Standout Papers
Citation Impact
Citing Papers
Direct observation of thymine dimer repair in DNA by photolyase
2005 StandoutNobel
Temporal calcium profiling of specific circadian neurons in freely moving flies
2017 StandoutNobel
Circadian oscillation of nucleotide excision repair in mammalian brain
2009 StandoutNobel
Loss of cryptochrome reduces cancer risk in p53 mutant mice
2009 StandoutNobel
Sleep Drives Metabolite Clearance from the Adult Brain
2013 StandoutScience
Identification of neuropeptide-like protein gene families in Caenorhabditis elegans and other species
2001
Photoreceptive net in the mammalian retina
2002 Nature
ANKTM1, a TRP-like Channel Expressed in Nociceptive Neurons, Is Activated by Cold Temperatures
2003 StandoutNobel
Molecular Analysis of Mammalian Circadian Rhythms
2001
Identification of Neuropeptide W as the Endogenous Ligand for Orphan G-protein-coupled Receptors GPR7 and GPR8
2002
Narcolepsy
1999
Metabolic cycles as an underlying basis of biological oscillations
2006
Circadian rhythms from multiple oscillators: lessons from diverse organisms
2005
Sustained elevation of extracellular adenosine and activation of A1 receptors underlie the post‐ischaemic inhibition of neuronal function in rat hippocampus in vitro
2006
Circadian clocks: genes, sleep, and cognition
2010
The Coevolution of Blue-Light Photoreception and Circadian Rhythms
2003 StandoutNobel
Genetics of normal and pathological sleep in humans
2005
Influence of Metabolism on Epigenetics and Disease
2013 StandoutNobel
Sustaining Sleep Spindles through Enhanced SK2-Channel Activity Consolidates Sleep and Elevates Arousal Threshold
2012
PDF Cells Are a GABA-Responsive Wake-Promoting Component of the Drosophila Sleep Circuit
2008 StandoutNobel
Novel neurotransmitters as natural ligands of orphan G-protein-coupled receptors
2001
Sleep as a fundamental property of neuronal assemblies
2008
Adenosine A2A, but not A1, receptors mediate the arousal effect of caffeine
2005
Are the Dorsal and Ventral Hippocampus Functionally Distinct Structures?
2010 Standout
Genome-wide association of sleep and circadian phenotypes
2007
Rest in Drosophila Is a Sleep-like State
2000
PERIOD3, circadian phenotypes, and sleep homeostasis
2009
Innervation of orexin/hypocretin neurons by GABAergic, glutamatergic or cholinergic basal forebrain terminals evidenced by immunostaining for presynaptic vesicular transporter and postsynaptic scaffolding proteins
2006
Optogenetic deconstruction of sleep-wake circuitry in the brain
2010
Fear conditioning increases NREM sleep.
2007
Sleep homeostasis: A role for adenosine in humans?
2008
Sleep enhances nocturnal plasma ghrelin levels in healthy subjects
2004
A deficit in the ability to form new human memories without sleep
2007
Neuroendocrine regulation of eating behavior
2002
Coordination of entorhinal–hippocampal ensemble activity during associative learning
2014 StandoutNatureNobel
P2X2R purinergic receptor subunit mRNA and protein are expressed by all hypothalamic hypocretin/orexin neurons
2006
Neurobiological mechanisms for the regulation of mammalian sleep–wake behavior: Reinterpretation of historical evidence and inclusion of contemporary cellular and molecular evidence
2007
Reduced Number of Hypocretin Neurons in Human Narcolepsy
2000 Standout
SLEEPLESS, a Ly-6/neurotoxin family member, regulates the levels, localization and activity of Shaker
2009
Hypocretin/Orexin Overexpression Induces An Insomnia-Like Phenotype in Zebrafish
2006
The circadian clock: pacemaker and tumour suppressor
2003
Coordinated Transcription of Key Pathways in the Mouse by the Circadian Clock
2002 Standout
Calcitonin Gene-Related Peptide Neurons Mediate Sleep-Specific Circadian Output in Drosophila
2014
Slow Wave Sleep Enhancement with Gaboxadol Reduces Daytime Sleepiness During Sleep Restriction
2008
Circadian regulation of sleep in mammals: Role of the suprachiasmatic nucleus
2005
Hypothalamic Orexin Neurons Regulate Arousal According to Energy Balance in Mice
2003
Profiles of novel diurnally regulated genes in mouse hypothalamus: Expression analysis of the cysteine and histidine-rich domain-containing, zinc-binding protein 1, the fatty acid-binding protein 7 and the GTPase, ras-like family member 11b
2006
Expression pattern of FOS in orexin neurons during sleep induced by an adenosine A2A receptor agonist
2006
Rapid changes in glutamate levels in the posterior hypothalamus across sleep-wake states in freely behaving rats
2008
Orphan G-protein-coupled receptors and natural ligand discovery
2001
TREK-1 is a heat-activated background K+ channel
2000
Regional Brain Glucose Metabolism During Morning and Evening Wakefulness in Humans: Preliminary Findings
2004
Adenosine and sleep–wake regulation
2004
Tuning arousal with optogenetic modulation of locus coeruleus neurons
2010
Central nervous system control of food intake
2000 StandoutNature
The mammalian circadian clock
2003
Genome-wide RNAi analysis of Caenorhabditis elegans fat regulatory genes
2003 StandoutNatureNobel
Genes for normal sleep and sleep disorders
2005
Sleep and its homeostatic regulation in mice lacking the adenosine A1receptor
2003
The neural circuit of orexin (hypocretin): maintaining sleep and wakefulness
2007
Prokineticin 2 transmits the behavioural circadian rhythm of the suprachiasmatic nucleus
2002 Nature
Physiology and Pathophysiology of Purinergic Neurotransmission
2007 Standout
Unearthing the Phylogenetic Roots of Sleep
2008
Neurobiology of the fruit fly's circadian clock
2004
Dynamics and mechanism of repair of ultraviolet-induced (6–4) photoproduct by photolyase
2010 StandoutNatureNobel
Overnight therapy? The role of sleep in emotional brain processing.
2009
Physiological markers of local sleep
2009
A clockwork web: circadian timing in brain and periphery, in health and disease
2003
Age‐related Changes in the Circadian and Homeostatic Regulation of Human Sleep
2006
Adenosine Inhibits Activity of Hypocretin/Orexin Neurons by the A1 Receptor in the Lateral Hypothalamus: A Possible Sleep-Promoting Effect
2006
Genetics of Sleep and Sleep Disorders
2011
Genetic Evidence for a Role for Protein Kinase A in the Maintenance of Sleep and Thalamocortical Oscillations
2010
The menthol receptor TRPM8 is the principal detector of environmental cold
2007 StandoutNatureNobel
Drosophila Clock Can Generate Ectopic Circadian Clocks
2003 StandoutNobel
Microarray Analysis and Organization of Circadian Gene Expression in Drosophila
2001 StandoutNobel
Pten Regulates Neuronal Arborization and Social Interaction in Mice
2006
The hypocretin/orexin ligand–receptor system: implications for sleep and sleep disorders
2000
Hypoxia-induced desensitization and internalization of adenosine A1 receptors in the rat hippocampus
2006
Systematic analysis of genes required for synapse structure and function
2005 StandoutNatureNobel
Molecular Mechanisms of Sleep and Wakefulness
2008
Clues to the functions of mammalian sleep
2005 Nature
Functional microstates within human REM sleep: first evidence from fMRI of a thalamocortical network specific for phasic REM periods
2007
Direct Excitation of Hypocretin/Orexin Cells by Extracellular ATP at P2X Receptors
2005
Ghrelin: Structure and Function
2005 Standout
The genetics of mammalian circadian order and disorder: implications for physiology and disease
2008
Transient 23–30 Hz oscillations in mouse hippocampus during exploration of novel environments
2008
A Role for REM Sleep in Recalibrating the Sensitivity of the Human Brain to Specific Emotions
2010
Coordination of circadian timing in mammals
2002 StandoutNature
The cognitive neuroscience of sleep: neuronal systems, consciousness and learning
2002
Genome-Wide Association Studies of Sleep Disorders
2011
Spikes and Bursts in Two Types of Thalamic Projection Neurons Differentially Shape Sleep Patterns and Auditory Responses in a Songbird
2008
Light Induction of a Vertebrate Clock Gene Involves Signaling through Blue-Light Receptors and MAP Kinases
2002 StandoutNobel
The energy hypothesis of sleep revisited
2008
Increased Sleep Fragmentation Leads to Impaired Off-Line Consolidation of Motor Memories in Humans
2012
The genetic and molecular regulation of sleep: from fruit flies to humans
2009
PLEIOTROPIC EFFECTS OF CRYPTOCHROMES 1 AND 2 ON FREE-RUNNING AND LIGHT-ENTRAINED MURINE CIRCADIAN RHYTHMS
2002 StandoutNobel
Leptin Activates Hypothalamic CART Neurons Projecting to the Spinal Cord
1998
Activation of EGFR and ERK by rhomboid signaling regulates the consolidation and maintenance of sleep in Drosophila
2007
PER3 Polymorphism Predicts Sleep Structure and Waking Performance
2007
Cholinergic Modulation of Purinergic and GABAergic Co-Transmission at In Vitro Hypothalamic Synapses
2002
The Metastasis Suppressor Gene KiSS-1 Encodes Kisspeptins, the Natural Ligands of the Orphan G Protein-coupled Receptor GPR54
2001 Standout
Prostanoid Receptors: Structures, Properties, and Functions
1999 Standout
Hypocretin (OREXIN): Role in Normal Behavior and Neuropathology
2004
Sleep disturbances and PTSD: a perpetual circle?
2012
Neurobiology of the Sleep-Wake Cycle: Sleep Architecture, Circadian Regulation, and Regulatory Feedback
2006
Systemic administration of hypocretin-1 reduces cataplexy and normalizes sleep and waking durations in narcoleptic dogs.
2000
Essential Role of BDNF in the Mesolimbic Dopamine Pathway in Social Defeat Stress
2006 StandoutScience
ACTIONS OF ADENOSINE AT ITS RECEPTORS IN THE CNS: Insights from Knockouts and Drugs
2004
Identification of SLEEPLESS, a Sleep-Promoting Factor
2008 Science
Regulation of C. elegans Life-Span by Insulinlike Signaling in the Nervous System
2000 StandoutScienceNobel
Ultrafast solvation dynamics at binding and active sites of photolyases
2010 StandoutNobel
Surprising gene expression patterns within and between PDF-containing circadian neurons in Drosophila
2010 StandoutNobel
Ghrelin-Induced Food Intake Is Mediated via the Orexin Pathway
2003
Synaptic plasticity in sleep: learning, homeostasis and disease
2011
Optogenetic disruption of sleep continuity impairs memory consolidation
2011
Control of Sleep and Wakefulness
2012
Reaction mechanism of Drosophila cryptochrome
2010 StandoutNobel
Circadian Rhythms: Mechanisms and Therapeutic Implications
2007
MAMMALIAN CIRCADIAN BIOLOGY: Elucidating Genome-Wide Levels of Temporal Organization
2004
The Ca V 3.3 calcium channel is the major sleep spindle pacemaker in thalamus
2011
Control of skin cancer by the circadian rhythm
2011 StandoutNobel
Regulation of apoptosis by the circadian clock through NF-κB signaling
2011 StandoutNobel
Melanopsin-Containing Retinal Ganglion Cells: Architecture, Projections, and Intrinsic Photosensitivity
2002 StandoutScience
About Sleep's Role in Memory
2013 Standout
The cancer connection
2002 StandoutNatureNobel
Genetics of Sleep
2008
Genetic contributions to generalized arousal of brain and behavior
2003 StandoutNobel
Pathophysiology of Sleep Apnea
2010 Standout
The role of hypoxia‐inducible factors in carotid body (patho) physiology
2018 StandoutNobel
Light-arousal and circadian photoreception circuits intersect at the large PDF cells of the Drosophila brain
2008 StandoutNobel
Adenosine in the tuberomammillary nucleus inhibits the histaminergic system via A1receptors and promotes non-rapid eye movement sleep
2008
It’s All in the Timing: Many Clocks, Many Outputs
2004
Neuroscience: Breaking Down Scientific Barriers to the Study of Brain and Mind
2000 StandoutScienceNobel
Immediate‐early genes in spontaneous wakefulness and sleep: expression of c‐fos and NGFI‐A mRNA and protein
1994
Coordinate Release of ATP and GABA at In VitroSynapses of Lateral Hypothalamic Neurons
2002
Nascent-Seq analysis of Drosophila cycling gene expression
2013 StandoutNobel
The CircadianClockMutation Alters Sleep Homeostasis in the Mouse
2000
A cryptochrome/photolyase class of enzymes with single-stranded DNA-specific photolyase activity
2006 StandoutNobel
PERIOD1-Associated Proteins Modulate the Negative Limb of the Mammalian Circadian Oscillator
2005 StandoutScienceNobel
Circadian control of XPA and excision repair of cisplatin-DNA damage by cryptochrome and HERC2 ubiquitin ligase
2010 StandoutNobel
2003
Determining complete electron flow in the cofactor photoreduction of oxidized photolyase
2013 StandoutNobel
Macromolecule biosynthesis: a key function of sleep
2007
Dynamics and mechanism of cyclobutane pyrimidine dimer repair by DNA photolyase
2011 StandoutNobel
Phototransduction by Retinal Ganglion Cells That Set the Circadian Clock
2002 StandoutScience
Phenotypic Rescue of a Peripheral Clock Genetic Defect via SCN Hierarchical Dominance
2002
Circadian neuron feedback controls the Drosophila sleep–activity profile
2016 StandoutNatureNobel
Mouse neurexin-1α deletion causes correlated electrophysiological and behavioral changes consistent with cognitive impairments
2009 StandoutNobel
Structure and Function of DNA Photolyase and Cryptochrome Blue-Light Photoreceptors
2003 StandoutNobel
Local sleep homeostasis in the avian brain: convergence of sleep function in mammals and birds?
2011
Works of Thomas E. Scammell being referenced
Orexin receptor 2 expression in the posterior hypothalamus rescues sleepiness in narcoleptic mice
2011
Distribution of fos-like immunoreactivity in the rat brain following intravenous lipopolysaccharide administration
1996
Activation of the basal forebrain by the orexin/hypocretin neurones
2009
Hypothalamic regulation of sleep and circadian rhythms
2005 StandoutNature
Sleep State Switching
2010
Melanopsin in cells of origin of the retinohypothalamic tract
2001
Afferents to the orexin neurons of the rat brain
2005
Orexin/Hypocretin: Wired for Wakefulness
2003
An adenosine A2a agonist increases sleep and induces Fos in ventrolateral preoptic neurons
2001
Effects of adenosine on gabaergic synaptic inputs to identified ventrolateral preoptic neurons
2003
Narcolepsy in orexin Knockout Mice
1999 Standout
Homeostatic, circadian, and emotional regulation of sleep
2005
Deletion of presynaptic adenosine A1 receptors impairs the recovery of synaptic transmission after hypoxia
2005
Behavioral State Instability in Orexin Knock-Out Mice
2004
Orexin Neurons Are Necessary for the Circadian Control of REM Sleep
2009
The neurobiology, diagnosis, and treatment of narcolepsy
2003
The sleep switch: hypothalamic control of sleep and wakefulness
2001
Wake-related activity of tuberomammillary neurons in rats
2003
Hyperthermia induces c-fos expression in the preoptic area
1993
Loss of hypocretin (orexin) neurons with traumatic brain injury
2009
Silent functional magnetic resonance imaging demonstrates focal activation in rapid eye movement sleep
1999
Fos Expression in Orexin Neurons Varies with Behavioral State
2001
Hypothalamic Arousal Regions Are Activated during Modafinil-Induced Wakefulness
2000
A consensus definition of cataplexy in mouse models of narcolepsy.
2009
Focal Deletion of the Adenosine A1 Receptor in Adult Mice Using an Adeno-Associated Viral Vector
2003
Afferents to the Ventrolateral Preoptic Nucleus
2002
Complementary roles of gasotransmitters CO and H2S in sleep apnea
2017 StandoutNobel
Thalamic Ca v 3.1 T-type Ca 2 + channel plays a crucial role in stabilizing sleep
2005 Nobel
Narcolepsy and low CSF orexin (hypocretin) concentration after a diencephalic stroke
2001
Regulation of Daily Locomotor Activity and Sleep by Hypothalamic EGF Receptor Signaling
2001 Science
Ventromedial Preoptic Prostaglandin E2 Activates Fever-Producing Autonomic Pathways
1996
Common scale-invariant patterns of sleep–wake transitions across mammalian species
2004
Activation of ventrolateral preoptic neurons by the somnogen prostaglandin D 2
1998
Orexin, drugs and motivated behaviors
2005
Critical Role of Dorsomedial Hypothalamic Nucleus in a Wide Range of Behavioral Circadian Rhythms
2003
Orexin (Hypocretin) Neurons Contain Dynorphin
2001
A Consensus Definition of Cataplexy in Mouse Models of Narcolepsy
2009