Citation Impact
Citing Papers
Partitioning of Lipid-Modified Monomeric GFPs into Membrane Microdomains of Live Cells
2002 StandoutScienceNobel
A monomeric G protein-coupled receptor isolated in a high-density lipoprotein particle efficiently activates its G protein
2007 StandoutNobel
β-Arrestin-mediated activation of MAPK by inverse agonists reveals distinct active conformations for G protein-coupled receptors
2003
High-Resolution Crystal Structure of an Engineered Human β 2 -Adrenergic G Protein–Coupled Receptor
2007 StandoutScienceNobel
GPCR Engineering Yields High-Resolution Structural Insights into β 2 -Adrenergic Receptor Function
2007 StandoutScienceNobel
Structure of the human TRPM4 ion channel in a lipid nanodisc
2017 StandoutScienceNobel
Conserved N-terminal cysteine dioxygenases transduce responses to hypoxia in animals and plants
2019 StandoutScienceNobel
Targeting of Cyclic AMP Degradation to β 2 -Adrenergic Receptors by β-Arrestins
2002 StandoutScienceNobel
De novo design of modular and tunable protein biosensors
2021 StandoutNatureNobel
Computational design of soluble and functional membrane protein analogues
2024 StandoutNatureNobel
Engineered receptors for soluble cellular communication and disease sensing
2024 StandoutNatureNobel
GPCR activation mechanisms across classes and macro/microscales
2021
Switching of the coupling of the β2-adrenergic receptor to different G proteins by protein kinase A
1997 StandoutNatureNobel
Ligand-selective receptor conformations revisited: the promise and the problem
2003
Distinct Signaling Profiles of β1 and β2 Adrenergic Receptor Ligands toward Adenylyl Cyclase and Mitogen-Activated Protein Kinase Reveals the Pluridimensionality of Efficacy
2006
Insights into α1 adrenoceptor function in health and disease from transgenic animal studies
2003
NO triggers RGS4 degradation to coordinate angiogenesis and cardiomyocyte growth
2013
Agonist-dependent Dissociation of Oligomeric Complexes of G Protein-coupled Cholecystokinin Receptors Demonstrated in Living Cells Using Bioluminescence Resonance Energy Transfer
2001
Fluorescent Labeling of Purified β2 Adrenergic Receptor
1995 StandoutNobel
Recent developments in constitutive receptor activity and inverse agonism, and their potential for GPCR drug discovery
2006
Quantitative Assessment of β1- and β2-Adrenergic Receptor Homo- and Heterodimerization by Bioluminescence Resonance Energy Transfer
2002
Cell Surface Expression of α1D-Adrenergic Receptors Is Controlled by Heterodimerization with α1B-Adrenergic Receptors
2004
Structure-based Analysis of GPCR Function: Evidence for a Novel Pentameric Assembly between the Dimeric Leukotriene B4 Receptor BLT1 and the G-protein
2003
Pharmacology of Muscarinic Receptor Subtypes Constitutively Activated by G Proteins
1997
The two-state model of receptor activation
1995
Crystal structure of the human β2 adrenergic G-protein-coupled receptor
2007 StandoutNatureNobel
High-resolution crystal structure of human protease-activated receptor 1
2012 StandoutNatureNobel
Dynamics of receptor/G protein coupling in living cells
2005
Lessons from constitutively active mutants of G protein-coupled receptors
2002
Adrenergic Receptors From Molecular Structure to in vivo function
1997 StandoutNobel
Minireview: Constitutively Active G Protein-Coupled Receptors: Potential Mechanisms of Receptor Activation
1997
A Cyclic Peptide Mimicking the Third Intracellular Loop of the V2 Vasopressin Receptor Inhibits Signaling through Its Interaction with Receptor Dimer and G Protein
2004
Ligand-regulated oligomerization of β2-adrenoceptors in a model lipid bilayer
2009 StandoutNobel
Dimerization and Phosphorylation of Thyrotropin-releasing Hormone Receptors Are Modulated by Agonist Stimulation
2002
PRESTO-Tango as an open-source resource for interrogation of the druggable human GPCRome
2015
Anti–β1-adrenergic receptor antibodies and heart failure: causation, not just correlation
2004 StandoutNobel
The Fourth Transmembrane Segment Forms the Interface of the Dopamine D2 Receptor Homodimer
2003
Functional Significance of Oligomerization of G-protein-coupled Receptors
2000
Structural basis of function in heterotrimeric G proteins
2006
A Trafficking Checkpoint Controls GABAB Receptor Heterodimerization
2000
Inverse agonism: pharmacological curiosity or potential therapeutic strategy?
1995
G protein coupled receptor dimerization: implications in modulating receptor function
2001
A stress response pathway regulates DNA damage through β2-adrenoreceptors and β-arrestin-1
2011 StandoutNatureNobel
GIPC Interacts with the β1-Adrenergic Receptor and Regulates β1-Adrenergic Receptor-mediated ERK Activation
2003 StandoutNobel
Structure and function of an irreversible agonist-β2 adrenoceptor complex
2011 StandoutNatureNobel
Coiled Coils Direct Assembly of a Cold-Activated TRP Channel
2006 StandoutNobel
Constitutive Dimerization of the G-Protein Coupled Receptor, Neurotensin Receptor 1, Reconstituted into Phospholipid Bilayers
2009
Dopamine D2 receptors form higher order oligomers at physiological expression levels
2008
Identification and Molecular Characterization of m3 Muscarinic Receptor Dimers
1999
Ligand-specific regulation of the extracellular surface of a G-protein-coupled receptor
2010 StandoutNatureNobel
G-protein-coupled receptor heterodimerization modulates receptor function
1999 Nature
C5a Receptor Oligomerization
2003
Kinetic Analysis of G Protein–Coupled Receptor Signaling Using Fluorescence Resonance Energy Transfer in Living Cells
2007
Differential Targeting of β-Adrenergic Receptor Subtypes and Adenylyl Cyclase to Cardiomyocyte Caveolae
2000
Chemokine receptor homo- or heterodimerization activates distinct signaling pathways
2001
Heterodimerization of μ- and δ-Opioid Receptors Occurs at the Cell Surface Only and Requires Receptor-G Protein Interactions
2005
Heterodimerization is required for the formation of a functional GABAB receptor
1998 Nature
Constitutively active mutants of the β1‐adrenergic receptor
1999
G Protein-coupled Receptors
1998 StandoutNobel
Chemokine receptors: Structure, function and role in microbial pathogenesis
1996
Adrenergic receptor signal transduction and regulation
1995 StandoutNobel
The coming of age of de novo protein design
2016 StandoutNatureNobel
Conformational changes in the G protein Gs induced by the β2 adrenergic receptor
2011 StandoutNatureNobel
Crystal structure of the β2 adrenergic receptor–Gs protein complex
2011 StandoutNatureNobel
Desensitization of G-protein-coupled Receptors
1999
The structure and function of G-protein-coupled receptors
2009 StandoutNatureNobel
TRPV1 structures in distinct conformations reveal activation mechanisms
2013 StandoutNatureNobel
Methods to monitor the quaternary structure of G protein‐coupled receptors
2005
Mutation of Asn111 in the Third Transmembrane Domain of the AT1A Angiotensin II Receptor Induces Its Constitutive Activation
1997
Ligand-dependent Inhibition of Oligomerization at the Human Thyrotropin Receptor
2002
Structure of a nanobody-stabilized active state of the β2 adrenoceptor
2011 StandoutNatureNobel
Oligomerization of Dopamine and Serotonin Receptors
2000
Improved protein structure prediction using potentials from deep learning
2020 StandoutNatureNobel
Export from the Endoplasmic Reticulum Represents the Limiting Step in the Maturation and Cell Surface Expression of the Human δ Opioid Receptor
2000
A Specific Cholesterol Binding Site Is Established by the 2.8 Å Structure of the Human β2-Adrenergic Receptor
2008
Homodimerization of the β2-Adrenergic Receptor as a Prerequisite for Cell Surface Targeting
2004
The Ants Go Marching Two by Two: Oligomeric Structure of G-Protein-Coupled Receptors
2004
The Second Intracellular Loop of the m5 Muscarinic Receptor Is the Switch Which Enables G-protein Coupling
1998
Molecular tinkering of G protein-coupled receptors: an evolutionary success
1999
Is there a ‘lock’ for all agonist ‘keys’ in 7TM receptors?
1996
Crystal structure of the µ-opioid receptor bound to a morphinan antagonist
2012 StandoutNatureNobel
Heterotrimeric G protein activation by G-protein-coupled receptors
2007
Seven-transmembrane-spanning receptors and heart function
2002 StandoutNatureNobel
Structure of a β1-adrenergic G-protein-coupled receptor
2008 StandoutNatureNobel
Reduced Cell Surface Expression of CCR5 in CCR5Δ32 Heterozygotes Is Mediated by Gene Dosage, Rather Than by Receptor Sequestration
2002 StandoutNobel
Structure of the δ-opioid receptor bound to naltrindole
2012 StandoutNatureNobel
Crystal structure of misoprostol bound to the labor inducer prostaglandin E2 receptor
2018
G‐protein‐coupled receptors: past, present and future
2006
Emerging role of homo- and heterodimerization in G-protein-coupled receptor biosynthesis and maturation
2005
β1-Adrenergic Receptor Association with the Synaptic Scaffolding Protein Membrane-associated Guanylate Kinase Inverted-2 (MAGI-2)
2001
Dimerization of the δ Opioid Receptor:
1997
Oligomerization of G-protein-coupled transmitter receptors
2001
Macrophage-tropic HIV and SIV envelope proteins induce a signal through the CCR5 chemokine receptor
1997 StandoutNatureNobel
Differential Cardiovascular Regulatory Activities of the α1B- and α1D-Adrenoceptor Subtypes
2003
X-ray structure of the mammalian GIRK2–βγ G-protein complex
2013 NatureNobel
Co-expression of Defective Luteinizing Hormone Receptor Fragments Partially Reconstitutes Ligand-induced Signal Generation
1997 StandoutNobel
Agonist and Inverse Agonist Actions of β-Blockers at the Human β2-Adrenoceptor Provide Evidence for Agonist-Directed Signaling
2003
G-protein-coupled receptors function as oligomers in vivo
2000
Allosteric Effects of G Protein Overexpression on the Binding of β-Adrenergic Ligands with Distinct Inverse Efficacies
2001
Identification of a Conserved Switch Residue Responsible for Selective Constitutive Activation of the β2-Adrenergic Receptor
1998
The Forgotten Serine
2000
Morphine-like Opiates Selectively Antagonize Receptor-Arrestin Interactions
2010
The P2Y1 receptor closes the N‐type Ca2+ channel in neurones, with both adenosine triphosphates and diphosphates as potent agonists
2000
The selectivity of β‐adrenoceptor antagonists at the human β1, β2 and β3 adrenoceptors
2005
Identification of the platelet ADP receptor targeted by antithrombotic drugs
2001 StandoutNatureNobel
Mutation of a Highly Conserved Aspartic Acid in the β2Adrenergic Receptor: Constitutive Activation, Structural Instability, and Conformational Rearrangement of Transmembrane Segment 6
1999
Lipid raft microdomains and neurotransmitter signalling
2006
GABAB receptors function as a heteromeric assembly of the subunits GABABR1 and GABABR2
1998 Nature
Structural Instability of a Constitutively Active G Protein-coupled Receptor
1997 StandoutNobel
GPCRdb: an information system for G protein-coupled receptors
2015
G Protein-Coupled Receptor Dimerization: Function and Ligand Pharmacology
2004
Recovery of Oligomers and Cooperativity When Monomers of the M2Muscarinic Cholinergic Receptor Are Reconstituted into Phospholipid Vesicles
2007
Homo-oligomeric Complexes of the Yeast α-Factor Pheromone Receptor Are Functional Units of Endocytosis
2000
Roles of G‐protein‐coupled receptor dimerization
2004
Cholesterol increases kinetic, energetic, and mechanical stability of the human β2-adrenergic receptor
2012 StandoutNobel
G Protein–Coupled Receptor Oligomerization
2004
β-Arrestin-Dependent Formation of β 2 Adrenergic Receptor-Src Protein Kinase Complexes
1999 StandoutScienceNobel
Genetically Encoded Fluorescent Biosensors Illuminate the Spatiotemporal Regulation of Signaling Networks
2018
Truncated V2 Vasopressin Receptors as Negative Regulators of Wild-Type V2 Receptor Function
1998
Myocyte Adrenoceptor Signaling Pathways
2003 StandoutScienceNobel
Functional Consequences of Altering Myocardial Adrenergic Receptor Signaling
2000 StandoutNobel
A dileucine motif in the C terminus of the β 2 -adrenergic receptor is involved in receptor internalization
1997
The chemokine monocyte chemoattractant protein-1 induces functional responses through dimerization of its receptor CCR2
1999
Complexes between photoactivated rhodopsin and transducin: progress and questions
2010
Reply: beyond receptor dimerization
2000
The evasive nature of drug efficacy: implications for drug discovery
2007
High agonist-independent activity is a distinguishing feature of the dopamine D1B receptor subtype.
1994
Uncovering Molecular Mechanisms Involved in Activation of G Protein-Coupled Receptors
2000
Detection of β 2 -adrenergic receptor dimerization in living cells using bioluminescence resonance energy transfer (BRET)
2000
Heterotrimeric G proteins precouple with G protein-coupled receptors in living cells
2005
Computational Modeling Approaches to Structure−Function Analysis of G Protein-Coupled Receptors
2005
Structural characterization and binding sites of G-protein-coupled receptors
1996
MOLECULAR MECHANISM OF 7TM RECEPTOR ACTIVATION—A GLOBAL TOGGLE SWITCH MODEL
2006
Different Effects of Gsα Splice Variants on β2-Adrenoreceptor-mediated Signaling
1998 StandoutNobel
Similarities and Differences in RANTES- and (AOP)-RANTES–triggered Signals: Implications for Chemotaxis
1999
Anti–β1-adrenergic receptor antibodies and heart failure: causation, not just correlation
2004 StandoutNobel
Dimerization: An Emerging Concept for G Protein–Coupled Receptor Ontogeny and Function
2002
Update 1 of: Computational Modeling Approaches to Structure–Function Analysis of G Protein-Coupled Receptors
2011
The effect of ligand efficacy on the formation and stability of a GPCR-G protein complex
2009 StandoutNobel
Receptors for Dopamine and Somatostatin: Formation of Hetero-Oligomers with Enhanced Functional Activity
2000 Science
Different Effects of Gsα Splice Variants on β2-Adrenoreceptor-mediated Signaling
1998 StandoutNobel
Covalent and Noncovalent Interactions Mediate Metabotropic Glutamate Receptor mGlu5Dimerization
2001
Molecular Basis for Interactions of G Protein βγ Subunits with Effectors
1998 StandoutScienceNobel
Dopamine D 1 and adenosine A 1 receptors form functionally interacting heteromeric complexes
2000
Transduction of Receptor Signals by ß-Arrestins
2005 StandoutScienceNobel
Works of Terence E. Hébert being referenced
Cardiac-specific Overexpression of a 1BAR Regulates AR Activity Via Molecular Crosstalk
1998
Stable Association of G Proteins with β2AR Is Independent of the State of Receptor Activation
1999
A Peptide Derived from a β2-Adrenergic Receptor Transmembrane Domain Inhibits Both Receptor Dimerization and Activation
1996
Real-time monitoring of receptor and G-protein interactions in living cells
2005
β1/β2-Adrenergic Receptor Heterodimerization Regulates β2-Adrenergic Receptor Internalization and ERK Signaling Efficacy
2002
A cell surface inactive mutant of the human lutropin receptor (hLHR) attenuates signaling of wild-type or constitutively active receptors via heterodimerization
2009
Palmitoylation of G-protein-coupled receptors: a dynamic modification with functional consequences
1995
Cardiac-specific Overexpression ofα1BAR RegulatesβAR Activity Via Molecular Crosstalk
1998
A Novel Biased Allosteric Compound Inhibitor of Parturition Selectively Impedes the Prostaglandin F2α-mediated Rho/ROCK Signaling Pathway
2010
Identification of a GABAB Receptor Subunit, gb2, Required for Functional GABAB Receptor Activity
1999
Gβ Residues That Do Not Interact with Gα Underlie Agonist-independent Activity of K+ Channels
2002
Inverse agonist activity of beta-adrenergic antagonists.
1994
Structural and functional aspects of G protein-coupled receptor oligomerization
1998
Agonist Stimulation Increases the Turnover Rate of β2AR-Bound Palmitate and Promotes Receptor Depalmitoylation
1996
γ-Aminobutyric Acid Type B Receptors with Specific Heterodimer Composition and Postsynaptic Actions in Hippocampal Neurons Are Targets of Anticonvulsant Gabapentin Action
2001
Biasing the Prostaglandin F2α Receptor Responses toward EGFR-Dependent Transactivation of MAPK
2012
Protein Complexes Involved in Heptahelical Receptor-Mediated Signal Transduction
2003
The Role of Gβγ Subunits in the Organization, Assembly, and Function of GPCR Signaling Complexes
2008
Cardiac-directed overexpression of wild-type α1B-adrenergic receptor induces dilated cardiomyopathy
2001
Activation-Induced Subcellular Redistribution of Gαs Is Dependent upon Its Unique N-Terminus
2002
Structural and functional aspects of G protein-coupled receptor oligomerization
1998