Citation Impact
Citing Papers
Genome-Scale CRISPR-Cas9 Knockout Screening in Human Cells
2013 StandoutScience
The Immune Microenvironment Confers Resistance to MAPK Pathway Inhibitors through Macrophage-Derived TNFα
2014
A Genome-Scale RNA Interference Screen Implicates NF1 Loss in Resistance to RAF Inhibition
2013
Acquired Resistance and Clonal Evolution in Melanoma during BRAF Inhibitor Therapy
2013
A Melanoma Cell State Distinction Influences Sensitivity to MAPK Pathway Inhibitors
2014
High burden and pervasive positive selection of somatic mutations in normal human skin
2015 StandoutScience
BRAF Inhibitor Resistance Mechanisms in Metastatic Melanoma: Spectrum and Clinical Impact
2014
Designed protein logic to target cells with precise combinations of surface antigens
2020 StandoutScienceNobel
Cancer and systemic inflammation: treat the tumour and treat the host
2014
Role of stromal myofibroblasts in invasive breast cancer: stromal expression of alpha-smooth muscle actin correlates with worse clinical outcome
2010
Engineered receptors for soluble cellular communication and disease sensing
2024 StandoutNatureNobel
Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitors
2012 Nature
Platelet factor 4–induced T H 1-T reg polarization suppresses antitumor immunity
2024 StandoutScienceNobel
Balancing Selectivity and Efficacy of Bispecific Epidermal Growth Factor Receptor (EGFR) × c-MET Antibodies and Antibody-Drug Conjugates
2016
Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries
2018 Standout
Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries
2021 Standout
Carcinoma‐associated fibroblasts: Non‐neoplastic tumour‐promoting mesenchymal cells
2013
Smarter drugs emerging in pancreatic cancer therapy
2014
Therapy-induced tumour secretomes promote resistance and tumour progression
2015 Nature
Elements of cancer immunity and the cancer–immune set point
2017 StandoutNature
A view on drug resistance in cancer
2019 StandoutNature
Body Fatness and Cancer — Viewpoint of the IARC Working Group
2016 Standout
Phosphoproteomic comparison of Pik3ca and Pten signalling identifies the nucleotidase NT5C as a novel AKT substrate
2017
A Peptide Mimicking VGLL4 Function Acts as a YAP Antagonist Therapy against Gastric Cancer
2014
Mechanobiology of YAP and TAZ in physiology and disease
2017
Tumor adaptation and resistance to RAF inhibitors
2013
Dependency of Colorectal Cancer on a TGF-β-Driven Program in Stromal Cells for Metastasis Initiation
2012
β-Catenin destruction complex-independent regulation of Hippo–YAP signaling by APC in intestinal tumorigenesis
2015
Macrocyclic peptide-based inhibition and imaging of hepatocyte growth factor
2019
Oncogenic BRAF Regulates Oxidative Metabolism via PGC1α and MITF
2013
Wnt signaling in cancer
2016 Standout
Lessons from the Cancer Genome
2013
Plasticity of tumour and immune cells: a source of heterogeneity and a cause for therapy resistance?
2013
Genome-scale transcriptional activation by an engineered CRISPR-Cas9 complex
2014 StandoutNature
Regulation of the Hippo pathway and implications for anticancer drug development
2013
Lung Cancer
2008 Standout
Clonal Heterogeneity and Tumor Evolution: Past, Present, and the Future
2017 Standout
Cancer drug resistance: an evolving paradigm
2013 Standout
Epithelial-to-mesenchymal transition is dispensable for metastasis but induces chemoresistance in pancreatic cancer
2015 StandoutNature
Global burden of colorectal cancer: emerging trends, risk factors and prevention strategies
2019 Standout
The biology and function of fibroblasts in cancer
2016 Standout
Influence of tumour micro-environment heterogeneity on therapeutic response
2013 StandoutNature
Immunological hallmarks of stromal cells in the tumour microenvironment
2015
Hippo Signaling Regulates Microprocessor and Links Cell-Density-Dependent miRNA Biogenesis to Cancer
2014
Effects of extracellular matrix viscoelasticity on cellular behaviour
2020 StandoutNature
Colorectal cancer
2013 Standout
Hippo Pathway in Organ Size Control, Tissue Homeostasis, and Cancer
2015 Standout
The impact of tumor stroma on drug response in breast cancer
2014
Prognostic Significance in Breast Cancer of a Gene Signature Capturing Stromal PDGF Signaling
2013
Role of the Microbiota in Immunity and Inflammation
2014 Standout
Super-Enhancers in the Control of Cell Identity and Disease
2013 Standout
RNF43 is frequently mutated in colorectal and endometrial cancers
2014
Fibroblast-mediated drug resistance in cancer
2013
Fibronectin induction abrogates the BRAF inhibitor response of BRAF V600E/PTEN-null melanoma cells
2015
Population-based screening for cancer: hope and hype
2016
Metazoan MicroRNAs
2018 Standout
Catabolic cancer-associated fibroblasts transfer energy and biomass to anabolic cancer cells, fueling tumor growth
2014
Immune Checkpoint Targeting in Cancer Therapy: Toward Combination Strategies with Curative Potential
2015 StandoutNobel
Prognostic significance of nemo-like kinase in nasopharyngeal carcinoma
2014
Immune-mediated mechanisms influencing the efficacy of anticancer therapies
2015
MET Gene Copy Number in Non-small Cell Lung Cancer: Molecular Analysis in a Targeted Tyrosine Kinase Inhibitor Naïve Cohort
2008
YAP/TAZ Incorporation in the β-Catenin Destruction Complex Orchestrates the Wnt Response
2014
Diminished WNT → β-catenin → c-MYC signaling is a barrier for malignant progression of BRAFV600E-induced lung tumors
2014
Stool DNA Testing for Screening Detection of Colorectal Neoplasia in Alaska Native People
2015
Melanomas resist T-cell therapy through inflammation-induced reversible dedifferentiation
2012 Nature
Emerging Biological Principles of Metastasis
2017 Standout
Endothelial-cell FAK targeting sensitizes tumours to DNA-damaging therapy
2014 Nature
Effect of flexible sigmoidoscopy screening on colorectal cancer incidence and mortality: long-term follow-up of the randomised US PLCO cancer screening trial
2018
Carcinoma-associated fibroblasts provide operational flexibility in metastasis
2014
EMT: 2016
2016 Standout
The role of tumour–stromal interactions in modifying drug response: challenges and opportunities
2013
The emerging roles of YAP and TAZ in cancer
2015
Drug Resistance via Feedback Activation of Stat3 in Oncogene-Addicted Cancer Cells
2014
Colorectal cancer screening: Recommendations for physicians and patients from the U.S. Multi-Society Task Force on Colorectal Cancer
2017
CXCL9, CXCL10, CXCL11/CXCR3 axis for immune activation – A target for novel cancer therapy
2017
YAP inhibits squamous transdifferentiation of Lkb1-deficient lung adenocarcinoma through ZEB2-dependent DNp63 repression
2014
Alternative Wnt Signaling Activates YAP/TAZ
2015
Increased Lactate Secretion by Cancer Cells Sustains Non-cell-autonomous Adaptive Resistance to MET and EGFR Targeted Therapies
2018
IL-6 and related cytokines as the critical lynchpins between inflammation and cancer
2014
Inflammation-induced cancer: crosstalk between tumours, immune cells and microorganisms
2013 Standout
Phenotypic and functional heterogeneity of cancer-associated fibroblast within the tumor microenvironment
2015
Melanoma-intrinsic β-catenin signalling prevents anti-tumour immunity
2015 StandoutNature
AKT/PKB Signaling: Navigating the Network
2017 Standout
Relief of Profound Feedback Inhibition of Mitogenic Signaling by RAF Inhibitors Attenuates Their Activity in BRAFV600E Melanomas
2012
Cancer-related inflammation and treatment effectiveness
2014 Standout
Intravital Imaging Reveals How BRAF Inhibition Generates Drug-Tolerant Microenvironments with High Integrin β1/FAK Signaling
2015
Metastatic colonization by circulating tumour cells
2016 StandoutNature
Adiposity and cancer risk: new mechanistic insights from epidemiology
2015
The Reprogramming of Tumor Stroma by HSF1 Is a Potent Enabler of Malignancy
2014
Discovery and saturation analysis of cancer genes across 21 tumour types
2014 StandoutNature
Microenvironmental regulation of tumor progression and metastasis
2013 Standout
Aspirin as adjuvant therapy for colorectal cancer—reinterpreting paradigms
2012
Wnt/β-Catenin Signaling, Disease, and Emerging Therapeutic Modalities
2017 Standout
Genome-Scale Discovery of DNA-Methylation Biomarkers for Blood-Based Detection of Colorectal Cancer
2012
Feedback and redundancy in receptor tyrosine kinase signaling: relevance to cancer therapies
2014
Whole‐genome methylation analysis of benign and malignant colorectal tumours
2012
Effectiveness of Screening Colonoscopy to Prevent Colorectal Cancer Among Medicare Beneficiaries Aged 70 to 79 Years
2016
Screening for Colorectal Cancer
2021
Fluorine in Pharmaceutical Industry: Fluorine-Containing Drugs Introduced to the Market in the Last Decade (2001–2011)
2013 Standout
Inferring tumour purity and stromal and immune cell admixture from expression data
2013 Standout
Screening for Thyroid Cancer
2017
Systematic identification of signaling pathways with potential to confer anticancer drug resistance
2014
Peptidic degron for IMiD-induced degradation of heterologous proteins
2019 StandoutNobel
Fibroblast Growth Factor Receptor Inhibitors as a Cancer Treatment: From a Biologic Rationale to Medical Perspectives
2013
Biochemical purification and pharmacological inhibition of a mammalian prolyl hydroxylase acting on hypoxia-inducible factor
2002 StandoutNobel
Screening for Colorectal Cancer
2016 Standout
Hippo Pathway Regulation of Gastrointestinal Tissues
2014
Combined BRAF and MEK Inhibition With Dabrafenib and Trametinib in BRAF V600–Mutant Colorectal Cancer
2015
An implantable microdevice to perform high-throughput in vivo drug sensitivity testing in tumors
2015
The von Hippel-Lindau Tumor Suppressor Gene
2020
Chemotherapy induces enrichment of CD47 + /CD73 + /PDL1 + immune evasive triple-negative breast cancer cells
2018 StandoutNobel
Metabolic reprogramming and cancer progression
2020 StandoutScience
Estimation of Benefits, Burden, and Harms of Colorectal Cancer Screening Strategies
2016
Screening for Colorectal Cancer: U.S. Preventive Services Task Force Recommendation Statement
2008
Control of stem cell self-renewal and differentiation by the heterochronic genes and the cellular asymmetry machinery in Caenorhabditis elegans
2015 StandoutNobel
Growing Self-Organizing Mini-Guts from a Single Intestinal Stem Cell: Mechanism and Applications
2013 Science
Cancer Genome Landscapes
2013 StandoutScience
Targeting the TGFβ pathway for cancer therapy
2014
Fibroblast heterogeneity in the cancer wound
2014
WNT5A enhances resistance of melanoma cells to targeted BRAF inhibitors
2014
T cell exclusion, immune privilege, and the tumor microenvironment
2015 StandoutScience
De Novo Carborane-Containing Macrocyclic Peptides Targeting Human Epidermal Growth Factor Receptor
2019 StandoutNobel
Colorectal cancer screening: a global overview of existing programmes
2015
Epithelial Plasticity: A Common Theme in Embryonic and Cancer Cells
2013 StandoutScience
MET Tyrosine Kinase Inhibitor Crizotinib (PF-02341066) Shows Differential Antitumor Effects in Non-small Cell Lung Cancer According to MET Alterations
2011
Colorectal Cancer Incidence Patterns in the United States, 1974–2013
2016
Two-signal requirement for growth-promoting function of Yap in hepatocytes
2015
Evolutionary dynamics of cancer in response to targeted combination therapy
2013
Colorectal cancer screening for average‐risk adults: 2018 guideline update from the American Cancer Society
2018
The Hippo pathway effectors TAZ and YAP in development, homeostasis and disease
2014
Chemotherapy activates cancer-associated fibroblasts to maintain colorectal cancer-initiating cells by IL-17A
2013
ACG Clinical Guidelines: Colorectal Cancer Screening 2021
2021
Works of Teppei Morikawa being referenced
Prognostic Role of PIK3CA Mutation in Colorectal Cancer: Cohort Study and Literature Review
2012
Activation of DNA Methyltransferase 1 by EBV Latent Membrane Protein 2A Leads to Promoter Hypermethylation of PTEN Gene in Gastric Carcinoma
2009
c‐Met activation in lung adenocarcinoma tissues: An immunohistochemical analysis
2007
Body Mass Index and Risk of Colorectal Cancer According to Fatty Acid Synthase Expression in the Nurses’ Health Study
2012
Regular Aspirin Use Associates With Lower Risk of Colorectal Cancers With Low Numbers of Tumor-Infiltrating Lymphocytes
2016
Assessment of colorectal cancer molecular features along bowel subsites challenges the conception of distinct dichotomy of proximal versus distal colorectum
2012
Microsatellite Instability and BRAF Mutation Testing in Colorectal Cancer Prognostication
2013
Restriction of intestinal stem cell expansion and the regenerative response by YAP
2012 Nature
A Prospective Study of Duration of Smoking Cessation and Colorectal Cancer Risk by Epigenetics-related Tumor Classification
2013
Aspirin Use, TumorPIK3CAMutation, and Colorectal-Cancer Survival
2012
Prognostic Significance and Molecular Associations of Tumor Growth Pattern in Colorectal Cancer
2011
Colorectal cancer: a tale of two sides or a continuum?: Figure 1
2012
TCEB1-mutated renal cell carcinoma: a distinct genomic and morphological subtype
2015
Subepithelial myofibroblast in lung adenocarcinoma: a histological indicator of excellent prognosis
2009
Long-Term Colorectal-Cancer Incidence and Mortality after Lower Endoscopy
2013
Association of CTNNB1 (β-Catenin) Alterations, Body Mass Index, and Physical Activity With Survival in Patients With Colorectal Cancer
2011
Tumour micro-environment elicits innate resistance to RAF inhibitors through HGF secretion
2012 Nature
TGFBR2 and BAX Mononucleotide Tract Mutations, Microsatellite Instability, and Prognosis in 1072 Colorectal Cancers
2011
Stromal epigenetic dysregulation is sufficient to initiate mouse prostate cancer via paracrine Wnt signaling
2012
STAT3 Expression, Molecular Features, Inflammation Patterns, and Prognosis in a Database of 724 Colorectal Cancers
2011
Prospective Analysis of Body Mass Index, Physical Activity, and Colorectal Cancer Risk Associated with β-Catenin (CTNNB1) Status
2013