Standout Papers
Citation Impact
Citing Papers
Genome-Scale CRISPR-Cas9 Knockout Screening in Human Cells
2013 StandoutScience
NOTCH Signaling Is Required for Formation and Self-Renewal of Tumor-Initiating Cells and for Repression of Secretory Cell Differentiation in Colon Cancer
2010 StandoutNobel
Metastasis: from dissemination to organ-specific colonization
2009 Standout
Base-excision repair of oxidative DNA damage
2007 StandoutNature
β-Catenin regulates expression of cyclin D1 in colon carcinoma cells
1999 StandoutNature
A view on drug resistance in cancer
2019 StandoutNature
Glycogen synthase kinase-3β regulates cyclin D1 proteolysis and subcellular localization
1998 Standout
The β-Catenin/TCF-4 Complex Imposes a Crypt Progenitor Phenotype on Colorectal Cancer Cells
2002 Standout
Strand-specific Mismatch Repair in Mammalian Cells
1997 StandoutNobel
Pancreatic cancer
2020 Standout
Ovarian cancer
2014 Standout
Pancreatic cancer
2016 Standout
The Hedgehog and Wnt signalling pathways in cancer
2001 StandoutNature
HIF-1α Induces Genetic Instability by Transcriptionally Downregulating MutSα Expression
2005 StandoutNobel
The Hallmarks of Cancer
2000 Standout
Lessons from Hereditary Colorectal Cancer
1996 Standout
Colorectal cancer
2013 Standout
The Epigenomics of Cancer
2007 Standout
Lynch Syndrome Patients with Limited Family History Identified in a Laboratory Setting: A Descriptive Study
2015 Standout
Wnt signaling: a common theme in animal development
1997 Standout
Colorectal cancer
2019 Standout
Cancer genes and the pathways they control
2004 Standout
β-catenin is a target for the ubiquitin–proteasome pathway
1997 Standout
Synthetic peptides define critical contacts between elongin C, elongin B, and the von Hippel-Lindau protein
1999 StandoutNobel
Colorectal carcinomas in mice lacking the catalytic subunit of PI(3)Kγ
2000 StandoutNatureNobel
Advances in the treatment of neurofibromatosis-associated tumours
2013
Wnt/β-Catenin Signaling and Disease
2012 Standout
The ABC of APC
2001
Familial infiltrative fibromatosis (desmoid tumours) (MIM135290) caused by a recurrent 3' APC gene mutation
1996
A Wnt kinase network alters nuclear localization of TCF-1 in colon cancer
2009 StandoutNobel
Inherited Pancreatic Cancer Syndromes
2012
Liquid biopsies come of age: towards implementation of circulating tumour DNA
2017 Standout
Oncogenic ras Provokes Premature Cell Senescence Associated with Accumulation of p53 and p16INK4a
1997 Standout
Novel germline mutations in the APC gene and their phenotypic spectrum in familial adenomatous polyposis kindreds
1997
Mechanism-driven biomarkers to guide immune checkpoint blockade in cancer therapy
2016 Standout
Hereditary Colorectal Cancer
2003 Standout
Wnt/β-Catenin Signaling in Development and Disease
2006 Standout
The adenomatous polyposis coli (APC) tumor suppressor
1997
Wnt signalling in stem cells and cancer
2005 StandoutNature
Crypt stem cells as the cells-of-origin of intestinal cancer
2008 StandoutNature
Review of the Lynch syndrome: history, molecular genetics, screening, differential diagnosis, and medicolegal ramifications
2009
Wnt/β-Catenin Signaling, Disease, and Emerging Therapeutic Modalities
2017 Standout
HIF activation identifies early lesions in VHL kidneys
2002 StandoutNobel
ACG Clinical Guideline: Genetic Testing and Management of Hereditary Gastrointestinal Cancer Syndromes
2015
Attenuated familial adenomatous polyposis due to a mutation in the 3′ part of the APC gene. A clue for understanding the function of the APC protein
1996
Somatic mutation of hPMS2 as a possible cause of sporadic human colon cancer with microsatellite instability
2000 StandoutNobel
Germ-line mutations in the neurofibromatosis 2 gene: correlations with disease severity and retinal abnormalities.
1996
Wnt signaling and cancer
2000 Standout
The Diagnostic Evaluation and Multidisciplinary Management of Neurofibromatosis 1 and Neurofibromatosis 2
1997 Standout
β-Arrestin1 modulates lymphoid enhancer factor transcriptional activity through interaction with phosphorylated dishevelled proteins
2001 StandoutNobel
Tumor Microsatellite-Instability Status as a Predictor of Benefit from Fluorouracil-Based Adjuvant Chemotherapy for Colon Cancer
2003 Standout
Constitutive Transcriptional Activation by a β-Catenin-Tcf Complex in APC −/− Colon Carcinoma
1997 StandoutScience
Identification of Individuals at Risk for Lynch Syndrome Using Targeted Evaluations and Genetic Testing: National Society of Genetic Counselors and the Collaborative Group of the Americas on Inherited Colorectal Cancer Joint Practice Guideline
2011
Dominant negative effect of the APC1309 mutation: a possible explanation for genotype-phenotype correlations in familial adenomatous polyposis.
1999
Results of Annual Screening in Phase I of the United Kingdom Familial Ovarian Cancer Screening Study Highlight the Need for Strict Adherence to Screening Schedule
2012
Activation of β-Catenin-Tcf Signaling in Colon Cancer by Mutations in β-Catenin or APC
1997 StandoutScience
The cyclin D1 gene is a target of the β-catenin/LEF-1 pathway
1999 Standout
Heptahelical Receptor Signaling: Beyond the G Protein Paradigm
1999 StandoutNobel
Biallelic inactivation of hMLH 1 by epigenetic gene silencing, a novel mechanism causing human MSI cancers
1998 StandoutNobel
Evaluation of DNA from the Papanicolaou Test to Detect Ovarian and Endometrial Cancers
2013
CpG island methylator phenotype in colorectal cancer
1999 Standout
Phosphorylation Meets Ubiquitination: The Control of NF-κB Activity
2000 Standout
Integrating Genetic Approaches into the Discovery of Anticancer Drugs
1997 StandoutScienceNobel
Dysregulation of the TSC-mTOR pathway in human disease
2004 Standout
Germline mutations in the 3′ part of APC exon 15 do not result in truncated proteins and are associated with attenuated adenomatous polyposis coli
1996
Works of Tara Clancy being referenced
Non-penetrance and late appearance of polyps in families with familial adenomatous polyposis.
1993
Colorectal cancer in HNPCC: cumulative lifetime incidence, survival and tumour distribution. A report of 121 families with proven mutations
2008
Birth incidence and prevalence of tumor‐prone syndromes: Estimates from a UK family genetic register service
2010 Standout
Cumulative lifetime incidence of extracolonic cancers in Lynch syndrome: a report of 121 families with proven mutations
2009
Life expectancy in hereditary cancer predisposing diseases: an observational study
2012
Severe Gardner syndrome in families with mutations restricted to a specific region of the APC gene.
1995