papers

Works of Thomas Helleday being referenced

Chk1 promotes replication fork progression by controlling replication initiation
2010
Hydroxyurea-Stalled Replication Forks Become Progressively Inactivated and Require Two Different RAD51-Mediated Pathways for Restart and Repair
2010 Standout
and 16 more

Author Peers

Author Last Decade Papers Cites
Thomas Helleday 17550 9992 3950 262 21.6k
Shunichi Takeda 16317 6889 3490 299 20.5k
André Nussenzweig 18815 6792 3585 160 21.8k
Yosef Shiloh 20836 9483 5762 204 23.8k
Eric W.‐F. Lam 15136 5354 3995 297 22.8k
Andrew L. Kung 16386 6498 4559 282 23.8k
Penny A. Jeggo 18359 6910 5055 187 21.5k
Andres J. Klein–Szanto 11861 6907 4799 380 20.9k
Allan Balmain 12359 7727 3923 203 18.1k
Christopher J. Lord 16571 14756 3997 192 23.8k
Nicola J. Curtin 11765 10662 1888 195 16.4k

All Works

Loading papers...

Rankless by CCL
2026