Citation Impact
Citing Papers
Complement and microglia mediate early synapse loss in Alzheimer mouse models
2016 StandoutScience
Tau: Enabler of diverse brain disorders and target of rapidly evolving therapeutic strategies
2021 Science
Neurodegenerative disease mutations in TREM2 reveal a functional surface and distinct loss-of-function mechanisms
2016
Diabetes and Alzheimer's Disease: Mechanisms and Nutritional Aspects
2018
Prion-like Properties of Tau Protein: The Importance of Extracellular Tau as a Therapeutic Target
2014
Roles of tau protein in health and disease
2017
Tau protein liquid–liquid phase separation can initiate tau aggregation
2018
Open questions for Alzheimer’s disease immunotherapy
2014
Tau aggregation and its interplay with amyloid-β
2014
Tau depletion prevents progressive blood-brain barrier damage in a mouse model of tauopathy
2015
Diverse Brain Myeloid Expression Profiles Reveal Distinct Microglial Activation States and Aspects of Alzheimer’s Disease Not Evident in Mouse Models
2018
The role of liquid–liquid phase separation in aggregation of the TDP-43 low-complexity domain
2019 Standout
Chronic Optogenetic Activation Augments Aβ Pathology in a Mouse Model of Alzheimer Disease
2015
Impact of TREM2 risk variants on brain region-specific immune activation and plaque microenvironment in Alzheimer’s disease patient brain samples
2019
Parkinson disease
2017 Standout
TREM2 in Neurodegenerative Diseases
2017
Glymphatic distribution of CSF-derived apoE into brain is isoform specific and suppressed during sleep deprivation
2016
Untangling Genetic Risk for Alzheimer’s Disease
2017
Interactions between the microbiota, immune and nervous systems in health and disease
2017 Standout
Microglia in neurodegeneration
2018
CD22 blockade restores homeostatic microglial phagocytosis in ageing brains
2019 StandoutNatureNobel
Tau-imaging in neurodegeneration
2017
The glymphatic pathway in neurological disorders
2018 Standout
Oxidative stress, dysfunctional glucose metabolism and Alzheimer disease
2019 Standout
The TREM2-DAP12 signaling pathway in Nasu–Hakola disease: a molecular genetics perspective
2015
Opposing effects of progranulin deficiency on amyloid and tau pathologies via microglial TYROBP network
2017
Immune hyperreactivity of Aβ plaque-associated microglia in Alzheimer's disease
2017
Pharmacological targeting of CSF1R inhibits microglial proliferation and prevents the progression of Alzheimer’s-like pathology
2016
The Neurovascular Unit Coming of Age: A Journey through Neurovascular Coupling in Health and Disease
2017 Standout
What happens to microglial TREM2 in Alzheimer’s disease: Immunoregulatory turned into immunopathogenic?
2014
Microglia emerge as central players in brain disease
2017
TREM2 variants: new keys to decipher Alzheimer disease pathogenesis
2016
Optogenetics: 10 years of microbial opsins in neuroscience
2015 Standout
Ageing as a risk factor for neurodegenerative disease
2019 Standout
The Triggering Receptor Expressed on Myeloid Cells 2: A Molecular Link of Neuroinflammation and Neurodegenerative Diseases
2015
Tetraspanin 6: a pivotal protein of the multiple vesicular body determining exosome release and lysosomal degradation of amyloid precursor protein fragments
2017
Depletion of microglia and inhibition of exosome synthesis halt tau propagation
2015
TREM2 Haplodeficiency in Mice and Humans Impairs the Microglia Barrier Function Leading to Decreased Amyloid Compaction and Severe Axonal Dystrophy
2016
Immunotherapeutic Approaches for Alzheimer’s Disease
2015
Interaction between microbiota and immunity in health and disease
2020 Standout
Local and systemic mechanisms linking periodontal disease and inflammatory comorbidities
2021 Standout
Neuronal uptake of tau/pS422 antibody and reduced progression of tau pathology in a mouse model of Alzheimer‘s disease
2014
Tau in physiology and pathology
2015 Standout
Blood–brain barrier breakdown in Alzheimer disease and other neurodegenerative disorders
2018 Standout
Overcoming the challenges in administering biopharmaceuticals: formulation and delivery strategies
2014
TREM2 Binds to Apolipoproteins, Including APOE and CLU/APOJ, and Thereby Facilitates Uptake of Amyloid-Beta by Microglia
2016
TREM2 Lipid Sensing Sustains the Microglial Response in an Alzheimer’s Disease Model
2015 Standout
Elevated TREM2 Gene Dosage Reprograms Microglia Responsivity and Ameliorates Pathological Phenotypes in Alzheimer’s Disease Models
2018
Immune attack: the role of inflammation in Alzheimer disease
2015 Standout
Implications of GABAergic Neurotransmission in Alzheimer’s Disease
2016
The Cellular Phase of Alzheimer’s Disease
2016
Gut Microbiota Regulate Motor Deficits and Neuroinflammation in a Model of Parkinson’s Disease
2016 Standout
Alzheimer Disease: An Update on Pathobiology and Treatment Strategies
2019 Standout
Shedding light on the cell biology of extracellular vesicles
2018 Standout
Inflammation and Oxidative Stress: The Molecular Connectivity between Insulin Resistance, Obesity, and Alzheimer’s Disease
2015
PEGylation as a strategy for improving nanoparticle-based drug and gene delivery
2015 Standout
Macrophages in Tissue Repair, Regeneration, and Fibrosis
2016 Standout
Parkinson's disease
2015 Standout
Gut microbiome alterations in Alzheimer’s disease
2017 Standout
Tau Monoclonal Antibody Generation Based on Humanized Yeast Models
2014
TREM2 Maintains Microglial Metabolic Fitness in Alzheimer’s Disease
2017
α-Synuclein Immunotherapy Blocks Uptake and Templated Propagation of Misfolded α-Synuclein and Neurodegeneration
2014
Lipid-droplet-accumulating microglia represent a dysfunctional and proinflammatory state in the aging brain
2020 StandoutNobel
The clinical impact of glycobiology: targeting selectins, Siglecs and mammalian glycans
2021 StandoutNobel
HNE-modified proteins in Down syndrome: Involvement in development of Alzheimer disease neuropathology
2016
Alzheimer's disease
2016 Standout
Role of metabolic programming in the modulation of microglia phagocytosis by lipids
2018
TREM2 regulates microglial cell activation in response to demyelination in vivo
2015
“New Old Pathologies”: AD, PART, and Cerebral Age-Related TDP-43 With Sclerosis (CARTS)
2016
PROTAC targeted protein degraders: the past is prologue
2022 Standout
The Triggering Receptor Expressed on Myeloid Cells 2 Binds Apolipoprotein E
2015
TREM2 deficiency exacerbates tau pathology through dysregulated kinase signaling in a mouse model of tauopathy
2017
Plaque-Associated Local Toxicity Increases over the Clinical Course of Alzheimer Disease
2015
The Intersection of Amyloid Beta and Tau at Synapses in Alzheimer’s Disease
2014
Distinct Tau Prion Strains Propagate in Cells and Mice and Define Different Tauopathies
2014
Reactive Astrocytes: Production, Function, and Therapeutic Potential
2017 Standout
Disease Progression-Dependent Effects of TREM2 Deficiency in a Mouse Model of Alzheimer's Disease
2016
Biomarkers of Traumatic Injury Are Transported from Brain to Blood via the Glymphatic System
2015
Increased tauopathy drives microglia-mediated clearance of beta-amyloid
2016
Apolipoprotein E as a Therapeutic Target in Alzheimer’s Disease: A Review of Basic Research and Clinical Evidence
2016
Understanding the Role of ApoE Fragments in Alzheimer’s Disease
2018
Impairment of Glymphatic Pathway Function Promotes Tau Pathology after Traumatic Brain Injury
2014
Passive Immunization with Tau Oligomer Monoclonal Antibody Reverses Tauopathy Phenotypes without Affecting Hyperphosphorylated Neurofibrillary Tangles
2014
Reassessment of Exosome Composition
2019 Standout
Microglial signatures and their role in health and disease
2018
Lysosome-targeting chimaeras for degradation of extracellular proteins
2020 StandoutNatureNobel
Molecular Chaperone Accumulation in Cancer and Decrease in Alzheimer's Disease: The Potential Roles of HSF1
2017
The preclinical phase of the pathological process underlying sporadic Alzheimer’s disease
2015
The road to restoring neural circuits for the treatment of Alzheimer's disease
2016 Nature
TREM2 Acts Downstream of CD33 in Modulating Microglial Pathology in Alzheimer’s Disease
2019
Reconsideration of Amyloid Hypothesis and Tau Hypothesis in Alzheimer's Disease
2018
A Unique Microglia Type Associated with Restricting Development of Alzheimer’s Disease
2017 Standout
Single-cell transcriptomic analysis of Alzheimer’s disease
2019 StandoutNature
Inflammation in obesity, diabetes, and related disorders
2022 Standout
Neuroinflammation and microglial activation in Alzheimer disease: where do we go from here?
2020 Standout
Antibiotic-induced perturbations in gut microbial diversity influences neuro-inflammation and amyloidosis in a murine model of Alzheimer’s disease
2016
Clearance systems in the brain—implications for Alzheimer disease
2015
Inflammation in Alzheimer’s disease: Lessons learned from microglia-depletion models
2016
The amyloid hypothesis of Alzheimer's disease at 25 years
2016 Standout
TREM2 deficiency reduces the efficacy of immunotherapeutic amyloid clearance
2016
The Triangle of Death in Alzheimer's Disease Brain: The Aberrant Cross-Talk Among Energy Metabolism, Mammalian Target of Rapamycin Signaling, and Protein Homeostasis Revealed by Redox Proteomics
2016
Comprehensive Review on Alzheimer’s Disease: Causes and Treatment
2020 Standout
Targeted degradation of aberrant tau in frontotemporal dementia patient-derived neuronal cell models
2019
Erythromyeloid-Derived TREM2: A Major Determinant of Alzheimer’s Disease Pathology in Down Syndrome
2017
Lecanemab in Early Alzheimer’s Disease
2022 Standout
Myeloid Cells in the Central Nervous System
2017
TREM2 deficiency eliminates TREM2+ inflammatory macrophages and ameliorates pathology in Alzheimer’s disease mouse models
2015
Immunotherapy in Parkinson’s Disease: Micromanaging Alpha-Synuclein Aggregation
2015
Replacement of brain-resident myeloid cells does not alter cerebral amyloid-β deposition in mouse models of Alzheimer’s disease
2015
Endoplasmic reticulum-associated SKN-1A/Nrf1 mediates a cytoplasmic unfolded protein response and promotes longevity
2019 StandoutNobel
Plaque‐dependent morphological and electrophysiological heterogeneity of microglia in an A lzheimer's disease mouse model
2018
Tau reduction prevents neuronal loss and reverses pathological tau deposition and seeding in mice with tauopathy
2017
Inflammation as a central mechanism in Alzheimer's disease
2018 Standout
Slow wave sleep disruption increases cerebrospinal fluid amyloid-β levels
2017
Disease Progression-Dependent Effects of TREM2 Deficiency in a Mouse Model of Alzheimer's Disease
2017
Microglia Function in the Central Nervous System During Health and Neurodegeneration
2017 Standout
Tau Protein Hyperphosphorylation and Aggregation in Alzheimer’s Disease and Other Tauopathies, and Possible Neuroprotective Strategies
2016
New insights on the role of microglia in synaptic pruning in health and disease
2015
DAMP-sensing receptors in sterile inflammation and inflammatory diseases
2019 Standout
A dural lymphatic vascular system that drains brain interstitial fluid and macromolecules
2015 Standout
How neuroinflammation contributes to neurodegeneration
2016 StandoutScience
Extracellular Vesicles Containing P301L Mutant Tau Accelerate Pathological Tau Phosphorylation and Oligomer Formation but Do Not Seed Mature Neurofibrillary Tangles in ALZ17 Mice
2016
The biology , function , and biomedical applications of exosomes
2020 StandoutScience
Higher Peripheral TREM2 mRNA Levels Relate to Cognitive Deficits and Hippocampal Atrophy in Alzheimer’s Disease and Amnestic Mild Cognitive Impairment
2017
Microglia in Alzheimer’s disease
2017
Impact of peripheral myeloid cells on amyloid-β pathology in Alzheimer’s disease–like mice
2015
Targeting neuroinflammation in Alzheimer’s disease: evidence for NSAIDs and novel therapeutics
2016
Direct Evidence of Internalization of Tau by Microglia In Vitro and In Vivo
2016
Microglia contributes to plaque growth by cell death due to uptake of amyloid β in the brain of Alzheimer's disease mouse model
2016
TREM2 deficiency attenuates neuroinflammation and protects against neurodegeneration in a mouse model of tauopathy
2017
Works of Thomas E. Mahan being referenced
The sleep-wake cycle regulates brain interstitial fluid tau in mice and CSF tau in humans
2019 Science
High‐affinity interactions and signal transduction between Aβ oligomers and TREM 2
2018
Potential role of orexin and sleep modulation in the pathogenesis of Alzheimer’s disease
2014
Altered microglial response to Aβ plaques in APPPS1-21 mice heterozygous for TREM2
2014
In vivo measurement of apolipoprotein E from the brain interstitial fluid using microdialysis
2013
Anti-Tau Antibodies that Block Tau Aggregate Seeding In Vitro Markedly Decrease Pathology and Improve Cognition In Vivo
2013
Age-Dependent Effects of apoE Reduction Using Antisense Oligonucleotides in a Model of β-amyloidosis
2017
Effects of growth hormone–releasing hormone on sleep and brain interstitial fluid amyloid-β in an APP transgenic mouse model
2014
Effects of CD2-associated protein deficiency on amyloid-β in neuroblastoma cells and in an APP transgenic mouse model
2015
Anti-ApoE Antibody Given after Plaque Onset Decreases Aβ Accumulation and Improves Brain Function in a Mouse Model of Aβ Amyloidosis
2014
Analysis of in vivo turnover of tau in a mouse model of tauopathy
2015
Hyperglycemia modulates extracellular amyloid-β concentrations and neuronal activity in vivo
2015
Anti‐tau antibody reduces insoluble tau and decreases brain atrophy
2015
ApoE facilitates the microglial response to amyloid plaque pathology
2018
Proteopathic tau seeding predicts tauopathy in vivo
2014
TREM2-mediated early microglial response limits diffusion and toxicity of amyloid plaques
2016
Neuronal activity regulates extracellular tau in vivo
2014