Citation Impact
Citing Papers
Formation of the First Peptide Bond: The Structure of EF-P Bound to the 70 S Ribosome
2009 StandoutScienceNobel
Targeted cell killing by reconstituted caspases
2007 StandoutNobel
Zinc Finger-DNA Recognition: Crystal Structure of a Zif268-DNA Complex at 2.1 Å
1991 StandoutScience
Mediation of Poly(ADP-Ribose) Polymerase-1-Dependent Cell Death by Apoptosis-Inducing Factor
2002 StandoutScience
PARP inhibitors: Synthetic lethality in the clinic
2017 StandoutScience
The promise and challenge of therapeutic genome editing
2020 StandoutNatureNobel
Association of poly(ADP-ribose) polymerase with the nuclear matrix: The role intermolecular disulfide bond formation, RNA retention, and cell type
1991
Reaction mechanism for automodification of poly(ADP-ribos synthetase
1987
Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase
2005 StandoutNature
Reconstitution of an in vitro poly(ADP-ribose) turnover system
1990
Poly(ADP ribose) polymerase-defective mutant cell clone of mouse L1210 cells
1992
Mammalian single-strand break repair: Mechanisms and links with chromatin
2006
Induction of islet B-cell regeneration in partially pancreatectomized rats by poly(ADP-ribose) synthetase inhibitors
1988
Structural and functional analysis of poly(ADP ribose) polymerase: an immunological study
1988
Cleavage of poly(ADP-ribose) polymerase by a proteinase with properties like ICE
1994 StandoutNature
Apaf-1, a Human Protein Homologous to C. elegans CED-4, Participates in Cytochrome c–Dependent Activation of Caspase-3
1997 Standout
Apoptosis by Death Factor
1997 Standout
Regulation of DNAS1L3 Endonuclease Activity by Poly(ADP-ribosyl)ation during Etoposide-induced Apoptosis
2002
Poly (ADP‐ribose) polymerase inhibits DNA replication by human replicative DNA polymerase α, δ and ε in vitro
1994
Inhibition of Poly(ADP-ribose) Polymerase Rescues Human T Lymphocytes from Methylmercury-Induced Apoptosis
1998
Poly(ADP-Ribose) Polymerase Inhibition in Oxidant-Stressed Endothelial Cells Prevents Oncosis and Permits Caspase Activation and Apoptosis
1999
Induction of Apoptotic Program in Cell-Free Extracts: Requirement for dATP and Cytochrome c
1996 Standout
Cell Death
2004 Standout
Zinc-binding domain of poly(ADP-ribose)polymerase participates in the recognition of single strand breaks on DNA
1989
Equilibrium model in an in vitro poly(ADP-ribose) turnover system
1995
The Therapeutic Potential of Poly(ADP-Ribose) Polymerase Inhibitors
2002 Standout
Poly(ADP-ribose) synthetase is phosphorylated by protein kinase C
1987
Transient Poly(ADP-ribosyl)ation of Nuclear Proteins and Role of Poly(ADP-ribose) Polymerase in the Early Stages of Apoptosis
1998
The Sequence-specific DNA Binding of NF-κB Is Reversibly Regulated by the Automodification Reaction of Poly (ADP-ribose) Polymerase 1
2001
A nuclear pore complex protein that contains zinc finger motifs, binds DNA, and faces the nucleoplasm
1993 StandoutNobel
The Caenorhabditis elegans cell-death protein CED-3 is a cysteine protease with substrate specificities similar to those of the human CPP32 protease.
1996 StandoutNobel
Involvement of MACH, a Novel MORT1/FADD-Interacting Protease, in Fas/APO-1- and TNF Receptor–Induced Cell Death
1996 Standout
Inhibitors of poly(ADP‐ribose) polymerase suppress nuclear fragmentation and apoptotic‐body formation during apoptosis in HL‐60 cells
1997
Inhibitors and activators of ADP-ribosylation reactions
1994
Effects of Parp Inhibition on Drug and FAS-Induced Apoptosis in Leukaemic Cells
1999
Cell cycle regulation of poly(ADP-ribose) synthetase in FR3T3 cells
1988
Role of poly(ADP-ribose) formation in DNA repair
1992 StandoutNatureNobel
Cytochrome c and dATP-Dependent Formation of Apaf-1/Caspase-9 Complex Initiates an Apoptotic Protease Cascade
1997 Standout
Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis
1995 StandoutNature
Yama/CPP32β, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymerase
1995 Standout
FLICE, A Novel FADD-Homologous ICE/CED-3–like Protease, Is Recruited to the CD95 (Fas/APO-1) Death-Inducing Signaling Complex
1996 Standout
Polypeptide domains of ADP-ribosyltransferase obtained by digestion with plasmin
1988
Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase
2000 StandoutNature
Bid, a Bcl2 Interacting Protein, Mediates Cytochrome c Release from Mitochondria in Response to Activation of Cell Surface Death Receptors
1998 Standout
Purification, Characterization, and Amino Acid Sequencing of DNase γ from Rat Spleen
1997
Poly(ADP-ribose) polymerase forms loops with DNA
1987
Poly(ADP-ribose) catabolism in mammalian cells exposed to DNA-damaging agents
1989
DFF, a Heterodimeric Protein That Functions Downstream of Caspase-3 to Trigger DNA Fragmentation during Apoptosis
1997 Standout
A caspase-activated DNase that degrades DNA during apoptosis, and its inhibitor ICAD
1998 StandoutNature
Apoptosis: The Biochemistry and Molecular Biology of Programmed Cell Death*
1993
Evidence for an inhibitory effect exerted by yeast NMN adenylyltransferase on poly(ADP-ribose)polymerase activity
1990
The NS5A Protein of Hepatitis C Virus Is a Zinc Metalloprotein
2004 StandoutNobel
All trans retinoic acid induces apoptosis in acute promyelocytic NB4 cells when combined with isoquinolinediol, a poly(ADP-ribose) polymerase inhibitor
2000
Effects of Uracil Incorporation, DNA Mismatches, and Abasic Sites on Cleavage and Religation Activities of Mammalian Topoisomerase I
1997 StandoutNobel
Expression in Escherichia coli of the 36 kDa domain of poly(ADP-ribose) polymerase and investigation of its DNA binding properties
1993
Review: Modulation of chromatin structure by poly(ADP-ribosyl)ation
1988
Role of poly(ADP-ribose) synthetase in inflammation and ischaemia–reperfusion
1998
Molecular and biochemical features of poly (ADP-ribose) metabolism
1993
Decreased apoptosis in the brain and premature lethality in CPP32-deficient mice
1996 StandoutNature
Activation of the apoptotic protease CPP32 by cytotoxic T-cell-derived granzyme B
1995 Nature
Defects in the Ubiquitin Pathway Induce Caspase-independent Apoptosis Blocked by Bcl-2
1998 StandoutNobel
A polyadenylate binding protein localized to the granules of cytolytic lymphocytes induces DNA fragmentation in target cells
1991
Purification and characterization of human lymphoid poly(adenosine diphosphate ribose) polymerase
1982
Purification and characterization of the major nonhistone protein acceptor for poly(adenosine diphosphate ribose) in HeLa cell nuclei
1980
Benzamide-DNA interactions: Deductions from binding, enzyme kinetics and from X-ray structural analysis of a 9-ethyladenine-benzamide adduct
1987
Multiple autopoly(ADP-ribosyl)ation of rat liver poly(ADP-ribose) synthetase. Mode of modification and properties of automodified synthetase.
1981
Selective isolation of domains of chromatin proximal to both carcinogen-induced DNA damage and poly-adenosine diphosphate-ribosylation.
1985
Poly(ADP‐ribose) polymerase is a zinc metalloenzyme
1984
DNA excision-repair defect of xeroderma pigmentosum prevents removal of a class of oxygen free radical-induced base lesions.
1993 StandoutNobel
Poly(ADP-ribosyl)ation of RNA polymerase II from wheat germ
1985
Reconstitution and poly(ADP-ribosyl)ation of proteolytically fragmented poly(ADP-ribose) synthetase.
1986
5,6-Dichloro-1-β-D-ribofuranosylbenzimidazole inhibits transcription elongation by RNA polymerase II in vitro
1989 StandoutNobel
DNA strand breaks, NAD metabolism, and programmed cell death
1986
Streptozotocin and alloxan induce DNA strand breaks and poly(ADP–ribose) synthetase in pancreatic islets
1981 Nature
Enhancing effect of 3-aminobenzamide on induction of γ-glutamyl transpeptidase positive foci in rat liver
1982
Prooxidant States and Tumor Promotion
1985 StandoutScience
Prevention of Apoptosis by Bcl-2: Release of Cytochrome c from Mitochondria Blocked
1997 StandoutScience
Poly(ADP-ribose) synthetase. The DNA binding domain and the automodification domain.
1982
Poly (ADP-Ribose) synthetase. Separation and identification of three proteolytic fragments as the substrate-binding domain, the DNA-binding domain, and the automodification domain.
1984
Poly(ADP-ribosylated) histones in chromatin replication.
1990
Zinc fingers and other metal-binding domains. Elements for interactions between macromolecules.
1990
Poly(ADP-ribose) catabolism in mammalian cells
1994
Studies of nuclear ADP-ribosylation
1980
[36] Eukaryotic gene transcription with purified components
1983
Regulation of biosynthesis of aminoacyl-tRNA synthetases and of tRNA in Escherichia coli
1977
Purification and analysis of a factor which suppresses nick-induced transcription by RNA polymerase II and its identity with poly(ADP-ribose) polymerase.
1983
The recognition by RNase P of precursor tRNAs.
1988 StandoutNobel
Reconstitution of DNA base excision-repair with purified human proteins: interaction between DNA polymerase beta and the XRCC1 protein.
1996 StandoutNobel
Characterization of a factor that can prevent random transcription of cloned rDNA and its probable relationship to poly(ADP-ribose) polymerase
1985
Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation.
1992 Standout
In vitro poly(ADP-ribosyl)ation of seminal ribonuclease.
1986
Dinucleotide priming of transcription mediated by RNA polymerase II.
1984 StandoutNobel
Specific interaction between the self-splicing RNA of Tetrahymena and its guanosine substrate: implications for biological catalysis by RNA
1984 StandoutNatureNobel
Interactions between RNA polymerase II, factors, and template leading to accurate transcription.
1984 StandoutNobel
Evidence for regulation of NF-κB by poly(ADP-ribose) polymerase
2000
3′-Deoxy-NAD+ as a substrate for poly(ADP-ribose)polymerase and the reaction mechanism of poly(ADP-ribose) elongation.
1988
Regulatory elements that modulate expression of human c-myc.
1987 StandoutNobel
Purification and properties of poly(ADPribose)) polymerase from lamb thymus
1981
Similarities in the molecular weight of poly(ADPR) polymerase from different tissues and species
1981
Participation of poly(ADP-ribosyl)ation in the depression of RNA synthesis caused by treatment of mouse lymphoma cells with methylnitrosourea.
1982
Relative affinities of poly(ADP-ribose) polymerase and DNA-dependent protein kinase for DNA strand interruptions
1999
A Shuttle Mechanism for DNA‐Protein Interactions
1982
Separation and characterization of factors mediating accurate transcription by RNA polymerase II.
1982 StandoutNobel
Poly(ADP-ribosyl)ation reactions in the regulation of nuclear functions
1999 Standout
Specific inhibitors of poly(ADP-ribose) synthetase and mono(ADP-ribosyl)transferase.
1992
Differential regulation of S-region hypermutation and class-switch recombination by noncanonical functions of uracil DNA glycosylase
2014 StandoutNobel
Poly(ADP-ribose) polymerase auto-modification and interaction with DNA: electron microscopic visualization.
1983
Nucleosomes are phased along the mouse β-major globin gene in erythroid and nonerythroid cells
1986 StandoutNobel
Molecular interactions between DNA, poly(ADP-ribose) polymerase, and histones.
1988
Modulation of chromatin superstructure induced by poly(ADP-ribose) synthesis and degradation.
1986
Influence of poly(ADP-ribose) polymerase on the enzymatic synthesis of SV40 DNA.
1991
Poly(ADP-ribose) polymerase stimulates DNA polymerase alpha by physical association.
1993
Poly(ADP-ribosylation) in vitro. Reaction parameters and enzyme mechanism.
1982
Worthy of a detour
1982 StandoutNatureNobel
Induction of a Ca2+, Mg2+-dependent endonuclease activity during the early stages of murine erythroleukemic cell differentiation.
1984
Identification of a soluble protein that stimulates peptide bond synthesis.
1975
Inhibition of DNA polymerase α, DNA polymerase β, terminal deoxynucleotidyl transferase, and DNA ligase II by poly(ADP-ribosyl)ation reaction in vitro
1985
Inhibitors of the proteasome pathway interfere with induction of nitric oxide synthase in macrophages by blocking activation of transcription factor NF-kappa B.
1996 StandoutNobel
ADP-ribosylation of diadenosine 5',5“-P1,P4-tetraphosphate by poly(ADP-ribose) polymerase in vitro.
1981
Formation and resealing of intercalator-induced DNA strand breaks in permeabilized L1210 cells without the stimulated synthesis of poly(ADP-ribose).
1982 StandoutNobel
Simple derivation of TFIID-dependent RNA polymerase II transcription systems from Schizosaccharomyces pombe and other organisms, and factors required for transcriptional activation.
1992 StandoutNobel
Poly(ADP-ribosyl)ation of DNA polymerase
1986
Purification and Characterization of an Interleukin-1β-converting Enzyme Family Protease That Activates Cysteine Protease P32 (CPP32)
1996
Poly(ADP-ribose) glycohydrolase mediates oxidative and excitotoxic neuronal death
2001
NAD(+)-dependent repair of damaged DNA by human cell extracts.
1993 StandoutNobel
Poly(ADP-ribose) synthetase and chick limb mesenchymal cell differentiation
1985
Effect of the DNA‐binding domain of poly(ADP‐ribose)synthetase on accurate transcription initiation in a HeLa cell lysate
1984
TNF- and Cancer Therapy-Induced Apoptosis: Potentiation by Inhibition of NF-κB
1996 StandoutScience
Works of T. Kamiya being referenced
Bovine thymus poly(adenosine diphosphate ribose) polymerase.
1978
Elongation Factor T Altered in a Temperature-sensitive Escherichia coli Mutant
1973
Mechanism of the inhibition of Ca2+, Mg2+-dependent endonuclease of bull seminal plasma induced by ADP-ribosylation.
1984
Purification and properties of bull seminal plasma Ca2+,Mg2+-dependent endonuclease.
1982
Inhibition and down-regulation of poly(ADP-ribose) polymerase results in a marked resistance of HL-60 cells to various apoptosis-inducers.
1995
Bovine thymus poly(adenosine diphosphate ribose) polymerase. Physical properties and binding to DNA.
1980
Mode of enzyme-bound poly(ADP-ribose) synthesis and histone modification by reconstituted poly(ADP-ribose) polymerase-DNA-cellulose complex.
1981