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Citing Papers
Complement Factor H Polymorphism and Age-Related Macular Degeneration
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2004 StandoutNobel
Complement Factor H Polymorphism in Age-Related Macular Degeneration
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Advanced Atherosclerotic Foam Cell Formation Has Features of an Acquired Lysosomal Storage Disorder
2006
Drusen associated with aging and age‐related macular degeneration contain proteins common to extracellular deposits associated with atherosclerosis, elastosis, amyloidosis, and dense deposit disease
2000
Differential expression of ACAT1 and ACAT2 among cells within liver, intestine, kidney, and adrenal of nonhuman primates
2000
Human apolipoprotein A-I prevents atherosclerosis associated with apolipoprotein[a] in transgenic mice.
1994
Identification of the Interaction Site within Acyl-CoA:Cholesterol Acyltransferase 2 for the Isoform-specific Inhibitor Pyripyropene A
2008 StandoutNobel
Disruption of the 12/15-lipoxygenase gene diminishes atherosclerosis in apo E–deficient mice
1999
Stranger in a strange land: The pathogenesis of saphenous vein graft stenosis with emphasis on structural and functional differences between veins and arteries
1991
Cancer Invasion and the Microenvironment: Plasticity and Reciprocity
2011 Standout
Abdominal obesity and metabolic syndrome
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1999
Potential therapeutics for obesity and atherosclerosis: Inhibitors of neutral lipid metabolism from microorganisms
2007 StandoutNobel
The Enzymes of Neutral Lipid Synthesis
2001
Role of Transforming Growth Factor β in Human Disease
2000 Standout
Acyl CoA
1998
Acute Kidney Injury and Chronic Kidney Disease as Interconnected Syndromes
2014 Standout
New approaches to atherosclerosis: An overview
1993
Pro-resolving lipid mediators are leads for resolution physiology
2014 StandoutNature
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1999
Absence of ACAT-1 Attenuates Atherosclerosis but Causes Dry Eye and Cutaneous Xanthomatosis in Mice with Congenital Hyperlipidemia
2000
Estrogen receptor α is a major mediator of 17β-estradiol’s atheroprotective effects on lesion size in Apoe–/– mice
2001 StandoutNobel
ECM remodeling in hypertensive heart disease
2007
Correlation of oxidative stress with activity of matrix metalloproteinase in patients with coronary artery disease Possible role for left ventricular remodelling
2003
Activation of transforming growth factor-β is inhibited in transgenic apolipoprotein(a) mice
1994 Nature
Macrophages in the Pathogenesis of Atherosclerosis
2011 Standout
Relation of Serum Lipoprotein(a) Concentration and Apolipoprotein(a) Phenotype to Coronary Heart Disease in Patients with Familial Hypercholesterolemia
1990
Ferroptosis turns 10: Emerging mechanisms, physiological functions, and therapeutic applications
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Catalytic Asymmetric Conjugate Addition/Oxidative Dearomatization Towards Multifunctional Spirocyclic Compounds
2011 StandoutNobel
Tumor Metastasis: Molecular Insights and Evolving Paradigms
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Oxysterols and atherosclerosis
1999
On the origin of the catalytic power of carboxypeptidase A and other metalloenzymes
2009 StandoutNobel
Simvastatin and Niacin, Antioxidant Vitamins, or the Combination for the Prevention of Coronary Disease
2001
Immunological Quantitation and Localization of ACAT-1 and ACAT-2 in Human Liver and Small Intestine
2000
Macrophage Diversity Enhances Tumor Progression and Metastasis
2010 Standout
Lipoprotein (a). Heterogeneity and biological relevance.
1990
Oxidants and antioxidants in atherosclerosis
2001
Antioxidants and Atherosclerotic Heart Disease
1997 Standout
Influence of serum lipoprotein(a) and homocyst(e)ine levels on graft patency after coronary artery bypass grafting
1994
Regulation of Ferroptotic Cancer Cell Death by GPX4
2014 Standout
Role of Oxidative Modifications in Atherosclerosis
2004 Standout
Intravascular hemolysis increases atherogenicity of diet-induced hypercholesterolemia in rabbits in spite of heme oxygenase-1 gene and protein induction
2001
Independent and additional prognostic value of aminoterminal propeptide of type III procollagen circulating levels in patients with chronic heart failure
2004
Stabilization of atherosclerotic plaques: New mechanisms and clinical targets
2002
3 ACAT Inhibitors: The Search for a Novel and Effective Treatment of Hypercholesterolemia and Atherosclerosis
2002
Massive xanthomatosis and altered composition of atherosclerotic lesions in hyperlipidemic mice lacking acyl CoA:cholesterol acyltransferase 1
2000
Effect of Vitamin E and Probucol on Dietary Cholesterol-Induced Atherosclerosis in Rabbits
1998
Atherogenesis in transgenic mice expressing human apolipoprotein(a)
1992 Nature
Mammalian acyl-CoA:cholesterol acyltransferases
2000
ACAT Inhibition and Progression of Carotid Atherosclerosis in Patients With Familial Hypercholesterolemia
2009
Effect of ACAT Inhibition on the Progression of Coronary Atherosclerosis
2006
Synthesis and Biological Activity of Methanesulfonamide Pyrimidine- and N-Methanesulfonyl Pyrrole-Substituted 3,5-Dihydroxy-6-heptenoates, a Novel Series of HMG-CoA Reductase Inhibitors
1997
ACAT-2, A Second Mammalian Acyl-CoA:Cholesterol Acyltransferase
1998
Oxidized LDL Regulates Macrophage Gene Expression through Ligand Activation of PPARγ
1998 Standout
Beta-carotene inhibits atherosclerosis in hypercholesterolemic rabbits.
1995
A Simple Enantioconvergent and Chemoenzymatic Synthesis of Optically Active α‐Substituted Amides
2011 StandoutNobel
Glutathione Peroxidase 4 Senses and Translates Oxidative Stress into 12/15-Lipoxygenase Dependent- and AIF-Mediated Cell Death
2008
Systemic Endocrine Instigation of Indolent Tumor Growth Requires Osteopontin
2008
Increased atherosclerosis in LDL receptor–null mice lacking ACAT1 in macrophages
2001
The Oxidation of Lipoproteins by Monocytes-Macrophages
1999
The Oxidative Modification Hypothesis of Atherosclerosis Does It Hold for Humans?
2001
Progress and challenges in translating the biology of atherosclerosis
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Nutrigenetic Disruption of Inflammation-Resolution Homeostasis and Atherogenesis
2011
Repertoires of Autophagy in the Pathogenesis of Ocular Diseases
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1996
The Pathogenesis of Coronary Artery Disease and the Acute Coronary Syndromes
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Inflammation, Atherosclerosis, and Coronary Artery Disease
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2000 StandoutNature
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2007
C-Reactive Protein and Other Emerging Blood Biomarkers to Optimize Risk Stratification of Vulnerable Patients
2006
NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals
2010 StandoutNature
Atherosclerosis
2001 Standout
Biomarkers in Heart Failure
2008 Standout
Inhibition of Acyl‐CoA Cholesterol Acyltransferase by F12511 (Eflucimibe): Could it be a New Antiatherosclerotic Therapeutic?
2008
Oxidants and antioxidants in the pathogenesis of atherosclerosis: implications for the oxidized low density lipoprotein hypothesis
1998
Natural Product-like Combinatorial Libraries Based on Privileged Structures. 1. General Principles and Solid-Phase Synthesis of Benzopyrans
2000
Lipoprotein(a). A unique risk factor for atherothrombotic disease.
1990
Oxidants, antioxidants, and the degenerative diseases of aging.
1993 Standout
Fluorine in medicinal chemistry
2007 Standout
Fluorine in Pharmaceutical Industry: Fluorine-Containing Drugs Introduced to the Market in the Last Decade (2001–2011)
2013 Standout
Deficiency of acyl CoA:cholesterol acyltransferase 2 prevents atherosclerosis in apolipoprotein E-deficient mice
2003
Reduced Inflammation and Tissue Damage in Transgenic Rabbits Overexpressing 15-Lipoxygenase and Endogenous Anti-inflammatory Lipid Mediators
2003
Characterization of the early lesion of 'degenerative' valvular aortic stenosis. Histological and immunohistochemical studies.
1994 Standout
Genetic Models of Human Vascular Disease
1995 StandoutNobel
Lipoprotein (a) inhibits the generation of transforming growth factor beta: an endogenous inhibitor of smooth muscle cell migration.
1991
Effects of the Acyl Coenzyme A:Cholesterol Acyltransferase Inhibitor Avasimibe on Human Atherosclerotic Lesions
2004
ACAT1 and ACAT2 Membrane Topology Segregates a Serine Residue Essential for Activity to Opposite Sides of the Endoplasmic Reticulum Membrane
2000
Proliferation of Human Smooth Muscle Cells Promoted by Lipoprotein(a)
1993 Science
Inhibitors of Acyl-CoA:Cholesterol O-Acyltransferase. 2. Identification and Structure−Activity Relationships of a Novel Series of N-Alkyl-N-(heteroaryl-substituted benzyl)-N‘-arylureas
1998
Functional Arteries Grown in Vitro
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2007 Standout
Next Generation of Fluorine-Containing Pharmaceuticals, Compounds Currently in Phase II–III Clinical Trials of Major Pharmaceutical Companies: New Structural Trends and Therapeutic Areas
2016 Standout
Matrix Metalloproteinases
2002
Identification of antigen-presenting dendritic cells in mouse aorta and cardiac valves
2009 StandoutNobel
12/15-Lipoxygenase Gene Disruption Attenuates Atherogenesis in LDL Receptor–Deficient Mice
2001
Malondialdehyde modification of lipoprotein(a) produces avid uptake by human monocyte-macrophages.
1992
Potent hypocholesterolemic activity of novel ureido phenoxyisobutyrates correlates with their intrinsic fibrate potency and not with their ACAT inhibitory activity
1997
Luminal Foam Cell Accumulation Is Associated With Smooth Muscle Cell Death in the Intimal Thickening of Human Saphenous Vein Grafts
1996
ACAT2 Is Localized to Hepatocytes and Is the Major Cholesterol-Esterifying Enzyme in Human Liver
2004 StandoutNobel
Prostaglandins and Leukotrienes: Advances in Eicosanoid Biology
2001 StandoutScience
On the Mechanism of Cytoprotection by Ferrostatin-1 and Liproxstatin-1 and the Role of Lipid Peroxidation in Ferroptotic Cell Death
2017 Standout
Inhibitors of Acyl-CoA:CholesterolO-Acyltransferase. 17. Structure−Activity Relationships of Several Series of Compounds Derived fromN-Chlorosulfonyl Isocyanate
1996
Antiatherogenic activity of fungal beauveriolides, inhibitors of lipid droplet accumulation in macrophages
2004
Overexpression of 15-Lipoxygenase in Vascular Endothelium Accelerates Early Atherosclerosis in LDL Receptor–Deficient Mice
2000
Oxidation of LDL by rabbit and human 15-lipoxygenase: prevalence of nonenzymatic reactions
2001
Human Atherosclerotic Plaque Contains Both Oxidized Lipids and Relatively Large Amounts of α-Tocopherol and Ascorbate
1995
Aortocoronary Saphenous Vein Graft Disease
1998 Standout
Fibrosis — A Common Pathway to Organ Injury and Failure
2015 Standout
Synthesis of Optically Active 6‐Alkynyl‐ and 6‐Alkylpurines as Cytokinin Analogs and Inhibitors of 15‐Lipoxygenase; Studies of Intramolecular Cyclization of 6‐(Hydroxyalkyn‐1‐yl)purines
2005
The Combinatorial Synthesis of Bicyclic Privileged Structures or Privileged Substructures
2003 Standout
Ultrastructure of the human aortic fibrolipid lesion. Formation of the atherosclerotic lipid-rich core.
1986
Secretory Phospholipase A2 and Lipoprotein Lipase Enhance 15-Lipoxygenase-Induced Enzymic and Nonenzymic Lipid Peroxidation in Low-Density Lipoproteins†
1998
Discovery of 1-(4-Fluorophenyl)-(3R)-[3-(4-fluorophenyl)-(3S)- hydroxypropyl]-(4S)-(4-hydroxyphenyl)-2-azetidinone (SCH 58235): A Designed, Potent, Orally Active Inhibitor of Cholesterol Absorption
1998
Fluorosulfuryl Isocyanate Enabled SuFEx Ligation of Alcohols and Amines
2021 StandoutNobel
Enantioconvergent synthesis of a promising HMG CoA reductase inhibitor NK-104 from both enantiomers of epichlorohydrin
1993
A series of conformationally and sterically constrained analogs of N-phenyl-N′-aralkylurea ACAT inhibitors
1995
Fluorine in health care: Organofluorine containing blockbuster drugs
2010 Standout
Role of Monocytes in Atherogenesis
2003
Lipid hydroperoxy and hydroxy derivatives in copper-catalyzed oxidation of low density lipoprotein.
1990
A novel enantioselective synthesis of HMG Co-A reductase inhibitor NK-104 and a related compound
1992
12/15-Lipoxygenase, Oxidative Modification of LDL and Atherogenesis
2001
Selective Matrix Metalloproteinase Inhibition With Developing Heart Failure
2003
Absence of 12/15-Lipoxygenase Expression Decreases Lipid Peroxidation and Atherogenesis in Apolipoprotein E–Deficient Mice
2001
MRC/BHF Heart Protection Study of cholesterol lowering with simvastatin in 20 536 high-risk individuals: a randomised placebocontrolled trial
2002 Standout
Selenium-Based Solid-Phase Synthesis of Benzopyrans II: Applications to Combinatorial Synthesis of Medicinally Relevant Small Organic Molecules
2000
Niemann-Pick C1 Like 1 Protein Is Critical for Intestinal Cholesterol Absorption
2004 StandoutScience
Association of levels of lipoprotein Lp(a), plasma lipids, and other lipoproteins with coronary artery disease documented by angiography.
1986
Works of Thomas Bocan being referenced
Atherosclerotic lesion development in hypercholesterolemic Japanese quail following probucol treatment: A biochemical and morphologic evaluation
1994
A specific 15-lipoxygenase inhibitor limits the progression and monocyte–macrophage enrichment of hypercholesterolemia-induced atherosclerosis in the rabbit
1998
The combined effect of inhibiting both ACAT and HMG-CoA reductase may directly induce atherosclerotic lesion regression
2001
Extracellular lipid deposition in atherosclerosis
1990
Antiatherosclerotic activity of inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A reductase in cholesterol-fed rabbits: a biochemical and morphological evaluation
1994
Attenuation of diet‐induced atherosclerosis in rabbits with a highly selective 15‐lipoxygenase inhibitor lacking significant antioxidant properties
1997
Antiatherosclerotic effects of antioxidants are lesion-specific when evaluated in hypercholesterolemic New Zealand White rabbits
1992
Relationship between tissue selectivity and lipophilicity for inhibitors of HMG-CoA reductase
1991
The relationship between the degree of dietary-induced hypercholesterolemia in the rabbit and atherosclerotic lesion formation
1993
HMG-CoA reductase and ACAT inhibitors act synergistically to lower plasma cholesterol and limit atherosclerotic lesion development in the cholesterol-fed rabbit
1998
Inhibition of acyl-CoA cholesterol O-acyltransferase reduces the cholesteryl ester enrichment of atherosclerotic lesions in the Yucatan micropig
1993
Comparison of CI-976, an ACAT inhibitor, and selected lipid-lowering agents for antiatherosclerotic activity in iliac-femoral and thoracic aortic lesions. A biochemical, morphological, and morphometric evaluation.
1991
Matrix Metalloproteinase Inhibition Attenuates Left Ventricular Remodeling and Dysfunction in a Rat Model of Progressive Heart Failure
2001
Quantitation and localization of apolipoproteins [a] and B in coronary artery bypass vein grafts resected at re-operation.
1989
Inhibitors of Acyl-CoA:Cholesterol O-Acyltransferase. Synthesis and Pharmacological Activity of (±)-2-Dodecyl-α-phenyl-N-(2,4,6-trimethoxyphenyl)-2H-tetrazole-5-acetamide and Structurally Related Tetrazole Amide Derivatives
1996
Human aortic fibrolipid lesions. Immunochemical localization of apolipoprotein B and apolipoprotein A.
1988
Section Review—Cardiovascular & Renal: Emerging Therapies in Atherosclerosis
1995
Quantitative ultrastructural analysis of perifibrous lipid and its association with elastin in nonatherosclerotic human aorta.
1985
Human aortic fibrolipid lesions. Progenitor lesions for fibrous plaques, exhibiting early formation of the cholesterol-rich core.
1985
Toxicologic Effects of a Novel Acyl-CoA: Cholesterol Acyltransferase Inhibitor in Cynomolgus Monkeys
1994
In vivo evidence that the lipid-regulating activity of the ACAT inhibitor CI-976 in rats is due to inhibition of both intestinal and liver ACAT.
1993
Emerging Therapeutic Advances for the Development of Second Generation Matrix Metalloproteinase Inhibitors
1997
α-Substituted Malonester Amides: Tools To Define the Relationship between ACAT Inhibition and Adrenal Toxicity
1998
Tetrazole-substituted ureas as inhibitors of acyl-CoA:cholesterol O-acyltransferase (ACAT). A novel preparation of ureas from weakly nucleophilic amines
1996
The ACAT Inhibitor Avasimibe Reduces Macrophages and Matrix Metalloproteinase Expression in Atherosclerotic Lesions of Hypercholesterolemic Rabbits
2000