Standout Papers
Citation Impact
Citing Papers
Computational protein design enables a novel one-carbon assimilation pathway
2015 StandoutNobel
Anti-Markovnikov alkene oxidation by metal-oxo–mediated enzyme catalysis
2017 StandoutScienceNobel
Computational Design of Self-Assembling Protein Nanomaterials with Atomic Level Accuracy
2012 StandoutScienceNobel
The Genetic Basis for Bacterial Mercury Methylation
2013 StandoutScience
An Engineered Microbial Platform for Direct Biofuel Production from Brown Macroalgae
2012 StandoutScienceNobel
Conserving a Volatile Metabolite: a Role for Carboxysome-Like Organelles in Salmonella enterica
2006
Directed Evolution Mimics Allosteric Activation by Stepwise Tuning of the Conformational Ensemble
2018 StandoutNobel
Asymmetric addition of achiral organomagnesium reagents or organolithiums to achiral aldehydes or ketones: a review
2009
A locking mechanism preventing radical damage in the absence of substrate, as revealed by the x-ray structure of lysine 5,6-aminomutase
2004
First enantioselective addition of dialkylzinc to ketones promoted by titanium(IV) derivatives
1998
Crystal structure of a methyltetrahydrofolate- and corrinoid-dependent methyltransferase
2000
QM/MM Methods for Biomolecular Systems
2009 Standout
Exploiting attractive non-covalent interactions for the enantioselective catalysis of reactions involving radical intermediates
2020
Natural engineering principles of electron tunnelling in biological oxidation–reduction
1999 StandoutNature
Friedel–Crafts‐Type Mechanism for the Enzymatic Elimination of Ammonia from Histidine and Phenylalanine
2005
Enzyme diversity and mosaic gene organization in denitrification
1997
Highly Enantioselective Desymmetrization of Anhydrides by Carbon Nucleophiles: Reactions of Grignard Reagents in the Presence of (−)-Sparteine
2002
Enantioselective Synthesis of Tertiary and Quaternary Stereogenic Centers: Copper/Phosphoramidite‐Catalyzed Allylic Alkylation with Organolithium Reagents
2012 StandoutNobel
Monovalent Cations Partially Repair a Conformational Defect in a Mutant Tryptophan Synthase α2β2 Complex (β-E109A)
1995
Metabolic Engineering of Propanediol Pathways
1998
Structural Insight into the Mechanisms of Transport across the Salmonella enterica Pdu Microcompartment Shell
2010
Adenosyl Radical: Reagent and Catalyst in Enzyme Reactions
2010
Vitamin B12 deficiency in Caenorhabditis elegans results in loss of fertility, extended life cycle, and reduced lifespan
2013
Enzymatic functionalization of carbon–hydrogen bonds
2010 StandoutNobel
Mechanism‐Inspired Engineering of Phenylalanine Aminomutase for Enhanced β‐Regioselective Asymmetric Amination of Cinnamates
2011 StandoutNobel
A Cyclic [4]rotaxane that Behaves as a Switchable Molecular Receptor: Formation of a Rigid Scaffold from a Collapsed Structure by Complexation with Copper(I) Ions
2010 StandoutNobel
Mechanisms for Insulin Resistance: Common Threads and Missing Links
2012 Standout
Macrophage biology in development, homeostasis and disease
2013 StandoutNature
Native structure of photosystem II at 1.95 Å resolution viewed by femtosecond X-ray pulses
2014 StandoutNature
Click Chemistry In Situ: Acetylcholinesterase as a Reaction Vessel for the Selective Assembly of a Femtomolar Inhibitor from an Array of Building Blocks
2002 StandoutNobel
Evolution of Coenzyme B12 Synthesis Among Enteric Bacteria: Evidence for Loss and Reacquisition of a Multigene Complex
1996
Metabolic engineering for the microbial production of 1,3-propanediol
2003
Sulfur(VI) Fluoride Exchange (SuFEx): Another Good Reaction for Click Chemistry
2014 StandoutNobel
Coenzyme B12 dependent glutamate mutase
2002
Purification and properties of a dissimilatory nitrate reductase from Haloferax denitrificans
1991
Engineering the third wave of biocatalysis
2012 StandoutNature
Biogenesis of Molybdenum Cofactors
1990
Enantioselective addition of diorganozincs to aldehydes catalyzed by β-amino alcohols
1990 StandoutNobel
The First Polymer-Supported and Recyclable Chiral Catalyst for Enantioselective Olefin Metathesis
2002 StandoutNobel
Quantitative exploration of the molecular origin of the activation of GTPase
2013 StandoutNobel
Cell biology and molecular basis of denitrification
1997 Standout
Enantioselective Synthesis with Lithium/(−)‐Sparteine Carbanion Pairs
1997
Regioselective, Diastereoselective, and Enantioselective Lithiation−Substitution Sequences: Reaction Pathways and Synthetic Applications
1996
Catalyzed Enantioselective Alkylation of Aldehydes
1992
Dynamical Contributions to Enzyme Catalysis: Critical Tests of A Popular Hypothesis
2006 StandoutNobel
Respiratory nitrate reductase from denitrifying Pseudomonas stutzeri, purification, properties and target of proteolysis
1991
Biochemistry, function, and deficiency of vitamin B12inCaenorhabditis elegans
2016
First enantioselective addition of diethylzinc and dimethylzinc to prostereogenic ketones catalysed by camphorsulfonamide-titanium alkoxide derivatives
1998
A Potent and Highly Selective Inhibitor of Human α-1,3-Fucosyltransferase via Click Chemistry
2003 StandoutNobel
The ONIOM Method and Its Applications
2015
Molecular mechanics studies of coenzyme B12 complexes with constrained Co-N(axial-base) bond lengths: introduction of the universal force field (UFF) to coenzyme B12 chemistry and its use to probe the plausibility of an axial-base-induced, ground-state corrin butterfly conformational steric effect
2000
A general two-metal-ion mechanism for catalytic RNA.
1993 StandoutNobel
Enzymatische Eliminierung von Ammoniak aus Histidin und Phenylalanin: der Friedel‐Crafts‐ähnliche Mechanismus
2005
In Situ Click Chemistry: Enzyme Inhibitors Made to Their Own Specifications
2004 StandoutNobel
Comparison of the Reactivity of Bis(μ-oxo)CuIICuIII and CuIIICuIII Species to Methane
2008
The Many Faces of Vitamin B12: Catalysis by Cobalamin-Dependent Enzymes
2003
A new paradigm for electrostatic catalysis of radical reactions in vitamin B 12 enzymes
2007 StandoutNobel
Engineering enzymes for noncanonical amino acid synthesis
2018 StandoutNobel
Lysosomal activity regulatesCaenorhabditis elegansmitochondrial dynamics through vitamin B12 metabolism
2020 StandoutNobel
Catalytic iron-carbene intermediate revealed in a cytochrome c carbene transferase
2018 StandoutNobel
The First Experimental Test of the Hypothesis that Enzymes Have Evolved To Enhance Hydrogen Tunneling
2003
Functional site of human placental estradiol 17β-dehydrogenase involves tyrosine residues, as evidenced by reaction to p-nitrobenzenesulfonyl fluoride
1983
Kinetic and Mechanistic Analysis of Nonenzymatic, Template-Directed Oligoribonucleotide Ligation
1996 StandoutNobel
Asymmetric Catalysis by Architectural and Functional Molecular Engineering: Practical Chemo- and Stereoselective Hydrogenation of Ketones
2001 StandoutNobel
Catalytic Asymmetric Hydroalkoxylation of C–C Multiple Bonds
2021 StandoutNobel
Chemistry and Enzymology of Vitamin B12
2005
Flocculence of Saccharomyces cerevisiae cells is induced by nutrient limitation, with cell surface hydrophobicity as a major determinant
1992
Stabilization of the adenosyl radical in coenzyme B12 – a theoretical study
2004
How many catalytic RNAs? Ions and the Cheshire cat conjecture.
1993
Unlocking Reactivity of TrpB: A General Biocatalytic Platform for Synthesis of Tryptophan Analogues
2017 StandoutNobel
Artificial Enzymes
1996
Biochemistry and physiology of aerobic carbon monoxide-utilizing bacteria
1986
Kinetic Resolution of Homoaldols via Catalytic Asymmetric Transacetalization
2010 StandoutNobel
Bioconjugation by Copper(I)-Catalyzed Azide-Alkyne [3 + 2] Cycloaddition
2003 StandoutNobel
Electrostatic Basis for Enzyme Catalysis
2006 StandoutNobel
Catalytic site cooperativity of beef heart mitochondrial F1 adenosine triphosphatase. Correlations of initial velocity, bound intermediate, and oxygen exchange measurements with an alternating three-site model.
1982 StandoutNobel
Chemomimetic Biocatalysis: Exploiting the Synthetic Potential of Cofactor-Dependent Enzymes To Create New Catalysts
2015 StandoutNobel
Adocobinamide, the Base-off Analog of Coenzyme B12 (Adocobalamin). 2.1 Probing the “Base-on” Effect in Coenzyme B12 via Cobalt−Carbon Bond Thermolysis Product and Kinetic Studies as a Function of Exogenous Pyridine Bases
1996
Toward an Improved Understanding of the Glutamate Mutase System
2007
COBALAMIN (COENZYME B12): Synthesis and Biological Significance
1996
In Situ Selection of Lead Compounds by Click Chemistry: Target-Guided Optimization of Acetylcholinesterase Inhibitors
2005 StandoutNobel
Spectroscopic and Computational Studies of Glutathionylcobalamin: Nature of Co–S Bonding and Comparison to Co–C Bonding in Coenzyme B12
2011
Quantitative Analysis of the Chiral Amplification in the Amino Alcohol-Promoted Asymmetric Alkylation of Aldehydes with Dialkylzincs
1998 StandoutNobel
Redox cycling and kinetic analysis of single molecules of solution-phase nitrite reductase
2011 StandoutNobel
Synthetic and Therapeutic Applications of Ammonia-lyases and Aminomutases
2017
Protein Radicals in Enzyme Catalysis
1998 Standout
Metals and Their Scaffolds To Promote Difficult Enzymatic Reactions
2006
Chiral Metal Complexes as Discriminating Molecular Catalysts
1990 StandoutScienceNobel
Radical Enzymes in Anaerobes
2006
Theoretical Insight into Gate-Opening Adsorption Mechanism and Sigmoidal Adsorption Isotherm into Porous Coordination Polymer
2018 StandoutNobel
Menaquinol-nitrate oxidoreductase of Bacillus halodenitrificans
1991
Short N-terminal sequences package proteins into bacterial microcompartments
2010
The immobilization of mitochondrial malate dehydrogenase on Sepharose beads and the demonstration of catalytically active subunits.
1981
Aquaporins in Saccharomyces : Characterization of a second functional water channel protein
2001 StandoutNobel
Asymmetric Enamine Catalysis
2007 StandoutNobel
How the Co−C Bond Is Cleaved in Coenzyme B12 Enzymes: A Theoretical Study
2005
Enantioselektive Addition von Organometallreagentien an Carbonylverbindungen: Übertragung, Vervielfältigung und Verstärkung der Chiralität
1991 StandoutNobel
Enantioselective Addition of Organometallic Reagents to Carbonyl Compounds: Chirality Transfer, Multiplication, and Amplification
1991 StandoutNobel
The axial N -base has minor influence on Co–C bond cleavage in cobalamins
2002
Enzyme-Controlled Nitrogen-Atom Transfer Enables Regiodivergent C–H Amination
2014 StandoutNobel
Quantum Chemical Studies of Mechanisms for Metalloenzymes
2014
Construction and Characterization of a 1,3-Propanediol Operon
1998
Exploring challenges in rational enzyme design by simulating the catalysis in artificial kemp eliminase
2010 StandoutNobel
Works of Tetsuo Toraya being referenced
Molecular architectures and functions of radical enzymes and their (re)activating proteins
2015
The crystal structure of coenzyme B12‐dependent glycerol dehydratase in complex with cobalamin and propane‐1,2‐diol
2002
Characterization and Mechanism of Action of a Reactivating Factor for Adenosylcobalamin-dependent Glycerol Dehydratase
2001
Characterization, Sequencing, and Expression of the Genes Encoding a Reactivating Factor for Glycerol-inactivated Adenosylcobalamin-dependent Diol Dehydratase
1997
A Reactivating Factor for Coenzyme B12-dependent Diol Dehydratase
1999
Crystal Structures of Ethanolamine Ammonia-lyase Complexed with Coenzyme B12 Analogs and Substrates
2010
Cloning, Sequencing, and High Level Expression of the Genes Encoding Adenosylcobalamin-dependent Glycerol Dehydrase of
1996
Crystallization and preliminary X-ray study of two crystal forms of Klebsiella oxytoca diol dehydratase–cyanocobalamin complex
1999
Does Cob(II)alamin Act as a Conductor in Coenzyme B 12 Dependent Mutases?
2006
Molecular Cloning and Expression of Starfish Protein Kinase C Isoforms
2009
Importance of the Nucleotide Loop Moiety Corrdinated to the Cobalt Atom of Adenosylcobalamin for Coenzymic Function in the Diol Dehydrase Reaction.
1993
Adenosylcobinamide methyl phosphate as a pseudocoenzyme for diol dehydrase
1993
Testicular Injury to Rats Fed on Soybean Protein-Based Vitamin B12-Deficient Diet Can Be Reduced by Methionine Supplementation
2007
Extremely Low Activity of Methionine Synthase in Vitamin B-12–Deficient Rats May Be Related to Effects on Coenzyme Stabilization Rather than to Changes in Coenzyme Induction
2000
Computational Mutation Analysis of Hydrogen Abstraction and Radical Rearrangement Steps in the Catalysis of Coenzyme B12‐Dependent Diol Dehydratase
2007
A Protein Factor Is Essential forin SituReactivation of Glycerol-inactivated Adenosylcobalamin-dependent Diol Dehydratase
1997
Radical production simulated by photoirradiation of the diol dehydratase–adeninylpentylcobalamin complex
2001
How a protein generates a catalytic radical from coenzyme B12: X-ray structure of a diol-dehydratase–adeninylpentylcobalamin complex
2000
Heterologous High Level Expression, Purification, and Enzymological Properties of Recombinant Rat Cobalamin-dependent Methionine Synthase
1999
Cobalamin-dependent dehydratases and a deaminase: Radical catalysis and reactivating chaperones
2013
Molecular Cloning, Sequencing, and Expression of the Genes Encoding Adenosylcobalamin-dependent Diol Dehydrase of Klebsiella oxytoca
1995
A new mode of B12 binding and the direct participation of a potassium ion in enzyme catalysis: X-ray structure of diol dehydratase
1999
Radical catalysis of B 12 enzymes: structure, mechanism, inactivation, and reactivation of diol and glycerol dehydratases
2000
Acceleration of cleavage of the carbon-cobalt bond of sterically hindered alkylcobalamins by binding to apoprotein of diol dehydrase
1988
Enzymatic Radical Catalysis: Coenzyme B12‐Dependent Diol Dehydratase
2002
Direct Participation of Potassium Ion in the Catalysis of Coenzyme B12-Dependent Diol Dehydratase
1999
The N-Terminal Regions of β and γ Subunits Lower the Solubility of Adenosylcobalamin-Dependent Diol Dehydratase
2005
Energetic Feasibility of Hydrogen Abstraction and Recombination in Coenzyme B12-Dependent Diol Dehydratase Reaction
2001
Catalytic Roles of Active-Site Amino Acid Residues of Coenzyme B12-Dependent Diol Dehydratase: Protonation State of Histidine and Pull Effect of Glutamate
2004
Distribution of coenzyme B12-dependent diol dehydratase and glycerol dehydratase in selected genera of Enterobacteriaceae and Propionibacteriaceae
1980
Immobilized diol dehydrase and its use in studies of cobalamin binding and subunit interaction
1975
Identification of the 1,2-Propanediol-1-yl Radical as an Intermediate in Adenosylcobalamin-Dependent Diol Dehydratase Reaction
2005
Effect of chemical modification of cell surface components of a brewer's yeast on the floc-forming ability
1977
Identification and Expression of the Genes Encoding a Reactivating Factor for Adenosylcobalamin-Dependent Glycerol Dehydratase
1999
Role of peripheral side chains of vitamin B12 coenzymes in the reaction catalyzed by dioldehydrase
1979
Essential Role of Monovalent Cations in the Firm Binding of Pyridoxal 5′‐Phosphate to Tryptophanase and β‐Tyrosinase
1976
Asymmetric syntheses by means of (−)-sparteine modified organometallic reagents
1971 StandoutNobel
Mechanism of Reactivation of Coenzyme B12-Dependent Diol Dehydratase by a Molecular Chaperone-like Reactivating Factor
1999
Modification of Trytophanase with Tetranitromethane
1981
Asymmetric carbinol synthesis by means of (−)-sparteine-modified organometallic reagents
1968
Formation of thieno[3,2-g]pterines from the molybdenum cofactor
1983
Roles of the D-ribose and 5,6-dimethylbenzimidazole moieties of the nucleotide loop of adenosylcobalamin in manifestation of coenzymic function in the diol dehydrase reaction.
1991
Radical Catalysis in Coenzyme B12-Dependent Isomerization (Eliminating) Reactions
2003
The structure and the mechanism of action of coenzyme B12-dependent diol dehydratases
2000
Flocculation of cell walls of brewer's yeast and effects of metal ions, protein-denaturants and enzyme treatments
1982
Substrate specificity of coenzyme B12-dependent diol dehydrase: Glycerol as both a good substrate and a potent inactivator
1976
Substrate-Induced Conformational Change of a Coenzyme B12-Dependent Enzyme: Crystal Structure of the Substrate-Free Form of Diol Dehydratase,
2002
In situ reactivation of glycerol-inactivated coenzyme B12-dependent enzymes, glycerol dehydratase and diol dehydratase
1980
Immunochemical Evidence for the Difference between Coenzyme‐B12‐Dependent Diol Dehydratase and Glycerol Dehydratase
1977
Purification, properties and limited proteolysis of nitrate reductase from Pseudomonas denitrificans
1984
Studies on the mechanism of the adenosylcobalamin-dependent diol dehydrase reaction by the use of analogs of the coenzyme.
1977
Activation and cleavage of the carbon-cobalt bond of adeninylethylcobalamin by diol dehydrase.
1987
Fermentation of 1,2-Propanediol and 1,2-Ethanediol by Some Genera of Enterobacteriaceae , Involving Coenzyme B 12 -Dependent Diol Dehydratase
1979
Essential Roles of Cell Surface Protein and Carbohydrate Components in Flocculation of a Brewer’s Yeast
1987
The mechanism of in situ reactivation of glycerol-inactivated coenzyme B12-dependent enzymes, glycerol dehydratase and diol dehydratase.
1982