Citation Impact
Citing Papers
Germline Transmission and Tissue-Specific Expression of Transgenes Delivered by Lentiviral Vectors
2002 StandoutScienceNobel
The Myeloma Drug Lenalidomide Promotes the Cereblon-Dependent Destruction of Ikaros Proteins
2013 StandoutScienceNobel
Nonredundant roles for Stat5a/b in directly regulating Foxp3
2007
Induction of interferon-stimulated gene expression and antiviral responses require protein deacetylase activity
2004 StandoutNobel
Janus Kinase (Jak) Subcellular Localization Revisited
2004
STAT5A is epigenetically silenced by the tyrosine kinase NPM1-ALK and acts as a tumor suppressor by reciprocally inhibiting NPM1-ALK expression
2007
Functional diversity of helper T lymphocytes
1996 StandoutNature
Recognition of double-stranded RNA and activation of NF-κB by Toll-like receptor 3
2001 StandoutNature
Cellular and Gene Expression Responses Involved in the Rapid Growth Inhibition of Human Cancer Cells by RNA Interference-mediated Depletion of Telomerase RNA
2005 StandoutNobel
The Carboxyl-terminal Domains of gp130-related Cytokine Receptors Are Necessary for Suppressing Embryonic Stem Cell Differentiation
1999
Inflammation and cancer
2002 StandoutNature
The Association of Atopy with a Gain-of-Function Mutation in the α Subunit of the Interleukin-4 Receptor
1997
Oncogenic kinase signalling
2001 StandoutNature
Cell Signaling by Receptor Tyrosine Kinases
2010 Standout
Synergistic Roles for Pim-1 and c-Myc in STAT3-Mediated Cell Cycle Progression and Antiapoptosis
1999
Constitutive Activation of Stat3 Signaling Confers Resistance to Apoptosis in Human U266 Myeloma Cells
1999 Standout
An Indirect Effect of Stat5a in IL-2–Induced Proliferation: A Critical Role for Stat5a in IL-2–Mediated IL-2 Receptor α Chain Induction
1997
Lymph nodes and Peyer's patches of IL-6 transgenic BALB/c mice harbor T(12;15) translocated plasma cells that contain illegitimate exchanges between the immunoglobulin heavy-chain μ locus and c-myc
2000
Regulatory T Cells and Immune Tolerance
2008 StandoutNobel
STAT family of transcription factors in cytokine-mediated biological responses
2000
Epstein–Barr virus-derived EBNA2 regulates STAT3 activation
2008
STAM, Signal Transducing Adaptor Molecule, Is Associated with Janus Kinases and Involved in Signaling for Cell Growth and c-myc Induction
1997
AID Is Required for c-myc/IgH Chromosome Translocations In Vivo
2004 StandoutNobel
Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells
2001 StandoutNature
Transformation of hematopoietic cell lines to growth-factor independence and induction of a fatal myelo- and lymphoproliferative disease in mice by retrovirally transduced TEL/JAK2 fusion genes
1998
IL-21 initiates an alternative pathway to induce proinflammatory TH17 cells
2007 StandoutNature
B lymphocytes from patients with chronic lymphocytic leukemia contain signal transducer and activator of transcription (STAT) 1 and STAT3 constitutively phosphorylated on serine residues.
1997
Role of the Common Cytokine Receptor γ Chain in Cytokine Signaling and Lymphoid Development
1995
Jaks and stats in cytokine signaling
1997
TAM Receptors Are Pleiotropic Inhibitors of the Innate Immune Response
2007
JAK/STAT signaling by cytokine receptors
1998
Interleukin 6 and its Receptor: Ten Years Later
1998
Interleukin-2 (IL-2)-mediated Induction of the IL-2 Receptor α Chain Gene
1997
Roles of STAT3 in mediating the cell growth, differentiation and survival signals relayed through the IL-6 family of cytokine receptors
2000
Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells
2006 StandoutNature
HIV-1 Genome Nuclear Import Is Mediated by a Central DNA Flap
2000 StandoutNobel
Interleukin-21: a modulator of lymphoid proliferation, apoptosis and differentiation
2005
A family of cytokine-inducible inhibitors of signalling
1997 StandoutNature
The role of STATs in transcriptional control and their impact on cellular function
2000
A Low Interleukin-2 Receptor Signaling Threshold Supports the Development and Homeostasis of T Regulatory Cells
2009
Stat6 Is Required for Mediating Responses to IL-4 and for the Development of Th2 Cells
1996
Two Signals Are Necessary for Cell Proliferation Induced by a Cytokine Receptor gp130: Involvement of STAT3 in Anti-Apoptosis
1996 Standout
Disruption of the Jak1 Gene Demonstrates Obligatory and Nonredundant Roles of the Jaks in Cytokine-Induced Biologic Responses
1998 Standout
STATs in oncogenesis
2000 Standout
Cooperation between STAT5 and phosphatidylinositol 3-kinase in the IL-3-dependent survival of a bone marrow derived cell line
2000
MX2 is an interferon-induced inhibitor of HIV-1 infection
2013 StandoutNatureNobel
Ikaros Sets Thresholds for T Cell Activation and Regulates Chromosome Propagation
1999
Immunity, Inflammation, and Cancer
2010 Standout
Activation of STAT transcription factors in oncogenic tyrosine kinase signaling
1998
Hematopoietic Stem-Cell Transplantation for the Treatment of Severe Combined Immunodeficiency
1999
STAT5 as a molecular regulator of proliferation, differentiation and apoptosis in hematopoietic cells
1999
Developmental defects of lymphoid cells in Jak3 kinase-deficient mice
1995
STATs in cancer inflammation and immunity: a leading role for STAT3
2009 Standout
Jak3 maps to Chromosome 8
1996
IL-3 dependent regulation of Bcl-xL gene expression by STAT5 in a bone marrow derived cell line
1999
Origin and physiological roles of inflammation
2008 StandoutNature
STAT signaling in the pathogenesis and treatment of leukemias
2000
Reduced Tyk2/SHP-1 interaction and lack of SHP-1 mutation in a kindred of familial hemophagocytic lymphohistiocytosis
1998
STAT proteins as novel targets for cancer therapy
1999
STATs and cytokine specificity
1996
Cytosolic Tyrosine Dephosphorylation of STAT5
2000
Jak3 Is Associated with CD40 and Is Critical for CD40 Induction of Gene Expression in B Cells
1997
Activation of STAT proteins and growth control
2001
Lack of IL-4-induced Th2 response and IgE class switching in mice with disrupted State6 gene
1996 StandoutNatureNobel
Impaired IL-12 responses and enhanced development of Th2 cells in Stat4-deficient mice
1996 Nature
Constitutive Activation of JAK1 in Src-transformed Cells
1997
Stat5a and Stat5b Proteins Have Essential and Nonessential, or Redundant, Roles in Cytokine Responses
1998
Constitutive activation of Jak-2 and Tyk-2 in a v-Src-transformed human gallbladder adenocarcinoma cell line
1998
Selectivity and therapeutic inhibition of kinases: to be or not to be?
2009
Jak2 Is Essential for Signaling through a Variety of Cytokine Receptors
1998 Standout
Requirement for Stat4 in interleukin-12-mediated responses of natural killer and T cells
1996 StandoutNatureNobel
Genomic Structure and Promoter Region of the Murine Janus-Family Tyrosine Kinase, Jak3
1997
A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera
2005 StandoutNature
The Homeoprotein Nanog Is Required for Maintenance of Pluripotency in Mouse Epiblast and ES Cells
2003 StandoutNobel
Cytokine receptor signalling
1995 Nature
Protein-tyrosine Phosphatase Shp-1 Is a Negative Regulator of IL-4- and IL-13-dependent Signal Transduction
1998
Mapping the Encapsidation Determinants of Feline Immunodeficiency Virus
2002
The Lck Binding Domain of Herpesvirus Saimiri Tip-484 Constitutively Activates Lck and STAT3 in T Cells
1999
Monocyte function in a severe combined immunodeficient patient with a donor splice site mutation in the Jak3 gene
1996
The molecular basis of IL-21–mediated proliferation
2007
STAT5 Activation by BCR-Abl Contributes to Transformation of K562 Leukemia Cells
1999
Complex Effects of Naturally Occurring Mutations in the JAK3 Pseudokinase Domain: Evidence for Interactions between the Kinase and Pseudokinase Domains
2000
STAT3 Serine Phosphorylation by ERK-Dependent and -Independent Pathways Negatively Modulates Its Tyrosine Phosphorylation
1997
Stat3 Activation Is Required for Cellular Transformation by v-src
1998
Mutation in the Jak Kinase JH2 Domain Hyperactivates Drosophila and Mammalian Jak-Stat Pathways
1997
HOW CELLS RESPOND TO INTERFERONS
1998 Standout
Activation-induced cytidine deaminase (AID) promotes B cell lymphomagenesis in Emu-cmyc transgenic mice
2007 StandoutNobel
STAT3 Is Required for the gp130-mediated Full Activation of the c-myc Gene
1999
STAT-related transcription factors are constitutively activated in peripheral blood cells from acute leukemia patients
1996
Jak3 activation in human lymphocyte precursor cells
1997
Stable and functional lymphoid reconstitution of common cytokine receptor γ chain deficient mice by retroviral-mediated gene transfer
2000
The Protein Kinase Complement of the Human Genome
2002 StandoutScience
STATs and Gene Regulation
1997 StandoutScience
Functional Roles of STAT Family Proteins: Lessons from Knockout Mice
1999
The amino terminus of JAK3 is necessary and sufficient for binding to the common γ chain and confers the ability to transmit interleukin 2-mediated signals
1997
JAKS AND STATS: Biological Implications
1998 Standout
Gene Therapy of Human Severe Combined Immunodeficiency (SCID)-X1 Disease
2000 StandoutScience
The IL-2 Receptor Promotes Lymphocyte Proliferation and Induction of the c-myc, bcl-2, and bcl-x Genes Through the trans-Activation Domain of Stat5
2000
Requirement for IL-13 Independently of IL-4 in Experimental Asthma
1998 StandoutScience
IL-6 transgenic mouse model for extraosseous plasmacytoma
2002
Identification and Characterization of a Constitutively Active STAT5 Mutant That Promotes Cell Proliferation
1998
Membrane proteomics of phagosomes suggests a connection to autophagy
2008 StandoutNobel
Constitutive activation ofStat5aby retrovirus integration in early pre-B lymphomas of SL/Kh strain mice
2002
Restoration of Lymphoid Populations in a Murine Model of X-Linked Severe Combined Immunodeficiency by a Gene-Therapy Approach
1999
Cloning of Human Stat5B
1996
Unique signal transduction of Eyk: constitutive stimulation of the JAK-STAT pathway by an oncogenic receptor-type tyrosine kinase.
1996
Structural and Functional Basis for JAK3-Deficient Severe Combined Immunodeficiency
1997
Signaling by IL-2 and related cytokines: JAKs, STATs, and relationship to immunodeficiency
1996
STAT Signaling in the Pathogenesis and Treatment of Cancer
1999
Tyrosyl phosphorylation and DNA binding activity of signal transducers and activators of transcription (STAT) proteins in hematopoietic cell lines transformed by Bcr/Abl.
1996
Deacetylase Activity Is Required for Recruitment of the Basal Transcription Machinery and Transactivation by STAT5
2003
Kinase requirements in human cells: III. Altered kinase requirements inVHL−/− cancer cells detected in a pilot synthetic lethal screen
2008 StandoutNobel
Distinct tyrosine phosphorylation sites in JAK3 kinase domain positively and negatively regulate its enzymatic activity
1997
Defects in B Lymphocyte Maturation and T Lymphocyte Activation in Mice Lacking Jak3
1995 Science
Jaks, STATs, Cytokine Signal Transduction, and Immunoregulation: Are We There Yet?
1997
In vitro correction of JAK3-deficient severe combined immunodeficiency by retroviral-mediated gene transduction.
1996
Requirement for Ras/Rac1-Mediated p38 and c-Jun N-Terminal Kinase Signaling in Stat3 Transcriptional Activity Induced by the Src Oncoprotein
1999
Stat3 Activation Is Responsible for IL-6-Dependent T Cell Proliferation Through Preventing Apoptosis: Generation and Characterization of T Cell-Specific Stat3-Deficient Mice
1998
Jak-STAT Signaling Induced by the v- abl oncogene
1995 Science
Functional Differences between Stat3α and Stat3β
1997 Nobel
Stat3 Activation by Src Induces Specific Gene Regulation and Is Required for Cell Transformation
1998
Constitutive activation of Stat3 in fibroblasts transformed by diverse oncoproteins and in breast carcinoma cells.
1997
Specific Inhibition of Stat3 Signal Transduction by PIAS3
1997 StandoutScience
Enhancement of Antiproliferative Activity of Gamma Interferon by the Specific Inhibition of Tyrosine Dephosphorylation of Stat1
1996
Peripheral Expression of Jak3 Is Required to Maintain T Lymphocyte Function
1997
THE MOLECULAR BASIS OF X-LINKED SEVERE COMBINED IMMUNODEFICIENCY: Defective Cytokine Receptor Signaling
1996
Constitutive activation of a slowly migrating isoform of Stat3 in mycosis fungoides: Tyrphostin AG490 inhibits Stat3 activation and growth of mycosis fungoides tumor cell lines
1997
Inhibition of cytokines and JAK-STAT activation by distinct signaling pathways.
1996
THE CROONIAN LECTURE 1997. The phosphorylation of proteins on tyrosine: its role in cell growth and disease
1998
RNA Scanning of a Molecular Machine with a Built-in Ruler
2016 StandoutNobel
Activation and Association of Stat3 with Src in v-Src-Transformed Cell Lines
1996
Constitutive activation of STAT proteins in primary lymphoid and myeloid leukemia cells and in Epstein-Barr virus (EBV)-related lymphoma cell lines
1996
Significance analysis of microarrays applied to the ionizing radiation response
2001 Standout
Negative Regulation of Cytokine Signaling Pathways
2000 Standout
Proliferation of adult T cell leukemia/lymphoma cells is associated with the constitutive activation of JAK/STAT proteins
1997
Correction of interleukin-2 receptor function in X-SCID lymphoblastoid cells by retrovirally mediated transfer of the gamma-c gene
1996
In Vivo Gene Delivery and Stable Transduction of Nondividing Cells by a Lentiviral Vector
1996 StandoutScience
Murine JAK3 is preferentially expressed in hematopoietic tissues and lymphocyte precursor cells
1996
Suppression of interleukin-3-induced gene expression by a C-terminal truncated Stat5: role of Stat5 in proliferation.
1996
Activation of STAT transcription factors by herpesvirus Saimiri Tip-484 requires p56lck
1997
A distinct subpopulation of CD25−T-follicular regulatory cells localizes in the germinal centers
2017 StandoutNobel
Cancer immunotherapy using checkpoint blockade
2018 StandoutScience
Activation of Jak/STAT proteins involved in signal transduction pathway mediated by receptor for interleukin 2 in malignant T lymphocytes derived from cutaneous anaplastic large T-cell lymphoma and Sezary syndrome.
1996
Suppression of TNF-α-Induced Apoptosis by NF-κB
1996 StandoutScience
THE IFNγ RECEPTOR:A Paradigm for Cytokine Receptor Signaling
1997
Defective Lymphoid Development in Mice Lacking Jak3
1995 StandoutScienceNobel
Crucial Role of Jak3 in Negative Selection of Self-reactive T Cells
1997
Autophagy in Health and Disease: A Double-Edged Sword
2004 StandoutScience
Works of Thi‐Sau Migone being referenced
B lymphocyte stimulator (BLyS) isoforms in systemic lupus erythematosus: disease activity correlates better with blood leukocyte BLyS mRNA levels than with plasma BLyS protein levels
2005
Distinct Tumorigenic Potential of abl and raf in B Cell Neoplasia: abl Activates the IL-6 Signaling Pathway
1996
Different interleukin 2 receptor beta-chain tyrosines couple to at least two signaling pathways and synergistically mediate interleukin 2-induced proliferation.
1996
Mutation of Jak3 in a Patient with SCID: Essential Role of Jak3 in Lymphoid Development
1995 Science
An integration-defective U5 deletion mutant of human immunodeficiency virus type 1 reverts by eliminating additional long terminal repeat sequences
1994
Constitutively Activated Jak-STAT Pathway in T Cells Transformed with HTLV-I
1995 Science
Recruitment of SH2-containing protein tyrosine phosphatase SHP-1 to the interleukin 2 receptor; loss of SHP-1 expression in human T-lymphotropic virus type I-transformed T cells
1998
Functional Cooperation of the Interleukin-2 Receptor β Chain and Jak1 in Phosphatidylinositol 3-Kinase Recruitment and Phosphorylation
1998
The deubiquitinating enzyme DUB-2 prolongs cytokine-induced signal transducers and activators of transcription activation and suppresses apoptosis following cytokine withdrawal
2001