Standout Papers
Citation Impact
Citing Papers
LIM Protein KyoT2 Negatively Regulates Transcription by Association with the RBP-J DNA-Binding Protein
1998 StandoutNobel
Twist1-Mediated Adriamycin-Induced Epithelial-Mesenchymal Transition Relates to Multidrug Resistance and Invasive Potential in Breast Cancer Cells
2009
Tissue macrophages act as cellular chaperones for vascular anastomosis downstream of VEGF-mediated endothelial tip cell induction
2010
Snail Up-regulates Proinflammatory Mediators and Inhibits Differentiation in Oral Keratinocytes
2008
Cell delamination in the mesencephalic neural fold and its implication for the origin of ectomesenchyme
2013
Notch2, but not Notch1, is required for proximal fate acquisition in the mammalian nephron
2007
Cooperative action of Sox9, Snail2 and PKA signaling in early neural crest development
2006
Slug Is Required for Cell Survival during Partial Epithelial-Mesenchymal Transition of HGF-induced Tubulogenesis
2007
ZBTB1 is a determinant of lymphoid development
2011 StandoutNobel
Jagged1-mediated Notch activation induces epithelial-to-mesenchymal transition through Slug-induced repression of E-cadherin
2007
Protein O -fucosyltransferase 1 is an essential component of Notch signaling pathways
2003
Mesenchyme Forkhead 1 ( FOXC2 ) plays a key role in metastasis and is associated with aggressive basal-like breast cancers
2007
Epstein-Barr virus immortalization: Notch2 interacts with CBF1 and blocks differentiation
1997
Hes1 and Hes5 regulate vascular remodeling and arterial specification of endothelial cells in brain vascular development
2013
Direct conversion of fibroblasts to functional neurons by defined factors
2010 StandoutNatureNobel
The transcriptional repressor Snail promotes mammary tumor recurrence
2005
Functional Interaction between SEL-10, an F-box Protein, and the Nuclear Form of Activated Notch1 Receptor
2001 StandoutNobel
Epithelial-Mesenchymal Transition in Cancer: Parallels Between Normal Development and Tumor Progression
2010
Hallmarks of Cancer: The Next Generation
2011 Standout
T‐cell fate
1998
The WRPW Motif of the Hairy-Related Basic Helix-Loop-Helix Repressor Proteins Acts as a 4-Amino-Acid Transcription Repression and Protein-Protein Interaction Domain
1996
Mouse Fbw7/Sel-10/Cdc4 Is Required for Notch Degradation during Vascular Development
2004
RAM-induced Allostery Facilitates Assembly of a Notch Pathway Active Transcription Complex
2008
Combined deficiency of Notch1 and Notch3 causes pericyte dysfunction, models CADASIL and results in arteriovenous malformations
2015
Reciprocal Repression between Sox3 and Snail Transcription Factors Defines Embryonic Territories at Gastrulation
2011
Regulation of Notch Signaling by Dynamic Changes in the Precision of S3 Cleavage of Notch-1
2007
Combined Loss of Hey1 and HeyL Causes Congenital Heart Defects Because of Impaired Epithelial to Mesenchymal Transition
2007
Roles of Pofut1 and O-Fucose in Mammalian Notch Signaling
2008
Mesp1 Coordinately Regulates Cardiovascular Fate Restriction and Epithelial-Mesenchymal Transition in Differentiating ESCs
2008
Vascular Development
2010
Notch and Presenilin Regulate Cellular Expansion and Cytokine Secretion but Cannot Instruct Th1/Th2 Fate Acquisition
2008
A secreted Delta1‐Fc fusion protein functions both as an activator and inhibitor of Notch1 signaling
2002
Chapter 2 PI3K/PTEN Signaling in Angiogenesis and Tumorigenesis
2009
LIN-12/Notch signaling: lessons from worms and flies
1998
Notch and neurogenesis
1998
Wound repair: a showcase for cell plasticity and migration
2016
Nuclear Notch1 signaling and the regulation of dendritic development
2000
The Influence of Chromosomal Location on the Expression of Two Transgenes in Mice
1999 StandoutNobel
Targeted disruption of TGF-β1/Smad3 signaling protects against renal tubulointerstitial fibrosis induced by unilateral ureteral obstruction
2003
Deficient T Cell Fate Specification in Mice with an Induced Inactivation of Notch1
1999
Notch1 Signaling Promotes the Maturation of CD4 and CD8 SP Thymocytes
2000
A comparison of epithelial-to-mesenchymal transition and re-epithelialization
2012
On the Role of the Pre–T Cell Receptor in αβ versus γδ T Lineage Commitment
1998
Target Selectivity of Vertebrate Notch Proteins
2005
Roles of the ankyrin repeats and C-terminal region of the mouse Notch1 intracellular region
1998 StandoutNobel
Angiogenesis: A Team Effort Coordinated by Notch
2009
An essential role for Notch in neural crest during cardiovascular development and smooth muscle differentiation
2007
Current biology of VEGF-B and VEGF-C
1999
Alagille syndrome is caused by mutations in human Jagged1, which encodes a ligand for Notch1
1997
Stabilization of Snail by NF-κB Is Required for Inflammation-Induced Cell Migration and Invasion
2009
An Activated Form of Notch Influences the Choice between CD4 and CD8 T Cell Lineages
1996
An activated Notch receptor blocks cell-fate commitment in the developing Drosophila eye
1993 Nature
Notch1 loss of heterozygosity causes vascular tumors and lethal hemorrhage in mice
2011
Notch and Neurogenesis
2018
The Delta paradox: DLL4 blockade leads to more tumour vessels but less tumour growth
2007
Nas transgenic mouse line allows visualization of Notch pathway activity in vivo
2006
Follicular Dendritic Cells and Germinal Centers
1996
Snai1 and Snai2 collaborate on tumor growth and metastasis properties of mouse skin carcinoma cell lines
2008
Peritoneal Dialysis and Epithelial-to-Mesenchymal Transition of Mesothelial Cells
2003
Oscillator mechanism of notch pathway in the segmentation clock
2007
Notch signaling: direct or what?
1998
Jagged: A mammalian ligand that activates notch1
1995
Back and forth between cell fate specification and movement during vertebrate gastrulation
2008
The Groucho/Transducin-like Enhancer of split Transcriptional Repressors Interact with the Genetically Defined Amino-terminal Silencing Domain of Histone H3
1997
Efficient method to generate single‐copy transgenic mice by site‐specific integration in embryonic stem cells
2006
Epithelial-Mesenchymal Transitions in Development and Disease
2009 Standout
Mutations in NOTCH1 cause aortic valve disease
2005 Nature
Notch activity acts as a sensor for extracellular calcium during vertebrate left–right determination
2004 Nature
Differential Expression of the Epithelial-Mesenchymal Transition Regulators Snail, SIP1, and Twist in Gastric Cancer
2002
New model of tumor angiogenesis: dynamic balance between vessel regression and growth mediated by angiopoietins and VEGF
1999
Three novel Notch genes in zebrafish: implications for vertebrate Notch gene evolution and function
1997
Epithelial-Mesenchymal Transition: At the Crossroads of Development and Tumor Metastasis
2008 Standout
Cutaneous wound reepithelialization is compromised in mice lacking functional Slug (Snai2)
2009
FGF Signaling Regulates Mesoderm Cell Fate Specification and Morphogenetic Movement at the Primitive Streak
2001
Notch Receptors, Partners and Regulators: From Conserved Domains to Powerful Functions
1998
Snail1 transcriptional repressor binds to its own promoter and controls its expression
2006
Fringe differentially modulates Jagged1 and Delta1 signalling through Notch1 and Notch2
2000
Induction of Pluripotent Stem Cells from Mouse Embryonic and Adult Fibroblast Cultures by Defined Factors
2006 StandoutNobel
Mouse Jagged1 Physically Interacts with Notch2 and Other Notch Receptors
1999
Regulation of αβ/γδ T Cell Lineage Commitment and Peripheral T Cell Responses by Notch/RBP-J Signaling
2004 StandoutNobel
If birds can fly, why can't we? Homeotic genes and evolution
1994
The mesenchymal cell, its role in the embryo, and the remarkable signaling mechanisms that create it
2005
In Vitro Reconstitution of the Modulation of Drosophila Notch-Ligand Binding by Fringe
2007
The transcription factor Snail controls epithelial–mesenchymal transitions by repressing E-cadherin expression
2000 Standout
Notch1 Regulates Maturation of CD4+ and CD8+ Thymocytes by Modulating TCR Signal Strength
2001
Overexpression of Snail family members highlights their ability to promote chick neural crest formation
2002
Isolation of Angiopoietin-1, a Ligand for the TIE2 Receptor, by Secretion-Trap Expression Cloning
1996 Standout
Molecular Mechanism of Liver Development and Regeneration
2007
Inactivation of Notch1 Impairs VDJβ Rearrangement and Allows pre-TCR-Independent Survival of Early αβ Lineage Thymocytes
2002
Delta-induced Notch Signaling Mediated by RBP-J Inhibits MyoD Expression and Myogenesis
1999 StandoutNobel
Colinearity and functional hierarchy among genes of the homeotic complexes
1994
Structures of CSL, Notch and Mastermind proteins: piecing together an active transcription complex
2006
Canonical Notch Signaling Is Dispensable for the Maintenance of Adult Hematopoietic Stem Cells
2008
Anchoring Notch Genetics and Biochemistry
2004
Notch alters VEGF responsiveness in human and murine endothelial cells by direct regulation of VEGFR-3 expression
2007
Vascular system defects and neuronal apoptosis in mice lacking Ras GTPase-activating protein
1995 Nature
A crucial function of PDGF in TGF-β-mediated cancer progression of hepatocytes
2006
Notch-1 inhibits apoptosis in murine erythroleukemia cells and is necessary for differentiation induced by hybrid polar compounds
1999
Regulation of Marginal Zone B Cell Development by MINT, a Suppressor of Notch/RBP-J Signaling Pathway
2003 StandoutNobel
In Situ Expression of Angiopoietins in Astrocytomas Identifies Angiopoietin-2 as an Early Marker of Tumor Angiogenesis
1999
Complex networks orchestrate epithelial–mesenchymal transitions
2006 Standout
Notch signaling in T cell development
2000
Small C-terminal Domain Phosphatase Enhances Snail Activity through Dephosphorylation
2008
Ets2-dependent trophoblast signalling is required for gastrulation progression after primitive streak initiation
2013
Palatal fusion – Where do the midline cells go?
2006
CADASIL: A Critical Look at a Notch Disease
2006
ESDN, a Novel Neuropilin-like Membrane Protein Cloned from Vascular Cells with the Longest Secretory Signal Sequence among Eukaryotes, Is Up-regulated after Vascular Injury
2001 StandoutNobel
Inducible gene knockout of transcription factor recombination signal binding protein‐J reveals its essential role in T versus B lineage decision
2002 StandoutNobel
Cell Type-Specific Expression of Angiopoietin-1 and Angiopoietin-2 Suggests a Role in Glioblastoma Angiogenesis
1998
Cellular and molecular control of neurogenesis in the mammalian telencephalon
2005
Insertional mutation of ‘classical’ and novel genes in transgenic mice
1992
Aberrant neural and cardiac development in mice lacking the ErbB4 neuregulin receptor
1995 Nature
Vascular morphogenesis: a Wnt for every vessel?
2009
The Ins and Outs of Notch Signaling
1997
The Receptor Tyrosine Kinase MuSK Is Required for Neuromuscular Junction Formation In Vivo
1996
Hepatocyte growth factor induces cell scattering through MAPK/Egr‐1‐mediated upregulation of Snail
2006
Molecular characterization of the Notch homologue from the Australian sheep blowfly, Lucilia cuprina
1998
Implications of the Hybrid Epithelial/Mesenchymal Phenotype in Metastasis
2015
Regulation of T lymphopoiesis by Notch1 and Lunatic fringe–mediated competition for intrathymic niches
2006
Vascular Dysmorphogenesis Caused by an Activating Mutation in the Receptor Tyrosine Kinase TIE2
1996
Epithelial–mesenchymal transitions in tumour progression
2002 Standout
Periodic Notch inhibition by Lunatic Fringe underlies the chick segmentation clock
2003 Nature
Pericytes: Developmental, Physiological, and Pathological Perspectives, Problems, and Promises
2011 Standout
E-cadherin, β-catenin, and ZEB1 in malignant progression of cancer
2009
Nrarp Coordinates Endothelial Notch and Wnt Signaling to Control Vessel Density in Angiogenesis
2009
Modulation of Notch Signaling by Antibodies Specific for the Extracellular Negative Regulatory Region of NOTCH3
2008
Notch in the pathway: The roles of Notch signaling in neural crest development
2005
Regenerative activity of the lung after epithelial injury
2012
Direct induction of T lymphocyte-specific gene expression by the mammalian Notch signaling pathway
2002
Embryonic lethality in mice homozygous for a processing-deficient allele of Notch1
2000 Nature
Notch and the Immune System
1999
Inactivation of Notch1 in immature thymocytes does not perturb CD4 or CD8 T cell development
2001
Snail, Zeb and bHLH factors in tumour progression: an alliance against the epithelial phenotype?
2007 Standout
Molecular regulation of angiogenesis and lymphangiogenesis
2007 Standout
Epithelial–Mesenchymal Plasticity: A Central Regulator of Cancer Progression
2015
Mice lacking both presenilin genes exhibitearlyembryonic patterningdefects
1999
The EphA4 and EphB1 receptor tyrosine kinases and ephrin-B2 ligand regulate targeted migration of branchial neural crest cells
1997
Mechanisms of palatal epithelial seam disintegration by transforming growth factor (TGF) β3
2007
Ajuba LIM Proteins Are Snail/Slug Corepressors Required for Neural Crest Development in Xenopus
2008
Specific truncations of Drosophila Notch define dominant activated and dominant negative forms of the receptor
1993
EMT: 2016
2016 Standout
Ligand-Induced Signaling in the Absence of Furin Processing of Notch1
2001
Pulmonary Microcirculation in Interstitial Lung Disease
2011
Inhibition of Dll4 signalling inhibits tumour growth by deregulating angiogenesis
2006 Nature
Vascular-specific growth factors and blood vessel formation
2000 StandoutNature
Blockade of Dll4 inhibits tumour growth by promoting non-productive angiogenesis
2006 Nature
Derivation of pluripotent epiblast stem cells from mammalian embryos
2007 StandoutNature
Crystal Structure of the CSL-Notch-Mastermind Ternary Complex Bound to DNA
2006
Analysis of Hoxa7/Hoxb7 mutants suggests periodicity in the generation of the different sets of vertebrae
1998 StandoutNobel
Structure/function studies of lin-12/Notch proteins
1994
The transcription factor Snail is a repressor of E-cadherin gene expression in epithelial tumour cells
2000 Standout
Mechanisms of angiogenesis
1997 StandoutNature
Segmental expression of Hoxb-1 is controlled by a highly conserved autoregulatory loop dependent upon exd/pbx
1995 StandoutNobel
The many facets of Notch ligands
2008
Hes1 and Hes5 as Notch effectors in mammalian neuronal differentiation
1999
Bare rudiments of notch signaling: how receptor levels are regulated
2007
Roles of ephrinB ligands and EphB receptors in cardiovascular development: demarcation of arterial/venous domains, vascular morphogenesis, and sprouting angiogenesis
1999
The Six1 homeoprotein induces human mammary carcinoma cells to undergo epithelial-mesenchymal transition and metastasis in mice through increasing TGF-β signaling
2009
Transient adenoviral gene transfer of Smad7 prevents injury-induced epithelial–mesenchymal transition of lens epithelium in mice
2004
Notch promotes epithelial-mesenchymal transition during cardiac development and oncogenic transformation
2003
Twist, a Master Regulator of Morphogenesis, Plays an Essential Role in Tumor Metastasis
2004 Standout
Expressing TrkC from the TrkA locus causes a subset of dorsal root ganglia neurons to switch fate
2004 StandoutNobel
Single-Cell Transcriptomic Analysis of Primary and Metastatic Tumor Ecosystems in Head and Neck Cancer
2017 Standout
F-box proteins: Keeping the epithelial-to-mesenchymal transition (EMT) in check
2015
Requisite Role of Angiopoietin-1, a Ligand for the TIE2 Receptor, during Embryonic Angiogenesis
1996 Standout
The Notch amino terminus regulates protein levels and Delta-induced clustering of Drosophila Notch receptors
2004
Glycosylation regulates Notch signalling
2003
Dorsalizing signal Wnt-7a required for normal polarity of D–V and A–P axes of mouse limb
1995 StandoutNature
Oscillations, clocks and segmentation
2003
Functional conservation of mouse Notch receptor family members
1996 StandoutNobel
Ectodomain Shedding and Intramembrane Cleavage of Mammalian Notch Proteins Are Not Regulated through Oligomerization
2004
Hox11 paralogous genes are essential for metanephric kidney induction
2002 StandoutNobel
Growth factors acting via endothelial cell-specific receptor tyrosine kinases: VEGFs, Angiopoietins, and ephrins in vascular development
1999
Mice with targeted disruptions in the paralogous genes hoxa-3 and hoxd-3 reveal synergistic interactions
1994 StandoutNatureNobel
Basic and Therapeutic Aspects of Angiogenesis
2011 Standout
Instruction of Distinct CD4 T Helper Cell Fates by Different Notch Ligands on Antigen-Presenting Cells
2004 StandoutNobel
Epithelial-Mesenchymal Transition
2009
The disintegrin/metalloprotease ADAM 10 is essential for Notch signalling but not for alpha-secretase activity in fibroblasts
2002
Angiogenic Signalling Pathways
2008
The novel Notch homologue mouse Notch 3 lacks specific epidermal growth factor-repeats and is expressed in proliferating neuroepithelium
1994
Angiopoietin-1 protects the adult vasculature against plasma leakage
2000
The mouse slalom mutant demonstrates a role for Jagged1 in neuroepithelial patterning in the organ of Corti
2001
A dorsal/ventral boundary established by Notch controls growth and polarity in the Drosophila eye
1998 Nature
Ingression of primary mesenchyme cells of the sea urchin embryo: A precisely timed epithelial mesenchymal transition
2007
A conserved role for Snail as a potentiator of active transcription
2014
Correlating Notch Signaling with Thymocyte Maturation
1998
The Canonical Notch Signaling Pathway: Unfolding the Activation Mechanism
2009 Standout
Lats2 kinase potentiates Snail1 activity by promoting nuclear retention upon phosphorylation
2011
Differential Notch signalling distinguishes neural stem cells from intermediate progenitors
2007 Nature
Angiopoietin-1/Tie2 Signal Augments Basal Notch Signal Controlling Vascular Quiescence by Inducing Delta-Like 4 Expression through AKT-mediated Activation of β-Catenin
2011
Involvement of Notch-1 in mammalian retinal neurogenesis: association of Notch-1 activity with both immature and terminally differentiated cells
1995
Dendritic cells and the control of immunity
1998 StandoutNatureNobel
Symmetrical Mutant Phenotypes of the Receptor EphB4 and Its Specific Transmembrane Ligand ephrin-B2 in Cardiovascular Development
1999
Notch-Deficient Skin Induces a Lethal Systemic B-Lymphoproliferative Disorder by Secreting TSLP, a Sentinel for Epidermal Integrity
2008
Localization of the Delta-like-1-binding Site in Human Notch-1 and Its Modulation by Calcium Affinity
2008
A nuclear DNA attachment element mediates elevated and position-independent gene activity
1989 Nature
What, if anything, is an angiogenic factor?
1996
Modulation of Notch-Ligand Binding by Protein O-Fucosyltransferase 1 and Fringe
2003
Renal agenesis and the absence of enteric neurons in mice lacking GDNF
1996 StandoutNature
Hox genes in vertebrate development
1994 Standout
Control of vascular morphogenesis and homeostasis through the angiopoietin–Tie system
2009
Quantitative Dissection of the Notch:CSL Interaction: Insights into the Notch-mediated Transcriptional Switch
2006
Selective ablation of immature blood vessels in established human tumors follows vascular endothelial growth factor withdrawal
1999
Implantation and the placenta: key pieces of the development puzzle
1994 StandoutScience
The shortest path from the surface to the nucleus: RBP‐Jκ/Su(H) transcription factor
1996 StandoutNobel
Physical interaction between a novel domain of the receptor Notch and the transcription factor RBP-Jκ/Su(H)
1995 StandoutNobel
Blood Vessel Formation: What Is Its Molecular Basis?
1996
Control of endothelial sprouting by a Tel–CtBP complex
2010
Oscillations of the Snail Genes in the Presomitic Mesoderm Coordinate Segmental Patterning and Morphogenesis in Vertebrate Somitogenesis
2006
Transcriptional regulation of cell polarity in EMT and cancer
2008
p38 and a p38-Interacting Protein Are Critical for Downregulation of E-Cadherin during Mouse Gastrulation
2006
Epigenetic Regulation of EMT: The Snail Story
2014
The Developmental Fate of T Cells Is Critically Influenced by TCRγδ Expression
1998
The Epithelial-Mesenchymal Transition Generates Cells with Properties of Stem Cells
2008 Standout
More complicated than it looks: assembly of Notch pathway transcription complexes
2008
Molecular Distinction and Angiogenic Interaction between Embryonic Arteries and Veins Revealed by ephrin-B2 and Its Receptor Eph-B4
1998 Standout
sel-10, a negative regulator of lin-12 activity inCaenorhabditis elegans, encodes a member of the CDC4 family of proteins
1997
Snail genes at the crossroads of symmetric and asymmetric processes in the developing mesoderm
2006
Identification of a monoclonal antibody specific for a murine T3 polypeptide.
1987 Standout
Isolation of Putative Progenitor Endothelial Cells for Angiogenesis
1997 StandoutScience
A plasticity window for blood vessel remodelling is defined by pericyte coverage of the preformed endothelial network and is regulated by PDGF-B and VEGF
1998 Standout
Uniform vascular-endothelial-cell-specific gene expression in both embryonic and adult transgenic mice
1997
TGF-β–induced epithelial-to-mesenchymal transition proceeds through stepwise activation of multiple feedback loops
2014
Notch signaling imposes two distinct blocks in the differentiation of C2C12 myoblasts
1999
Alterations in Notch signaling in neoplastic lesions of the human cervix.
1995
Segmental expression of Hoxa-2 in the hindbrain is directly regulated by Krox-20
1996
The Tie receptor tyrosine kinase is expressed by human hematopoietic progenitor cells and by a subset of megakaryocytic cells
1996
glp-1 can substitute for lin-12 in specifying cell fate decisions in Caenorhabditis elegans
1993
Pericyte Loss and Microaneurysm Formation in PDGF-B-Deficient Mice
1997 StandoutScience
Predominant expression of a receptor tyrosine kinase, TIE, in hematopoietic stem cells and B cells
1996
Notch-dependent control of myelopoiesis is regulated by fucosylation
2008
Null mutation of Dlx-2 results in abnormal morphogenesis of proximal first and second branchial arch derivatives and abnormal differentiation in the forebrain.
1995
Epithelial-mesenchymal transitions: insights from development
2012
Endothelial-Mural Cell Signaling in Vascular Development and Angiogenesis
2009
Roles of the RAM and ANK domains in signaling by the C. elegans GLP-1 receptor.
1996
The Snail genes as inducers of cell movement and survival: implications in development and cancer
2005
Notch4/int-3, a mammary proto-oncogene, is an endothelial cell-specific mammalian Notch gene
1996
Hoxa 11 structure, extensive antisense transcription, and function in male and female fertility
1995
Arterial–Venous Specification During Development
2009
Vascular Endothelial Growth Factor Expression in Peritoneal Mesothelial Cells Undergoing Transdifferentiation
2008
Transient and restricted expression during mouse embryogenesis of Dll1, a murine gene closely related to Drosophila Delta
1995
Signal transduction by activated mNotch: importance of proteolytic processing and its regulation by the extracellular domain.
1996
Angiopoietin-2, a Natural Antagonist for Tie2 That Disrupts in vivo Angiogenesis
1997 StandoutScience
Role of a Conserved Retinoic Acid Response Element in Rhombomere Restriction of Hoxb-1
1994 Science
EPB41L5 functions to post-transcriptionally regulate cadherin and integrin during epithelial–mesenchymal transition
2008
Aberrant Expression of the Transcription Factors Snail and Slug Alters the Response to Genotoxic Stress
2004
The role of Hoxa-3 in mouse thymus and thyroid development
1995 StandoutNobel
Mice with targeted disruption of Hoxb-1 fail to form the motor nucleus of the VIIth nerve
1996 StandoutNobel
Snail blocks the cell cycle and confers resistance to cell death
2004
Ligand endocytosis drives receptor dissociation and activation in the Notch pathway
2000
Opposing actions of angiopoietin-2 on Tie2 signaling and FOXO1 activation
2016
Fringe modulation of Jagged1-induced Notch signaling requires the action of β4galactosyltransferase-1
2001
Complementary and combinatorial patterns of Notch gene family expression during early mouse development
1995
Presenilin 2 deficiency causes a mild pulmonary phenotype and no changes in amyloid precursor protein processing but enhances the embryonic lethal phenotype of presenilin 1 deficiency
1999
Antineurogenic phenotypes induced by truncated Notch proteins indicate a role in signal transduction and may point to a novel function for Notch in nuclei.
1993
The conserved role of Krox-20 in directing Hox gene expression during vertebrate hindbrain segmentation.
1996 StandoutNobel
Mice mutant for both Hoxa1 and Hoxb1 show extensive remodeling of the hindbrain and defects in craniofacial development
1999 StandoutNobel
Targeted disruption of TGF-β1/Smad3 signaling protects against renal tubulointerstitial fibrosis induced by unilateral ureteral obstruction
2003
Dendritic cells are critical accessory cells for thymus-dependent antibody responses in mouse and in man.
1983 StandoutNobel
Pivotal roles for eomesodermin during axis formation,epithelium-to-mesenchyme transition and endoderm specification in the mouse
2008
Snail2 directly represses cadherin6B during epithelial-to-mesenchymal transitions of the neural crest
2007
Vessel Cooption, Regression, and Growth in Tumors Mediated by Angiopoietins and VEGF
1999 StandoutScience
Impaired Nociception and Pain Sensation in Mice Lacking the Capsaicin Receptor
2000 StandoutScienceNobel
Notch signalling via RBP-J promotes myeloid differentiation
2000
Premature Expression of T Cell Receptor (Tcr)αβ Suppresses Tcrγδ Gene Rearrangement but Permits Development of γδ Lineage T Cells
2000
The kreisler mouse: a hindbrain segmentation mutant that lacks tworhombomeres
1994
Signaling During Epicardium and Coronary Vessel Development
2011
Mapping the consequence of Notch1 proteolysis in vivo with NIP-CRE
2007
Polycomb Complex 2 Is Required for E-cadherin Repression by the Snail1 Transcription Factor
2008
Neoplastic Transformation by Truncated Alleles of Human NOTCH1/TAN1 and NOTCH2
1997 Nobel
Frequent provirus insertional mutagenesis of Notch1 in thymomas of MMTVD/myc transgenic mice suggests a collaboration of c-myc and Notch1 for oncogenesis.
1996
Cytosolic interaction between deltex and Notch ankyrin repeats implicates deltex in the Notch signaling pathway
1994
Phosphorylation Regulates the Subcellular Location and Activity of the Snail Transcriptional Repressor
2003
Conservation of the biochemical mechanisms of signal transduction among mammalian Notch family members
2001 StandoutNobel
A Ligand-Induced Extracellular Cleavage Regulates γ-Secretase-like Proteolytic Activation of Notch1
2000
The divergent DSL ligand Dll3 does not activate Notch signaling but cell autonomously attenuates signaling induced by other DSL ligands
2005
Mutation in ankyrin repeats of the mouse Notch2 gene induces early embryonic lethality
1999
Role of PDGF-B and PDGFR-β in recruitment of vascular smooth muscle cells and pericytes during embryonic blood vessel formation in the mouse
1999
Increased Vascularization in Mice Overexpressing Angiopoietin-1
1998 Science
Regulation of intrathymic T‐cell development by Lunatic Fringe– Notch1 interactions
2006
The Notch ligand Jagged1 is required for inner ear sensory development
2001
Divergent functions and distinct localization of the Notch ligands DLL1 and DLL3 in vivo
2007
ESOP-1, a secreted protein expressed in the hematopoietic, nervous, and reproductive systems of embryonic and adult mice
2000 StandoutNobel
Neuregulins with an Ig-like domain are essential for mouse myocardial and neuronal development.
1996
Erk5 Controls Slug Expression and Keratinocyte Activation during Wound Healing
2008
A murine homolog of the yeast RNA1 gene is required for postimplantation development.
1994
Disruption of the mouse RBP-Jк gene results in early embryonic death
1995 StandoutNobel
Phenotypic analysis of the inflammatory exudate in murine lymphocytic choriomeningitis.
1987 StandoutNobel
Notch1 Deficiency Dissociates the Intrathymic Development of Dendritic Cells and T Cells
2000
The angiopietin-1–Tie2 pathway prevents rather than promotes pulmonary arterial hypertension in transgenic mice
2009
TheO-fucose glycan in the ligand-binding domain of Notch1 regulates embryogenesis and T cell development
2008
Isolation and Characterization of Multipotent Skin‐Derived Precursors from Human Skin
2005
Nuclear Localization of CBF1 Is Regulated by Interactions with the SMRT Corepressor Complex
2001
Endothelial Hypoxia-Inducible Factor-2α Is Required for the Maintenance of Airway Microvasculature
2019 StandoutNobel
Activated Notch Inhibits Myogenic Activity of the MADS-Box Transcription Factor Myocyte Enhancer Factor 2C
1999
The protein tyrosine phosphatase Pez regulates TGFβ, epithelial–mesenchymal transition, and organ development
2007
Conservation of the Notch signalling pathway in mammalian neurogenesis
1997 StandoutNobel
Notch Signaling
1995 Science
Tie2 Expression and Phosphorylation in Angiogenic and Quiescent Adult Tissues
1997
Truncated Mammalian Notch1 Activates CBF1/RBPJk-Repressed Genes by a Mechanism Resembling That of Epstein-Barr Virus EBNA2
1996
Snail family members and cell survival in physiological and pathological cleft palates
2003
Isolation and Functional Analysis of a cDNA for Human Jagged2, a Gene Encoding a Ligand for the Notch1 Receptor
1997
Expression of the FGFR2 mesenchymal splicing variant in epithelial cells drives epithelial-mesenchymal transition
2015
Targeted disruption of the even-skipped gene, evx1, causes early postimplantation lethality of the mouse conceptus.
1994 StandoutNobel
Axial homeosis and appendicular skeleton defects in mice with a targeted disruption of hoxd-11
1994 StandoutNobel
Serrate and Notch specify cell fates in the heart field by suppressing cardiomyogenesis
2000
The epithelial mesenchymal transition confers resistance to the apoptotic effects of transforming growth factor Beta in fetal rat hepatocytes.
2002
Slug is a direct Notch target required for initiation of cardiac cushion cellularization
2008
Endothelial PAS domain protein 1 (EPAS1), a transcription factor selectively expressed in endothelial cells.
1997
What Determines Blood Vessel Structure? Genetic Prespecification vs. Hemodynamics
2006
RBP-L, a Transcription Factor Related to RBP-Jκ
1997 StandoutNobel
Notch Inhibition of E47 Supports the Existence of a Novel Signaling Pathway
1998
Constitutively active human Notch1 binds to the transcription factor CBF1 and stimulates transcription through a promoter containing a CBF1-responsive element.
1996
Core epithelial-to-mesenchymal transition interactome gene-expression signature is associated with claudin-low and metaplastic breast cancer subtypes
2010
Role of angiogenesis and vascular remodeling in chronic obstructive pulmonary disease.
2007
Notch Signaling: Cell Fate Control and Signal Integration in Development
1999 StandoutScience
Notch signalling mediates segmentation of the Drosophila leg
1998
Sub-circuits of a gene regulatory network control a developmental epithelial-mesenchymal transition
2014
Snail Mediates E-Cadherin Repression by the Recruitment of the Sin3A/Histone Deacetylase 1 (HDAC1)/HDAC2 Complex
2003
Notch1 is required for the coordinate segmentation of somites
1995
An activated Notch suppresses neurogenesis and myogenesis but not gliogenesis in mammalian cells
1994 StandoutNobel
The FERM protein Epb4.1l5 is required for organization of the neural plate and for the epithelial-mesenchymal transition at the primitive streak of the mouse embryo
2007
Angiopoietins 3 and 4: Diverging gene counterparts in mice and humans
1999
Snail and E47 repressors ofE-cadherininduce distinct invasive and angiogenic properties in vivo
2004
The intracellular domain of mouse Notch: a constitutively activated repressor of myogenesis directed at the basic helix-loop-helix region of MyoD
1994
THE EPHRINS AND EPH RECEPTORS IN NEURAL DEVELOPMENT
1998
MOLECULAR GENETICS OF T CELL DEVELOPMENT
2004
THE LIN-12/Notch SIGNALING PATHWAY AND ITS REGULATION
1997
Contact-Dependent Inhibition of Cortical Neurite Growth Mediated by Notch Signaling
1999 Science
Bi-compartmental communication contributes to the opposite proliferative behavior of Notch1-deficient hair follicle and epidermal keratinocytes
2007
Genetic interactions between Hoxa1 and Hoxb1 reveal new roles in regulation of early hindbrain patterning
1998
Recombination signal sequence-binding protein Jκ alters mesodermal cell fate decisions by suppressing cardiomyogenesis
2003 StandoutNobel
Binding of Delta1, Jagged1, and Jagged2 to Notch2 Rapidly Induces Cleavage, Nuclear Translocation, and Hyperphosphorylation of Notch2
2000
Attachment of an anti-receptor antibody to non-target cells renders them susceptible to lysis by a clone of cytotoxic T lymphocytes.
1984 StandoutNobel
Endocardial Notch Signaling in Cardiac Development and Disease
2015
Works of Thomas Gridley being referenced
Notch signaling coordinates the patterning of striatal compartments
2005
Oncogenic activation of the Notch1 gene by deletion of its promoter in Ikaros-deficient T-ALL
2010 StandoutNobel
Snail regulates p21WAF/CIP1 expression in cooperation with E2A and Twist
2004
Protein characterization and targeted disruption of Grg, a mouse gene related to the groucho transcript of the Drosophila enhancer of split complex
1995
Notch2 is required for maintaining sustentacular cell function in the adult mouse main olfactory epithelium
2007
Hoxa-2 mutant mice exhibit homeotic transformation of skeletal elements derived from cranial neural crest
1993
Slug Is a Novel Downstream Target of MyoD
2002
Notch signaling and inherited disease syndromes
2003
Segmentation defects of Notch pathway mutants and absence of a synergistic phenotype in lunatic fringe/radical fringe double mutant mice
2002
The molecular evolution of the immune response
1985
Distinct roles of the receptor tyrosine kinases Tie-1 and Tie-2 in blood vessel formation
1995 Nature
Cell movements during gastrulation: Snail dependent and independent pathways
2002
Notch signaling regulates left–right asymmetry determination by inducingNodalexpression
2003
Notch Signaling in the Vasculature
2010
Cloning, Analysis, and Chromosomal Localization of Notch-1, a Mouse Homolog of Drosophila Notch
1993
Direct Regulation of Gata3 Expression Determines the T Helper Differentiation Potential of Notch
2007
Slug expression during organogenesis in mice
2003
Notch Activity Influences the αβ versus γδ T Cell Lineage Decision
1997
A mutation in the Lunatic fringe gene suppresses the effects of a Jagged2 mutation on inner hair cell development in the cochlea
2000
Brain lipid-binding protein is a direct target of Notch signaling in radial glial cells
2005
Snail1 Gene Function During Early Embryo Patterning in Mice
2006
The Nrarp Gene Encodes an Ankyrin-Repeat Protein That Is Transcriptionally Regulated by the Notch Signaling Pathway
2001
Lunatic Fringe, FGF, and BMP Regulate the Notch Pathway during Epithelial Morphogenesis of Teeth
2002
Notch Signaling in Vertebrate Development and Disease
1997
Molecular Pathways of Notch Signaling in Vascular Smooth Muscle Cells
2012
Epiblast-specific Snai1 deletion results in embryonic lethality due to multiple vascular defects
2009
The Type II Activin Receptors Are Essential for Egg Cylinder Growth, Gastrulation, and Rostral Head Development in Mice
1999
Defects in somite formation in lunatic fringe-deficient mice
1998 Nature
Interaction between Reelin and Notch Signaling Regulates Neuronal Migration in the Cerebral Cortex
2008
Characterization of Notch3‐deficient mice: Normal embryonic development and absence of genetic interactions with a Notch1 mutation
2003
Notch signalling pathway mediates hair cell development in mammalian cochlea
1999
A mouse model of Alagille syndrome:Notch2as a genetic modifier ofJag1haploinsufficiency
2002
The Snail Family Gene Snai3 Is Not Essential for Embryogenesis in Mice
2013
Cloning and developmental expression of Grg, a mouse gene related to the groucho transcript of the Drosophila Enhancer of split complex
1993
Defects in limb, craniofacial, and thymic development in Jagged2 mutant mice
1998
Embryonic Lethality and Vascular Defects in Mice Lacking the Notch Ligand Jagged1
1999
Loss of Notch Activity in the Developing Central Nervous System Leads to Increased Cell Death
2006
Developmental transcription factor slug is required for effective re‐epithelialization by adult keratinocytes
2004
Mmp15 is a direct target of Snai1 during endothelial to mesenchymal transformation and endocardial cushion development
2011
γ-Secretase Functions through Notch Signaling to Maintain Skin Appendages but Is Not Required for Their Patterning or Initial Morphogenesis
2004
Haploinsufficient lethality and formation of arteriovenous malformations in Notch pathway mutants
2004 StandoutNobel
Notch3 is required for arterial identity and maturation of vascular smooth muscle cells
2004
The Developmental Transcription Factor Slug Is Widely Expressed in Tissues of Adult Mice
2004
Expression pattern of Motch, a mouse homolog of Drosophila Notch, suggests an important role in early postimplantation mouse development
1992
Perinatal lethality and defects in hindbrain development in mice homozygous for a targeted mutation of the zinc finger gene Krox20.
1993
Notch1 is essential for postimplantation development in mice.
1994
The Notch ligands DLL1 and JAG2 act synergistically to regulate hair cell development in the mammalian inner ear
2005
Notch signaling is essential for vascular morphogenesis in mice
2000 Standout
The slug gene is not essential for mesoderm or neural crest development in mice
1998
goosecoid is not an essential component of the mouse gastrula organizer but is required for craniofacial and rib development
1995
Retroviruses and insertional mutagenesis in mice: proviral integration at the Mov 34 locus leads to early embryonic death.
1987
Patent ductus arteriosus in mice with smooth muscle-specific Jag1 deletion
2010
Properties and Applications of Monoclonal Antibodies Directed against Determinants of the Thy-1 Locus
1979
Isolation of Sna, a mouse gene homologous to the Drosophila genes snail and escargot: its expression pattern suggests multiple roles during postimplantation development
1992
Notch signaling in vascular development and physiology
2007
Jagged1 is the pathological link between Wnt and Notch pathways in colorectal cancer
2009
Defects in development of the kidney, heart and eye vasculature in mice homozygous for a hypomorphic Notch2 mutation
2001
Insertional mutagenesis in mice
1987
Ectopic Hoxa-1 induces rhombomere transformation in mouse hindbrain
1994
Snail family genes are required for left–right asymmetry determination, but not neural crest formation, in mice
2006
Molecular analysis of the Mov 34 mutation: transcript disrupted by proviral integration in mice is conserved in Drosophila
1990 Nobel
A requirement for Notch1 distinguishes 2 phases of definitive hematopoiesis during development
2004
Multiple functions of Snail family genes during palate development in mice
2007
The Mouse Snail Gene Encodes a Key Regulator of the Epithelial-Mesenchymal Transition
2001
Repression of PTEN Phosphatase by Snail1 Transcriptional Factor during Gamma Radiation-Induced Apoptosis
2008