Citation Impact
Citing Papers
Sec61p Contributes to Signal Sequence Orientation According to the Positive-Inside Rule
2003
Olefin Cyclopropanation via Carbene Transfer Catalyzed by Engineered Cytochrome P450 Enzymes
2012 StandoutScienceNobel
Comprehensive computational design of ordered peptide macrocycles
2017 StandoutScienceNobel
Progress towards the easier use of P450 enzymes
2006
The c-erbB-2 proto-oncogene as a prognostic and predictive marker in breast cancer: A paradigm for the development of other macromolecular markers-A review
1995
The relationship between prognostic and predictive factors in the management of breast cancer
1998
Protein engineering of oxygenases for biocatalysis
2002 StandoutNobel
Reconstitution of Human DNA Repair Excision Nuclease in a Highly Defined System
1995 StandoutNobel
I. Specificity of the glutathione S-transferases in the conversion of leukotriene A4 to leukotriene C4
1987 StandoutNobel
C. elegans EGL-9 and Mammalian Homologs Define a Family of Dioxygenases that Regulate HIF by Prolyl Hydroxylation
2001 StandoutNobel
Enantioselective Intramolecular CH Amination Catalyzed by Engineered Cytochrome P450 Enzymes In Vitro and In Vivo
2013 StandoutNobel
Genetic effects on gene expression across human tissues
2017 StandoutNature
Use of Cells Expressing γ Subunit Variants to Identify Diverse Mechanisms of AMPK Activation
2010
II. Isozyme specificity of rat liver glutathione S-transferases in the formation of PGF2α and PGE2 from PGH2
1987
Mutations in VKORC1 cause warfarin resistance and multiple coagulation factor deficiency type 2
2004 StandoutNature
Assembly of the Warfarin-sensitive Vitamin K 2,3-Epoxide Reductase Enzyme Complex in the Endoplasmic Reticulum Membrane
1997
Detergents for the stabilization and crystallization of membrane proteins
2007
Modification of the Nucleotide Cofactor-binding Site of Cytochrome P-450 Reductase to Enhance Turnover with NADH in Vivo
2002
Molecular mechanism of signal sequence orientation in the endoplasmic reticulum
2003
The Active Site of the Thermophilic CYP119 from Sulfolobus solfataricus
2000
A mutant with a defect in telomere elongation leads to senescence in yeast
1989 StandoutNobel
Epoxygenase Pathways of Arachidonic Acid Metabolism
2001
Oxygen sensing by HIF hydroxylases
2004 StandoutNobel
The role of regulatory variation in complex traits and disease
2015
A Self‐Sufficient Peroxide‐Driven Hydroxylation Biocatalyst
2003 StandoutNobel
Telomeres and telomerase: the path from maize, Tetrahymena and yeast to human cancer and aging
2006 StandoutNobel
Functional hepatocyte heterogeneity
1989
Gene Evolution of Epoxide Hydrolases and Recommended Nomenclature
1995
Abolition of oxygenase function, retention of NADPH oxidase activity, and emergence of peroxidase activity upon replacement of the axial cysteine-436 ligand by histidine in cytochrome P450 2B4
2004
Asp333, Asp495, and His52.3 Form the Catalytic Triad of Rat Soluble Epoxide Hydrolase
1996
β-Lactam analogues of combretastatin A-4 prevent metabolic inactivation by glucuronidation in chemoresistant HT-29 colon cancer cells
2017
Construction of mutant and chimeric genes using the polymerase chain reaction
1989
P450BM3(CYP102A1): connecting the dots
2011
Organocatalytic Asymmetric Hydrolysis of Epoxides
2014 StandoutNobel
The G Protein-coupled Receptor Kinase 2 Is a Microtubule-associated Protein Kinase That Phosphorylates Tubulin
1998 StandoutNobel
Heme-iron oxygenases: powerful industrial biocatalysts?
2008
Epoxide hydrolases: their roles and interactions with lipid metabolism
2005
Enzymatic functionalization of carbon–hydrogen bonds
2010 StandoutNobel
A Multigene Assay to Predict Recurrence of Tamoxifen-Treated, Node-Negative Breast Cancer
2004 Standout
Telomeric repeat from T. thermophila cross hybridizes with human telomeres
1988 StandoutNatureNobel
Tobacco Smoke Carcinogens and Lung Cancer
1999 Standout
Cytochrome P450 monooxygenases: an update on perspectives for synthetic application
2011
Somatic cell genetics approach to dissecting mammalian DNA repair
1989
Direct electron transfer between cytochrome P450scc and gold nanoparticles on screen-printed rhodium–graphite electrodes
2004
A telomeric sequence in the RNA of Tetrahymena telomerase required for telomere repeat synthesis
1989 StandoutNatureNobel
What makes a P450 tick?
2013
Use of Chemotherapy plus a Monoclonal Antibody against HER2 for Metastatic Breast Cancer That Overexpresses HER2
2001 Standout
The Hallmarks of Aging
2013 Standout
Improved Cyclopropanation Activity of Histidine‐Ligated Cytochrome P450 Enables the Enantioselective Formal Synthesis of Levomilnacipran
2014 StandoutNobel
Cytochrome P450 enzymes in drug metabolism: Regulation of gene expression, enzyme activities, and impact of genetic variation
2013 Standout
EGLN1 Inhibition and Rerouting of α-Ketoglutarate Suffice for Remote Ischemic Protection
2016 StandoutNobel
Electrochemistry of cytochrome P450 enzyme on nanoparticle-containing membrane-coated electrode and its applications for drug sensing
2007
Analysis of the proteome of Mycobacterium tuberculosis in silico
1999
Preparative use of isolated CYP102 monooxygenases—A critical appraisal
2006
Engineered Alkane‐Hydroxylating Cytochrome P450BM3 Exhibiting Nativelike Catalytic Properties
2007 StandoutNobel
Isolation and characterization of the multiple glutathione S-transferases from human liver. Evidence for unique heme-binding sites.
1985
A highly conserved tyrosine residue in G protein-coupled receptors is required for agonist-mediated beta 2-adrenergic receptor sequestration.
1994 StandoutNobel
Orally Absorbed Cyclic Peptides
2017
SuFEx Click Chemistry Enabled Late-Stage Drug Functionalization
2018 StandoutNobel
Direct Electrochemistry of Immobilized Human Cytochrome P450 2E1
2004
The nucleotide sequence of a rat liver glutathione S-transferase subunit cDNA clone.
1984
Exploring the nature of the translocon-assisted protein insertion
2012 StandoutNobel
G-strings at chromosome ends
1988 StandoutNatureNobel
Telomere shortening associated with chromosome instability is arrested in immortal cells which express telomerase activity.
1992 StandoutNobel
A glutathione conjugate of hepoxilin A3: formation and action in the rat central nervous system.
1990 StandoutNobel
Enantioselective α-Hydroxylation of 2-Arylacetic Acid Derivatives and Buspirone Catalyzed by Engineered Cytochrome P450 BM-3
2006 StandoutNobel
Induction of cell growth regulatory genes by p53.
1996
Tuning P450 Enzymes as Oxidation Catalysts
2012
Rat liver glutathione S-transferases. Nucleotide sequence analysis of a Yb1 cDNA clone and prediction of the complete amino acid sequence of the Yb1 subunit.
1985
Rat liver glutathione S-transferases. Construction of a cDNA clone complementary to a Yc mRNA and prediction of the complete amino acid sequence of a Yc subunit.
1985
MOLECULAR MECHANISMS OF GENETIC POLYMORPHISMS OF DRUG METABOLISM
1997
Tandem Facial Amphiphiles for Membrane Protein Stabilization
2010 StandoutNobel
Prostaglandins and Leukotrienes: Advances in Eicosanoid Biology
2001 StandoutScience
General approach to reversing ketol-acid reductoisomerase cofactor dependence from NADPH to NADH
2013 StandoutNobel
MmpL8 is required for sulfolipid-1 biosynthesis and Mycobacterium tuberculosis virulence
2003 StandoutNobel
Gold Nanoparticles in Chemical and Biological Sensing
2012 Standout
The induction of specific rat liver glutathione S-transferase subunits under inadequate selenium nutrition causes an increase in prostaglandin F2 alpha formation.
1990
Catalytic Hydroxylation in Biphasic Systems using CYP102A1 Mutants
2005
Identification of Mechanism-Based Inactivation in P450-Catalyzed Cyclopropanation Facilitates Engineering of Improved Enzymes
2016 StandoutNobel
Chemomimetic Biocatalysis: Exploiting the Synthetic Potential of Cofactor-Dependent Enzymes To Create New Catalysts
2015 StandoutNobel
Reduction of Dioxygen Catalyzed by Pyrene-Wired Heme Domain Cytochrome P450 BM3 Electrodes
2004 StandoutNobel
Functional Evidence for an RNA Template in Telomerase
1990 StandoutScienceNobel
Isozyme specificity in the conversion of hepoxilin A3 (HxA3) into a glutathionyl hepoxilin (HxA3-C) by the Yb2 subunit of rat liver glutathione S-transferase.
1990 StandoutNobel
Mechanism-Based Inactivation of Human Cytochromes P450s: Experimental Characterization, Reactive Intermediates, and Clinical Implications
2007
Pharmacogenomics: Translating Functional Genomics into Rational Therapeutics
1999 StandoutScience
Mechanism of Oxidation Reactions Catalyzed by Cytochrome P450 Enzymes
2004 Standout
Design of Heme Enzymes with a Tunable Substrate Binding Pocket Adjacent to an Open Metal Coordination Site
2023 StandoutNobel
Molecular cloning of the human nucleotide-excision-repair gene ERCC4.
1994 StandoutNobel
Enzyme-Controlled Nitrogen-Atom Transfer Enables Regiodivergent C–H Amination
2014 StandoutNobel
Enantioselective Total Synthesis of Nigelladine A via Late-Stage C–H Oxidation Enabled by an Engineered P450 Enzyme
2017 StandoutNobel
Structural Adaptability Facilitates Histidine Heme Ligation in a Cytochrome P450
2015 StandoutNobel
Works of Thomas Friedberg being referenced
Glucuronidation as a mechanism of intrinsic drug resistance in colon cancer cells: contribution of drug transport proteins
2003
C-erbB-2-oncogene expression in breast carcinoma: Analysis by S1 nuclease protection assay and immunohistochemistry in relation to clinical parameters
1992
A Keratinocyte-specific Epoxygenase, CYP2B12, Metabolizes Arachidonic Acid with Unusual Selectivity, Producing a Single Major Epoxyeicosatrienoic Acid
1998
A General Strategy for the Expression of Recombinant Human Cytochrome P450s inEscherichia coliUsing Bacterial Signal Peptides: Expression of CYP3A4, CYP2A6, and CYP2E1
1997
Establishment of Functional Human Cytochrome P450 Monooxygenase Systems in <i>Escherichia coli</i>
2006
MERITS AND LIMITATIONS OF RECOMBINANT MODELS FOR THE STUDY OF HUMAN P450-MEDIATED DRUG METABOLISM AND TOXICITY: AN INTRALABORATORY COMPARISON
1999
Proteasomal Degradation of Human CYP1B1: Effect of the Asn453Ser Polymorphism on the Post-Translational Regulation of CYP1B1 Expression
2004
Tissue-specific expression and differential inducibility of several microsomal epoxide hydrolase mRNAs which are formed by alternative splicing
1991
AMP-activated Protein Kinase Mediates Phenobarbital Induction of CYP2B Gene Expression in Hepatocytes and a Newly Derived Human Hepatoma Cell Line
2004
The Role of the Hydrophobic Domain in Orienting Natural Signal Sequences within the ER Membrane
1998
Polymorphisms in P450 CYP1B1 affect the conversion of estradiol to the potentially carcinogenic metabolite 4-hydroxyestradiol
2000
Endogenous drug transporters in in vitro and in vivo models for the prediction of drug disposition in man
2002
Colorimetric quantitation of trace amounts of sodium lauryl sulfate in the presence of nucleic acids and proteins
1992
Effects of Human Cytochrome b5on CYP3A4 Activity and Stabilityin Vivo
1999
Sequence similarity of mammalian epoxide hydrolases to the bacterial haloalkane dehalogenase and other related proteins
1994
Studies on the importance of microsomal epoxide hydrolase in the detoxification of arene oxides using the heterologous expression of the enzyme in mammalian cells
1994
The Membrane Anchor of Microsomal Epoxide Hydrolase from Human, Rat, and Rabbit Displays an Unexpected Membrane Topology
1997
An amperometric biosensor with human CYP3A4 as a novel drug screening tool
2003
Characterization, localization and regulation of a novel phenobarbital-inducible form of cytochrome P450, compared with three further P450-isoenzymes, NADPH P450-reductase, glutathione transferases and microsomal epoxide hydrolase
1984
Human cytochrome P-450 PB-1: a multigene family involved in mephenytoin and steroid oxidations that maps to chromosome 10.
1988
Engineering of a functional human NADH-dependent cytochrome P450 system
2001
Stable expression of rat cytochrome P-450IIB1 cDNA in Chinese hamster cells (V79) and metabolic activation of aflatoxin B1.
1988
Mechanism-Based Inactivation of Cytochrome P450 3A4 by L-754,394
2000
[19] Production of site-specific P450 antibodies using recombinant fusion proteins as antigens
1991
Determinants of the substrate specificity of human cytochrome P-450 CYP2D6: design and construction of a mutant with testosterone hydroxylase activity
1998
The microsomal epoxide hydrolase has a single membrane signal anchor sequence which is dispensable for the catalytic activity of this protein
1994
The identification, solubilization, and characterization of microsome-associated glutathione S-transferases.
1979
Electrospray Ionization Mass Spectrometric Analysis of Intact Cytochrome P450: Identification of Tienilic Acid Adducts to P450 2C9
1999
Studies on the subunit composition of rat liver glutathione S-transferases.
1983
Expression and alternative splicing of the cytochrome P-450 CYP2A7
1995