Standout Papers
- Solid-Phase Synthesis of Pyrroloisoquinolines via the Intramolecular N-Acyliminium Pictet−Spengler Reaction (2005)
- Solid-Phase Synthesis of Bicyclic Dipeptide Mimetics by Intramolecular Cyclization of Alcohols, Thiols, Amines, and Amides with N-Acyliminium Intermediates (2005)
- Click-Chemistry-Mediated Synthesis of Selective Melanocortin Receptor 4 Agonists (2017)
- Ralph F. Hirschmann award address 2009: Merger of organic chemistry with peptide diversity (2010)
- Divergent Pathway for the Solid-Phase Conversion of Aromatic Acetylenes to Carboxylic Acids, α-Ketocarboxylic Acids, and Methyl Ketones (2008)
- Solid-phase synthesis of complex and pharmacologically interesting heterocycles. (2009)
- Solid-Phase Synthesis of Carboxylic and Oxamic Acids via OsO4/NaIO4/HMTA-Mediated Oxidative Cleavage of Acetylenic Peptides (2007)
- Scaffold Diversity through Intramolecular Cascade Reactions of Solid-Supported Cyclic N-Acyliminium Intermediates (2007)
- Solid-Phase Intramolecular N-Acyliminium Pictet−Spengler Reactions as Crossroads to Scaffold Diversity (2004)
- N‐acyliminium intermediates in solid‐phase synthesis (2010)
- Solid-Phase Synthesis of Aryl-Substituted Thienoindolizines: Sequential Pictet−Spengler, Bromination and Suzuki Cross-Coupling Reactions of Thiophenes (2008)
- Highly Efficient Solid-Phase Oxidative Cleavage of Olefins by OsO4−NaIO4 in the Intramolecular N-Acyliminium Pictet−Spengler Reaction (2005)
- Solid-phase synthesis of biarylalanines via Suzuki cross-coupling and intramolecular N-acyliminium Pictet–Spengler reactions (2005)
- The Pictet-Spengler reaction in solid-phase combinatorial chemistry. (2003)
Citation Impact
Citing Papers
Expanded therapeutic potential in activity space of next-generation 5-nitroimidazole antimicrobials with broad structural diversity
2013 StandoutNobel
DNA-Encoded Chemical Libraries: A Selection System Based on Endowing Organic Compounds with Amplifiable Information
2018
Self-produced exopolysaccharide is a signal that stimulates biofilm formation in Pseudomonas aeruginosa
2012
Unified Synthesis of Polycyclic Alkaloids by Complementary Carbonyl Activation**
2021 StandoutNobel
High‐Throughput Quality Control Assay for the Solid‐Phase Synthesis of DNA‐Encoded Libraries of Macrocycles**
2021
Expansive discovery of chemically diverse structured macrocyclic oligoamides
2024 StandoutScienceNobel
De novo design of allosterically switchable protein assemblies
2024 StandoutNatureNobel
Accurate de novo design of heterochiral protein–protein interactions
2024 StandoutNobel
Targeting microbial biofilms: current and prospective therapeutic strategies
2017 Standout
MC4R Agonists: Structural Overview on Antiobesity Therapeutics
2018 StandoutNobel
Anti‐MRSA Agent Discovery Using Diversity‐Oriented Synthesis
2008
ESKAPEing the labyrinth of antibacterial discovery
2015
Recent advances in multicomponent reactions for diversity-oriented synthesis
2010
Single-sequence protein structure prediction using a language model and deep learning
2022
Synthesis of Small Molecules with High Scaffold Diversity: Exploitation of Metathesis Cascades in Combination with Inter‐ and Intramolecular Diels–Alder Reactions
2010
Diversity-oriented synthesis; a spectrum of approaches and results
2008
Quorum sensing signal–response systems in Gram-negative bacteria
2016 Standout
Catalytic Asymmetric Conjugate Addition/Oxidative Dearomatization Towards Multifunctional Spirocyclic Compounds
2011 StandoutNobel
Antimicrobial resistance, respiratory tract infections and role of biofilms in lung infections in cystic fibrosis patients
2014
Applications of Multicomponent Reactions to the Synthesis of Diverse Heterocyclic Scaffolds
2009
The Pictet–Spengler Reaction in Nature and in Organic Chemistry
2011 Standout
Recent Applications of Diversity-Oriented Synthesis Toward Novel, 3-Dimensional Fragment Collections
2018
Asymmetric spiroacetalization catalysed by confined Brønsted acids
2012 StandoutNatureNobel
Total synthesis of (−)-indolactam V
2011
A Multicomponent Reaction Towards N‐(Cyanomethyl)amides
2009
The discovery of antibacterial agents using diversity-oriented synthesis
2009
Extracellular DNA as a target for biofilm control
2014
Anti-biofilm peptides as a new weapon in antimicrobial warfare
2016
Diversity‐Oriented Synthesis of Polycyclic Scaffolds by Modification of an Anodic Product Derived from 2,4‐Dimethylphenol
2011
Chemical variation of natural product-like scaffolds: design and synthesis of spiroketal derivatives
2006
Solid‐Phase Synthesis of Tetrahydro‐β‐carbolines and Tetrahydroisoquinolines by Stereoselective Intramolecular N‐Carbamyliminium Pictet–Spengler Reactions
2006 StandoutNobel
The Organocatalytic Asymmetric Prins Cyclization
2015 StandoutNobel
Diversity‐Oriented Enantioselective Synthesis of Highly Functionalized Cyclic and Bicyclic Alcohols
2012 StandoutNobel
Multicomponent Reaction Design in the Quest for Molecular Complexity and Diversity
2011 Standout
Antibacterial drug discovery in the resistance era
2016 StandoutNature
Nitric Oxide: A Key Mediator of Biofilm Dispersal with Applications in Infectious Diseases
2014
Die organokatalytische asymmetrische Prins‐Cyclisierung
2015 StandoutNobel
Peganumine A, a β-Carboline Dimer with a New Octacyclic Scaffold from Peganum harmala
2014
Divergent and Expeditious Access to Fused Skeletons Inspired by Indole Alkaloids and Transtaganolides
2009
Enantioselective synthesis of 4,5,6,7-tetrahydroindoles via olefin cross-metathesis/intramolecular Friedel–Crafts alkylation reaction of pyrroles
2015
The Activation of Carboxylic Acids via Self-Assembly Asymmetric Organocatalysis: A Combined Experimental and Computational Investigation
2016 StandoutNobel
Catalytic Asymmetric Additions of Enol Silanes to In Situ Generated Cyclic, AliphaticN‐Acyliminium Ions
2021 StandoutNobel
A Novel Three-Component Reaction toward Dihydrooxazolopyridines
2008
Gold(I)-Catalyzed Coupling Reactions for the Synthesis of Diverse Small Molecules Using the Build/Couple/Pair Strategy
2009
Macrocycles in Drug Discovery─Learning from the Past for the Future
2023
The tert-Butylsulfinamide Lynchpin in Transition-Metal-Mediated Multiscaffold Library Synthesis
2010
Enantioselective Prins cyclization: BINOL-derived phosphoric acid and CuCl synergistic catalysis
2014
Skeletal and Stereochemical Diversification of Tricyclic Frameworks Inspired by Ca2+-ATPase Inhibitors, Artemisinin and Transtaganolide D
2008
Bioactivity-Guided Navigation of Chemical Space
2010
Antibiotic Adjuvants: Diverse Strategies for Controlling Drug‐Resistant Pathogens
2014
The Catalytic Asymmetric Mukaiyama–Michael Reaction of Silyl Ketene Acetals with α,β‐Unsaturated Methyl Esters
2017 StandoutNobel
A General Catalytic Asymmetric Prins Cyclization
2016 StandoutNobel
Diversity‐Oriented Syntheses by Combining CuAAC and Stereoselective INCIC Reactions with Peptides
2017 StandoutNobel
Strong and Confined Acids Catalyze Asymmetric Intramolecular Hydroarylations of Unactivated Olefins with Indoles
2021 StandoutNobel
Die Pictet‐Spengler‐Reaktion in der Natur und der organischen Chemie
2011
Chemical Proteomic Profiling of Human Methyltransferases
2016
Skeletally Diverse Small Molecules Using a Build/Couple/Pair Strategy
2009
Catalytic asymmetric synthesis of tetrahydrocarbazoles
2019
Recent advances in organocatalytic asymmetric Michael reactions
2011
Catalytic Asymmetric [4+2]-Cycloaddition of Dienes with Aldehydes
2017 StandoutNobel
Extremely Active Organocatalysts Enable a Highly Enantioselective Addition of Allyltrimethylsilane to Aldehydes
2016 StandoutNobel
Unveiling the Delicate Balance of Steric and Dispersion Interactions in Organocatalysis Using High-Level Computational Methods
2020 StandoutNobel
Addition and Correction to Complete Field Guide to Asymmetric BINOL-Phosphate Derived Brønsted Acid and Metal Catalysis: History and Classification by Mode of Activation; Brønsted Acidity, Hydrogen Bonding, Ion Pairing, and Metal Phosphates
2017
Scope and Limitations of an Efficient Four-Component Reaction for Dihydropyridin-2-ones
2010
The progress in the chemistry of N-acyliminium ions and their use in stereoselective organic synthesis
2016
Chemical space as a source for new drugs
2010
Biocompatible SuFEx Click Chemistry: Thionyl Tetrafluoride (SOF4)‐Derived Connective Hubs for Bioconjugation to DNA and Proteins
2019 StandoutNobel
Stereochemical and Skeletal Diversity Arising from Amino Propargylic Alcohols
2010
Stereodivergence in Asymmetric Catalysis
2017
The Catalytic Asymmetric Intermolecular Prins Reaction
2021 StandoutNobel
Unlocking Reactivity of TrpB: A General Biocatalytic Platform for Synthesis of Tryptophan Analogues
2017 StandoutNobel
Molecular diversity by design
2009 Nature
Cyclic di-GMP: the First 25 Years of a Universal Bacterial Second Messenger
2013 Standout
A Pictet-Spengler ligation for protein chemical modification
2012 StandoutNobel
Recent applications of click chemistry in drug discovery
2019
Unified Approach to Imidodiphosphate-Type Brønsted Acids with Tunable Confinement and Acidity
2021 StandoutNobel
Evolutionary-scale prediction of atomic-level protein structure with a language model
2023 StandoutScience
Synthetic Organic Electrochemical Methods Since 2000: On the Verge of a Renaissance
2017 Standout
Comprehensive Survey of Combinatorial Library Synthesis: 2005
2006
Insulin Treatment Modulates the Host Immune System To Enhance Pseudomonas aeruginosa Wound Biofilms
2013
Identification of simple arylfluorosulfates as potent agents against resistant bacteria
2021 StandoutNobel
The Combinatorial Synthesis of Bicyclic Privileged Structures or Privileged Substructures
2003 Standout
Engineering allosteric regulation in protein kinases
2018
Diversity Oriented Clicking (DOC): Divergent Synthesis of SuFExable Pharmacophores from 2‐Substituted‐Alkynyl‐1‐Sulfonyl Fluoride (SASF) Hubs
2020 StandoutNobel
Impact of Natural Products on Developing New Anti-Cancer Agents
2009 Standout
Rapid Assembly of Polyfunctional Structures Using a One‐Pot Five‐ and Six‐Component Sequential Groebke–Blackburn/Ugi/Passerini Process
2010
IDPi Catalysis
2019 StandoutNobel
Chiral Phosphoric Acid Catalyzed Conversion of Epoxides into Thiiranes: Mechanism, Stereochemical Model, and New Catalyst Design
2021 StandoutNobel
Strategies for the Diversity-Oriented Synthesis of Macrocycles
2019
Catalytic Asymmetric Intramolecular [4+2] Cycloaddition of In Situ Generated ortho‐Quinone Methides
2017 StandoutNobel
Asymmetric Catalysis via Cyclic, Aliphatic Oxocarbenium Ions
2017 StandoutNobel
Nitrated Confined Imidodiphosphates Enable a Catalytic Asymmetric Oxa-Pictet–Spengler Reaction
2016 StandoutNobel
Cu-Catalyzed Azide−Alkyne Cycloaddition
2008 StandoutNobel
Next generation diversity-oriented synthesis: a paradigm shift from chemical diversity to biological diversity
2018
Confinement-Controlled, Either syn- or anti-Selective Catalytic Asymmetric Mukaiyama Aldolizations of Propionaldehyde Enolsilanes
2021 StandoutNobel
“Inverse Drug Discovery” Strategy To Identify Proteins That Are Targeted by Latent Electrophiles As Exemplified by Aryl Fluorosulfates
2017 StandoutNobel
Catalytic Asymmetric Vinylogous Prins Cyclization: A Highly Diastereo- and Enantioselective Entry to Tetrahydrofurans
2016 StandoutNobel
Catalytic Asymmetric Conjugate Addition of Indolizines to α,β‐Unsaturated Ketones
2017 StandoutNobel
Generation of Anti-trypanosomal Agents through Concise Synthesis and Structural Diversification of Sesquiterpene Analogues
2011 StandoutNobel
Works of Thomas E. Nielsen being referenced
Synthesis of proteins by automated flow chemistry
2020 Science
Synthesis and biological evaluation of triazole-containing N-acyl homoserine lactones as quorum sensing modulators
2012
Allosteric small-molecule kinase inhibitors
2015
C-di-GMP regulates Pseudomonas aeruginosa stress response to tellurite during both planktonic and biofilm modes of growth
2015
Synthesis of Heterocycles through a Ruthenium‐Catalyzed Tandem Ring‐Closing Metathesis/Isomerization/N‐Acyliminium Cyclization Sequence
2011
Synthesis of tetrahydro-β-carbolines via isomerization of N-allyltryptamines: a metal-catalyzed variation on the Pictet–Spengler theme
2012
Ralph F. Hirschmann award address 2009: Merger of organic chemistry with peptide diversity
2010 StandoutNobel
Towards the Optimal Screening Collection: A Synthesis Strategy
2007
Synthesis of Oxacyclic Scaffolds via Dual Ruthenium Hydride/Brønsted Acid‐Catalyzed Isomerization/Cyclization of Allylic Ethers
2014
Small-molecule kinase inhibitors: an analysis of FDA-approved drugs
2015
Solid-Phase Synthesis of Pyrroloisoquinolines via the Intramolecular N-Acyliminium Pictet−Spengler Reaction
2005 StandoutNobel
Solid-Phase Intramolecular N-Acyliminium Pictet−Spengler Reactions as Crossroads to Scaffold Diversity
2004 StandoutNobel
Scaffold Diversity through Intramolecular Cascade Reactions of Solid-Supported Cyclic N-Acyliminium Intermediates
2007 StandoutNobel
Der optimale Molekülsatz für Screening‐Anwendungen: eine Synthesestrategie
2007
Extracellular DNA Shields against Aminoglycosides in Pseudomonas aeruginosa Biofilms
2013
Reductive Cyclization and Petasis‐Like Reaction for the Synthesis of Functionalized γ‐Lactams
2015
Solid-Phase Synthesis of Bicyclic Dipeptide Mimetics by Intramolecular Cyclization of Alcohols, Thiols, Amines, and Amides with N-Acyliminium Intermediates
2005 StandoutNobel
Solid-phase synthesis of biarylalanines via Suzuki cross-coupling and intramolecular N-acyliminium Pictet–Spengler reactions
2005 StandoutNobel
Solid-Phase Synthesis of Aryl-Substituted Thienoindolizines: Sequential Pictet−Spengler, Bromination and Suzuki Cross-Coupling Reactions of Thiophenes
2008 StandoutNobel
Click-Chemistry-Mediated Synthesis of Selective Melanocortin Receptor 4 Agonists
2017 StandoutNobel
Ruthenium Hydride/Brønsted Acid-Catalyzed Tandem Isomerization/N-Acyliminium Cyclization Sequence for the Synthesis of Tetrahydro-β-carbolines
2013
Comparative Systems Biology Analysis To Study the Mode of Action of the Isothiocyanate Compound Iberin on Pseudomonas aeruginosa
2014
Clearance of Pseudomonas aeruginosa Foreign-Body Biofilm Infections through Reduction of the Cyclic Di-GMP Level in the Bacteria
2013
Scaffold Diversity from N-Acyliminium Ions
2017
Fluorescence-Based Reporter for Gauging Cyclic Di-GMP Levels in Pseudomonas aeruginosa
2012
Identification of Five Structurally Unrelated Quorum-Sensing Inhibitors of Pseudomonas aeruginosa from a Natural-Derivative Database
2013
Catalytic Enantioselective Synthesis of Tetrahydocarbazoles and Exocyclic Pictet–Spengler-Type Reactions
2016