Standout Papers
Citation Impact
Citing Papers
Inhibition of vascular endothelial growth factor with a sequence-specific hypoxia response element antagonist
2004 StandoutNobel
Loss of cryptochrome reduces cancer risk in p53 mutant mice
2009 StandoutNobel
Activation of Stat3 in Human Melanoma Promotes Brain Metastasis
2006
Induction of interferon-stimulated gene expression and antiviral responses require protein deacetylase activity
2004 StandoutNobel
Sunitinib Inhibition of Stat3 Induces Renal Cell Carcinoma Tumor Cell Apoptosis and Reduces Immunosuppressive Cells
2009
Comparison of gene expression in HCT116 treatment derivatives generated by two different 5-fluorouracil exposure protocols.
2004
Knockdown of STAT3 expression by RNAi induces apoptosis in astrocytoma cells
2003
ErbB Receptor-induced Activation of Stat Transcription Factors Is Mediated by Src Tyrosine Kinases
1999
An integrated encyclopedia of DNA elements in the human genome
2012 StandoutNature
Functional analysis of transcription factor binding sites in human promoters
2012
Stat3 regulates genes common to both wound healing and cancer
2005
Requirement of Stat3 signaling for HGF/SF-Met mediated tumorigenesis
2002
Differential contributions of ERK and PI3-kinase to the regulation of cyclin D1 expression and to the control of the G1/S transition in mouse embryonic stem cells
2002
Inhibition of Bcr–Abl kinase activity by PD180970 blocks constitutive activation of Stat5 and growth of CML cells
2002
Src activation of Stat3 is an independent requirement from NF-κB activation for constitutive IL-8 expression in human pancreatic adenocarcinoma cells
2006
Stat3 is required for ALK-mediated lymphomagenesis and provides a possible therapeutic target
2005
Elements of cancer immunity and the cancer–immune set point
2017 StandoutNature
Inflammation and cancer
2002 StandoutNature
Regulation of the innate and adaptive immune responses by Stat-3 signaling in tumor cells
2003
HIF-1α, STAT3, CBP/p300 and Ref-1/APE are components of a transcriptional complex that regulates Src-dependent hypoxia-induced expression of VEGF in pancreatic and prostate carcinomas
2005 StandoutNobel
STAT proteins: From normal control of cellular events to tumorigenesis
2003
Direct reprogramming of somatic cells is promoted by maternal transcription factor Glis1
2011 StandoutNatureNobel
Src family kinases in tumor progression and metastasis
2003
JAKs, STATs and Src kinases in hematopoiesis
2002
Oncogenic kinase signalling
2001 StandoutNature
Epithelial-Mesenchymal Transitions in Development and Disease
2009 Standout
Role of ERas in promoting tumour-like properties in mouse embryonic stem cells
2003 StandoutNatureNobel
The Stat family in cytokine signaling
2001
Innate and adaptive immune cells in the tumor microenvironment
2013 Standout
SOCS1 methylation in patients with newly diagnosed acute myeloid leukemia
2003
Molecular mechanisms of drug resistance
2005
Synergistic Roles for Pim-1 and c-Myc in STAT3-Mediated Cell Cycle Progression and Antiapoptosis
1999
Genome-scale transcriptional activation by an engineered CRISPR-Cas9 complex
2014 StandoutNature
Induction of Pluripotent Stem Cells from Mouse Embryonic and Adult Fibroblast Cultures by Defined Factors
2006 StandoutNobel
Constitutive Activation of Stat3 Signaling Confers Resistance to Apoptosis in Human U266 Myeloma Cells
1999 Standout
Transcription factors as targets for cancer therapy
2002
Chemotherapy-Induced Ca2+ Release Stimulates Breast Cancer Stem Cell Enrichment
2017 StandoutNobel
Induction of Pluripotent Stem Cells from Adult Human Fibroblasts by Defined Factors
2007 StandoutNobel
STAT family of transcription factors in cytokine-mediated biological responses
2000
Stat3 as an Oncogene
1999 Standout
Epstein–Barr virus-derived EBNA2 regulates STAT3 activation
2008
The ground state of embryonic stem cell self-renewal
2008 StandoutNature
The role of p53 in tumour suppression: lessons from mouse models
1999
Cytosolic delivery of peptidic STAT3 SH2 domain inhibitors
2020
Targeting Stat3 blocks both HIF-1 and VEGF expression induced by multiple oncogenic growth signaling pathways
2005 StandoutNobel
Mechanisms of Disease: insights into the emerging role of signal transducers and activators of transcription in cancer
2005
Serine phosphorylation of STATs
2000
Lack of toxicity of a STAT3 decoy oligonucleotide
2008
Roles of STAT3 in mediating the cell growth, differentiation and survival signals relayed through the IL-6 family of cytokine receptors
2000
Src Kinases Mediate STAT Growth Pathways in Squamous Cell Carcinoma of the Head and Neck
2003
Role of Src expression and activation in human cancer
2000
Single Cell Profiling of Potentiated Phospho-Protein Networks in Cancer Cells
2004
Zinc transporter LIVI controls epithelial-mesenchymal transition in zebrafish gastrula organizer
2004 Nature
The role of STATs in transcriptional control and their impact on cellular function
2000
Inhibition of STAT3 signaling leads to apoptosis of leukemic large granular lymphocytes and decreased Mcl-1 expression
2001
A Novel Platinum Compound Inhibits Constitutive Stat3 Signaling and Induces Cell Cycle Arrest and Apoptosis of Malignant Cells
2005
Disruption of Stat3 reveals a critical role in both the initiation and the promotion stages of epithelial carcinogenesis
2004
Persistently Activated Stat3 Maintains Constitutive NF-κB Activity in Tumors
2009
Phosphotyrosyl Peptides Block Stat3-mediated DNA Binding Activity, Gene Regulation, and Cell Transformation
2001
Nuclear factor-κB and inhibitor of κB kinase pathways in oncogenic initiation and progression
2006
Immunity, Inflammation, and Cancer
2010 Standout
VHL loss actuates a HIF-independent senescence programme mediated by Rb and p400
2008 StandoutNobel
Hepatitis C virus, ER stress, and oxidative stress
2005
Activation of STAT transcription factors in oncogenic tyrosine kinase signaling
1998
SH2-B Family Members Differentially Regulate JAK Family Tyrosine Kinases
2002
Generation of germline-competent induced pluripotent stem cells
2007 StandoutNatureNobel
Constitutive Stat3 activity up-regulates VEGF expression and tumor angiogenesis
2002
Interleukin-6 induces an epithelial–mesenchymal transition phenotype in human breast cancer cells
2009
STATs in cancer inflammation and immunity: a leading role for STAT3
2009 Standout
Mutations in the EGFR kinase domain mediate STAT3 activation via IL-6 production in human lung adenocarcinomas
2007
Stat3 enhances vimentin gene expression by binding to the antisilencer element and interacting with the repressor protein, ZBP-89
2004
Co-operative Effect of c-Src Tyrosine Kinase and Stat3 in Activation of Hepatocyte Growth Factor Expression in Mammary Carcinoma Cells
2001
Anaplastic lymphoma kinase (ALK) activates Stat3 and protects hematopoietic cells from cell death
2002
Control of TH17/Treg Balance by Hypoxia-Inducible Factor 1
2011 StandoutNobel
STAT proteins: novel molecular targets for cancer drug discovery
2000
STAT proteins as novel targets for cancer therapy
1999
Innate production of TH2 cytokines by adipose tissue-associated c-Kit+Sca-1+ lymphoid cells
2009 StandoutNature
Deletion of the SOCS3 Gene in Liver Parenchymal Cells Promotes Hepatitis–Induced Hepatocarcinogenesis
2006
Transcriptional regulation of the cyclin D1 promoter by STAT5: its involvement in cytokine-dependent growth of hematopoietic cells
1999
The STATs of cancer — new molecular targets come of age
2004 Standout
Crosstalk between cancer and immune cells: role of STAT3 in the tumour microenvironment
2006
The Coactivator of Transcription CREB-binding Protein Interacts Preferentially with the Glycosylated Form of Stat5
2004
Specific Ablation of Stat3β Distorts the Pattern of Stat3-Responsive Gene Expression and Impairs Recovery from Endotoxic Shock
2002 Nobel
Cytokine Signaling in 2002
2002 Standout
Macrophage biology in development, homeostasis and disease
2013 StandoutNature
STAT signaling in head and neck cancer
2000
Cancer-related inflammation
2008 StandoutNature
IL-3 signaling and the role of Src kinases, JAKs and STATs: a covert liaison unveiled
2000
Lysosome-targeting chimaeras for degradation of extracellular proteins
2020 StandoutNatureNobel
Loss of IFN-γ Pathway Genes in Tumor Cells as a Mechanism of Resistance to Anti-CTLA-4 Therapy
2016 StandoutNobel
The roles of IFNγ in protection against tumor development and cancer immunoediting
2002
Activation of Stat3 preassembled with platelet-derived growth factor β receptors requires Src kinase activity
2000
The Jak-STAT pathway
2000
Activation of Stat3 by receptor tyrosine kinases and cytokines regulates survival in human non-small cell carcinoma cells
2003
Requirement of Stat3 but not Stat1 activation for epidermal growth factor receptor- mediated cell growth In vitro.
1998
STATs: transcriptional control and biological impact
2002 Standout
Suppression of induced pluripotent stem cell generation by the p53–p21 pathway
2009 StandoutNatureNobel
Nuclear reprogramming to a pluripotent state by three approaches
2010 StandoutNatureNobel
Neuroendocrine Modulation of Signal Transducer and Activator of Transcription-3 in Ovarian Cancer
2007
Indirubin derivatives inhibit Stat3 signaling and induce apoptosis in human cancer cells
2005
Knockdown of STAT3 Expression by RNA Interference Inhibits the Induction of Breast Tumors in Immunocompetent Mice
2005
Signal Transducer and Activator of Transcription 3 Is a Key Regulator of Keratinocyte Survival and Proliferation following UV Irradiation
2005
Activation-induced cytidine deaminase (AID) promotes B cell lymphomagenesis in Emu-cmyc transgenic mice
2007 StandoutNobel
Hyperactivation of STAT3 Is Involved in Abnormal Differentiation of Dendritic Cells in Cancer
2004
Role of c-MYC in alternative activation of human macrophages and tumor-associated macrophage biology
2011
The role of protein kinase C δ activation and STAT3 Ser727 phosphorylation in insulin-induced keratinocyte proliferation
2006
The Protein Kinase Complement of the Human Genome
2002 StandoutScience
Identification of a Nuclear Stat1 Protein Tyrosine Phosphatase
2002
Sorafenib inhibits signal transducer and activator of transcription 3 signaling associated with growth arrest and apoptosis of medulloblastomas
2008
Epidermal growth factor receptor-independent constitutive activation of STAT3 in head and neck squamous cell carcinoma is mediated by the autocrine/paracrine stimulation of the interleukin 6/gp130 cytokine system.
2003
Inhibition of constitutive signal transducer and activator of transcription 3 activation by novel platinum complexes with potent antitumor activity
2004
Hypoxia-inducible factor 1 is a master regulator of breast cancer metastatic niche formation
2011 StandoutNobel
Targeted inhibition of Stat3 with a decoy oligonucleotide abrogates head and neck cancer cell growth
2003
Constitutive activation ofStat5aby retrovirus integration in early pre-B lymphomas of SL/Kh strain mice
2002
Stat3 Activity in Melanoma Cells Affects Migration of Immune Effector Cells and Nitric Oxide-Mediated Antitumor Effects
2005
Constitutively activated Stat3 protects fibroblasts from serum withdrawal and UV-induced apoptosis and antagonizes the proapoptotic effects of activated Stat1
2001
Protein Kinase Cε, which Sensitizes Skin to Sun's UV Radiation–Induced Cutaneous Damage and Development of Squamous Cell Carcinomas, Associates with Stat3
2007
EglN3 hydroxylase stabilizes BIM-EL linking VHL type 2C mutations to pheochromocytoma pathogenesis and chemotherapy resistance
2019 StandoutNobel
Overexpression of a dominant-negative signal transducer and activator of transcription 3 variant in tumor cells leads to production of soluble factors that induce apoptosis and cell cycle arrest.
2001
Involvement of JAK/STAT (Janus Kinase/Signal Transducer and Activator of Transcription) in the Thyrotropin Signaling Pathway
2000
Hypoxia-inducible factor 1-dependent expression of adenosine receptor 2B promotes breast cancer stem cell enrichment
2018 StandoutNobel
Novel peptidomimetic inhibitors of signal transducer and activator of transcription 3 dimerization and biological activity
2004
Chemotherapy induces enrichment of CD47 + /CD73 + /PDL1 + immune evasive triple-negative breast cancer cells
2018 StandoutNobel
Disruption of Stat3 reveals a critical role in both the initiation and the promotion stages of epithelial carcinogenesis
2004
Multilevel Dysregulation of STAT3 Activation in Anaplastic Lymphoma Kinase-Positive T/Null-Cell Lymphoma
2002
Constitutive activation of Stat3 signaling abrogates apoptosis in squamous cell carcinogenesisin vivo
2000
Resveratrol inhibits Src and Stat3 signaling and induces the apoptosis of malignant cells containing activated Stat3 protein
2006
Activation of STAT3 by the Hepatitis C Virus Core Protein Leads to Cellular Transformation
2002
pVHL suppresses kinase activity of Akt in a proline-hydroxylation–dependent manner
2016 StandoutScienceNobel
STAT3 activation abrogates growth factor dependence and contributes to head and neck squamous cell carcinoma tumor growth in vivo.
2002
PD-L1 and PD-L2 are differentially regulated by Th1 and Th2 cells
2003 StandoutNobel
Activated Stat-3 in Melanoma
2008
Activated STAT signaling in human tumors provides novel molecular targets for therapeutic intervention.
2002
Activation of PI3K/Akt and MAPK pathways regulates Myc-mediated transcription by phosphorylating and promoting the degradation of Mad1
2008
Understanding Melanoma Signaling Networks as the Basis for Molecular Targeted Therapy
2009
Cellular cofactors affecting hepatitis C virus infection and replication
2007 StandoutNobel
Gene therapy with dominant-negative Stat3 suppresses growth of the murine melanoma B16 tumor in vivo.
1999
Single-Cell Mass Cytometry of Differential Immune and Drug Responses Across a Human Hematopoietic Continuum
2011 StandoutScience
PTEN is a negative regulator of STAT3 activation in human papillomavirus-infected cells
2002
Nuclear interaction of EGFR and STAT3 in the activation of the iNOS/NO pathway
2005
LIF/STAT3 controls ES cell self-renewal and pluripotency by a Myc-dependent mechanism
2005
A Single Amino Acid Substitution in the v-Eyk Intracellular Domain Results in Activation of Stat3 and Enhances Cellular Transformation
1999
Negative Regulation of Cytokine Signaling Pathways
2000 Standout
Immunotherapy: Bewitched, Bothered, and Bewildered No More
2004 StandoutScienceNobel
Cyclooxygenase-2-Dependent Activation of Signal Transducer and Activator of Transcription 3 by Interleukin-6 in Non–Small Cell Lung Cancer
2005
Discovery of JSI-124 (cucurbitacin I), a selective Janus kinase/signal transducer and activator of transcription 3 signaling pathway inhibitor with potent antitumor activity against human and murine cancer cells in mice.
2003
IL-18 and IL-33 elicit Th2 cytokines from basophils via a MyD88- and p38α-dependent pathway
2009
Paradoxical roles for lysyl oxidases in cancer—A prospect
2007
Inhibition of STAT3 signaling induces apoptosis and decreases survivin expression in primary effusion lymphoma
2003
Epidermal Growth Factor Receptor Cooperates with Signal Transducer and Activator of Transcription 3 to Induce Epithelial-Mesenchymal Transition in Cancer Cells via Up-regulation of TWIST Gene Expression
2007
Promotion of direct reprogramming by transformation-deficient Myc
2010 StandoutNobel
Stapled β-Hairpins Featuring 4-Mercaptoproline
2021 StandoutNobel
Conformationally Constrained Peptidomimetic Inhibitors of Signal Transducer and Activator of Transcription 3: Evaluation and Molecular Modeling
2009
Photopharmacology: Beyond Proof of Principle
2014 StandoutNobel
Metabolic labeling enables selective photocrosslinking of O-GlcNAc-modified proteins to their binding partners
2012 StandoutNobel
Selective chemical probe inhibitor of Stat3, identified through structure-based virtual screening, induces antitumor activity
2007
Autophagy in Health and Disease: A Double-Edged Sword
2004 StandoutScience
Works of Tammy Bowman being referenced
Activation of Stat3 in Primary Tumors from High-Risk Breast Cancer Patients Is Associated with Elevated Levels of Activated Src and Survivin Expression
2006
Activation of STAT3 by the c-Fes Protein-tyrosine Kinase
1998
STATs in oncogenesis
2000 Standout
Induction of p21WAF1/CIP1 and cyclin D1 expression by the Src oncoprotein in mouse fibroblasts: role of activated STAT3 signaling
2000
Roles of activated Src and Stat3 signaling in melanoma tumor cell growth
2002
4. Stat Proteins and Cancer
1999
Persistent Activation of Stat3 Signaling Induces Survivin Gene Expression and Confers Resistance to Apoptosis in Human Breast Cancer Cells
2006
Tissue-specific inactivation of p53 tumor suppression in the mouse.
1996
Requirement for Ras/Rac1-Mediated p38 and c-Jun N-Terminal Kinase Signaling in Stat3 Transcriptional Activity Induced by the Src Oncoprotein
1999
Stat3 Activation by Src Induces Specific Gene Regulation and Is Required for Cell Transformation
1998
Signal Transducers and Activators of Transcription: Novel Targets for Anticancer Therapeutics
1999
Constitutive activation of Stat3 by the Src and JAK tyrosine kinases participates in growth regulation of human breast carcinoma cells
2001
Constitutive activation of Stat3 in human prostate tumors and cell lines: direct inhibition of Stat3 signaling induces apoptosis of prostate cancer cells.
2002
Stat3-mediated Myc expression is required for Src transformation and PDGF-induced mitogenesis
2001