Citation Impact
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Cholesterol Modification of Sonic Hedgehog Is Required for Long-Range Signaling Activity and Effective Modulation of Signaling by Ptc1
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2000
Posttranscriptional Regulation of Smoothened Is Part of a Self-Correcting Mechanism in the Hedgehog Signaling System
2000
Dispatched, a Novel Sterol-Sensing Domain Protein Dedicated to the Release of Cholesterol-Modified Hedgehog from Signaling Cells
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Interactions with Costal2 and Suppressor of fused regulate nuclear translocation and activity of Cubitus interruptus
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Structural basis of the Axin–adenomatous polyposis coli interaction
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cAMP-dependent protein kinase and hedgehog act antagonistically in regulating decapentaplegic transcription in drosophila imaginal discs
1995
Physical Principles of Membrane Shape Regulation by the Glycocalyx
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Robustness of the BMP morphogen gradient in Drosophila embryonic patterning
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Smad2, Smad3 and Smad4 cooperate with Sp1 to induce p15Ink4B transcription in response to TGF-β
2000
Hedgehog Elicits Signal Transduction by Means of a Large Complex Containing the Kinesin-Related Protein Costal2
1997 Nobel
Hedgehog Movement Is Regulated through tout velu–Dependent Synthesis of a Heparan Sulfate Proteoglycan
1999
Two distinct mechanisms for long-range patterning by Decapentaplegic in the Drosophila wing
1996 Nature
Physical and Functional Interaction of Murine and Xenopus Smad7 with Bone Morphogenetic Protein Receptors and Transforming Growth Factor-β Receptors
1998
Smad transcription factors
2005 Standout
Cells’ Perception of Position in a Concentration Gradient
1998 StandoutNobel
Smads and early developmental signaling by the TGFβ superfamily
1998
Sertoli cell signaling by Desert hedgehog regulates the male germline
1996
NEW EMBO MEMBER'S REVIEW: Nuclear interpretation of Dpp signaling in Drosophila
2001
Dpp Gradient Formation in the Drosophila Wing Imaginal Disc
2000
Repression of Dpp Targets by Binding of Brinker to Mad Sites
2001
TGF-β signalling from cell membrane to nucleus through SMAD proteins
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Regulation of Organ Growth by Morphogen Gradients
2009
Three distinct roles for the engrailed gene in Drosophila wing development
1994
Morphogen gradients: new insights from DPP
1999
Smad6 as a Transcriptional Corepressor
2000
Cell interaction between compartments establishes the proximal-distal axis of Drosophila legs
1994 Nature
Tout-velu is a Drosophila homologue of the putative tumour suppressor EXT-1 and is needed for Hh diffusion
1998 Nature
An Acylatable Residue of Hedgehog Is Differentially Required in Drosophila and Mouse Limb Development
2001
Contrasting distributions of patched and hedgehog proteins in the Drosophila embryo
1993
Modulation of Hedgehog target gene expression by the Fused serine–threonine kinase in wing imaginal discs
1998
The TGFβ homolog dpp and the segment polarity gene hedgehog are required for propagation of a morphogenetic wave in the Drosophila retina
1993
TRIBE: Hijacking an RNA-Editing Enzyme to Identify Cell-Specific Targets of RNA-Binding Proteins
2016 StandoutNobel
Stability and association of Smoothened, Costal2 and Fused with Cubitus interruptus are regulated by Hedgehog
2003
Floor plate and motor neuron induction by different concentrations of the amino-terminal cleavage product of sonic hedgehog autoproteolysis
1995
Morphogenetic Signalling: Responses to Hedgehog
1995
The Interpretation of Position in a Morphogen Gradient as Revealed by Occupancy of Activin Receptors
1998 StandoutNobel
EVOLUTION OF HOX GENES
1994
Cytonemes are required for the establishment of a normal Hedgehog morphogen gradient in Drosophila epithelia
2013
A Hedgehog-Insensitive Form of Patched Provides Evidence for Direct Long-Range Morphogen Activity of Sonic Hedgehog in the Neural Tube
2001
Long-range sclerotome induction by sonic hedgehog: Direct role of the amino-terminal cleavage product and modulation by the cyclic AMP signaling pathway
1995
Smad6 Is a Smad1/5-induced Smad Inhibitor
2000
Hedgehog Induces Opposite Changes in Turnover and Subcellular Localization of Patched and Smoothened
2000
Signalling by hedgehog family proteins in Drosophila and vertebrate development
1995
Localized hedgehog activity controls spatial limits of wingless transcription in the Drosophila embryo
1993 Nature
Aplysia CREB2 represses long-term facilitation: Relief of repression converts transient facilitation into long-term functional and structural change
1995 StandoutNobel
Patterning of mammalian somites by surface ectoderm and notochord: Evidence for sclerotome induction by a hedgehog homolog
1994
Vertebrate Homologs of Drosophila Suppressor of Fused Interact with the Gli Family of Transcriptional Regulators
1999
Proteolysis That Is Inhibited by Hedgehog Targets Cubitus interruptus Protein to the Nucleus and Converts It to a Repressor
1997
Induction of Inhibitory Smad6 and Smad7 mRNA by TGF-β Family Members
1998
Evidence for a Role of Smad6 in Chick Cardiac Development
1999
Analysis of Epithelial–Mesenchymal Interactions in the Initial Morphogenesis of the Mammalian Tooth
1998
Activin signalling and response to a morphogen gradient
1994 StandoutNatureNobel
Hedgehog Signaling in Germ Cell Migration
2001
Developmental roles and molecular characterization of a Drosophila homologue of Arabidopsis Argonaute1, the founder of a novel gene superfamily
2001
The Drosophila smoothened Gene Encodes a Seven-Pass Membrane Protein, a Putative Receptor for the Hedgehog Signal
1996
Floor plate and motor neuron induction by vhh-1, a vertebrate homolog of hedgehog expressed by the notochord
1994 Standout
Tob proteins enhance inhibitory Smad-receptor interactions to repress BMP signaling
2003
Genes and Mechanisms Related to RNA Interference Regulate Expression of the Small Temporal RNAs that Control C. elegans Developmental Timing
2001 StandoutNobel
Drosophila Mad binds to DNA and directly mediates activation of vestigial by Decapentaplegic
1997 Nature
Transcriptional regulation of the Drosophila gene zen by competing Smad and Brinker inputs
2001
The Drosophila Activin receptor Baboon signals through dSmad2 and controls cell proliferation but not patterning during larval development
1999
Distinct pathways for autocrine and paracrine Wingless signalling inDrosophila embryos
1994 Nature
A functionally conserved homolog of the Drosophila segment polarity gene hh is expressed in tissues with polarizing activity in zebrafish embryos
1993
Smad6 inhibits BMP/Smad1 signaling by specifically competing with the Smad4 tumor suppressor
1998
Morphogen gradients
2000
PAS is a dimerization domain common to Drosophila Period and several transcription factors
1993 StandoutNatureNobel
A Homeodomain Protein Code Specifies Progenitor Cell Identity and Neuronal Fate in the Ventral Neural Tube
2000
Dividing cellular asymmetry: asymmetric cell division and its implications for stem cells and cancer
2009
Pattern Formation: Hedgehog points the way
1994
Cooperative Inhibition of Bone Morphogenetic Protein Signaling by Smurf1 and Inhibitory Smads
2003
Sightless has homology to transmembrane acyltransferases and is required to generate active Hedgehog protein
2001
Generation of germline-competent induced pluripotent stem cells
2007 StandoutNatureNobel
The DSmurf Ubiquitin-Protein Ligase Restricts BMP Signaling Spatially and Temporally during Drosophila Embryogenesis
2001
Hedgehog Patterning Activity: Role of a Lipophilic Modification Mediated by the Carboxy-Terminal Autoprocessing Domain
1996
Cell-Type-Specific Profiling of Gene Expression and Chromatin Binding without Cell Isolation: Assaying RNA Pol II Occupancy in Neural Stem Cells
2013
Hedgehog signaling in animal development: paradigms and principles
2001 Standout
Smoothened transduces Hedgehog signal by physically interacting with Costal2/Fused complex through its C-terminal tail
2003
Sonic hedgehog and Fgf-4 act through a signaling cascade and feedback loop to integrate growth and patterning of the developing limb bud
1994 Standout
The COE transcription factor Collier is a mediator of short-range Hedgehog-induced patterning of the Drosophila wing
1999
Conversion of an Extracellular Dpp/BMP Morphogen Gradient into an Inverse Transcriptional Gradient
2003
Neuroligins and neurexins link synaptic function to cognitive disease
2008 StandoutNatureNobel
Spatial Representation of the Glomerular Map in the Drosophila Protocerebrum
2002 StandoutNobel
Patched represses the Hedgehog signalling pathway by promoting modification of the Smoothened protein
2000
Schnurri mediates Dpp-dependent repression of brinker transcription
2000
TGF-β Family Signal Transduction in Drosophila Development: From Mad to Smads
1999
Wingless Repression of Drosophila frizzled 2 Expression Shapes the Wingless Morphogen Gradient in the Wing
1998
Efflux-dependent auxin gradients establish the apical–basal axis of Arabidopsis
2003 StandoutNature
Surrogate Wnt agonists that phenocopy canonical Wnt and β-catenin signalling
2017 StandoutNatureNobel
Conservation of the hedgehog/patched signaling pathway from flies to mice: induction of a mouse patched gene by Hedgehog.
1996 Standout
Patterning activities of vertebrate hedgehog proteins in the developing eye and brain
1995
Signal transduction by cAMP-dependent protein kinase A in Drosophila limb patterning
1995 Nature
Hedgehog, Transmitted along Retinal Axons, Triggers Neurogenesis in the Developing Visual Centers of the Drosophila Brain
1996
Smad7 and Smad6 Differentially Modulate Transforming Growth Factor β-induced Inhibition of Embryonic Lung Morphogenesis
2000
C/EBP is an immediate-early gene required for the consolidation of long-term facilitation in Aplysia
1994 StandoutNobel
Physical and Functional Interaction of SMADs and p300/CBP
1998
An FGF receptor signaling pathway is required for the normal cell migrations of the sex myoblasts in C. elegans hermaphrodites
1995 StandoutNobel
How cells read TGF-β signals
2000 Standout
A Gain-of-Function Mutant of patched Dissects Different Responses to the Hedgehog Gradient
2000
The product of hedgehog autoproteolytic cleavage active in local and long-range signalling
1995 Nature
Integration of positional signals and regulation of wing formation and identity by Drosophila vestigial gene
1996 Nature
The segment polarity gene hedgehog is required for progression of the morphogenetic furrow in the developing Drosophila eye
1993
Are Complex Behaviors Specified by Dedicated Regulatory Genes? Reasoning from Drosophila
2001 StandoutNobel
fringe, a boundary-specific signaling molecule, mediates interactions between dorsal and ventral cells during Drosophila wing development
1994 StandoutNobel
Secretion of the amino-terminal fragment of the Hedgehog protein is necessary and sufficient for hedgehog signalling in Drosophila
1995
Sonic hedgehog, a member of a family of putative signaling molecules, is implicated in the regulation of CNS polarity
1993 Standout
Absence of radius and ulna in mice lacking hoxa-11 andhoxd-11
1995 StandoutNatureNobel
Distinct and regulated activities of human Gli proteins in Drosophila
1999
Expression of a novel Toll-like gene spans the parasegment boundary and contributes to hedgehog function in the adult eye of Drosophila
1994
Sonic Hedgehog-induced Activation of the Gli1Promoter Is Mediated by GLI3
1999
Protein kinase A and hedgehog signaling in drosophila limb development
1995
c-Ski Acts as a Transcriptional Co-repressor in Transforming Growth Factor-β Signaling through Interaction with Smads
1999
The TRA-1A Sex Determination Protein of C. elegans Regulates Sexually Dimorphic Cell Deaths by Repressing the egl-1 Cell Death Activator Gene
1999 StandoutNobel
Quantitative effects of hedgehog and decapentaplegic activity on the patterning of the Drosophila wing
1995
Regulation of the Hedgehog and Wingless signalling pathways by the F-box/WD40-repeat protein Slimb
1998 StandoutNature
Dual Roles for Patched in Sequestering and Transducing Hedgehog
1996 Standout
NEW EMBO MEMBERS REVIEW: Transcriptional control by the TGF-beta/Smad signaling system
2000 Standout
tea1 and the Microtubular Cytoskeleton Are Important for Generating Global Spatial Order within the Fission Yeast Cell
1997 StandoutNobel
Drosophila hedgehog acts as a morphogen in cellular patterning
1994
Complementary and Mutually Exclusive Activities of Decapentaplegic and Wingless Organize Axial Patterning during Drosophila Leg Development
1996
Sonic hedgehog mediates the polarizing activity of the ZPA
1993 Standout
Compartment boundaries and the control of Drosopfiffa limb pattern by hedgehog protein
1994 Nature
The Drosophila cubitus interruptus protein and its role in the wingless and hedgehog signal transduction pathways
1995
Controlling TGF-β signaling
2000
Wnt Signaling in Neural Circuit Assembly
2008
Defective LPS Signaling in C3H/HeJ and C57BL/10ScCr Mice: Mutations in Tlr4 Gene
1998 StandoutScienceNobel
Cholesterol Modification of Hedgehog Signaling Proteins in Animal Development
1996 Science
Sonic hedgehog is an endodermal signal inducing Bmp-4 and Hox genes during induction and regionalization of the chick hindgut
1995
Distinct expression and shared activities of members of the hedgehog gene family of Xenopus laevis
1995
Lineage-specific regulators couple cell lineage asymmetry to the transcription of the Caenorhabditis elegans POU gene unc-86 during neurogenesis.
1996 StandoutNobel
Combinatorial Gli gene function in floor plate and neuronal inductions by Sonic hedgehog
1998
TGF-β SIGNAL TRANSDUCTION
1998 Standout
Hedgehog signaling patterns the tracheal branches
2001
The hedgehog gene family in Drosophila and vertebrate development
1994
Hedgehog organises the pattern and polarity of epidermal cells in the Drosophila abdomen
1997
Mouse Gli1 mutants are viable but have defects in SHH signaling in combination with a Gli2 mutation
2000 Standout
β-Arrestin–Mediated Localization of Smoothened to the Primary Cilium
2008 StandoutScienceNobel
Heterodimerization between light-regulated and ubiquitously expressed Arabidopsis GBF bZIP proteins.
1992
Cubitus interruptus-independent transduction of the Hedgehog signal in Drosophila
2000
GATA- and Smad1-Dependent Enhancers in the Smad7 Gene Differentially Interpret Bone Morphogenetic Protein Concentrations
2003
open brain, a new mouse mutant with severe neural tube defects, shows altered gene expression patterns in the developing spinal cord
1994
Expression of Sonic hedgehog and its putative role as a precursor cell mitogen in the developing mouse retina
1997
Dpp signaling thresholds in the dorsal ectoderm of the Drosophila embryo
2000
Long-range action of Wingless organizes the dorsal-ventral axis of the Drosophila wing
1997
Activation of knot (kn) specifies the 3-4 intervein region in the Drosophila wing
2000
Hox10 and Hox11 Genes Are Required to Globally Pattern the Mammalian Skeleton
2003 StandoutScienceNobel
Hedgehog signaling regulates transcription through cubitus interruptus, a sequence-specific DNA binding protein
1997
Sending and Receiving the Hedgehog Signal: Control by the Drosophila Gli Protein Cubitus interruptus
1996 Science
Wingless and Hedgehog pattern Drosophila denticle belts by regulating the production of short-range signals
1999
Distribution of Sonic hedgehog peptides in the developing chick and mouse embryo
1995
Cell patterning in the Drosophila segment: engrailed and wingless antigen distributions in segment polarity mutant embryos
1993
Proteolytic Processing Yields Two Secreted Forms of Sonic hedgehog
1995
Dorsal-ventral patterning of the Drosophila embryo depends on a putative negative growth factor encoded by the short gastrulation gene.
1994
Predicting Coiled Coils from Protein Sequences
1991 StandoutScience
The L3 loop: a structural motif determining specific interactions between SMAD proteins and TGF-beta receptors
1998
Targeted expression of the signaling molecule decapentaplegic induces pattern duplications and growth alterations in Drosophila wings.
1994
Morphogens, Compartments, and Pattern: Lessons from Drosophila?
1996
Protein kinase A directly regulates the activity and proteolysis of cubitus interruptus
1998
Genetic analysis of hedgehog signalling in the Drosophila embryo
1993
A General Mechanism for Network-Dosage Compensation in Gene Circuits
2010 StandoutScienceNobel
The concentric structure of the developing gut is regulated by Sonic hedgehog derived from endodermal epithelium
2000
Nuclear import of Cubitus interruptus is regulated by Hedgehog via a mechanism distinct from Ci stabilization and Ci activation
2000
Subcellular localization of the segment polarity protein patched suggests an interaction with the wingless reception complex in Drosophila embryos
1994
Autoproteolysis in hedgehog protein biogenesis
1994 Science
The Taxonomy of Developmental Control in Caenorhabditis elegans
1998 StandoutScienceNobel
Hox genes and the evolution of vertebrate axial morphology
1995
The subcellular localization and activity of Drosophila Cubitus interruptus are regulated at multiple levels
1999
A Hedgehog activity gradient contributes to AP axial patterning of the Drosophila wing
1997
Signaling from Smo to Ci/Gli: conservation and divergence of Hedgehog pathways fromDrosophilato vertebrates
2005
The Drosophila segment polarity gene patched interacts with decapentaplegic in wing development.
1994
The ubiquitin ligase Hyperplastic discs negatively regulateshedgehoganddecapentaplegicexpression by independent mechanisms
2002
patched overexpression alters wing disc size and pattern: transcriptional and post-transcriptional effects on hedgehog targets
1995
Hox genes and morphological identity: axial versus lateral patterning in the vertebrate mesoderm
2000
Sonic Hedgehog Induces the Segregation of Patched and Smoothened in Endosomes
2002
Hedgehog activity, independent of Decapentaplegic, participates in wing disc patterning
1997
Sonic Hedgehog Promotes Rod Photoreceptor Differentiation in Mammalian Retinal CellsIn Vitro
1997
Enhanced Potency of Human Sonic Hedgehog by Hydrophobic Modification
2001
Differential requirements of the Fused kinase for Hedgehog signalling in the Drosophila embryo
1999
Receptor-mediated endocytosis of soluble and membrane-tethered Sonic hedgehog by Patched-1
2000
Scissors-Grip Model for DNA Recognition by a Family of Leucine Zipper Proteins
1989 Science
Signaling through both type I DPP receptors is required for anterior-posterior patterning of the entire Drosophila wing
1997
Hedgehog signals regulate multiple aspects of gastrointestinal development
2000
hedgehog is required for the proliferation and specification of ovarian somatic cells prior to egg chamber formation in Drosophila
1996
Smoothened Mutants Reveal Redundant Roles for Shh and Ihh Signaling Including Regulation of L/R Asymmetry by the Mouse Node
2001
Hedgehog Signaling Regulation of Homeodomain Protein Islet Duodenum Homeobox-1 Expression in Pancreatic β-Cells*
2001
Involvement of Sonic hedgehog (Shh) in mouse embryonic lung growth and morphogenesis
1997
Requirement of 19K form of Sonic hedgehog for induction of distinct ventral cell types in CNS explants
1995 Nature
A Localized Wnt Signal Orients Asymmetric Stem Cell Division in Vitro
2013 StandoutScienceNobel
The sterol-sensing domain of Patched protein seems to control Smoothened activity through Patched vesicular trafficking
2001
Signals transmitted along retinal axons in Drosophila: Hedgehog signal reception and the cell circuitry of lamina cartridge assembly
1998
Transcriptional activation of hedgehog target genes in Drosophila is mediated directly by the cubitus interruptus protein, a member of the GLI family of zinc finger DNA-binding proteins.
1996
Cognate DNA Binding Specificity Retained After Leucine Zipper Exchange Between GCN4 and C/EBP
1989 StandoutScienceNobel
Biphasic activation of the BMP pathway patterns the Drosophila embryonic dorsal region
2001
Function of protein kinase A in hedgehog signal transduction and Drosophila imaginal disc development
1995
Segment polarity gene interactions modulate epidermal patterning in Drosophila embryos
1993 StandoutNobel
Sonic hedgehog protein signals not as a hydrolytic enzyme but as an apparent ligand for Patched
1999
Integrating Genetic Approaches into the Discovery of Anticancer Drugs
1997 StandoutScienceNobel
Conservation in hedgehog signaling: induction of a chicken patched homolog by Sonic hedgehog in the developing limb
1996
Developmental Control of Cell Cycle Regulators: A Fly's Perspective
1996 Science
Regulation of patched by sonic hedgehog in the developing neural tube.
1996 Standout
Interaction with Smad4 Is Indispensable for Suppression of BMP Signaling by c-Ski
2003
Xenopus Smad7 inhibits both the activin and BMP pathways and acts as a neural inducer
1998
Regulation of Rate of Cartilage Differentiation by Indian Hedgehog and PTH-Related Protein
1996 StandoutScience
Controlling TGF-beta signaling.
2000 Standout
A model for anteroposterior patterning of the vertebrate limb based on sequential long- and short-range Shh signalling and Bmp signalling
2000
Products, genetic linkage and limb patterning activity of a murine hedgehog gene
1994
ß-Arrestin 2 Mediates Endocytosis of Type III TGF-ß Receptor and Down-Regulation of Its Signaling
2003 StandoutScienceNobel
Transgenic Analysis of the Smad Family of TGF-β Signal Transducers in Drosophila melanogaster Suggests New Roles and New Interactions Between Family Members
2001
Morphogen gradient interpretation
2001 StandoutNatureNobel
An absolute requirement for Cubitus interruptus in Hedgehog signaling
2001
Mutants of cubitus interruptus that are independent of PKA regulation are independent of hedgehog signaling
1999
Sequential organizing activities of engrailed, hedgehog and decapentaplegic in the Drosophila wing
1995
Works of Tetsuya Tabata being referenced
Coordinated sequential action of EGFR and Notch signaling pathways regulates proneural wave progression in the Drosophila optic lobe
2010
brinker is a target of Dpp in Drosophila that negatively regulates Dpp-dependent genes
1999 Nature
Hedgehog is a signaling protein with a key role in patterning Drosophila imaginal discs
1994
Hedgehog Signal Transduction in the Posterior Compartment of the Drosophila Wing Imaginal Disc
2000
Identification and characterization of E‐APC, a novel Drosophila homologue of the tumour suppressor APC
1999
Hedgehog Creates a Gradient of DPP Activity in Drosophila Wing Imaginal Discs
2000
Genetics of morphogen gradients
2001
DWnt4 regulates the dorsoventral specificity of retinal projections in the Drosophila melanogaster visual system
2005
Daughters against dpp modulates dpp organizing activity in Drosophila wing development
1997 Nature
ThreeDrosophilaEXT genes shape morphogen gradients through synthesis of heparan sulfate proteoglycans
2003
A Protein That Binds to a cis-acting Element of Wheat Histone Genes Has a Leucine Zipper Motif
1989 Science
The Drosophila hedgehog gene is expressed specifically in posterior compartment cells and is a target of engrailed regulation.
1992
Drosophilaoptic lobe neuroblasts triggered by a wave of proneural gene expression that is negatively regulated by JAK/STAT
2008
Interplay of Signal Mediators of Decapentaplegic (Dpp): Molecular Characterization of Mothers against dpp, Medea, and Daughters against dpp
1998
Morphogens, their identification and regulation
2004
HBP-1a and HBP-1b: leucine zipper-type transcription factors of wheat.
1991
Xenopus Smad8 acts downstream of BMP-4 to modulate its activity during vertebrate embryonic patterning
1998
Creating a Drosophila wing de novo, the role of engrailed, and the compartment border hypothesis
1995