Standout Papers
Citation Impact
Citing Papers
The Hepatitis C Virus NS3 Protein: A Model RNA Helicase and Potential Drug Target
2007
Hepatitis C virus protease NS3/4A cleaves mitochondrial antiviral signaling protein off the mitochondria to evade innate immunity
2005
Complete Replication of Hepatitis C Virus in Cell Culture
2005 StandoutScienceNobel
Transferrin receptor targeting by de novo sheet extension
2021 StandoutNobel
A drug-controllable tag for visualizing newly synthesized proteins in cells and whole animals
2008 StandoutNobel
Targeted cell killing by reconstituted caspases
2007 StandoutNobel
Evidence for a functional RNA element in the hepatitis C virus core gene
2007 StandoutNobel
Proteomics of HCV virions reveals an essential role for the nucleoporin Nup98 in virus morphogenesis
2016 StandoutNobel
The hepatitis C virus NS3 protein: a model RNA helicase and potential drug target.
2007
Three conformational snapshots of the hepatitis C virus NS3 helicase reveal a ratchet translocation mechanism
2009 StandoutNobel
The Metal Binding Site of the Hepatitis C Virus NS3 Protease
1998
Expansive discovery of chemically diverse structured macrocyclic oligoamides
2024 StandoutScienceNobel
Inhibition of Trypanosomal Cysteine Proteinases by Their Propeptides
1998
Activation of Caspase-2 in Apoptosis
1997
The Long Form of FLIP Is an Activator of Caspase-8 at the Fas Death-inducing Signaling Complex
2002
Mechanisms of Caspase Activation and Inhibition during Apoptosis
2002 Standout
Challenges and successes in developing new therapies for hepatitis C
2005 Nature
Hepatitis C virus NS3 RNA helicase domain with a bound oligonucleotide: the crystal structure provides insights into the mode of unwinding
1998
Structure of rat procathepsin B: model for inhibition of cysteine protease activity by the proregion
1996
A conformational switch controls hepatitis delta virus ribozyme catalysis
2004 StandoutNatureNobel
The structure of Sky1p reveals a novel mechanism for constitutive activity.
2001
Structural basis for the activation of flaviviral NS3 proteases from dengue and West Nile virus
2006
Mechanism of autoproteolysis at the NS2–NS3 junction of the hepatitis C virus polyprotein
1998
Proregion structure of members of the papain superfamily. Mode of inhibition of enzymatic activity
1997
Caspases and caspase inhibitors
1997
Signal Transduction by the JNK Group of MAP Kinases
2000 Standout
Treatment triumphs
2014 StandoutNatureNobel
Caspase Activation
2004
Caspases: pharmacological manipulation of cell death
2005 Standout
Unravelling hepatitis C virus replication from genome to function
2005 StandoutNatureNobel
Structural Basis for the Inhibition of Caspase-3 by XIAP
2001
The solution structure of the N-terminal proteinase domain of the hepatitis C virus (HCV) NS3 protein provides new insights into its activation and catalytic mechanism
1999
Caspase-8 specificity probed at subsite S 4 :crystal structure of the caspase-8-Z-DEVD-cho complex 1 1Edited by R. Huber
2000
Structural basis for selective inhibition of Src family kinases by PP1
1999
CRISPR-Cas9 Circular Permutants as Programmable Scaffolds for Genome Modification
2019 StandoutNobel
“Strong reasons make strong actions” — The antiviral efficacy of NS3/4A protease inhibitors†
2005
Approaching a new era for hepatitis C virus therapy: inhibitors of the NS3-4A serine protease and the NS5B RNA-dependent RNA polymerase
2003
Role of the Biomolecular Energy Gap in Protein Design, Structure, and Evolution
2012 StandoutNobel
Molecular views of viral polyprotein processing revealed by the crystal structure of the hepatitis C virus bifunctional protease–helicase
1999
Revised Definition of Substrate Binding Sites of Papain-Like Cysteine Proteases
1998
ERICE, a Novel FLICE-activatable Caspase
1998
The NS3/4A proteinase of the hepatitis C virus: unravelling structure and function of an unusual enzyme and a prime target for antiviral therapy
1999
Crystal Structure of an Invertebrate Caspase
2004
Lysosomal cysteine proteases: more than scavengers
2000
Proteolytic cleavage of HsRad51 during apoptosis
1998
The role of pro regions in protein folding
1993 StandoutNobel
Internal Processing of Hepatitis C Virus NS3 Protein
1999
The hepatitis C viral NS3 protein is a processive DNA helicase with cofactor enhanced RNA unwinding
2002
The biochemistry of apoptosis
2000 StandoutNature
Structural and Biological Identification of Residues on the Surface of NS3 Helicase Required for Optimal Replication of the Hepatitis C Virus
2005
In Vitro Characterization of a Purified NS2/3 Protease Variant of Hepatitis C Virus
2001
Conformational restrictions in the active site of unliganded human caspase‐3
2003
Structure and Function of the Hepatitis C Virus NS3-NS4A Serine Proteinase
2000
Substrate Recognition Domains within Extracellular Signal-regulated Kinase Mediate Binding and Catalytic Activation of Mitogen-activated Protein Kinase Phosphatase-3
2000
Molecular Determinants of TRIF Proteolysis Mediated by the Hepatitis C Virus NS3/4A Protease
2005
Conservation, Variability and the Modeling of Active Protein Kinases
2007 StandoutNobel
Inhibition of protein synthesis by the nonstructural proteins NS4A and NS4B of hepatitis C virus
2002
A conserved docking motif in MAP kinases common to substrates, activators and regulators
2000
Complex Formation of NS5B with NS3 and NS4A Proteins of Hepatitis C Virus
1998
Molecular Characterization of Hepatitis C Virus
1998 StandoutNobel
Construction, expression, and characterization of a novel fully activated recombinant single‐chain hepatitis C virus protease
1998
Complex of NS3 protease and NS4A peptide of BK strain hepatitis C virus: A 2.2 Å resolution structure in a hexagonal crystal form
1998
A Single BIR Domain of XIAP Sufficient for Inhibiting Caspases
1998
A method to predict residues conferring functional differences between related proteins: Application to MAP kinase pathways
2000
STAT1 Is Inactivated by a Caspase
1998
Crystal Structure of the TAO2 Kinase Domain
2004
Binding of Different Divalent Cations to the Active Site of Avian Sarcoma Virus Integrase and Their Effects on Enzymatic Activity
1997
Hepatitis C Virus RNA-Dependent RNA Polymerase (NS5B Polymerase)
2000
Ubiquitin C-Terminal Hydrolase Is an Immediate-Early Gene Essential for Long-Term Facilitation in Aplysia
1997 StandoutNobel
A ribonuclease zymogen activated by the NS3 protease of the hepatitis C virus
2006
The conformation of hepatitis C virus NS3 proteinase with and without NS4A: a structural basis for the activation of the enzyme by its cofactor
1998
Caspase Substrates and Inhibitors
2013
Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death
2015 StandoutNature
Crystal structure of the RNA-dependent RNA polymerase of hepatitis C virus
1999
Protein–protein interaction through β-strand addition
2006
Dimerization in MAP-kinase signaling
2000
Hepatitis C Virus-Specific Directly Acting Antiviral Drugs
2013
Molecular mechanisms of caspase regulation during apoptosis
2004 Standout
Crystal Structure of Hck in Complex with a Src Family–Selective Tyrosine Kinase Inhibitor
1999
A novel recombinant single‐chain hepatitis C virus ns3‐ns4a protein with improved helicase activity
1999
Structure of the hepatitis C virus RNA helicase domain
1997
Cleavage of Automodified Poly(ADP-ribose) Polymerase during Apoptosis
1999
Expression and characterization of a recombinant cysteine proteinase of Leishmania mexicana
2000 StandoutNobel
CASK Functions as a Mg2+-Independent Neurexin Kinase
2008 StandoutNobel
From Structure to Function: New Insights into Hepatitis C Virus RNA Replication
2005
A reporter cell line for rapid and sensitive evaluation of hepatitis C virus infectivity and replication
2009
Structural biology of hepatitis C virus
2004
Structure of the zinc-binding domain of an essential component of the hepatitis C virus replicase
2005 StandoutNatureNobel
New Insights into the Control of MAP Kinase Pathways
1999
The propeptide of Fasciola hepatica cathepsin L is a potent and selective inhibitor of the mature enzyme
1999
Viral and cellular RNA helicases as antiviral targets
2005
Crystal Structure of Caspase-2, Apical Initiator of the Intrinsic Apoptotic Pathway
2003
Novel Insights into Hepatitis C Virus Replication and Persistence
2004
The molecular virology of hepatitis C
1997
Structural Basis of Caspase-7 Inhibition by XIAP
2001
Crystal Structure of a Procaspase-7 Zymogen
2001
A decade of caspases
2003
25 years of interferon-based treatment of chronic hepatitis C: an epoch coming to an end
2013
Separating water isotopologues using diffusion-regulatory porous materials
2022 StandoutNatureNobel
Regulation of Protein Kinases
2004
Modified apoptotic molecule (BID) reduces hepatitis C virus infection in mice with chimeric human livers
2003
Mechanisms of caspase activation
2003
Regulation of Protein Phosphatase 2A Activity by Caspase-3 during Apoptosis
1998
Structure of Mycobacterium tuberculosis PknB supports a universal activation mechanism for Ser/Thr protein kinases
2003
Replication of hepatitis C virus
2007 StandoutNobel
Replication of hepatitis C virus
2000
Serpin Structure, Mechanism, and Function
2002 Standout
Mechanism of action of a pestivirus antiviral compound
2000 StandoutNobel
Peroxide-Dependent Formation of a Covalent Link between Trp51 and the Heme in Cytochrome c Peroxidase
2009
Characterization and mutational analysis of the helicase and NTPase activities of hepatitis C virus full-length NS3 protein.
1999
Noncovalent complexes between the lysosomal proteinase cathepsin B and its propeptide account for stable, extracellular, high molecular mass forms of the enzyme.
1994
Mitogen-Activated Protein (MAP) Kinase Pathways: Regulation and Physiological Functions*
2001 Standout
Viral Proteomics
2007
Ultrastructural analysis of hepatitis C virus particles
2013 StandoutNobel
Probing the substrate specificity of hepatitis C virus NS3 serine protease by using synthetic peptides
1997
Subcellular Localization, Stability, and trans -Cleavage Competence of the Hepatitis C Virus NS3-NS4A Complex Expressed in Tetracycline-Regulated Cell Lines
2000 StandoutNobel
Lysosomal cathepsin D mediates endogenous mucin glycodomain catabolism in mammals
2022 StandoutNobel
Structural Basis of Caspase Inhibition by XIAP
2001
Biochemical properties of hepatitis C virus NS5B RNA-dependent RNA polymerase and identification of amino acid sequence motifs essential for enzymatic activity
1997
Biochemical and structural analysis of the NS5B RNA‐dependent RNA polymerase of the hepatitis C virus
2000
The Hepatitis C Virus NS3 Proteinase: Structure and Function of a Zinc-Containing Serine Proteinase
1998
Activation of JNK3α1 Requires both MKK4 and MKK7: Kinetic Characterization of in Vitro Phosphorylated JNK3α1
2000
The protein structures that shape caspase activity, specificity, activation and inhibition
2004
Efficient Initiation of HCV RNA Replication in Cell Culture
2000 StandoutScienceNobel
Uses for JNK: the Many and Varied Substrates of the c-Jun N-Terminal Kinases
2006
The C Terminus of Hepatitis C Virus NS4A Encodes an Electrostatic Switch That Regulates NS5A Hyperphosphorylation and Viral Replication
2007 StandoutNobel
对含砂低液限占土（CLS）最大干密度问题的探索
2001
Structural determinants for membrane association and dynamic organization of the hepatitis C virus NS3-4A complex
2008
Structural basis for the activation of human procaspase-7
2001 Nobel
Structure of human procathepsin L reveals the molecular basis of inhibition by the prosegment.
1996
Update 1 of: Proteases Universally Recognize Beta Strands In Their Active Sites
2010
Studying Hepatitis C Virus: Making the Best of a Bad Virus
2007 StandoutNobel
Mutations That Affect Dimer Formation and Helicase Activity of the Hepatitis C Virus Helicase
2001 StandoutNobel
Specific Interaction of Hepatitis C Virus Protease/Helicase NS3 with the 3′-Terminal Sequences of Viral Positive- and Negative-Strand RNA
2001
Dimer formation drives the activation of the cell death protease caspase 9
2001
PROTEOLYTIC ACTIVITIES THAT MEDIATE APOPTOSIS
1998
Substrate Binding and Catalysis by Ubiquitin C-Terminal Hydrolases: Identification of Two Active Site Residues
1996
Essential role of mda-5 in type I IFN responses to polyriboinosinic:polyribocytidylic acid and encephalomyocarditis picornavirus
2006 StandoutNobel
Characterization of engineered hepatitis C virus NS3 protease inhibitors affinity selected from human pancreatic secretory trypsin inhibitor and minibody repertoires
1997
Nuclear localization of the NS3 protein of hepatitis C virus and factors affecting the localization
1997
Continuous human cell lines inducibly expressing hepatitis C virus structural and nonstructural proteins
1998 StandoutNobel
Mammalian Caspases: Structure, Activation, Substrates, and Functions During Apoptosis
1999 Standout
Conserved C-Terminal Threonine of Hepatitis C Virus NS3 Regulates Autoproteolysis and Prevents Product Inhibition
2003
A point mutation abolishes the helicase but not the nucleoside triphosphatase activity of hepatitis C virus NS3 protein
1997
A cell protection screen reveals potent inhibitors of multiple stages of the hepatitis C virus life cycle
2010 StandoutNobel
The hepatitis C virus NS4A protein: interactions with the NS4B and NS5A proteins
1997
Proton-Coupled Electron Transfer
2007
Protein-Protein Interactions between Hepatitis C Virus Nonstructural Proteins
2003
Structural Basis for Double-Stranded RNA Processing by Dicer
2006 StandoutScienceNobel
In Vitro Selection and Characterization of Hepatitis C Virus Serine Protease Variants Resistant to an Active-Site Peptide Inhibitor
2003
Commitment and Effector Phases of the Physiological Cell Death Pathway Elucidated with Respect to Bcl-2, Caspase, and Cyclin-Dependent Kinase Activities
1998
Modulation of Hepatitis C Virus NS5A Hyperphosphorylation by Nonstructural Proteins NS3, NS4A, and NS4B
1999
Internally quenched fluorescent peptide substrates disclose the subsite preferences of human caspases 1, 3, 6, 7 and 8
2000 StandoutNobel
Multiple Enzymatic Activities Associated with Recombinant NS3 Protein of Hepatitis C Virus
1998
Reconfigurable asymmetric protein assemblies through implicit negative design
2022 StandoutScienceNobel
Proton-Coupled Electron Transfer
2012 Standout
JNK1 controls mast cell degranulation and IL-1β production in inflammatory arthritis
2010 StandoutNobel
Phosphorylation of hepatitis C virus nonstructural protein 5A modulates its protein interactions and viral RNA replication
2004 StandoutNobel
Bovine viral diarrhea virus NS3 serine proteinase: polyprotein cleavage sites, cofactor requirements, and molecular model of an enzyme essential for pestivirus replication
1997 StandoutNobel
Structure of the catalytic domain of the hepatitis C virus NS2-3 protease
2006 StandoutNatureNobel
Works of Ted Fox being referenced
Purification and characterization of the NS3 serine protease domain of hepatitis C virus expressed in Saccharomyces cerevisiae.
1997
The structure of phosphorylated P38γ is monomeric and reveals a conserved activation-loop conformation
1999
Potent slow-binding inhibition of cathepsin B by its propeptide
1992
Crystal structure of JNK3: a kinase implicated in neuronal apoptosis
1998
Fluorescence investigation of yeast cytochrome c peroxidase oxidation by hydrogen peroxide and enzyme activities of the oxidized enzyme
1994
Substrate and Inhibitor Specificity of Interleukin-1β-converting Enzyme and Related Caspases
1997
Modification of S1 subsite specificity in the cysteine protease cathepsin B
1995
The structures of caspases-1, -3, -7 and -8 reveal the basis for substrate and inhibitor selectivity
2000
Crystal Structure of the Hepatitis C Virus NS3 Protease Domain Complexed with a Synthetic NS4A Cofactor Peptide
1996 StandoutNobel
A single amino acid substitution makes ERK2 susceptible to pyridinyl imidazole inhibitors of p38 MAP kinase
1998
The Occluding Loop in Cathepsin B Defines the pH Dependence of Inhibition by Its Propeptide
1999
Rate of intramolecular reduction of ferryl iron in compound I of cytochrome c peroxidase
1990