Citation Impact
Citing Papers
[41] Cathepsin B, cathepsin H, and cathepsin L
1981 Standout
Computational design of closely related proteins that adopt two well-defined but structurally divergent folds
2020 StandoutNobel
Structural basis for the recognition of SARS-CoV-2 by full-length human ACE2
2020 StandoutScience
Hallmarks of Cancer: The Next Generation
2011 Standout
N‐Peptidyl‐O‐carbamoyl amino acid hydroxamates: Irreversible inhibitors for the study of the S2′ specificity of cysteine proteinases
1993
L-trans-Epoxysuccinyl-leucylamido(4-guanidino)butane (E-64) and its analogues as inhibitors of cysteine proteinases including cathepsins B, H and L
1982
Novel physiological functions of cathepsins B and L on antigen processing and osteoclastic bone resorption
1998
Crystal structure of cathepsin B inhibited with CA030 at 2.0-.ANG. resolution: A basis for the design of specific epoxysuccinyl inhibitors
1995 Nobel
Cysteine cathepsin proteases as pharmacological targets in cancer
2007
Inhibition of cruzipain visualized in a fluorescence quenched solid-phase inhibitor library assay.D-Amino Acid Inhibitors for cruzipain, cathepsin B and cathepsin L
1998 StandoutNobel
SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor
2020 Standout
Novel insights into proteolytic cleavage of influenza virus hemagglutinin
2010
Transforming Growth Factor-β: Activation by Neuraminidase and Role in Highly Pathogenic H5N1 Influenza Pathogenesis
2010
E-64 analogues as inhibitors of cathepsin B. On the role of the absolute configuration of the epoxysuccinyl group
1997
The Teratogenic Effects of E‐64 on Rat Embryogenesis
1990
Structural basis of inhibition of cysteine proteases by E-64 and its derivatives
1999
Virological assessment of hospitalized patients with COVID-2019
2020 StandoutNature
Human ADAR1 Prevents Endogenous RNA from Triggering Translational Shutdown
2018 StandoutNobel
Role of host cellular proteases in the pathogenesis of influenza and influenza-induced multiple organ failure
2011
Cleavage of poly(ADP-ribose) polymerase by a proteinase with properties like ICE
1994 StandoutNature
X-Ray crystal structure of papain complexed with cathepsin B-specific covalent-type inhibitor: substrate specificity and inhibitory activity
1998
Substrate/propeptide‐derived endo‐epoxysuccinyl peptides as highly potent and selective cathepsin B inhibitors
1998
Active center differences between cathepsins L and B: The S1 binding region
1988
The crystal structure of human cathepsin L complexed with E‐64
1997
Epoxysuccinyl peptide‐derived affinity labels for cathepsin B
2000
β-Cyclodextrin/epoxysuccinyl peptide conjugates: a new drug targeting system for tumor cells
2000
Refined X-ray crystallographic structure of the poliovirus 3C gene product 1 1Edited By D. Rees
1997
Treatment with cathepsin L inhibitor potentiates Th2-type immune response in Leishmania major-infected BALB/c mice
2001
Crystal Structures of Recombinant Rat Cathepsin B and a Cathepsin B-Inhibitor Complex
1995
Human Cathepsin F
1998
[32] Families of cysteine peptidases
1994
Turgor-responsive gene transcription and RNA levels increase rapidly when pea shoots are wilted. Sequence and expression of three inducible genes
1990
Lysosomal cysteine proteases: more than scavengers
2000
Cysteine proteases of parasitic organisms
2002
Participation of cathepsin B in processing of antigen presentation to MHC class II
1993
Crystal structure of a caricain D158E mutant in complex with E‐64
1996
Self-cleaving proteases
1991
Further Evidence for the Importance of Free Carboxylate in Epoxysuccinate Inhibitors of Thiol Proteases
1993
Topology fingerprint approach to the inverse protein folding problem
1992
[48] N,O-Diacyl hydroxamates as selective and irreversible inhibitors of cysteine proteinases
1994
The picornaviral 3C proteinases: Cysteine nucleophiles in serine proteinase folds
1995
A Serpin Shapes the Extracellular Environment to Prevent Influenza A Virus Maturation
2015 StandoutNobel
Membrane Fusion
2003 StandoutNobel
Tmprss2 Is Essential for Influenza H1N1 Virus Pathogenesis in Mice
2013
aziridinyl peptides as inhibitors of cysteine proteases: Effect of a free carboxylic acid function on inhibition
2000
Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis
1995 StandoutNature
Regulation of a novel pathway for cell death by lysosomal aspartic and cysteine proteinases
1999
Serpins in the Caenorhabditis elegans genome
1999
Binding modes of a new epoxysuccinyl–peptide inhibitor of cysteine proteases. Where and how do cysteine proteases express their selectivity?
1999
Cysteinyl Proteinases and Their Selective Inactivation
1990
Selective targeting of lysosomal cysteine proteases with radiolabeled electrophilic substrate analogs
2000
Postictal Blockade of Ischemic Hippocampal Neuronal Death in Primates Using Selective Cathepsin Inhibitors
1999
multifunctional enzymes in cancer
2006
(S)-Thiirancarboxylic acid as a reactive building block for a new class of cysteine protease inhibitors
2000
Inhibition of cysteine proteases by peptides containing aziridine-2,3-dicarboxylic acid building blocks
1999
Cholesterol Crystals Activate the NLRP3 Inflammasome in Human Macrophages: A Novel Link between Cholesterol Metabolism and Inflammation
2010
Picornaviral 3C cysteine proteinases have a fold similar to chymotrypsin-like serine proteinases
1994 Nature
Crystal structure of a papain-E-64 complex
1989
Structure-Based Design of Specific Cathepsin Inhibitors and Their Application to Protection of Bone Metastases of Cancer Cells
2002
Epoxide electrophiles as activity-dependent cysteine protease profiling and discovery tools
2000
Structural basis for development of cathepsin B-specific noncovalent-type inhibitor: crystal structure of cathepsin B–E64c complex
2002
Progress and challenges in translating the biology of atherosclerosis
2011 StandoutNature
Crystal Structure of the Hepatitis C Virus NS3 Protease Domain Complexed with a Synthetic NS4A Cofactor Peptide
1996 StandoutNobel
Cysteine proteases of positive strand RNA viruses and chymotrypsin‐like serine proteases
1989
CA074 methyl ester: A proinhibitor for intracellular cathepsin B
1992
Inhibition of ischaemic hippocampal neuronal death in primates with cathepsin B inhibitor CA‐074: a novel strategy for neuroprotection based on ‘calpain–cathepsin hypothesis’
1998
Cysteine Protease Inhibitors Produced by the Industrial Koji Mold,Aspergillus oryzaeO-1018
1998
In vivo imaging of tumors with protease-activated near-infrared fluorescent probes
1999 Standout
Structure based development of novel specific inhibitors for cathepsin L and cathepsin S in vitro and in vivo
1999
Structural determinants of specificity in the cysteine protease cruzain
1997
Inhibition Mechanism of Cathepsin L-Specific Inhibitors Based on the Crystal Structure of Papain–CLIK148 Complex
1999
The 2.2 å crystal structure of human chymase in complex with succinyl-ala-ala-pro-phe-chloromethylketone: structural explanation for its dipeptidyl carboxypeptidase specificity
1999 Nobel
Endosomal proteolysis and MHC class II function
1998
Prolongation of life span of dystrophic hamster by cysteine proteinase inhibitor, loxistatin (EST).
1987
Study of the functional share of lysosomal cathepsins by the development of specific inhibitors
1999
Immunization of chimpanzees confers protection against challenge with human immunodeficiency virus.
1991 StandoutNobel
Proteolytic Activation of Influenza Viruses by Serine Proteases TMPRSS2 and HAT from Human Airway Epithelium
2006
Golgi/granule processing of peptide hormone and neuropeptide precursors: A minireview
1984
MHC Class I Presentation of an Exogenous Polypeptide Antigen Encoded by the Murine AIDS Defective Virus
1997 StandoutNobel
Molecular Recognition of Protein−Ligand Complexes: Applications to Drug Design
1997 Standout
E64 [trans-epoxysuccinyl-l -leucylamido-(4-guanidino)butane] analogues as inhibitors of cysteine proteinases: investigation of S2 subsite interactions
1994
An exploration of the primary specificity site of cathepsin B
1983
Comparison of the virulent Asibi strain of yellow fever virus with the 17D vaccine strain derived from it.
1987 StandoutNobel
Nucleotide Sequence of Yellow Fever Virus: Implications for Flavivirus Gene Expression and Evolution
1985 StandoutScienceNobel
Site-directed mutagenesis suggests close functional relationship between a human rhinovirus 3C cysteine protease and cellular trypsin-like serine proteases.
1990
Cathepsins X and B Can Be Differentiated through Their Respective Mono- and Dipeptidyl Carboxypeptidase Activities
2001
Gravity Force Transduced by the MEC-4/MEC-10 DEG/ENaC Channel Modulates DAF-16/FoxO Activity in Caenorhabditis elegans
2007 StandoutNobel
De Novo-Designed Enzymes as Small-Molecule-Regulated Fluorescence Imaging Tags and Fluorescent Reporters
2014 StandoutNobel
Mechanistic Studies on the Inactivation of Papain by Epoxysuccinyl Inhibitors
1996
Synthesis and inhibiting activities of 1-peptidyl-2-haloacetyl hydrazines toward cathepsin B and calpains
1993
Novel folded protein domains generated by combinatorial shuffling of polypeptide segments
2000 StandoutNobel
Identification of cDNA clones encoding a precursor of rat liver cathepsin B.
1985
Specific proteolytic cleavage of poly(ADP-ribose) polymerase: an early marker of chemotherapy-induced apoptosis.
1993 Standout
Evolution of Proteolytic Enzymes
1984 Science
Cysteine Proteases and Their Inhibitors
1997
A second hepatitis C virus-encoded proteinase.
1993 StandoutNobel
Human liver cathepsin L
1985
A Strategy for the Selective Imaging of Glycans Using Caged Metabolic Precursors
2010 StandoutNobel
Lysosomal cathepsin D mediates endogenous mucin glycodomain catabolism in mammals
2022 StandoutNobel
Viral cysteine proteases are homologous to the trypsin-like family of serine proteases: structural and functional implications.
1988
Comparative behaviour of calpain and cathepsin B toward peptidyl acyloxymethyl ketones, sulphonium methyl ketones and other potential inhibitors of cysteine proteinases
1992
Molecular cloning of a bovine cathepsin
1985 StandoutNobel
In vitro and in vivo inhibition of cysteine proteinases by EST, a new analog of E-64.
1986
Activation of the SARS coronavirus spike protein via sequential proteolytic cleavage at two distinct sites
2009
Mapping epitopes and antigenicity by site-directed masking
2006 StandoutNobel
Isolation of the cDNA for erythrocyte integral membrane protein of 28 kilodaltons: member of an ancient channel family.
1991 StandoutNobel
Effect of Ca2+ on the inhibition of calcium‐activated neutral protease by leupeptin, antipain and epoxysuccinate derivatives
1981
Refined x-ray structure of papain.E-64-c complex at 2.1-A resolution
1991
Action of human liver cathepsin B on the oxidized insulin B chain
1983
Crystal structure of human cathepsin S
1998
ATP-dependent degradation of ubiquitin-protein conjugates.
1984 StandoutNobel
Mass spectrometry-based proteomics
2003 StandoutNature
Copper-Catalyzed Synthesis of Mixed Alkyl Aryl Phosphonates
2014 StandoutNobel
Improved recognition of native-like protein structures using a family of designed sequences
2002 StandoutNobel
Measurement of individual rate constants of irreversible inhibition of a cysteine proteinase by an epoxysuccinyl inhibitor
1995
Selective inhibition of lysosomal protein degradation by the thiol proteinase inhibitors e-64, ep-459 and ep-475 in isolated rat hepatocytes
1982
Ribosomal Synthesis of Dehydroalanine-Containing Peptides
2006 StandoutNobel
Identification of a 31,500 molecular weight islet cell protease as cathepsin B.
1983
Receptor Binding and Membrane Fusion in Virus Entry: The Influenza Hemagglutinin
2000 Standout
Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation
2020 StandoutScience
Design, Synthesis and Evaluation of d-Homophenylalanyl Epoxysuccinate Inhibitors of the Trypanosomal Cysteine Protease Cruzain
2000
The purification and properties of cathepsin L from rabbit liver
1984
THE LYSOSOMAL CYSTEINE PROTEASES
1999
Cathepsins B and H from porcine spleen. Purification, polypeptide chain arrangements, and carbohydrate content.
1984
Transport of Peptide-MHC Class II Complexes in Developing Dendritic Cells
2000 StandoutScienceNobel
Iodo and diiodotyrosine epoxysuccinyl derivatives as selective inhibitors of cathepsin B
1993
Solid‐Phase Synthesis of Double‐Headed Epoxysuccinyl Activity‐Based Probes for Selective Targeting of Papain Family Cysteine Proteases
2005
Appearance of Water Channels in Xenopus Oocytes Expressing Red Cell CHIP28 Protein
1992 StandoutScienceNobel
ATP-dependent incorporation of 20S protease into the 26S complex that degrades proteins conjugated to ubiquitin.
1989 StandoutNobel
Action of rat liver cathepsin L on collagen and other substrates.
1982
The N-terminal amino acid sequences of the heavy and light chains of human cathepsin L Relationship to a cDNA clone for a major cysteine proteinase from a mouse macrophage cell line
1986 StandoutNobel
Characterization of the terminal regions of hepatitis C viral RNA: identification of conserved sequences in the 5' untranslated region and poly(A) tails at the 3' end.
1991 StandoutNobel
Poliovirus thiol proteinase 3C can utilize a serine nucleophile within the putative catalytic triad.
1991
The major excreted protein of transformed fibroblasts is an activable acid-protease.
1986
Aprotinin, a Protease Inhibitor, Suppresses Proteolytic Activation of Pandemic H1N1v Influenza Virus
2011
Autoproteolysis in nucleoporin biogenesis
1999 StandoutNobel
HTLV-III/LAV-Neutralizing Antibodies to an E. coli -Produced Fragment of the Virus Envelope
1986 Science
Identification of the active site cysteine and of the disulfide bonds in the N‐terminal part of the molecule of bovine spleen cathepsin B
1982
cDNA isolated from a human T-cell library encodes a member of the protein-tyrosine-phosphatase family.
1989 StandoutNobel
Cathepsin B-related proteases in the insulin secretory granule.
1984
A classification of enzyme inhibitors
1992
Peptidyl vinyl sulphones: a new class of potent and selective cysteine protease inhibitors: S2P2 specificity of human cathepsin O2 in comparison with cathepsins S and L
1996
An epoxysuccinic acid derivative(loxistatin)-induced hepatic injury in rats and hamsters
1990
Ghrelin is a growth-hormone-releasing acylated peptide from stomach
1999 StandoutNature
Autophagy as a Regulated Pathway of Cellular Degradation
2000 StandoutScience
Altered ubiquitination and stability of aquaporin-1 in hypertonic stress
2001 StandoutNobel
The 2.0 A X-ray crystal structure of chicken egg white cystatin and its possible mode of interaction with cysteine proteinases.
1988 StandoutNobel
Identification and partial purification of an ATP-stimulated alkaline protease in rat liver.
1979
TMPRSS2 and TMPRSS4 Facilitate Trypsin-Independent Spread of Influenza Virus in Caco-2 Cells
2010
SPOCC: A Resin for Solid-Phase Organic Chemistry and Enzymatic Reactions on Solid Phase
1999 StandoutNobel
Irreversible Inhibitors of Serine, Cysteine, and Threonine Proteases
2002 Standout
Azapeptides as Inhibitors and Active Site Titrants for Cysteine Proteinases
1998
Switch of CD4+ T Cell Differentiation from Th2 to Th1 by Treatment with Cathepsin B Inhibitor in Experimental Leishmaniasis
1998
Amino acid sequence of human liver cathepsin B
1985
Furin: a mammalian subtilisin/Kex2p-like endoprotease involved in processing of a wide variety of precursor proteins
1997
Serpins in theCaenorhabditis elegans genome
1999
Evidence that the N-terminal domain of nonstructural protein NS3 from yellow fever virus is a serine protease responsible for site-specific cleavages in the viral polyprotein.
1990 StandoutNobel
Structure of the catalytic domain of the hepatitis C virus NS2-3 protease
2006 StandoutNatureNobel
Partial N-terminal amino acid sequences of three nonstructural proteins of two flaviviruses
1986 StandoutNobel
Works of Takae Towatari being referenced
Purification and characterization of cathepsin J from rat liver
1992
Molecular Basis of Proteolytic Activation of Sendai Virus Infection and the Defensive Compounds for Infection
1997
Molecular cloning and sequencing of cDNA for rat cathepsin L
1987
Effects of selective inhibition of cathepsin B and general inhibition of cysteine proteinases on lysosomal proteolysis in rat liver in vivo and in vitro
1992
Amino acid sequence of rat liver cathepsin L
1988
Mast cell tryptase from pig lungs triggers infection by pneumotropic Sendai and influenza A viruses
2000
Identification of ectopic anionic trypsin I in rat lungs potentiating pneumotropic virus infectivity and increased enzyme level after virus infection
2002
The human mucus protease inhibitor and its mutants are novel defensive compounds against infection with influenza A and Sendai viruses
1999
Cellular proteases involved in the pathogenicity of enveloped animal viruses, human immunodeficiency virus, influenza virus A and Sendai virus
1996
Human Mucus Protease Inhibitor in Airway Fluids Is a Potential Defensive Compound against Infection with Influenza A and Sendai Viruses
1997
Mini‐plasmin found in the epithelial cells of bronchioles triggers infection by broad‐spectrum influenza A viruses and Sendai virus
2001
Novel epoxysuccinyl peptides A selective inhibitor of cathepsin B, in vivo
1991
Crystallization and Properties of Cathepsin B from Rat Liver
1979
Crystallization and amino acid composition of cathepsin B from rat liver lysosomes
1978
Purification and Properties of a New Cathepsin from Rat Liver1
1978
Use of New Synthetic Substrates for Assays of Cathepsin L and Cathepsin B1
1983
Cellular Proteinases Trigger the Infectivity of the Influenza A and Sendai Viruses
1999
The refined 2.15 A X-ray crystal structure of human liver cathepsin B: the structural basis for its specificity.
1991 Nobel
Separation of a new protease from cathepsin B1 of rat liver lysosomes
1976
Studies on New Intracellular Proteases in Various Organs of Rat
1975
Space shuttle flight (STS‐90) enhances degradation of rat myosin heavy chain in association with activation of ubiquitin‐proteasome pathway
2001
Inhibitions by E-64 Derivatives of Rat Liver Cathepsin B and Cathepsin L In Vitro and In Vivo 1
1980
Expression and site-specific mutagenesis of the poliovirus 3C protease in Escherichia coli.
1986
Novel epoxysuccinyl peptides Selective inhibitors of cathepsin B, in vitro
1991
Primary structure study of rat liver cathepsin B -----A striking resemblance to papain
1980
Homology of amino acid sequences of rat liver cathepsins B and H with that of papain.
1983
Structural Studies on the Carbohydrate Moieties of Rat Liver Cathepsins B and H1
1985