Standout Papers
Citation Impact
Citing Papers
Oxidative Stress
2017 Standout
Ferroptosis regulation by the NGLY1/NFE2L1 pathway
2022 StandoutNobel
Survey of Human Chromosome 21 Gene Expression Effects on Early Development in Danio rerio
2018
Reactive Oxygen Species in Inflammation and Tissue Injury
2013 Standout
Cancer Chemoprevention Mechanisms Mediated Through the Keap1–Nrf2 Pathway
2010
Reactive oxygen species, toxicity, oxidative stress, and antioxidants: chronic diseases and aging
2023 Standout
A RASSF1A-HIF1α loop drives Warburg effect in cancer and pulmonary hypertension
2019 StandoutNobel
Identification of the translocation breakpoints in the Ts65Dn and Ts1Cje mouse lines: relevance for modeling down syndrome
2011
Decreased histone deacetylase 2 impairs Nrf2 activation by oxidative stress
2011
Active NF-E2-related Factor (Nrf2) Contributes to Keep Endothelial NO Synthase (eNOS) in the Coupled State
2009
HIF Hydroxylase Pathways in Cardiovascular Physiology and Medicine
2015 StandoutNobel
Activation of the Keap1/Nrf2 stress response pathway in autophagic vacuolar myopathies
2016
Evidence of Notch-Hesr-Nrf2 Axis in Muscle Stem Cells, but Absence of Nrf2 Has No Effect on Their Quiescent and Undifferentiated State
2015
Smoking accelerates aging of the small airway epithelium
2014
Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries
2021 Standout
Interstitial Lung Disease: NHLBI Workshop on the Primary Prevention of Chronic Lung Diseases
2014
NRF2 Cysteine Residues Are Critical for Oxidant/Electrophile-Sensing, Kelch-Like ECH-Associated Protein-1-Dependent Ubiquitination-Proteasomal Degradation, and Transcription Activation
2009
Targeting the KEAP1-NRF2 System to Prevent Kidney Disease Progression
2017 Standout
Mechanisms of activation of the transcription factor Nrf2 by redox stressors, nutrient cues, and energy status and the pathways through which it attenuates degenerative disease
2015
An Exceptionally Potent Inducer of Cytoprotective Enzymes
2010
Idiopathic pulmonary fibrosis
2017 Standout
Short-Term Effects of Nose-Only Cigarette Smoke Exposure on Glutathione Redox Homeostasis, Cytochrome P450 1A1/2 and Respiratory Enzyme Activities in Mice Tissues
2013 Standout
Myeloid Deletion of Nuclear Factor Erythroid 2−Related Factor 2 Increases Atherosclerosis and Liver Injury
2012
Nrf2: friend or foe for chemoprevention?
2009
Global mapping of binding sites for Nrf2 identifies novel targets in cell survival response through ChIP-Seq profiling and network analysis
2010
Polymorphism of Nrf2, an Antioxidative Gene, is Associated with Blood Pressure and Cardiovascular Mortality in Hemodialysis Patients
2014
Nrf2-Keap1 signaling in oxidative and reductive stress
2018 Standout
Validation of the multiple sensor mechanism of the Keap1-Nrf2 system
2012
The biology and management of non-small cell lung cancer
2018 StandoutNature
Telomere dysfunction in ageing and age-related diseases
2022
The NLRP3 inflammasome: molecular activation and regulation to therapeutics
2019 Standout
Cellular senescence in aging and age-related disease: from mechanisms to therapy
2015 Standout
NRF2 and cancer: the good, the bad and the importance of context
2012
Hallmarks of aging: An expanding universe
2023 Standout
Influence of prenatal EGCG treatment andDyrk1adosage reduction on craniofacial features associated with Down syndrome
2016
Macrophages in the Pathogenesis of Atherosclerosis
2011 Standout
SynCAM 1 Adhesion Dynamically Regulates Synapse Number and Impacts Plasticity and Learning
2010 StandoutNobel
Toward clinical application of the Keap1–Nrf2 pathway
2013
Redox regulation of antioxidants, autophagy, and the response to stress: Implications for electrophile therapeutics
2014
CRISPR-Cas9 Circular Permutants as Programmable Scaffolds for Genome Modification
2019 StandoutNobel
The Science of Stroke: Mechanisms in Search of Treatments
2010 Standout
Structure of the BTB Domain of Keap1 and Its Interaction with the Triterpenoid Antagonist CDDO
2014
A Gene in the Pseudomonas syringae pv. tomato Hrp Pathogenicity Island Conserved Effector Locus, hopPtoA1, Contributes to Efficient Formation of Bacterial Colonies in Planta and Is Duplicated Elsewhere in the Genome
2002
Pharmacokinetics and pharmacodynamics of orally administered acetylenic tricyclic bis (cyanoenone), a highly potent Nrf2 activator with a reversible covalent mode of action
2015
Inherited Cancer Syndromes in Children and Young Adults
2010
Lack of Effect of Oral Sulforaphane Administration on Nrf2 Expression in COPD: A Randomized, Double-Blind, Placebo Controlled Trial
2016
Heat Shock Protein A12B Protects Vascular Endothelial Cells Against Sepsis-Induced Acute Lung Injury in Mice
2017 Standout
Natural product-derived pharmacological modulators of Nrf2/ARE pathway for chronic diseases
2013
ROS Function in Redox Signaling and Oxidative Stress
2014 Standout
Endoplasmic reticulum stress and Nrf2 signaling in cardiovascular diseases
2015
Age-related macular degeneration
2012 Standout
The telomere syndromes
2012 Nobel
Hypoxia and the extracellular matrix: drivers of tumour metastasis
2014 StandoutNobel
Premature lung aging and cellular senescence in the pathogenesis of idiopathic pulmonary fibrosis and COPD/emphysema
2013
Redox status in mammalian cells and stem cells during culture in vitro: Critical roles of Nrf2 and cystine transporter activity in the maintenance of redox balance
2014
Reactive oxygen species (ROS) as pleiotropic physiological signalling agents
2020 Standout
SIRT1 protects against emphysema via FOXO3-mediated reduction of premature senescence in mice
2012
The Nrf2 triterpenoid activator, CDDO-imidazolide, protects kidneys from ischemia–reperfusion injury in mice
2013
The DNA Damage Response: Making It Safe to Play with Knives
2010 Standout
Paracrine Induction of HIF by Glutamate in Breast Cancer: EglN1 Senses Cysteine
2016 StandoutNobel
Host-Microbe Interactions: Shaping the Evolution of the Plant Immune Response
2006 Standout
The Transcriptome of Nrf2−/− Mice Provides Evidence for Impaired Cell Cycle Progression in the Development of Cigarette Smoke–Induced Emphysematous Changes
2010
Low risk of solid tumors in persons with Down syndrome
2016
Two-Component Sensor RhpS Promotes Induction of Pseudomonas syringae Type III Secretion System by Repressing Negative Regulator RhpR
2007 StandoutNobel
The absence of macrophage Nrf2 promotes early atherogenesis
2013
Macrophage plasticity and interaction with lymphocyte subsets: cancer as a paradigm
2010 Standout
The causes and consequences of genetic heterogeneity in cancer evolution
2013 StandoutNature
Bioinformatic characterization of the SynCAM family of immunoglobulin-like domain-containing adhesion molecules
2005
The Emerging Hallmarks of Cancer Metabolism
2016 Standout
Synthetic Oleanane Triterpenoids: Multifunctional Drugs with a Broad Range of Applications for Prevention and Treatment of Chronic Disease
2012
Human Alveolar Epithelial Cell Injury Induced by Cigarette Smoke
2011
Critical Cysteine Residues of Kelch-Like ECH-Associated Protein 1 in Arsenic Sensing and Suppression of Nuclear Factor Erythroid 2-Related Factor 2
2009
Deletion of Keap1 in the Lung Attenuates Acute Cigarette Smoke–Induced Oxidative Stress and Inflammation
2009
Therapeutic targeting of the NRF2 and KEAP1 partnership in chronic diseases
2019 Standout
Nrf2 is essential for cholesterol crystal‐induced inflammasome activation and exacerbation of atherosclerosis
2011
The human colon cancer methylome shows similar hypo- and hypermethylation at conserved tissue-specific CpG island shores
2009 Standout
Genetic versus chemoprotective activation of Nrf2 signaling: overlapping yet distinct gene expression profiles between Keap1 knockout and triterpenoid-treated mice
2009
The Hallmarks of Aging
2013 Standout
Boveri revisited: chromosomal instability, aneuploidy and tumorigenesis
2009
Nrf2-ARE stress response mechanism: A control point in oxidative stress-mediated dysfunctions and chronic inflammatory diseases
2010
Down syndrome
2020 Standout
Protein Sequence Editing of SKN-1A/Nrf1 by Peptide:N-Glycanase Controls Proteasome Gene Expression
2019 StandoutNobel
Putative direct and indirect Wnt targets identified through consistent gene expression changes in APC-mutant intestinal adenomas from humans and mice
2008
Molecular mechanisms of the Keap1-Nrf2 pathway in stress response and cancer evolution
2011
The rise of antioxidant signaling—The evolution and hormetic actions of Nrf2
2010
The plant immune system
2006 StandoutNature
Up-regulation of p27kip1 contributes to Nrf2-mediated protection against angiotensin II-induced cardiac hypertrophy
2011
Cellular senescence: from physiology to pathology
2014 Standout
Principles of Cancer Therapy: Oncogene and Non-oncogene Addiction
2009 Standout
Lipid Oxidation and Peroxidation in CNS Health and Disease: From Molecular Mechanisms to Therapeutic Opportunities
2009
Nuclear Factor (Erythroid-Derived 2)-Like 2 and Thioredoxin-1 in Atherosclerosis and Ischemia/Reperfusion Injury in the Heart
2016
Aneuploidy Affects Proliferation and Spontaneous Immortalization in Mammalian Cells
2008 Science
Outdoor air pollution and cancer: An overview of the current evidence and public health recommendations
2020
Down Syndrome
2020 Standout
Role of Nrf2 in Oxidative Stress and Toxicity
2013 Standout
Nuclear factor E2-related factor 2 deficiency impairs atherosclerotic lesion development but promotes features of plaque instability in hypercholesterolaemic mice
2018
NF-E2–Related Factor 2 Promotes Atherosclerosis by Effects on Plasma Lipoproteins and Cholesterol Transport That Overshadow Antioxidant Protection
2010
TYPE III SECRETION SYSTEM EFFECTOR PROTEINS: Double Agents in Bacterial Disease and Plant Defense
2004
Novel concepts of acute lung injury and alveolar-capillary barrier dysfunction
2013
The Keap1–Nrf2–ARE Pathway As a Potential Preventive and Therapeutic Target: An Update
2016
Degradable Controlled-Release Polymers and Polymeric Nanoparticles: Mechanisms of Controlling Drug Release
2016 Standout
Signal transduction by reactive oxygen species
2011 Standout
Treatment of Geographic Atrophy by the Topical Administration of OT-551: Results of a Phase II Clinical Trial
2010
Oxygen Sensing, Hypoxia-Inducible Factors, and Disease Pathophysiology
2013 StandoutNobel
Nicotine, Carcinogen, and Toxin Exposure in Long-Term E-Cigarette and Nicotine Replacement Therapy Users
2017
Aneuploidy: Cells Losing Their Balance
2008
The use of mouse models to understand and improve cognitive deficits in Down syndrome
2011
New Synthetic Triterpenoids: Potent Agents for Prevention and Treatment of Tissue Injury Caused by Inflammatory and Oxidative Stress
2011
Telomere-mediated lung disease
2022
NEW INSIGHTS TO THE FUNCTION OF PHYTOPATHOGENIC BACTERIAL TYPE III EFFECTORS IN PLANTS
2005
Inositol Polyphosphate Multikinase Inhibits Angiogenesis via Inositol Pentakisphosphate-Induced HIF-1α Degradation
2017 StandoutNobel
Genetic dissection of Down syndrome-associated congenital heart defects using a new mouse mapping panel
2016
The KEAP1-NRF2 System: a Thiol-Based Sensor-Effector Apparatus for Maintaining Redox Homeostasis
2018 Standout
Therapeutic Potential of Nrf2 Activators in Streptozotocin-Induced Diabetic Nephropathy
2011
Ferroptosis as a target for protection against cardiomyopathy
2019 Standout
Nrf2 augments skeletal muscle regeneration after ischaemia–reperfusion injury
2014
Targeting Nrf2 Signaling Improves Bacterial Clearance by Alveolar Macrophages in Patients with COPD and in a Mouse Model
2011
Telomeropathies: An emerging spectrum disorder
2014
Functional Haplotypes in the Promoter Region of Transcription FactorNrf2in Chronic Obstructive Pulmonary Disease
2010
Trans-Acting Epigenetic Effects of Chromosomal Aneuploidies: Lessons From Down Syndrome and Mouse Models
2016
Liquid Biopsies: Genotyping Circulating Tumor DNA
2014 Standout
Novel Chalcone Derivatives as Potent Nrf2 Activators in Mice and Human Lung Epithelial Cells
2011
Functional haplotypes in the promoter region of transcription factor Nrf2 in chronic obstructive pulmonary disease.
2010
Cul3-mediated Nrf2 ubiquitination and antioxidant response element (ARE) activation are dependent on the partial molar volume at position 151 of Keap1
2009
NRF2-mediated Notch pathway activation enhances hematopoietic reconstitution following myelosuppressive radiation
2014
Stress-Activated Cap'n'collar Transcription Factors in Aging and Human Disease
2010
Rodent models in Down syndrome research: impact and future opportunities
2017
Aging and Atherosclerosis
2012
Derivative of Bardoxolone Methyl, dh404, in an Inverse Dose-Dependent Manner Lessens Diabetes-Associated Atherosclerosis and Improves Diabetic Kidney Disease
2014
Nrf2 Deficiency Exaggerates Doxorubicin-Induced Cardiotoxicity and Cardiac Dysfunction
2014
Therapeutic effects of telomerase in mice with pulmonary fibrosis induced by damage to the lungs and short telomeres
2018
Identification of a Novel Macrophage Phenotype That Develops in Response to Atherogenic Phospholipids via Nrf2
2010
Disruption of Nrf2 Synergizes with High Glucose to Cause Heightened Myocardial Oxidative Stress and Severe Cardiomyopathy in Diabetic Mice
2013
Idiopathic Pulmonary Fibrosis
2018 Standout
Systemic Activation of NRF2 Alleviates Lethal Autoimmune Inflammation in Scurfy Mice
2017 StandoutNobel
Works of Thomas E. Sussan being referenced
Targeting Nrf2 with the triterpenoid CDDO- imidazolide attenuates cigarette smoke-induced emphysema and cardiac dysfunction in mice
2008
Air pollution-derived particulate matter dysregulates hepatic Krebs cycle, glucose and lipid metabolism in mice
2019
Trisomy represses ApcMin -mediated tumours in mouse models of Down’s syndrome
2008 Nature
Identification of a Novel Pseudomonas syringae Psy61 Effector with Virulence and Avirulence Functions by a HrpL-Dependent Promoter-Trap Assay
2004
Complex contributions of Ets2 to craniofacial and thymus phenotypes of trisomic “Down syndrome” mice
2009
Identification of tumor suppressor candidate genes by physical and sequence mapping of the TSLC1 region of human chromosome 11q23
2001
Chronic Cigarette Smoke Causes Oxidative Damage and Apoptosis to Retinal Pigmented Epithelial Cells in Mice
2008
Exposure to Electronic Cigarettes Impairs Pulmonary Anti-Bacterial and Anti-Viral Defenses in a Mouse Model
2015
Genetic silencing of Nrf2 enhances X-ROS in dysferlin-deficient muscle
2014
Disruption of Nrf2, a Key Inducer of Antioxidant Defenses, Attenuates ApoE-Mediated Atherosclerosis in Mice
2008
Chronic Intermittent Hypoxia Induces Atherosclerosis via Activation of Adipose Angiopoietin-like 4
2013 StandoutNobel
Telomere Length Is a Determinant of Emphysema Susceptibility
2011
PGI synthase overexpression protects against bleomycin-induced mortality and is associated with increased Nqo 1 expression
2011
Enhancer-Binding Proteins HrpR and HrpS Interact To Regulatehrp-Encoded Type III Protein Secretion inPseudomonas syringaeStrains
2001
Nrf2 reduces allergic asthma in mice through enhanced airway epithelial cytoprotective function
2015