Standout Papers
Citation Impact
Citing Papers
Complexin Controls the Force Transfer from SNARE Complexes to Membranes in Fusion
2009 StandoutScienceNobel
A balance between excitatory and inhibitory synapses is controlled by PSD-95 and neuroligin
2004
Single Reconstituted Neuronal SNARE Complexes Zipper in Three Distinct Stages
2012 StandoutScienceNobel
SNARE Proteins: One to Fuse and Three to Keep the Nascent Fusion Pore Open
2012 StandoutScienceNobel
SNARE Function Analyzed in Synaptobrevin/VAMP Knockout Mice
2001 StandoutScienceNobel
SNARE-complex disassembly by NSF follows synaptic-vesicle fusion
2001
A Neural Circuit for Memory Specificity and Generalization
2013 StandoutScienceNobel
Conformational Switch of Syntaxin-1 Controls Synaptic Vesicle Fusion
2008 StandoutScienceNobel
A Neuroligin-3 Mutation Implicated in Autism Increases Inhibitory Synaptic Transmission in Mice
2007 StandoutScienceNobel
Video-Rate Far-Field Optical Nanoscopy Dissects Synaptic Vesicle Movement
2008 StandoutScienceNobel
A Clamping Mechanism Involved in SNARE-Dependent Exocytosis
2006 Science
Binding to Rab3A-interacting Molecule RIM Regulates the Presynaptic Recruitment of Munc13-1 and ubMunc13-2
2006
Convergence and divergence in the mechanism of SNARE binding by Sec1/Munc18-like proteins
2002 StandoutNobel
Developmental refinement of hair cell synapses tightens the coupling of Ca 2 + influx to exocytosis
2014 StandoutNobel
Crystal Structure of the Second LNS/LG Domain from Neurexin 1α
2006 StandoutNobel
Regulation of a DLK-1 and p38 MAP Kinase Pathway by the Ubiquitin Ligase RPM-1 Is Required for Presynaptic Development
2005
Ca2+-dependent splicing of neurexin IIα
2006
Temperature-Sensitive Paralytic Mutations Demonstrate that Synaptic Exocytosis Requires SNARE Complex Assembly and Disassembly
1998
Understanding Synapses: Past, Present, and Future
2008 StandoutNobel
Neuroligin 2 is exclusively localized to inhibitory synapses
2004
Early steps in the assembly of photoreceptor ribbon synapses in the mouse retina: The involvement of precursor spheres
2008
The riddle of the Sec1/Munc-18 proteins – new twists added to their interactions with SNAREs
2003
Syntaxin and synaptobrevin function downstream of vesicle docking in drosophila
1995
Sec18p (NSF)-Driven Release of Sec17p (α-SNAP) Can Precede Docking and Fusion of Yeast Vacuoles
1996
SNARE Complex Oligomerization by Synaphin/Complexin Is Essential for Synaptic Vesicle Exocytosis
2001
Probing Vesicle Dynamics in Single Hippocampal Synapses
2005
SNAREs and SNARE regulators in membrane fusion and exocytosis
1999
Vesicle trafficking: pleasure and pain from SM genes
2003
Putting the clamps on membrane fusion: How complexin sets the stage for calcium‐mediated exocytosis
2007
Molecular mechanisms of COMPLEXIN fusion clamp function in synaptic exocytosis revealed in a new Drosophila mutant
2013
Distinct domains of complexin I differentially regulate neurotransmitter release
2007
Membrane Tethering and Fusion in the Secretory and Endocytic Pathways
2000
Molecular mechanisms of active zone function
2003
Functional and physical coupling of voltage‐sensitive calcium channels with exocytotic proteins: ramifications for the secretion mechanism
2001
The cancer glycocalyx mechanically primes integrin-mediated growth and survival
2014 StandoutNatureNobel
Neuroligin‐3 is a neuronal adhesion protein at GABAergic and glutamatergic synapses
2007
α-Latrotoxin and Its Receptors
2007
A complexin fusion clamp regulates spontaneous neurotransmitter release and synaptic growth
2007
Differential regulation of evoked and spontaneous neurotransmitter release by C-terminal modifications of complexin
2012
Genomic definition of RIM proteins: evolutionary amplification of a family of synaptic regulatory proteins☆☆Sequence data from this article have been deposited with the GenBank Data Library under Accession Nos. AF548738 and AF548739.
2003 StandoutNobel
N-Ethylmaleimide-sensitive Factor Acts at a Prefusion ATP-dependent Step in Ca2+-activated Exocytosis
1996
Structural Basis for Variant-Specific Neuroligin-Binding by α-Neurexin
2011
Munc18-1 Promotes Large Dense-Core Vesicle Docking
2001 StandoutNobel
The diverse roles of ribbon synapses in sensory neurotransmission
2010
The neuroligin and neurexin families: from structure to function at the synapse
2006
C-Terminal Complexin Sequence Is Selectively Required for Clamping and Priming But Not for Ca2+Triggering of Synaptic Exocytosis
2012 StandoutNobel
Formation of Golgi-Derived Active Zone Precursor Vesicles
2012
Drosophila CAPS Is an Essential Gene that Regulates Dense-Core Vesicle Release and Synaptic Vesicle Fusion
2001
Otoferlin: a multi-C2 domain protein essential for hearing
2012
Activity-dependent changes in partial VAMP complexes during neurotransmitter release
1999
Molecular anatomy and physiology of exocytosis in sensory hair cells
2012
Cooperation of Syd-1 with Neurexin synchronizes pre- with postsynaptic assembly
2012
Local routes revisited: the space and time dependence of the Ca2+ signal for phasic transmitter release at the rat calyx of Held
2003 Nobel
Complexins: Cytosolic proteins that regulate SNAP receptor function
1995
Snares and munc18 in synaptic vesicle fusion
2002 StandoutNobel
Hemifusion arrest by complexin is relieved by Ca2+–synaptotagmin I
2006
Docking of Secretory Vesicles Is Syntaxin Dependent
2006
Genomewide suggestive linkage of opioid dependence to chromosome 14q
2007
Structure and function of SNARE and SNARE-interacting proteins
2005
The sequence of events that underlie quantal transmission at central glutamatergic synapses
2007
Molecular basis of ancestral vertebrate electroreception
2017 StandoutNatureNobel
Structural and functional plasticity of the cytoplasmic active zone
2010
Neurexin–neuroligin signaling in synapse development
2007
Structures of Neuroligin-1 and the Neuroligin-1/Neurexin-1β Complex Reveal Specific Protein-Protein and Protein-Ca2+ Interactions
2007 StandoutNobel
Molecular mechanisms of CNS synaptogenesis
2002
FMRP Stalls Ribosomal Translocation on mRNAs Linked to Synaptic Function and Autism
2011 Standout
Binding of the complexin N terminus to the SNARE complex potentiates synaptic-vesicle fusogenicity
2010
The Presynaptic Active Zone Protein Bassoon Is Essential for Photoreceptor Ribbon Synapse Formation in the Retina
2003
Crystal Structures of β-Neurexin 1 and β-Neurexin 2 Ectodomains and Dynamics of Splice Insertion Sequence 4
2008
Neuroligins Determine Synapse Maturation and Function
2006 StandoutNobel
Neurexin Iβ and neuroligin are localized on opposite membranes in mature central synapses
2007
Synaptic vesicle fusion
2008
The Molecular Architecture of Ribbon Presynaptic Terminals
2009
The N-Ethylmaleimide-sensitive Fusion Protein and α-SNAP Induce a Conformational Change in Syntaxin
1995
Local Calcium Signaling in Neurons
2003
MAGUKs in synapse assembly and function: an emerging view
2004
Actin has a molecular scaffolding, not propulsive, role in presynaptic function
2003
Synaptic Vesicles Position Complexin to Block Spontaneous Fusion
2013
Regulatory roles of complexins in neurotransmitter release from mature presynaptic nerve terminals
1998
Compartmental specificity of cellular membrane fusion encoded in SNARE proteins
2000 StandoutNatureNobel
Septins Regulate Developmental Switching from Microdomain to Nanodomain Coupling of Ca2+ Influx to Neurotransmitter Release at a Central Synapse
2010
Two functionally distinct α2-adrenergic receptors regulate sympathetic neurotransmission
1999 StandoutNatureNobel
Membrane-Tethered Monomeric Neurexin LNS-Domain Triggers Synapse Formation
2013 StandoutNobel
Interaction of the ERC Family of RIM-binding Proteins with the Liprin-α Family of Multidomain Proteins
2003
Bassoon and Piccolo maintain synapse integrity by regulating protein ubiquitination and degradation
2013
For Better or for Worse: Complexins Regulate SNARE Function and Vesicle Fusion
2008
Differential Regulation of Synaptic Vesicle Tethering and Docking by UNC-18 and TOM-1
2010
Defects in synaptic vesicle docking in unc-18 mutants
2003
Synaptic Arrangement of the Neuroligin/β-Neurexin Complex Revealed by X-Ray and Neutron Scattering
2007
Computational redesign of endonuclease DNA binding and cleavage specificity
2006 StandoutNatureNobel
Bruchpilot in Ribbon-Like Axonal Agglomerates, Behavioral Defects, and Early Death in SRPK79D Kinase Mutants of Drosophila
2009
Single Molecule Mechanical Probing of the SNARE Protein Interactions
2006
Molecular organization of the presynaptic active zone
2006
A possible docking and fusion particle for synaptic transmission
1995 Nature
Regulation of Membrane Fusion in Synaptic Excitation-Secretion Coupling: Speed and Accuracy Matter
2007
Neuroligins and neurexins link synaptic function to cognitive disease
2008 StandoutNatureNobel
Distinct Subsets of Syt-IV/BDNF Vesicles Are Sorted to Axons versus Dendrites and Recruited to Synapses by Activity
2012 StandoutNobel
Distinct Domains of Complexins Bind SNARE Complexes and Clamp Fusion in Vitro
2008 StandoutNobel
Redundant functions of RIM1α and RIM2α in Ca2+‐triggered neurotransmitter release
2006 StandoutNobel
Some assembly required: the development of neuronal synapses
2003
Molecular form follows function: (un)snaring the SNAREs
2008
A dual-Ca2+-sensor model for neurotransmitter release in a central synapse
2007 StandoutNatureNobel
Glutamate receptor dynamics organizing synapse formation in vivo
2005
Bruchpilot, a Protein with Homology to ELKS/CAST, Is Required for Structural Integrity and Function of Synaptic Active Zones in Drosophila
2006
The GIT Family of Proteins Forms Multimers and Associates with the Presynaptic Cytomatrix Protein Piccolo
2003
The PtdIns(3,4)P2 phosphatase INPP4A is a suppressor of excitotoxic neuronal death
2010 StandoutNatureNobel
ELKS, a protein structurally related to the active zone protein CAST, is involved in Ca2+‐dependent exocytosis from PC12 cells
2006
Crystal Structure of the Vesicular Transport Protein Sec17
1999
Destabilization of the Postsynaptic Density by PSD-95 Serine 73 Phosphorylation Inhibits Spine Growth and Synaptic Plasticity
2008
Complexin activates and clamps SNAREpins by a common mechanism involving an intermediate energetic state
2011 StandoutNobel
Molecular tuning of electroreception in sharks and skates
2018 StandoutNatureNobel
Comparative analysis of Drosophila and mammalian complexins as fusion clamps and facilitators of neurotransmitter release
2010
Retrograde modulation of presynaptic release probability through signaling mediated by PSD-95–neuroligin
2007
Direct interaction of SNARE complex binding protein synaphin/complexin with calcium sensor synaptotagmin 1
2008
Systematic analysis of genes required for synapse structure and function
2005 StandoutNatureNobel
Postsynaptic neuroligin enhances presynaptic inputs at neuronal nicotinic synapses
2007
Cdk5 Regulates the Phosphorylation of Tyrosine 1472 NR2B and the Surface Expression of NMDA Receptors
2008
Activity-Dependent Validation of Excitatory versus Inhibitory Synapses by Neuroligin-1 versus Neuroligin-2
2007 StandoutNobel
Silencing of Neuroligin Function by Postsynaptic Neurexins
2007
Calcium-dependent interaction of N-type calcium channels with the synaptic core complex
1996 Nature
Tilting the Balance between Facilitatory and Inhibitory Functions of Mammalian and Drosophila Complexins Orchestrates Synaptic Vesicle Exocytosis
2009
Complexin and Ca2+ stimulate SNARE-mediated membrane fusion
2008
Complexin Activates Exocytosis of Distinct Secretory Vesicles Controlled by Different Synaptotagmins
2013 StandoutNobel
Syntaxin 1A Interacts with Multiple Exocytic Proteins to Regulate Neurotransmitter Release In Vivo
1999
Transsynaptic modulation of the synaptic vesicle cycle by cell‐adhesion molecules
2007
Localization of the presynaptic cytomatrix protein Piccolo at ribbon and conventional synapses in the rat retina: Comparison with Bassoon
2001
Structural basis for synaptic adhesion mediated by neuroligin-neurexin interactions
2007
Mechanisms of Synapse Assembly and Disassembly
2003
Complexin-I Is Required for High-Fidelity Transmission at the Endbulb of Held Auditory Synapse
2009
Neurexin 3 polymorphisms are associated with alcohol dependence and altered expression of specific isoforms
2007
Differential expression of active zone proteins in neuromuscular junctions suggests functional diversification
2006 StandoutNobel
α-Neurexins couple Ca2+ channels to synaptic vesicle exocytosis
2003 StandoutNatureNobel
Neuroligin‐1 performs neurexin‐dependent and neurexin‐independent functions in synapse validation
2009 StandoutNobel
A Protein Interaction Node at the Neurotransmitter Release Site: Domains of Aczonin/Piccolo, Bassoon, CAST, and Rim Converge on the N-Terminal Domain of Munc13-1
2009
STED microscopy reveals that synaptotagmin remains clustered after synaptic vesicle exocytosis
2006 StandoutNatureNobel
Cast
2002
THE SYNAPTIC VESICLE CYCLE
2004 StandoutNobel
The carboxy-terminal domain of complexin I stimulates liposome fusion
2009
Molecular Mechanisms of Presynaptic Differentiation
2008
Dynein light chain regulates axonal trafficking and synaptic levels of Bassoon
2009
Expression of Multiple UNC-13 Proteins in theCaenorhabditis elegansNervous System
2000
The Postsynaptic Architecture of Excitatory Synapses: A More Quantitative View
2007
Postsynaptic Membrane Fusion and Long-Term Potentiation
1998 StandoutScienceNobel
Ordering the Final Events in Yeast Exocytosis
2000
Synaptic Physiology and Ultrastructure incomatoseMutants Define anIn VivoRole for NSF in Neurotransmitter Release
1998
Mechanisms of Synaptic Vesicle Exocytosis
2000
RIM-Binding Protein, a Central Part of the Active Zone, Is Essential for Neurotransmitter Release
2011 StandoutScienceNobel
The Architecture of the Active Zone in the Presynaptic Nerve Terminal
2004
Structural basis for the Golgi membrane recruitment of Sly1p by Sed5p
2002
NSF Function in Neurotransmitter Release Involves Rearrangement of the SNARE Complex Downstream of Synaptic Vesicle Docking
1998
The mammalian central nervous synaptic cleft contains a high density of periodically organized complexes
2005 StandoutNobel
Aberrant function and structure of retinal ribbon synapses in the absence of complexin 3 and complexin 4
2009
Bruchpilot Promotes Active Zone Assembly, Ca 2+ Channel Clustering, and Vesicle Release
2006 StandoutScienceNobel
Anatomy and Dynamics of a Supramolecular Membrane Protein Cluster
2007 StandoutScienceNobel
Piccolo modulation of Synapsin1a dynamics regulates synaptic vesicle exocytosis
2008
Protein Sorting by Transport Vesicles
1996 StandoutScienceNobel
Binding of Munc18-1 to Synaptobrevin and to the SNARE Four-Helix Bundle
2010
Syntaxin Modulation of Calcium Channels in Cortical Synaptosomes As Revealed by Botulinum Toxin C1
2000
PRESYNAPTIC RECEPTORS
1998
Balancing Structure and Function at Hippocampal Dendritic Spines
2008
Molecular dissection of the photoreceptor ribbon synapse
2005
Membrane Fusion: Grappling with SNARE and SM Proteins
2009 StandoutScienceNobel
Clostridial neurotoxins compromise the stability of a low energy SNARE complex mediating NSF activation of synaptic vesicle fusion.
1995
Nucleation of COPII Vesicular Coat Complex by Endoplasmic Reticulum to Golgi Vesicle SNAREs
1998 StandoutScienceNobel
Physical and functional interaction of the active zone proteins, CAST, RIM1, and Bassoon, in neurotransmitter release
2004
Piccolo and bassoon maintain synaptic vesicle clustering without directly participating in vesicle exocytosis
2010 StandoutNobel
Yeast Homotypic Vacuole Fusion: A Window on Organelle Trafficking Mechanisms
2000
Deconstructing complexin function in activating and clamping Ca 2+ -triggered exocytosis by comparing knockout and knockdown phenotypes
2013 StandoutNobel
Complexin II plays a positive role in Ca 2+ -triggered exocytosis by facilitating vesicle priming
2008
Works of Thomas Dresbach being referenced
Exchange and Redistribution Dynamics of the Cytoskeleton of the Active Zone Molecule Bassoon
2009
The X-ray crystal structure of neuronal Sec1 from squid sheds new light on the role of this protein in exocytosis
2000
The presynaptic cytomatrix of brain synapses
2001
Crystallization and preliminary X-ray analysis of squid neuronal Sec1
2000
Postsynaptic Density Assembly Is Fundamentally Different from Presynaptic Active Zone Assembly
2004
SNAP-mediated protein–protein interactions essential for neurotransmitter release
1995 StandoutNatureNobel
Investigating Interactions Mediated by the Presynaptic Protein Bassoon in Living Cells by Foerster's Resonance Energy Transfer and Fluorescence Lifetime Imaging Microscopy
2007
Functional regions of the presynaptic cytomatrix protein bassoon: significance for synaptic targeting and cytomatrix anchoring
2003
Local Sharing as a Predominant Determinant of Synaptic Matrix Molecular Dynamics
2006
Assembly of Active Zone Precursor Vesicles
2005
Neuroligins and neurexins: linking cell adhesion, synapse formation and cognitive function
2005
Unitary Assembly of Presynaptic Active Zones from Piccolo-Bassoon Transport Vesicles
2003
Synaptic targeting of neuroligin is independent of neurexin and SAP90/PSD95 binding
2004
Polarized Targeting of Neurexins to Synapses Is Regulated by their C-Terminal Sequences
2008
A Neuronal Sec1 Homolog Regulates Neurotransmitter Release at the Squid Giant Synapse
1998
Structurally and functionally unique complexins at retinal ribbon synapses
2005
Disruption of syntaxin-mediated protein interactions blocks neurotransmitter secretion
1997
Postsynaptic Neuroligin1 regulates presynaptic maturation
2009
Regulation of Neurotransmitter Release Kinetics by NSF
1998 Science