Citation Impact
Citing Papers
Suppression of bone resorption by madindoline A, a novel nonpeptide antagonist to gp130
2002 StandoutNobel
A Di-leucine Motif and an Upstream Serine in the Interleukin-6 (IL-6) Signal Transducer gp130 Mediate Ligand-induced Endocytosis and Down-regulation of the IL-6 Receptor
1996
Soluble IL-6 Receptor Potentiates the Antagonistic Activity of Soluble gp130 on IL-6 Responses
1998
Type I IFN Signaling Is Crucial for Host Resistance against Different Species of Pathogenic Bacteria
2007
IFN-α Is Not Sufficient to Drive Th1 Development Due to Lack of Stable T-bet Expression
2007
IFN-α/β Signaling Is Required for Polarization of Cytokine Responses toward a Protective Type 1 Pattern during Experimental Cryptococcosis
2008
Phorbol ester modulates interleukin 6- and interleukin 1-regulated expression of acute phase plasma proteins in hepatoma cells.
1988
Neutralizing interferon alpha as a therapeutic approach to autoimmune diseases
2003
The Cytoplasmic Tyrosine Motifs in Full-Length Glycoprotein 130 Have Different Roles in IL-6 Signal Transduction
2000
A Toll-like receptor recognizes bacterial DNA
2000 StandoutNature
Cooperative Influence of Genetic Polymorphisms on Interleukin 6 Transcriptional Regulation
2000
Regulation of interleukin‐6 receptor expression in human monocytes and hepatocytes
1989
Peroxisome Proliferator-activated Receptor α Negatively Regulates the Vascular Inflammatory Gene Response by Negative Cross-talk with Transcription Factors NF-κB and AP-1
1999
Revisiting the 1986 Molecular Cloning of Interleukin 6
2014
Hepatosplanchnic clearance of interleukin-6 in humans during exercise
2003
Autocrine generation and requirement of BSF-2/IL-6 for human multiple myelomas
1988 StandoutNature
Human ADAR1 Prevents Endogenous RNA from Triggering Translational Shutdown
2018 StandoutNobel
Molecular cloning and expression of an IL-6 signal transducer, gp130
1990
High amounts of circulating interleukin (IL)‐6 in the form of monomeric immune complexes during anti‐IL‐6 therapy. Towards a new methodology for measuring overall cytokine production in human in vivo
1992
Interleukin-6 in Biology and Medicine
1993
The paradigm of IL-6: from basic science to medicine.
2002
Programmable RNA Tracking in Live Cells with CRISPR/Cas9
2016 StandoutNobel
Interferons α and β as Immune Regulators—A New Look
2001
Recognition of microorganisms and activation of the immune response
2007 StandoutNature
IL6 and the acute phase reaction
1992
Type I interferons in infectious disease
2015 Standout
Interleukin 1 receptor antagonist (IL-1Ra) is an acute-phase protein.
1997
Effect of Human Recombinant Interleukin-6 on the Proliferation of Mouse Hepatocytes in the Primary Culture
1990
Continuous perfusion with interleukin 6 (IL-6) enhances production of hematopoietic stem cells (CFU-S)
1989
Structure and mechanism of interleukin-lβ converting enzyme
1994 Nature
O‐ and N‐glycosylation lead to different molecular mass forms of human monocyte interleukin‐6
1989
Antitumour actions of interferons: implications for cancer therapy
2016
Interleukin 6 stimulates synthesis of complement proteins factor B and C3 in human skin fibroblasts
1989
Interleukin-6 triggers the association of its receptor with a possible signal transducer, gp130
1989
Interleukin 6 and its Receptor: Ten Years Later
1998
IL-6 as a keystone cytokine in health and disease
2015 Standout
SHP2 and SOCS3 Contribute to Tyr-759-dependent Attenuation of Interleukin-6 Signaling through gp130
2002
The biochemistry of apoptosis
2000 StandoutNature
Inhibition of Classic Signaling Is a Novel Function of Soluble Glycoprotein 130 (sgp130), Which Is Controlled by the Ratio of Interleukin 6 and Soluble Interleukin 6 Receptor
2011
Supplementation with vitamins C and E inhibits the release of interleukin‐6 from contracting human skeletal muscle
2004
Viruses Evade the Immune System through Type I Interferon-Mediated STAT2-Dependent, but STAT1-Independent, Signaling
2005
Prospects for a vaccine against the hepatitis C virus
2005 StandoutNatureNobel
Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells
2006 StandoutNature
Altered thymic T-cell selection due to a mutation of the ZAP-70 gene causes autoimmune arthritis in mice
2003 StandoutNatureNobel
A protein kinase involved in the regulation of inflammatory cytokine biosynthesis
1994 StandoutNature
A role of PIEZO1 in iron metabolism in mice and humans
2021 StandoutNobel
Interleukin‐6 production in human subcutaneous abdominal adipose tissue: the effect of exercise
2002
The Competitive Binding of STAT3 and NF-κB on an Overlapping DNA Binding Site
1997
TANGO1 Facilitates Cargo Loading at Endoplasmic Reticulum Exit Sites
2009 StandoutNobel
Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase
1999 StandoutNature
Interleukin‐6‐induced serine phosphorylation of transcription factor APRF: evidence for a role in interleukin‐6 target gene induction
1995
Targeting RAS signalling pathways in cancer therapy
2003 Standout
IL‐6 and NF‐IL6 in Acute‐Phase Response and Viral Infection
1992
Molecular Regulation of B Lymphocyte Response
1988
Iron in joint inflammation.
1993
Raf kinases: Oncogenesis and drug discovery
2006
Type I Interferons Potently Enhance Humoral Immunity and Can Promote Isotype Switching by Stimulating Dendritic Cells In Vivo
2001
Targeting the Raf-MEK-ERK mitogen-activated protein kinase cascade for the treatment of cancer
2007 Standout
Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis
1995 StandoutNature
The synthesis of human α‐2‐HS glycoprotein is down‐regulated by cytokines in hepatoma HepG2 cells
1988
Inflammation in atherosclerosis
2002 StandoutNature
Excessive production of interleukin 6/B cell stimulatory factor‐2 in rheumatoid arthritis
1988
Subcutaneous Adipose Tissue Releases Interleukin-6, But Not Tumor Necrosis Factor-α,in Vivo1
1997 Standout
Bacterial CpG DNA Activates Immune Cells to Signal Infectious Danger
1999
Origin and physiological roles of inflammation
2008 StandoutNature
Different protein turnover of interleukin‐6‐type cytokine signalling components
1999
Role of interleukin-6 in regulating synthesis of C-reactive protein and serum amyloid A in human hepatoma cell lines
1988
The hormone resistin links obesity to diabetes
2001 StandoutNature
C/EBP is an immediate-early gene required for the consolidation of long-term facilitation in Aplysia
1994 StandoutNobel
A MAP Kinase Targeted by Endotoxin and Hyperosmolarity in Mammalian Cells
1994 StandoutScience
Regulation of Interferon‐γ During Innate and Adaptive Immune Responses
2007
Differential regulation of IL-6 and TNF-α via calcineurin in human skeletal muscle cells
2006
Inhibition of death receptor signals by cellular FLIP
1997 StandoutNature
Characterization of a recombinant murine interleukin-6: Assignment of disulfide bonds
1988
Absence of antiviral activity in recombinant B cell stimulatory factor 2 (BSF-2)
1988
Jak2 Is Essential for Signaling through a Variety of Cytokine Receptors
1998 Standout
Bicyclic Imidazoles as a Novel Class of Cytokine Biosynthesis Inhibitors
1993
Muscle as an Endocrine Organ: Focus on Muscle-Derived Interleukin-6
2008 Standout
Recombinant human interleukin 6 (B‐cell stimulatory factor 2) is a potent inducer of differentiation of mouse myeloid leukemia cells (M1)
1988
A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera
2005 StandoutNature
Recombinant human interleukin‐6 (IL‐6/BSF‐2/HSF) regulates the synthesis of acute phase proteins in human hepatocytes
1988
Inferences, questions and possibilities in Toll-like receptor signalling
2004 StandoutNatureNobel
Adipose tissue as an endocrine and paracrine organ
1998
Roles of PPARs in health and disease
2000 StandoutNature
Human interleukin 6 and tumor necrosis factor α production studied at a single‐cell level
1989
The Tumor Necrosis Factor Ligand and Receptor Families
1996 StandoutNobel
Plasmacytoid dendritic cells: from specific surface markers to specific cellular functions
2002
Angiotensinogen production by rat hepatoma cells is stimulated by B cell stimulatory factor 2/interleukin‐6
1989
Identification of the promoter sequences involved in the interleukin-6 dependent expression of the rat α2-macroglobulin gene
1989
Molecular cloning and expression of human hepatocyte growth factor
1989 StandoutNature
Shared Actions of Endotoxin and Taxol on TNF Receptors and TNF release
1990 Science
Pharmacokinetics, toxicity, and efficacy of ends-modified raf antisense oligodeoxyribonucleotide encapsulated in a novel cationic liposome.
2002
Cloning and Expression of the Human Interleukin-6 (BSF-2/IFNβ 2) Receptor
1988 Science
Genomic structure of the murine IL-6 gene. High degree conservation of potential regulatory sequences between mouse and human.
1988
Dendritic cells require a systemic type I interferon response to mature and induce CD4+ Th1 immunity with poly IC as adjuvant
2009 StandoutNobel
Liver Failure and Defective Hepatocyte Regeneration in Interleukin-6-Deficient Mice
1996 Science
β-Arrestin inhibits NF-κB activity by means of its interaction with the NF-κB inhibitor IκBα
2004 StandoutNobel
Immunization with HIV Gag targeted to dendritic cells followed by recombinant New York vaccinia virus induces robust T-cell immunity in nonhuman primates
2011 StandoutNobel
Human interleukin-10-related T cell-derived inducible factor: Molecular cloning and functional characterization as an hepatocyte-stimulating factor
2000
RNA Targeting Therapeutics: Molecular Mechanisms of Antisense Oligonucleotides as a Therapeutic Platform
2010
Principles of interleukin (IL)-6-type cytokine signalling and its regulation
2003 Standout
Type I IFNs Enhance the Terminal Differentiation of Dendritic Cells
1998
Mutational Analysis of Acute-Phase Response Factor/Stat3 Activation and Dimerization
1997
IL-6-Induced Homodimerization of gp130 and Associated Activation of a Tyrosine Kinase
1993 Science
The yeasts Rho1p and Pkc1p regulate the transport of chitin synthase III (Chs3p) from internal stores to the plasma membrane
2003 StandoutNobel
Interleukin-6 and the acute phase response
1990 Standout
Delivery of a Liposomal c-raf-1 Antisense Oligonucleotide by Weekly Bolus Dosing in Patients with Advanced Solid Tumors
2004
Targeted liposomal c-myc antisense oligodeoxynucleotides induce apoptosis and inhibit tumor growth and metastases in human melanoma models.
2003
Pathogenic significance of interleukin-6 (IL-6/BSF-2) in Castleman's disease
1989 Standout
Induction of Neuronal Differentiation in PC12 Cells by B-Cell Stimulatory Factor 2/Interleukin 6
1988
Type I IFN Protects Against Murine Lupus
2004
Cutting Edge: A Murine, IL-12-Independent Pathway of IFN-γ Induction by Gram-Negative Bacteria Based on STAT4 Activation by Type I IFN and IL-18 Signaling
2002
Interleukin 1β inhibits interleukin 6–mediated rat γ fibrinogen gene expression
2000
Establishment of an interleukin 6 (IL 6)/B cell stimulatory factor 2‐dependent cell line and preparation of anti‐IL 6 monoclonal antibodies
1988
Contributions of Leukemia Inhibitory Factor Receptor and Oncostatin M Receptor to Signal Transduction in Heterodimeric Complexes with Glycoprotein 130
1999
Identification of ERGIC-53 as an intracellular transport receptor of α1-antitrypsin
2008
Induction of rat α2‐macroglobulin in vivo and in hepatocyte primary cultures: synergistic action of glucocorticoids and a Kupffer cell‐derived factor
1984
Pyridinium Trifluoroacetate/N-Methylimidazole as an Efficient Activator for Oligonucleotide Synthesis via the Phosphoramidite Method
2000
Growth inhibition of human breast carcinoma and leukemia/lymphoma cell lines by recombinant interferon-beta 2.
1988
Comparable T helper 1 (Th1) and CD8 T-cell immunity by targeting HIV gag p24 to CD8 dendritic cells within antibodies to Langerin, DEC205, and Clec9A
2011 StandoutNobel
Activation of Protein Kinase Cζ Induces Serine Phosphorylation of VAMP2 in the GLUT4 Compartment and Increases Glucose Transport in Skeletal Muscle
2001
A new interleukin with pleiotropic activities
1988
Interleukin-6 in acute exercise and training: what is the biological relevance?
2006
TYPE I INTERFERONS (α/β) IN IMMUNITY AND AUTOIMMUNITY
2004 StandoutNobel
Interleukin-6 stimulates the secretion of adrenocorticotropic hormone in conscious, freely-moving rats
1988
Natural Interferon-α Producing Cells: The Plasmacytoid Dendritic Cells
2002
The Inhibitory Effect of IL-1β on IL-6-Induced α2-Macroglobulin Expression Is Due to Activation of NF-κB
2001
Essential Role of Neutrophils in the Initiation and Progression of a Murine Model of Rheumatoid Arthritis
2001
Decrease in BSF-2/IL-6 response in advanced cases of multiple myeloma
1988
Interferon-α as an immunotherapeutic protein
2002
Interleukin-6-type cytokine signalling through the gp130/Jak/STAT pathway
1998 Standout
Innate Inhibition of Adaptive Immunity:Mycobacterium tuberculosis-Induced IL-6 Inhibits Macrophage Responses to IFN-γ
2003
Foxp3+natural regulatory T cells preferentially form aggregates on dendritic cellsin vitroand actively inhibit their maturation
2008 StandoutNobel
The cytoplasmic domain of the interleukin-6 receptor gp80 mediates its basolateral sorting in polarized Madin-Darby canine kidney cells
2000
Differential Regulation of Human Blood Dendritic Cell Subsets by IFNs
2001
Macrophage differentiation-specific expression of NF-IL6, a transcription factor for interleukin-6
1992
Drug Delivery Systems: Entering the Mainstream
2004 StandoutScience
A randomized phase II and pharmacokinetic study of the antisense oligonucleotides ISIS 3521 and ISIS 5132 in patients with hormone-refractory prostate cancer.
2002
Signal Transduction of IL-6, Leukemia-Inhibitory Factor, and Oncostatin M: Structural Receptor Requirements for Signal Attenuation
2000
The phylogeny and evolution of the thioester bond‐containing proteins C3, C4 and α2–macroglobulin
1998
Recurrent Staphylococcal Cellulitis and Subcutaneous Abscesses in a Child with Autoantibodies against IL-6
2008
Interleukin 6: A Multifunctional Cytokine Regulating Immune Reactions and the Acute Phase Protein Response
1990
Correlations and interactions in the production of interleukin-6 (IL- 6), IL-1, and tumor necrosis factor (TNF) in human blood mononuclear cells: IL-6 suppresses IL-1 and TNF
1990
Liver Regeneration
1997 StandoutScience
Interleukin 2-dependent and interleukin 2-independent pathways of regulation of thymocyte function by interleukin 6.
1988
Recombinant interleukin 6 regulates the transcriptional activation of a set of human acute phase genes.
1988
Biosynthesis and half‐life of the interleukin‐6 receptor and its signal transducer gp130
1994
Comparative analysis of IRF and IFN-alpha expression in human plasmacytoid and monocyte-derived dendritic cells
2003
Multiple biological activities are expressed by a mouse interleukin 6 cDNA clone isolated from bone marrow stromal cells.
1988
[35] The acute phase response: An overview
1988
Fibrates Suppress Fibrinogen Gene Expression in Rodents Via Activation of the Peroxisome Proliferator-Activated Receptor-
1999
Regulation of nuclear factor κB activation by G-protein-coupled receptors
2001
Acute-phase response factor, a nuclear factor binding to acute-phase response elements, is rapidly activated by interleukin-6 at the posttranslational level.
1993
Acute-Phase Response Factor, a Nuclear Factor Binding to Acute-Phase Response Elements, is Rapidly Activated by Interleukin-6 at the Posttranslational Level
1993
Constitutive expression of a complement-like protein in Toll and JAK gain-of-function mutants ofDrosophila
2000 StandoutNobel
Human hepatocyte-stimulating factor-III and interleukin-6 are structurally and immunologically distinct but regulate the production of the same acute phase plasma proteins
1989
Multiple regulatory elements in the interleukin-6 gene mediate induction by prostaglandins, cyclic AMP, and lipopolysaccharide.
1994
Interleukin-6 interacts with interleukin-4 and other hematopoietic growth factors to selectively enhance the growth of megakaryocytic, erythroid, myeloid, and multipotential progenitor cells
1989
Inhibition of protein synthesis and early protein processing by thapsigargin in cultured cells
1993
IgG1 plasmacytosis in interleukin 6 transgenic mice.
1989
Lineage commitment in the immune system: the T helper lymphocyte grows up
2000
The biology of interleukin-6
1989 Standout
The anti-inflammatory effect of exercise
2005 Standout
Interleukin-1β is a potent growth inhibitor of adult rat hepatocytes in primary culture
1988
Caspases: Enemies Within
1998 StandoutScience
Roles of IFN-gamma and IFN-alpha in IL-12-induced T helper cell-1 development.
1996
Regulation of the Hypothalamic-Pituitary-Adrenal Axis by Cytokines: Actions and Mechanisms of Action
1999
Acid/Azole Complexes as Highly Effective Promoters in the Synthesis of DNA and RNA Oligomers via the Phosphoramidite Method
2001 StandoutNobel
Activation of the protein tyrosine phosphatase SHP2 via the interleukin-6 signal transducing receptor protein gp130 requires tyrosine kinase Jak1 and limits acute-phase protein expression
1998
JNK1 controls mast cell degranulation and IL-1β production in inflammatory arthritis
2010 StandoutNobel
Deoxycytidyl-Deoxyguanosine Oligonucleotide Classes A, B, and C Induce Distinct Cytokine Gene Expression Patterns in Rhesus Monkey Peripheral Blood Mononuclear Cells and Distinct Alpha Interferon Responses in TLR9-Expressing Rhesus Monkey Plasmacytoid Dendritic Cells
2005
Two Roads Diverged: Interferon α/β– and Interleukin 12–mediated Pathways in Promoting T Cell Interferon γ Responses during Viral Infection
1999
Interferon-alpha as an immunotherapeutic protein.
2002
Works of Thomas Geiger being referenced
An assay for the detection of interleukin-1 synthesis inhibitors: effects of antirheumatic drugs.
1989
Interleukin‐6 is the major regulator of acute phase protein synthesis in adult human hepatocytes
1989
Induction of rat acute‐phase proteins by interleukin 6 in vivo
1988
Regulation of synthesis and secretion of major rat acute‐phase proteins by recombinant human interleukin‐6 (BSF‐2/1L‐6) in hepatocyte primary cultures
1988
Fate and biological action of human recombinant interleukin 1β in the rat in vivo
1989
Action of recombinant human interleukin 6, interleukin 1β and tumor necrosis factor α on the mRNA induction of acute‐phase proteins
1988
Antitumor activity of a phosphorothioate antisense oligodeoxynucleotide targeted against C-raf kinase
1996
Cell‐free‐synthesized interleukin‐6 (BSF‐2/IFN‐β2) exhibits hepatocyte‐stimulating activity
1988
Recombinant human B cell stimulatory factor 2 (BSF‐2/IFN‐β2) regulates β‐fibrinogen and albumin mRNA levels in Fao‐9 cells
1987
Biosynthesis of rat alpha 1-macroglobulin. Identification of an intracellular precursor.
1987
Recombinant human C5a induces transcription but not translation of interleukin 1 beta mRNA in human monocytes.
1992
Interferon alpha increases the frequency of interferon gamma-producing human CD4+ T cells.
1993
Synthesis of α1‐Antitrypsin in Rat‐Liver Hepatocytes and in a Cell‐Free System
1982
Antisense oligonucleotide inhibitors of isozymes of protein kinase C: in vitro and in vivo activity, and clinical development as anti-cancer therapeutics.
1997
Plasma clearance, organ distribution and target cells of interleukin‐6/hepatocyte‐stimulating factor in the rat
1988
Regulation of interleukin-6 expression in cultured human blood monocytes and monocyte-derived macrophages
1988
Induction of alpha 1-acid glycoprotein by recombinant human interleukin-1 in rat hepatoma cells.
1988
Antitumor activity of a PKC-alpha antisense oligonucleotide in combination with standard chemotherapeutic agents against various human tumors transplanted into nude mice.
1998
Identification and sequencing of cDNA clones for the rodent negative acute‐phase protein α1‐inhibitor 3
1987
Antitumor activity of a C-raf antisense oligonucleotide in combination with standard chemotherapeutic agents against various human tumors transplanted subcutaneously into nude mice.
1997
Biosynthesis and Secretion of α1‐Antitrypsin in Primary Cultures of Rat Hepatocytes
1982
Neutralization of interleukin-1 beta activity in vivo with a monoclonal antibody alleviates collagen-induced arthritis in DBA/1 mice and prevents the associated acute-phase response.
1994
Sequence-specific antitumor activity of a phosphorothioate oligodeoxyribonucleotide targeted to human C- raf kinase supports an antisense mechanism of action in vivo
1996