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Citing Papers
Global phosphorylation analysis of β-arrestin–mediated signaling downstream of a seven transmembrane receptor (7TMR)
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Angiotensin II causes hypertension and cardiac hypertrophy through its receptors in the kidney
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β-Arrestin-dependent, G Protein-independent ERK1/2 Activation by the β2 Adrenergic Receptor
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Pericytes are required for blood–brain barrier integrity during embryogenesis
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Angiotensin II induces a complex activation of transcription factors in the rat brain: expression of Fos, Jun and Krox proteins
1995
Independent β-Arrestin2 and Gq/Protein Kinase Cζ Pathways for ERK Stimulated by Angiotensin Type 1A Receptors in Vascular Smooth Muscle Cells Converge on Transactivation of the Epidermal Growth Factor Receptor
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Side-Chain Substitutions within Angiotensin II Reveal Different Requirements for Signaling, Internalization, and Phosphorylation of Type 1A Angiotensin Receptors
2002
β-Arrestin Scaffolding of the ERK Cascade Enhances Cytosolic ERK Activity but Inhibits ERK-mediated Transcription following Angiotensin AT1a Receptor Stimulation
2002 StandoutNobel
Differential Kinetic and Spatial Patterns of β-Arrestin and G Protein-mediated ERK Activation by the Angiotensin II Receptor
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Targeted Disruption of the β2 Adrenergic Receptor Gene
1999 StandoutNobel
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Distinct β-Arrestin- and G Protein-dependent Pathways for Parathyroid Hormone Receptor-stimulated ERK1/2 Activation
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1995
β-Arrestin-biased Agonism at the β2-Adrenergic Receptor
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β-Arrestin 1 and Gαq/11 Coordinately Activate RhoA and Stress Fiber Formation following Receptor Stimulation
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Atrial natriuretic factor gene expression in ventricles of rats with spontaneous biventricular hypertrophy.
1988
Biosynthesis of Angiotensinogen and Angiotensins by Brain Cells in Primary Culture
1988
Increased brain angiotensin receptor in rats with chronic high-output heart failure
2000
Atrial natriuretic factor inhibits vasopressin-stimulated osmotic water permeability in rat inner medullary collecting duct.
1988
Identification, Distribution, and Expression of Angiotensin II Receptors in the Normal Human Prostate and Benign Prostatic Hyperplasia1
2001
The renin-angiotensin system in the rat brain
1988
Blockade of Angiotensin Receptors in the Anterior Hypothalamic Preoptic Area Lowers Blood Pressure in DOCA-Salt Hypertensive Rats.
2000
S‐nitrosylation of cysteine 289 of the AT1receptor decreases its binding affinity for angiotensin II
2006
Central renin injections: effects on drinking and expression of immediate early genes
1998
Arresting angiotensin type 1 receptors
2003
Dynamical features of thePlasmodium falciparumribosome during translation
2015 StandoutNobel
Chromosomal mapping of two genetic loci associated with blood-pressure regulation in hereditary hypertensive rats
1991 Nature
Regulation of β-Adrenergic Receptor Signaling by S-Nitrosylation of G-Protein-Coupled Receptor Kinase 2
2007 StandoutNobel
Ren1c Homozygous Null Mice Are Hypotensive and Polyuric, but Heterozygotes Are Indistinguishable from Wild-Type
2004 StandoutNobel
Canagliflozin and Cardiovascular and Renal Events in Type 2 Diabetes
2017 Standout
Renin-angiotensin system expression and secretory function in cultured human ciliary body non-pigmented epithelium
2002
Trafficking Patterns of β-Arrestin and G Protein-coupled Receptors Determined by the Kinetics of β-Arrestin Deubiquitination
2003 StandoutNobel
Identification and distribution of atrial natriuretic polypeptide in ventricular myocardium of humans with myocardial infarction
1990
Mapping of angiotensin II receptor subtype heterogeneity in rat brain
1992
Is atriopeptin a physiological or pathophysiological substance? Studies in the autoimmune rat.
1988
Oligomerization of Wild Type and Nonfunctional Mutant Angiotensin II Type I Receptors Inhibits Gαq Protein Signaling but Not ERK Activation
2004
Presence of renin in primary neuronal and glial cells from rat brain
1987
β-Arrestin 2-Dependent Angiotensin II Type 1A Receptor-Mediated Pathway of Chemotaxis
2005 StandoutNobel
Increased colonic mucosal angiotensin I and II concentrations in Crohn's colitis
1990
Angiotensinogen production by rat astroglial cells in vitro and in vivo
1990
Male–female differences in fertility and blood pressure in ACE-deficient mice
1995 StandoutNatureNobel
Physiology of Local Renin-Angiotensin Systems
2006 Standout
Important roles for angiotensin III and IV in the brain renin-angiotensin system
1997
Angiotensin II Type 1–Receptor Activating Antibodies in Renal-Allograft Rejection
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Release of angiostensin in the paraventricular nucleus in response to hyperosmotic stimulation in conscious rats: a microdialysis study
1994
The tissue renin-angiotensin systems in cardiovascular disease
1992
Dose-dependent inhibitory effects of angiotensin II on visual responses of the rat superior colliculus: AT1 and AT2 receptor contributions
1997
Angiotensin II Controls Occludin Function and Is Required for Blood–Brain Barrier Maintenance: Relevance to Multiple Sclerosis
2007
Homeostasis in Mice with Genetically Decreased Angiotensinogen Is Primarily by an Increased Number of Renin-producing Cells
1999 StandoutNobel
STRATEGY FOR THE DEVELOPMENT OF A MATCHED SET OF TRANSPORT-COMPETENT, ANGIOTENSIN RECEPTOR–DEFICIENT PROXIMAL TUBULE CELL LINES
2006
Angiotensin AT receptor contributes to cardiovascular remodelling of aged rats during chronic AT receptor blockade
2004
Seven-transmembrane receptors
2002 StandoutNobel
Radiation-induced changes in gene expression and distribution of atrial natriuretic peptide (ANP) in different anatomical regions of the rat heart
2002
A local pancreatic renin-angiotensin system: endocrine and exocrine roles
2003
Naturally occurring p16Ink4a-positive cells shorten healthy lifespan
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Attenuation of Diet-Induced Weight Gain and Adiposity through Increased Energy Expenditure in Mice Lacking Angiotensin II Type 1a Receptor
2005
Tissue renin-angiotensin systems: new insights from experimental animal models in hypertension research
2001
Angiotensin AT2 receptors: cardiovascular hope or hype?
2003
Participation of AT1 and AT2 receptor subtypes in the tonic inhibitory modulation of baroreceptor reflex response by endogenous angiotensins at the nucleus tractus solitarii in the rat
1998
The Stability of the G Protein-coupled Receptor-β-Arrestin Interaction Determines the Mechanism and Functional Consequence of ERK Activation
2003 StandoutNobel
Role of Angiotensin II–Regulated Apoptosis Through Distinct AT 1 and AT 2 Receptors in Neointimal Formation
2002
Fibrosis, not cell size, delineates β-myosin heavy chain reexpression during cardiac hypertrophy and normal aging in vivo
2006 StandoutNobel
β-Arrestin inhibits NF-κB activity by means of its interaction with the NF-κB inhibitor IκBα
2004 StandoutNobel
Localization of brain angiotensinogen mRNA by hybridization histochemistry
1987
Regulation of renin angiotensins by gonadotropic hormones in cultured murine Leydig tumor cells. Release of angiotensin but not renin.
1986
Distinct conformational changes in β-arrestin report biased agonism at seven-transmembrane receptors
2008 StandoutNobel
Evidence That Angiotensin II Is Present in Human Monocytes
1995
Atrial Natriuretic Hormone, the Renin–Aldosterone Axis, and Blood Pressure–Electrolyte Homeostasis
1985
Atriopeptin: A Cardiac Hormone Intimately Involved in Fluid, Electrolyte, and Blood-Pressure Homeostasis
1986
Biologically active atrial peptides.
1985
Plasma catecholamines and essential hypertension. An analytical review.
1983
Agonists and antagonists of protein kinase C function, derived from its binding proteins.
1994
The Role of a Conserved Region of the Second Intracellular Loop in AT1 Angiotensin Receptor Activation and Signaling
2003
β-Arrestin–Mediated Localization of Smoothened to the Primary Cilium
2008 StandoutScienceNobel
Side-Chain Substitutions within Angiotensin II Reveal Different Requirements for Signaling, Internalization, and Phosphorylation of Type 1A Angiotensin Receptors
2002
CENTRAL ADMINISTRATION OF ATRIAL NATRIURETIC FACTOR INHIBITS SALINE PREFERENCE IN THE RAT
1986
Independent β-arrestin 2 and G protein-mediated pathways for angiotensin II activation of extracellular signal-regulated kinases 1 and 2
2003 StandoutNobel
Signal Transduction Mechanisms Mediating the Physiological and Pathophysiological Actions of Angiotensin II in Vascular Smooth Muscle Cells
2000
Overexpression of angiotensin AT 1 receptor transgene in the mouse myocardium produces a lethal phenotype associated with myocyte hyperplasia and heart block
1997 StandoutNobel
Localization of renin (EC 3.4.23) and converting enzyme (EC 3.4.15.1) in nerve endings of rat brain
1985
Angiotensin-converting enzyme labeled with [3H]captopril. Tissue localizations and changes in different models of hypertension in the rat.
1987
Cardiac hypertrophy and sudden death in mice with a genetically clamped renin transgene
2004 StandoutNobel
Angiotensinogen gene is expressed and differentially regulated in multiple tissues of the rat.
1986
The cardiac renin-angiotensin system. An appraisal of present experimental and clinical evidence.
1991
β-Arrestin2-mediated inotropic effects of the angiotensin II type 1A receptor in isolated cardiac myocytes
2006 StandoutNobel
Antisera to atrial natriuretic factor reduces urinary sodium excretion and increases plasma renin activity in rats
1985
β-arrestin- but not G protein-mediated signaling by the “decoy” receptor CXCR7
2009 StandoutNobel
Characterization and distribution of receptors for the atrial natriuretic peptides in mammalian brain.
1986
Cardiac renin and angiotensins. Uptake from plasma versus in situ synthesis.
1994
Different G protein-coupled receptor kinases govern G protein and β-arrestin-mediated signaling of V2 vasopressin receptor
2005 StandoutNobel
Atrial natriuretic peptide inhibits renin release from juxtaglomerular cells by a cGMP-mediated process.
1986
Renin Uptake by the Endothelium Mediates Vascular Angiotensin Formation
2001
Hypertension, cardiac hypertrophy, and sudden death in mice lacking natriuretic peptide receptor A
1997 StandoutNobel
Angiotensin II in rat brain comigrates with authentic angiotensin II in high pressure liquid chromatography.
1985
Evidence for intracellular formation of angiotensins: Coexistence of renin and angiotensin-converting enzyme in Leydig cells of rat testis
1984
Physiologic regulation of atrial natriuretic peptide receptors in rat renal glomeruli.
1985
Natriuretic peptide receptor 1 expression influences blood pressures of mice in a dose-dependent manner
1998 StandoutNobel
Purification and subunit composition of atrial natriuretic peptide receptor.
1987
Genetic Dissection of Complex Traits
1994 StandoutScience
Effects of Atrial Natriuretic Factor on the Kidney and the Renin-Angiotensin-Aldosterone System
1987
Angiotensin-(1–7) Acts as a Vasodepressor Agent Via Angiotensin II Type 2 Receptors in Conscious Rats
2005
Functional antagonism of different G protein-coupled receptor kinases for β-arrestin-mediated angiotensin II receptor signaling
2005 StandoutNobel
Natural Products as Sources of New Drugs over the Last 25 Years
2007 Standout
Distribution and functional significance of cardiac angiotensin converting enzyme in hypertrophied rat hearts.
1993
Detection of renin mRNA in mouse testis by hybridization with renin cDNA probe
1984
Renin Is Expressed in Rat Macrophage/Monocyte Cells
1996
A micromethod for the measurement of renin in brain nuclei: Its application in spontaneously hypertensive rats
1982
Atrial natriuretic peptide binding, cross-linking, and stimulation of cyclic GMP accumulation and particulate guanylate cyclase activity in cultured cells.
1988 StandoutNobel
The natriuretic peptide clearance receptor locally modulates the physiological effects of the natriuretic peptide system
1999 StandoutNobel
Selective engagement of G protein coupled receptor kinases (GRKs) encodes distinct functions of biased ligands
2009 StandoutNobel
Structure, expression, and regulation of the murine renin genes.
1991
Genetic Decreases in Atrial Natriuretic Peptide and Salt-Sensitive Hypertension
1995 StandoutScienceNobel
Blood pressure reduction and diabetes insipidus in transgenic rats deficient in brain angiotensinogen
1999
Uncompensated polyuria in a mouse model of Bartter's syndrome
2000 StandoutNobel
Losartan, an AT1 Antagonist, Prevents Aortic Aneurysm in a Mouse Model of Marfan Syndrome
2006 StandoutScience
Distribution of [125I]angiotensin II binding sites in the rat brain: A quantitative autoradiographic study
1986
Localization of angiotensin converting enzyme in rat heart.
1991
Gene targeting approaches to complex genetic diseases: atherosclerosis and essential hypertension.
1995 StandoutNobel
Induction of Renin Activity by Gonadotropic Hormones in Cultured Leydig Tumor Cells*
1985
Autoradiographic visualization of angiotensin-converting enzyme in rat brain with [3H]captopril: localization to a striatonigral pathway.
1984
Transduction of Receptor Signals by ß-Arrestins
2005 StandoutScienceNobel
Elevated plasma atrial natriuretic peptide levels in diabetic rats. Potential mediator of hyperfiltration.
1987
Desensitization, internalization, and signaling functions of β-arrestins demonstrated by RNA interference
2003 StandoutNobel
Molecular phenotyping for analyzing subtle genetic effects in mice: Application to an angiotensinogen gene titration
2002 StandoutNobel
Works of Th. Unger being referenced
Brain Angiotensin: Receptors, Actions and Possible Role in Hypertension
1992
Complex activation of inducible transcription factors in the brain of normotensive and spontaneously hypertensive rats following central angiotensin II administration
1996
Receptors and their classification: focus on angiotensin II and the AT2 receptor
1998
Angiotensin as Neuromodulator/Neurotransmitter in Central Control of Body Fluid and Electrolyte Homeostasis
1995
Angiotensin II Induces the Expression of C-FOS mRNA in the Central Nervous System of the Rat
1995
The K+-induced increases in noradrenaline and dopamine release are accompanied by reductions in the release of their intraneuronal metabolites from the rat anterior hypothalamus
2004
The AT2 receptor—A matter of love and hate
2005
The phorbol ester induced atrial natriuretic peptide secretion is stimulated by forskolin and bay K8644 and inhibited by 8-bromo-cyclicGMP
1986
The intrarenal renin-angiotensin-system
1982
Effects of Sympathetic Nerve Stimulation are Attenuated by the Converting Enzyme Inhibitor Hoe 498 in Isolated Rabbit Hearts
1984
International Union of Pharmacology. XXIII. The Angiotensin II Receptors
2000 Standout
Combined high-performance liquid chromatography-radioimmunoassay for the characterizationand quantitative measurement of neuropeptides
1984
Atrial natriuretic factor—a circulating hormone stimulated by volume loading
1985 Nature
Free and Conjugated Catecholamines in Human Hypertension
1978
Peptidergic Systems
1984
Converting-enzyme in the choroid plexus, brain, and kidney: Immunocytochemical and biochemical studies in rats
1981
Angiotensin stimulates oxytocin release
1981
Effect of sodium chloride and sodium bicarbonate on blood pressure in stroke-prone spontaneously hypertensive rats
1988
Angiotensin-like activity in resistance vessels
1983
Angiotensin Synthesis in the Brain and Increased Turnover in Hypertensive Rats
1983 Science
Brain Peptides and Blood Pressure Regulation
1982
In vivo activity of purified mouse brain renin
1981
The tissue Renin-Angiotensin Systems: Focus on Brain Angiotensin, Adrenal Gland and Arterial Wall
1983