Standout Papers
- Deconvoluting the Functions of Polypeptide N-α-Acetylgalactosaminyltransferase Family Members by Glycopeptide Substrate Profiling (2004)
- Glycopeptide-preferring Polypeptide GalNAc Transferase 10 (ppGalNAc T10), Involved in Mucin-type O-Glycosylation, Has a Unique GalNAc-O-Ser/Thr-binding Site in Its Catalytic Domain Not Found in ppGalNAc T1 or T2 (2009)
Citation Impact
Citing Papers
Visualizing enveloping layer glycans during zebrafish early embryogenesis
2010 StandoutNobel
Probing mucin-type O-linked glycosylation in living animals
2006 StandoutNobel
Genome-wide CRISPR screens reveal a specific ligand for the glycan-binding immune checkpoint receptor Siglec-7
2021 StandoutNobel
The mucin-selective protease StcE enables molecular and functional analysis of human cancer-associated mucins
2019 StandoutNobel
A metabolic labeling approach toward proteomic analysis of mucin-type O-linked glycosylation
2003 StandoutNobel
Regulation of O -glycosylation through Golgi-to-ER relocation of initiation enzymes
2010
Probing isoform-specific functions of polypeptide GalNAc-transferases using zinc finger nuclease glycoengineered SimpleCells
2012
Structural Basis of Carbohydrate Transfer Activity by Human UDP-GalNAc: Polypeptide α-N-Acetylgalactosaminyltransferase (pp-GalNAc-T10)
2006
The repertoire of glycan determinants in the human glycome
2009
Dynamic Association between the Catalytic and Lectin Domains of Human UDP-GalNAc:Polypeptide α-N-Acetylgalactosaminyltransferase-2
2006
Probing the contribution of individual polypeptide GalNAc-transferase isoforms to the O-glycoproteome by inducible expression in isogenic cell lines
2018
Exploring Regulation of Protein O-Glycosylation in Isogenic Human HEK293 Cells by Differential O-Glycoproteomics
2019
Probing the O-Glycoproteome of Gastric Cancer Cell Lines for Biomarker Discovery*
2015
A Mucin-type O-Glycosyltransferase Modulates Cell Adhesion during Drosophila Development
2008
TAILS N-terminomics and proteomics reveal complex regulation of proteolytic cleavage by O-glycosylation
2018
De novo expression of human polypeptide N-acetylgalactosaminyltransferase 6 (GalNAc-T6) in colon adenocarcinoma inhibits the differentiation of colonic epithelium
2017
Mapping the O-Mannose Glycoproteome in Saccharomyces cerevisiae
2016
Dynamic interplay between catalytic and lectin domains of GalNAc-transferases modulates protein O-glycosylation
2015
Bump-and-Hole Engineering Identifies Specific Substrates of Glycosyltransferases in Living Cells
2020 StandoutNobel
A molecular switch orchestrates enzyme specificity and secretory granule morphology
2018
Alkali-catalyzed β-elimination of periodate-oxidized glycans: A novel method of chemical deglycosylation of mucin gene products in paraffin embedded sections
2000
Crystal Structure of lac Repressor Core Tetramer and Its Implications for DNA Looping
1995 StandoutScienceNobel
Detection of protein–ligand interactions by NMR using reductive methylation of lysine residues
2008
Precision mapping of the human O‐GalNAc glycoproteome through SimpleCell technology
2013
Mucin-Type Glycoproteins
1992
The chemistry and biology of mucin-type O-linked glycosylation
2005 StandoutNobel
Glycosylation: Heterogeneity and the 3D Structure of Proteins
1997
Physical Principles of Membrane Shape Regulation by the Glycocalyx
2019 StandoutNobel
Chemical Technologies for Probing Glycans
2006 StandoutNobel
Structural basis of carbohydrate transfer activity of UDP-GalNAc: Polypeptide N-acetylgalactosaminyltransferase 7
2019
The GalNAc-type O-Glycoproteome of CHO Cells Characterized by the SimpleCell Strategy
2014
Expression of the UDP-GalNAc : polypeptide N-acetylgalactosaminyltransferase family is spatially and temporally regulated during Drosophila development
2005
High-Resolution Mapping Reveals a Conserved, Widespread, Dynamic mRNA Methylation Program in Yeast Meiosis
2013 StandoutNobel
The cancer glycocalyx mechanically primes integrin-mediated growth and survival
2014 StandoutNatureNobel
The Tn Antigen—Structural Simplicity and Biological Complexity
2011
Discrimination of epimeric glycans and glycopeptides using IM-MS and its potential for carbohydrate sequencing
2013
Modulation of Glycan Recognition by Clustered Saccharide Patches
2014
Crystal structure and mechanism of a calcium-gated potassium channel
2002 StandoutNatureNobel
The role of mucin-type O-glycans in eukaryotic development
2010
Analysis of Mammalian O-Glycopeptides—We Have Made a Good Start, but There is a Long Way to Go
2017
Vertebrate protein glycosylation: diversity, synthesis and function
2012
Golgi Glycosylation
2011
Significance of glycosylation in Notch signaling
2014
Lectins as pattern recognition molecules: The effects of epitope density in innate immunity
2009
A UDP-GalNAc:Polypeptide N-Acetylgalactosaminyltransferase Is Required for Epithelial Tube Formation
2006
O-Glycosylation Modulates Proprotein Convertase Activation of Angiopoietin-like Protein 3
2010
A Strategy for O-Glycoproteomics of Enveloped Viruses—the O-Glycoproteome of Herpes Simplex Virus Type 1
2015
The lectin domains of polypeptide GalNAc-transferases exhibit carbohydrate-binding specificity for GalNAc: lectin binding to GalNAc-glycopeptide substrates is required for high density GalNAc-O-glycosylation
2007
Structure and function of an irreversible agonist-β2 adrenoceptor complex
2011 StandoutNatureNobel
Identification of Molecular Intermediates in the Assembly Pathway of the MUC5AC Mucin
2004
Chemical de‐O‐glycosylation of glycoproteins for application in LC‐based proteomics
2009
Eater, a Transmembrane Protein Mediating Phagocytosis of Bacterial Pathogens in Drosophila
2005 StandoutNobel
Enhanced Mass Spectrometric Mapping of the Human GalNAc-type O-Glycoproteome with SimpleCells
2013
Biological roles of glycans
2016 Standout
Ligand-specific regulation of the extracellular surface of a G-protein-coupled receptor
2010 StandoutNatureNobel
A high-throughput assay for O-GlcNAc transferase detects primary sequence preferences in peptide substrates
2007 StandoutNobel
Mass Spectrometry Based Glycoproteomics—From a Proteomics Perspective
2010
Glycoprotein Identification and Localization of O-Glycosylation Sites by Mass Spectrometric Analysis of Deglycosylated/Alkylaminylated Peptide Fragments
2001
Targeting the glycoproteome
2012
Concepts and Principles of O-Linked Glycosylation
1998
Chemical remodelling of cell surfaces in living animals
2004 StandoutNatureNobel
Multiple Members of the UDP-GalNAc: Polypeptide N-Acetylgalactosaminyltransferase Family Are Essential for Viability in Drosophila
2011
Revealing the human mucinome
2022 StandoutNobel
Comprehensive Analysis of mRNA Methylation Reveals Enrichment in 3′ UTRs and near Stop Codons
2012 Standout
Oncogenic Mutations Counteract Intrinsic Disorder in the EGFR Kinase and Promote Receptor Dimerization
2012 StandoutNobel
The heterotaxy gene GALNT11 glycosylates Notch to orchestrate cilia type and laterality
2013 Nature
Phagocytosis and innate immunity
2002
Prediction, conservation analysis, and structural characterization of mammalian mucin-type O-glycosylation sites
2004
Biosynthesis of O-N-acetylgalactosamine glycans in the human cell nucleus
2018
Glycosylation in health and disease
2019
Core-glycosylated Mucin-like Repeats from MUC1 Are an Apical Targeting Signal
2011
Low Density Lipoprotein Receptor Class A Repeats Are O-Glycosylated in Linker Regions
2014
Liquid chromatography-tandem mass spectrometry-based fragmentation analysis of glycopeptides
2016
Lectin Microarrays for Glycoprotein Analysis
2007
pKa's of ionizable groups in proteins: atomic detail from a continuum electrostatic model
1990
A metabolic labeling approach for glycoproteomic analysis reveals altered glycoprotein expression upon GALNT3 knockdown in ovarian cancer cells
2016 StandoutNobel
Periplasmic binding protein structure and function
1989
Multivalent Carbohydrate Recognition on a Glycodendrimer‐Functionalized Flow‐Through Chip
2008
CFTR regulatory region interacts with NBD1 predominantly via multiple transient helices
2007
All in the family: the UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferases
2002
Perspectives on the significance of altered glycosylation of glycoproteins in cancer
1997
Synthetic glycopeptides and glycoproteins as tools for biology
2004 StandoutNobel
A Pragmatic Guide to Enrichment Strategies for Mass Spectrometry–Based Glycoproteomics
2020 StandoutNobel
Combination of β-elimination and liquid chromatography/quadrupole time-of-flight mass spectrometry for the determination of O-glycosylation sites
2008
O-linked glycan expression during Drosophila development
2007
Construction of a fluorescent biosensor family
2002
The O-glycomap of Lubricin, a Novel Mucin Responsible for Joint Lubrication, Identified by Site-specific Glycopeptide Analysis
2014
Lectin Domains of Polypeptide GalNAc Transferases Exhibit Glycopeptide Binding Specificity
2011 StandoutNobel
Crystal structure of a soluble form of the human T cell coreceptor CD8 at 2.6 Å resolution
1992 StandoutNobel
Molecular analysis of a UDP-GlcNAc:polypeptide α-N-acetylglucosaminyltransferase implicated in the initiation of mucin-type O-glycosylation in Trypanosoma cruzi
2009
Expression of polypeptide GalNAc-transferases in stratified epithelia and squamous cell carcinomas: immunohistological evaluation using monoclonal antibodies to three members of the GalNAc-transferase family
1999
Lysosome-targeting chimaeras for degradation of extracellular proteins
2020 StandoutNatureNobel
Design of glycosylation sites by rapid synthesis and analysis of glycosyltransferases
2018
Protein Sequence Editing of SKN-1A/Nrf1 by Peptide:N-Glycanase Controls Proteasome Gene Expression
2019 StandoutNobel
Glycosylation in cancer: mechanisms and clinical implications
2015 Standout
Substrate‐Guided Front‐Face Reaction Revealed by Combined Structural Snapshots and Metadynamics for the Polypeptide N‐Acetylgalactosaminyltransferase 2
2014
Chemical reporters for biological discovery
2013
Biomimetic Engineering of Carbon Nanotubes by Using Cell Surface Mucin Mimics
2004 StandoutNobel
Multivalent Lectin—Carbohydrate Interactions
2010
Small RNAs are modified with N-glycans and displayed on the surface of living cells
2021 StandoutNobel
Targeted glycoproteomics: Serial lectin affinity chromatography in the selection of O-glycosylation sites on proteins from the human blood proteome
2006
Mucin‐type O‐glycosylation – putting the pieces together
2009
Polypeptide GalNAc-transferase T3 and Familial Tumoral Calcinosis
2006
Small Molecule Inhibitors of Mucin-Type O-Linked Glycosylation from a Uridine-Based Library
2004 StandoutNobel
Advances in mass spectrometry driven O-glycoproteomics
2014
Deconstruction of O‐glycosylation—Gal NA c‐T isoforms direct distinct subsets of the O‐glycoproteome
2015
Role of the alpha-amino group of protein in ubiquitin-mediated protein breakdown.
1984 StandoutNobel
Probing cell-surface architecture through synthesis: An NMR-determined structural motif for tumor-associated mucins
1999
Hierarchical Assembly of Model Cell Surfaces: Synthesis of Mucin Mimetic Polymers and Their Display on Supported Bilayers
2007 StandoutNobel
A Strategy for the Chemoselective Synthesis of O-Linked Glycopeptides with Native Sugar−Peptide Linkages
1997 StandoutNobel
Model of specific complex between catabolite gene activator protein and B-DNA suggested by electrostatic complementarity.
1984 StandoutNobel
In Vivo Imaging of Membrane-Associated Glycans in Developing Zebrafish
2008 StandoutScienceNobel
Rates of ligand binding to periplasmic proteins involved in bacterial transport and chemotaxis.
1983
Initiation of GalNAc-type O-glycosylation in the endoplasmic reticulum promotes cancer cell invasiveness
2013
Mucins and the Microbiome
2020
Macroscopic models for studies of electrostatic interactions in proteins: limitations and applicability.
1984 StandoutNobel
Density Variant Glycan Microarray for Evaluating Cross-Linking of Mucin-like Glycoconjugates by Lectins
2012 StandoutNobel
Mechanisms of integration of de novo-synthesized polypeptides into membranes: signal-recognition particle is required for integration into microsomal membranes of calcium ATPase and of lens MP26 but not of cytochrome b5.
1983 StandoutNobel
Labeling of proteins by reductive methylation using sodium cyanoborohydride.
1979
Protein Analysis by Shotgun/Bottom-up Proteomics
2013
Colonization of Mucin by Human Intestinal Bacteria and Establishment of Biofilm Communities in a Two-Stage Continuous Culture System
2005
Control of Multivalent Interactions by Binding Epitope Density
2002
The mucus and mucins of the goblet cells and enterocytes provide the first defense line of the gastrointestinal tract and interact with the immune system
2014
Glycoproteomic Analysis of Serum from Patients with Gastric Precancerous Lesions
2013
Antibodies against Tumor Cell Glycolipids and Proteins, but Not Mucins, Mediate Complement-Dependent Cytotoxicity
2005
Amino acid distributions around O-linked glycosylation sites
1991
Homogeneous Glycopeptides and Glycoproteins for Biological Investigation
2002 StandoutNobel
Role of Glycosylation in Development
2004
Determination of the side chain pKa values of the lysine residues in calmodulin.
1993
Chemoselective Elaboration of O-Linked Glycopeptide Mimetics by Alkylation of 3-ThioGalNAc
2001 StandoutNobel
Engineering Orthogonal Polypeptide GalNAc-Transferase and UDP-Sugar Pairs
2019 StandoutNobel
Effects of Clustered Epitopes in Multivalent Ligand−Receptor Interactions
2008
Chemically tunable mucin chimeras assembled on living cells
2015 StandoutNobel
Optical measurement of synaptic glutamate spillover and reuptake by linker optimized glutamate-sensitive fluorescent reporters
2008 StandoutNobel
Targeted methods for quantitative analysis of protein glycosylation
2014
The beginnings of mucin biosynthesis: The crystal structure of UDP-GalNAc:polypeptide α- N -acetylgalactosaminyltransferase-T1
2004
Mapping the O‐glycoproteome using site‐specific extraction of O‐linked glycopeptides (EXoO)
2018
Glycosylation and the Immune System
2001 Science
Imaging the glycome
2008 StandoutNobel
Anion binding and pH-dependent electrostatic effects in ribonuclease
1982
Initiation of Protein O Glycosylation by the Polypeptide GalNAcT-1 in Vascular Biology and Humoral Immunity
2007
Neurological Aspects of Human Glycosylation Disorders
2015
Quantum Mechanical Continuum Solvation Models
2005 Standout
Simple Sugars to Complex Disease—Mucin-Type O-Glycans in Cancer
2015
A High-Throughput O-Glycopeptide Discovery Platform for Seromic Profiling
2010
When Galectins Recognize Glycans: From Biochemistry to Physiology and Back Again
2011
Deglycosylation of glycoproteins with trifluoromethanesulphonic acid: elucidation of molecular structure and function
2003
Noncovalent Cell Surface Engineering: Incorporation of Bioactive Synthetic Glycopolymers into Cellular Membranes
2008 StandoutNobel
The dimensions of the T lymphocyte glycoprotein leukosialin and identification of linear protein epitopes that can be modified by glycosylation.
1991
Mechanisms in Protein O-Glycan Biosynthesis and Clinical and Molecular Aspects of Protein O-Glycan Biosynthesis Defects: A Review
2006
Engineered bidirectional communication mediates a consensus in a microbial biofilm consortium
2007 StandoutNobel
GALNT9 Gene Expression Is a Prognostic Marker in Neuroblastoma Patients
2012
Physical studies of 13C-methylated concanavalin A. pH- and Co2+-induced nuclear magnetic resonance shifts.
1983
Creatine and Creatinine Metabolism
2000 Standout
Metabolic labeling enables selective photocrosslinking of O-GlcNAc-modified proteins to their binding partners
2012 StandoutNobel
Principles of Mucin Architecture: Structural Studies on Synthetic Glycopeptides Bearing Clustered Mono-, Di-, Tri-, and Hexasaccharide Glycodomains
2002
Chemical Glycoproteomics
2016 StandoutNobel
Works of Thomas Gerken being referenced
Binding Studies of α-GalNAc-specific Lectins to the α-GalNAc (Tn-antigen) Form of Porcine Submaxillary Mucin and Its Smaller Fragments
2007
UDP-N-acetyl-α-d-galactosamine:polypeptide N-acetylgalactosaminyltransferases: Completion of the family tree
2011
Control of mucin-type O-glycosylation: A classification of the polypeptide GalNAc-transferase gene family
2011
Deconvoluting the Functions of Polypeptide N-α-Acetylgalactosaminyltransferase Family Members by Glycopeptide Substrate Profiling
2004 StandoutNobel
Conservation of peptide acceptor preferences between Drosophila and mammalian polypeptide-GalNAc transferase ortholog pairs
2008
Structure and dynamics of mucin-like glycopeptides. Examination of peptide chain expansion and peptide-carbohydrate interactions by stochastic dynamics simulations
1993
The Catalytic and Lectin Domains of UDP-GalNAc:Polypeptide α-N-Acetylgalactosaminyltransferase Function in Concert to Direct Glycosylation Site Selection
2008
Glycopeptide-preferring Polypeptide GalNAc Transferase 10 (ppGalNAc T10), Involved in Mucin-type O-Glycosylation, Has a Unique GalNAc-O-Ser/Thr-binding Site in Its Catalytic Domain Not Found in ppGalNAc T1 or T2
2009 StandoutNobel
Emerging Paradigms for the Initiation of Mucin-type Protein O-Glycosylation by the Polypeptide GalNAc Transferase Family of Glycosyltransferases
2011
A novel approach for chemically deglycosylating O-linked glycoproteins. The deglycosylation of submaxillary and respiratory mucins
1992
Functional Characterization and Expression Analysis of Members of the UDP-GalNAc:Polypeptide N-Acetylgalactosaminyltransferase Family from Drosophila melanogaster
2003
The Lectin Domain of the Polypeptide GalNAc Transferase Family of Glycosyltransferases (ppGalNAc Ts) Acts as a Switch Directing Glycopeptide Substrate Glycosylation in an N- or C-terminal Direction, Further Controlling Mucin Type O-Glycosylation
2013
Isoform-specific O-Glycosylation of Osteopontin and Bone Sialoprotein by Polypeptide N-Acetylgalactosaminyltransferase-1
2009
A Mouse Model for the Metabolic Effects of the Human Fat Mass and Obesity Associated FTO Gene
2009
Polypeptide GalNAc-Ts: from redundancy to specificity
2019
Mucin Core O-Glycosylation Is Modulated by Neighboring Residue Glycosylation Status
2002
Site-specific Core 1 O-Glycosylation Pattern of the Porcine Submaxillary Gland Mucin Tandem Repeat
1998
Systematic determination of the peptide acceptor preferences for the human UDP-Gal:glycoprotein-α-GalNAc β3 galactosyltranferase (T-synthase)
2008
Mucin-type O-glycosylation is controlled by short- and long-range glycopeptide substrate recognition that varies among members of the polypeptide GalNAc transferase family
2015
Myocardial protection during ischemia by prior feeding with the creatine analog: Cyclocreatine
1989
Revisiting the human polypeptide GalNAc-T1 and T13 paralogs
2016
The interdomain flexible linker of the polypeptide GalNAc transferases dictates their long-range glycosylation preferences
2017
A Short Segment of the R Domain of Cystic Fibrosis Transmembrane Conductance Regulator Contains Channel Stimulatory and Inhibitory Activities That Are Separable by Sequence Modification
2002
Identification of Common and Unique Peptide Substrate Preferences for the UDP-GalNAc:Polypeptide α-N-acetylgalactosaminyltransferases T1 and T2 Derived from Oriented Random Peptide Substrates
2006
Determination of the Site-specific Oligosaccharide Distribution of the O-Glycans Attached to the Porcine Submaxillary Mucin Tandem Repeat
2002
Effects of glycosylation on the conformation and dynamics of O-linked glycoproteins: carbon-13 NMR studies of ovine submaxillary mucin
1989
Structure and dynamics of porcine submaxillary mucin as determined by natural abundance carbon-13 NMR spectroscopy
1987
Role of glycosylation on the conformation and chain dimensions of O-linked glycoproteins: light-scattering studies of ovine submaxillary mucin
1989
Determination of the Site-specific O-Glycosylation Pattern of the Porcine Submaxillary Mucin Tandem Repeat Glycopeptide
1997
Biophysical Approaches to Salivary Mucin Structure, Conformation and Dynamics
1993
ISOGlyP: de novo prediction of isoform-specific mucin-type O-glycosylation
2020
The solution structure of mucous glycoproteins: Proton NMR studies of native and modified ovine submaxillary mucin
1986
Mucin Glycoprotein Degradation by Mucin Oligosaccharide-degrading Strains of Human Faecal Bacteria. Characterisation of Saccharide Cleavage Products and their Potential Role in Nutritional Support of Larger Faecal Bacterial Populations
1992
Light-scattering studies of fractionated ovine sub-maxillary mucins
1987
Amino group environments and metal binding properties of carbon-13 reductively methylated bovine .alpha.-lactalbumin
1984
Probing polypeptide GalNAc-transferase isoform substrate specificities by in vitro analysis
2014
A Macrophage Invasion Mechanism for Mycobacteria Implicating the Extracellular Domain of Cd43
2000
Proton nuclear magnetic resonance spectroscopy and ligand binding dynamics of the Escherichia coli L-arabinose binding protein
1982
[13C]Methylated ribonuclease A. 13C NMR studies of the interaction of lysine 41 with active site ligands.
1981
Intramolecular interactions of amino groups in 13C reductively methylated hen egg-white lysozyme.
1982
Kinetic Modeling Confirms the Biosynthesis of Mucin Core 1 (β-Gal(1−3) α-GalNAc-O-Ser/Thr) O-glycan Structures Are Modulated by Neighboring Glycosylation Effects
2004
13C NMR studies of ribonuclease A methylated with [13C]Formaldehyde.
1979
Thermodynamics of Multivalent Carbohydrate−Lectin Cross-Linking Interactions: Importance of Entropy in the Bind and Jump Mechanism
2009
Structural and Mechanistic Insights into the Catalytic-Domain-Mediated Short-Range Glycosylation Preferences of GalNAc-T4
2018
Role of Peptide Sequence and Neighboring Residue Glycosylation on the Substrate Specificity of the Uridine 5'-Diphosphate−α-N-acetylgalactosamine:Polypeptide N-acetylgalactosaminyl Transferases T1 and T2: Kinetic Modeling of the Porcine and Canine Submaxillary Gland Mucin Tandem Repeats
2004