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Citing Papers
Mouse model for noninvasive imaging of HIF prolyl hydroxylase activity: Assessment of an oral agent that stimulates erythropoietin production
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[1] Selected methods for the determination of ascorbic acid in animal cells, tissues, and fluids
1979 Standout
Lipid composition and turnover of rough and smooth microsomal membranes in rat liver
1968
Measurement of doxorubicin-induced lipid peroxidation under the conditions that determine cytotoxicity in cultured tumor cells
1992
The effect of the anthrapyrazole antitumour agent CI941 on rat liver microsome and cytochrome P-450 reductase mediated free radical processes
1987
Free radicals, antioxidants, and human disease: curiosity, cause, or consequence?
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Subcellular effects of adriamycin in the heart: A concise review
1987
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Mutations in VKORC1 cause warfarin resistance and multiple coagulation factor deficiency type 2
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JNK1: A protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain
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A critical evaluation of the mechanisms of action proposed for the antitumor effects of the anthracycline antibiotics adriamycin and daunorubicin
1999 Standout
Effect of cigarette smoke inhalation on antioxidant enzymes and lipid peroxidation in the rat
1988
The role of redox-active metals in the mechanism of action of bleomycin
1990
Combination therapy with probucol prevents adriamycin-induced cardiomyopathy
1995
Anthracycline-induced DNA breaks and resealing in doxorubicin-resistant murine leukemic P388 cells
1988
Lipid Peroxidation and Mechanisms of Toxicity
1987
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Development of Mechanisms of Protection Against Oxidative Stress in Doxorubicin-Resistant Rat Tumoral Cells in Culture
1990
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1988
Interactions of Adriamycin aglycones with mitochondria may mediate Adriamycin cardiotoxicity
1994
PZ-51 (Ebselen) in vivo protection against Adriamycin-induced mouse cardiac and hepatic lipid peroxidation and toxicity
1992
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DNA Damage and Oxygen Radical Toxicity
1988 StandoutScience
Antioxidants and multistage carcinogenesis in mouse skin
1989
5-Hydroxymethylfurfural: assessment of mutagenicity, DNA-damaging potential and reactivity towards cellular glutathione
2000
PHOTOCHEMICAL STUDIES ON THE ANTIINFLAMMATORY DRUG DICLOFENAC
1990
Quantitative reactivity profiling predicts functional cysteines in proteomes
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1988
An overview of the relationship between oxidative stress and chemical carcinogenesis
1991
TRPA1 Mediates the Inflammatory Actions of Environmental Irritants and Proalgesic Agents
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Pharmacokinetics and tissue distribution of cisplatin in nude mice: platinum levels and cisplatin-DNA adducts
1995
Mice with a Homozygous Null Mutation for the Most Abundant Glutathione Peroxidase, Gpx1, Show Increased Susceptibility to the Oxidative Stress-inducing Agents Paraquat and Hydrogen Peroxide
1998
Doxorubicin (adriamycin): A critical review of free radical-dependent mechanisms of cytotoxicity
1990
Doxorubicin-Induced Cardiomyopathy
1998 Standout
The protective role of manganese superoxide dismutase against adriamycin-induced acute cardiac toxicity in transgenic mice.
1996
Cutaneous Squamous-Cell Carcinoma
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The p66shc adaptor protein controls oxidative stress response and life span in mammals
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[27] Measurement of substrate and inhibitor binding to microsomal cytochrome P-450 by optical-difference spectroscopy
1978
Anticancer Activity Expressed by a Library of 2,9-Diazaperopyrenium Dications
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ExCage
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Central control of hepatic steroid metabolism and “lactogenic” receptor
1980
The multiple effects of ethylenediaminetetraacetate in several model lipid peroxidation systems
1982
Geometric and Electronic Structure/Function Correlations in Non-Heme Iron Enzymes
1999 Standout
Oxidant-dependent metabolic activation of polycyclic aromatic hydrocarbons by phorbol ester-stimulated human polymorphonuclear leukocytes: possible link between inflammation and cancer.
1985
Doxorubicin induced alterations in lipid metabolism of cultured myocardial cells
1985
Relationship between reduced nicotinamide adenine dinucleotide phosphate-dependent lipid peroxidation and drug hydroxylation in rat liver inicrosomes
1974
Nitric Oxide And Carbon Monoxide Produce Activity-Dependent Long-Term Synaptic Enhancement in Hippocampus
1993 StandoutScienceNobel
Kinetics of hepatic cytochrome P-450 reduction: correlation with spin state of the ferric heme
1982
Evidence for the involvement of cytochrome P-450 in reduction of benzo(a)pyrene 4,5-oxide by rat liver microsomes
1976
SPIN-STATE CHANGES IN CYTOCHROME P-450 cam ON BINDING OF SPECIFIC SUBSTRATES
1970
Evaluation of adriamycin-induced lipid peroxidation
1992
Protective role of the glutathione redox cycle against adriamycin-mediated toxicity in isolated hepatocytes
1981
Ascorbate is an outstanding antioxidant in human blood plasma.
1989 Standout
Hazardous air pollutants and asthma.
2002
Metabolism of adriamycin in hepatocytes isolated from the rat and the rabbit
1987
Prooxidant States and Tumor Promotion
1985 StandoutScience
Measurement of adriamycin (doxorubicin) and its metabolites in human plasma using reversed-phase high-performance liquid chromatography and fluorescence detection
1979
Current Status of Platinum-Based Antitumor Drugs
1999 Standout
Reconstituted Liver Microsomal Enzyme System That Hydroxylates Drugs, Other Foreign Compounds, and Endogenous Substrates
1972
Cell Cycle Control and Cancer
1994 StandoutScienceNobel
HUMAN ARTERIAL AND VENOUS TISSUES GENERATE PROSTACYCLIN (PROSTAGLANDIN X), A POTENT INHIBITOR OF PLATELET AGGREGATION
1977 StandoutNobel
Zinc · protoporphyrin is a selective inhibitor of heme oxygenase activity in the neonatal rat
1981
[30] Microsomal lipid peroxidation
1978 Standout
Free Radical Mechanisms in Tissue Injury
1988
Prevention of doxorubicin cardiac toxicity in the mouse by N-acetylcysteine.
1981
Superoxide- and singlet oxygen-catalyzed lipid peroxidation as a possible mechanism for paraquat (methyl viologen) toxicity
1974 Standout
Adriamycin-induced free radical formation in the perfused rat heart: implications for cardiotoxicity.
1988
Usefulness of a free radical scavenger in preventing doxorubicin-induced heart failure in dogs
1985
Normal oxidative damage to mitochondrial and nuclear DNA is extensive.
1988 Standout
Evidence for inhibition of growth related to compromised DNA synthesis in the interaction of daunorubicin with H-35 rat hepatoma.
1988
The requirement for iron (III) in the initiation of lipid peroxidation by iron (II) and hydrogen peroxide.
1987
A radiometric assay for hepatic epoxide hydrase activity with [7-3H] styrene oxide
1971
Anthracycline glycoside-membrane interactions
1984
Reduced Triphosphopyridine Nucleotide Oxidase-catalyzed Alterations of Membrane Phospholipids
1971
Paraquat: model for oxidant-initiated toxicity.
1984 Standout
Lipid peroxidation and the degradation of cytochrome P-450 heme
1973
Adriamycin cardiomyopathy: pathophysiology and prevention
1997
Membrane flow and interconversions among endomembranes
1979
Dietary Carcinogens and Anticarcinogens
1983 StandoutScience
Inactivation of cytochrome c oxidase activity in mitochondrial membranes during redox cycling of doxorubicin
1991
A chemical perspective on the anthracycline antitumor antibiotics.
1985
ω-Oxidation of Fatty Acids
1971
Pharmaceuticals of Emerging Concern in Aquatic Systems: Chemistry, Occurrence, Effects, and Removal Methods
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Chemistry of Biologically Important Synthetic Organoselenium Compounds
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1992
Pentalenolactone Biosynthesis. Molecular Cloning and Assignment of Biochemical Function to PtlI, a Cytochrome P450 of Streptomyces avermitilis
2006 StandoutNobel
Chemiluminescence as an Analytical Tool in Cell Biology and Medicine
1985
Carcinogens are Mutagens: A Simple Test System Combining Liver Homogenates for Activation and Bacteria for Detection
1973 Standout
Rate-Limiting Steps in Cytochrome P450 Catalysis
2002
Bilirubin Is an Antioxidant of Possible Physiological Importance
1987 StandoutScience
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1984 StandoutScience
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2007
Microsomal Electron Transport
1973
Arene Oxides: A New Aspect of Drug Metabolism
1974 StandoutScience
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1985
The Anthracycline Antineoplastic Drugs
1981 Standout
Anthracycline antibiotic-stimulated superoxide, hydrogen peroxide, and hydroxyl radical production by NADH dehydrogenase.
1983
Heme-Containing Oxygenases
1996 Standout
Sexual Differentiation of the Central Nervous System
1981 StandoutScience
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Mechanism of Oxidation Reactions Catalyzed by Cytochrome P450 Enzymes
2004 Standout
Testosterone: A Major Determinant of Extragenital Sexual Dimorphism
1981 Science
Aggressive cutaneous malignancies following cardiothoracic transplantation
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COMPOSITION OF CELLULAR MEMBRANES IN THE PANCREAS OF THE GUINEA PIG
1971 StandoutNobel
Reduced Triphosphopyridine Nucleotide Oxidase-catalyzed Alterations of Membrane Phospholipids
1970
Proton Magnetic Resonance Reveals High-Spin Iron (II) in Ferrous Cytochrome P450 cam from Pseudomonas putida
1972 StandoutNobel
Evaluation of free radical effects and catecholamine alterations in adriamycin cardiotoxicity.
1984
DNA glycosylase activities for thymine residues damaged by ring saturation, fragmentation, or ring contraction are functions of endonuclease III in Escherichia coli.
1984 StandoutNobel
Organoselenium and Organotellurium Compounds: Toxicology and Pharmacology
2004 Standout
Preparation and anticancer activity of two tryptamine derived platinum complexes
1991
Intramolecular determination of primary kinetic isotope effects in hydroxylations catalyzed by cytochrome P-450
1977
Insertion of specific bases during DNA synthesis past the oxidation-damaged base 8-oxodG
1991 StandoutNature
Cytochrome P-450 reduction exhibits burst kinetics
1980
Enzymatic activation and binding of adriamycin to nuclear DNA.
1984
Vitamin K dependent carboxylase: subcellular location of the carboxylase and enzymes involved in Vitamin K metabolism in rat liver
1980
Hydroxymethylfurfural, A Versatile Platform Chemical Made from Renewable Resources
2013 Standout
Cytochrome P450 and biological hydroxylation reactions
2005
Compartmentalized assembly of oligosaccharides on exported glycoproteins in yeast
1981 StandoutNobel
Antioxidant defenses and lipid peroxidation in human blood plasma.
1988 Standout
Structure and Chemistry of Cytochrome P450
2005 Standout
Works of Theodore E. Gram being referenced
Pulmonary toxicity of 4-ipomeanol
1989
FURTHER STUDIES ON THE METABOLISM OF DRUGS BY SUBFRACTIONS OF HEPATIC MICROSOMES
1967
Studies on the interaction of bleomycin A2 with rat lung microsomes. II. Involvement of adventitious iron and reactive oxygen in bleomycin-mediated DNA chain breakage.
1982
Studies on the Rate of Reduction of Hepatic Microsomal Cytochrome P-450 by Reduced Nicotinamide Adenine Dinucleotide Phosphate: Effect of Drug Substrates
1969
Studies on the interaction of bleomycin A2 with rat lung microsomes. I. Characterization of factors which influence bleomycin-mediated DNA chain breakage.
1982
Clara cell damage and inhibition of pulmonary mixed-function oxidase activity by naphthalene
1981
Distribution and disposition of platinum following intravenous administration of cis-diamminedichloroplatinum(II) (NSC 119875) to dogs.
1976
Chemically Reactive Intermediates and Pulmonary Xenobiotic Toxicity
1997
COMPARISON OF IN VITRO DRUG METABOLISM BY LUNG, LIVER, AND KIDNEY OF SEVERAL COMMON LABORATORY SPECIES
1975
The effects of α-tocopherol on the toxicity, disposition, and metabolism of adriamycin in mice
1979
Drug metabolism by microsomes from extrahepatic organs of rat and rabbit prepared by calcium aggregation
1975
Stimulation of mouse heart and liver microsomal lipid peroxidation by anthracycline anticancer drugs: characterization and effects of reactive oxygen scavengers.
1983
A possible role for membrane lipid peroxidation in anthracycline nephrotoxicity
1986
Differential effects of anthracycline drugs on rat heart and liver microsomal reduced nicotinamide adenine dinucleotide phosphate-dependent lipid peroxidation.
1982
Stimulation by adriamycin of rat heart and liver microsomal NADPH-dependent lipid peroxidation
1981
Changes in certain kinetic properties of hepatic microsomal aniline hydroxylase and ethylmorphine demethylase associated with postnatal development and maturation in male rats
1969
[21] Separation of hepatic smooth and rough microsomes associated with drug-metabolizing enzymes
1974
Effect of whole-body hyperthermia on the disposition and metabolism of adriamycin in rabbits.
1978
Enhancement of reactive oxygen-dependent mitochondrial membrane lipid peroxidation by the anticancer drug adriamycin
1985
Effect of α-tocopherol upon lipid peroxidation and drug metabolism in hepatic microsomes
1966
In vitro stimulation by paraquat of reactive oxygen-mediated lipid peroxidation in rat lung microsomes
1981
The distribution of the components of mixed-function oxidase between the rough and the smooth endoplasmic reticulum of liver cells
1968
Effects of dietary ascorbic acid supplementation on hepatic drug-metabolizing enzymes in the guinea pig
1977
Comparative Aspects of Mixed Function Oxidation by Lung and Liver of Rabbits
1974
Studies on the in vitro interaction of mitomycin C, nitrofurantoin and paraquat with pulmonary microsomes
1982
Activation of pharmacologic agents to radical intermediates
1982
Effect of drug substrates on the reduction of hepatic microsomal cytochrome P-450 by NADPH
1968
Vehicle alteration of paraquat lethality in mice
1979
Bleomycin-metal interaction: Ferrous iron-initiated chemiluminescence
1983
Hepatic Ethylmorphine Demethylase and A4-Steroid Reductase in the Androgen-Insensitive Pseudohermaphroditic Rat
1971
The kinetics of 32P incorporation into the phospholipids of hepatic rough and smooth microsomal membranes of male and female rats
1970
ENZYMATIC CONJUGATION OF FOREIGN CHEMICAL COMPOUNDS BY RABBIT LUNG AND LIVER
1974