Citation Impact
Citing Papers
Navigating the protein fitness landscape with Gaussian processes
2012 StandoutNobel
A monomeric G protein-coupled receptor isolated in a high-density lipoprotein particle efficiently activates its G protein
2007 StandoutNobel
Protein stability promotes evolvability
2006 StandoutNobel
The P450 Superfamily: Updated Listing of All Genes and Recommended Nomenclature for the Chromosomal Loci
1989
Crystal structure and refinement of cytochrome P450terp at 2·3 Å resolution
1994 Nobel
Regulation of Cytochrome P450 2C11 (CYP2C11) Gene Expression by Interleukin-1, Sphingomyelin Hydrolysis, and Ceramides in Rat Hepatocytes
1995
Dynamic personalities of proteins
2007 StandoutNature
Laboratory evolution of peroxide-mediated cytochrome P450 hydroxylation
1999 StandoutNatureNobel
Cloned and expressed nitric oxide synthase structurally resembles cytochrome P-450 reductase
1991 StandoutNature
Drosophila melanogaster NADPH–cytochrome P450 oxidoreductase: pronounced expression in antennae may be related toodorantclearance
1997
Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation
1999 StandoutNature
High-Throughput Screen for Aromatic Hydroxylation
2003
Modification of the Nucleotide Cofactor-binding Site of Cytochrome P-450 Reductase to Enhance Turnover with NADH in Vivo
2002
Directed Evolution of the Fatty-Acid Hydroxylase P450 BM-3 into an Indole-Hydroxylating Catalyst
2000
Nitric oxide directly activates calcium-dependent potassium channels in vascular smooth muscle
1994 StandoutNature
An unusual yet strongly conserved flavoprotein reductase in bacteria and mammals
1991
Functional Evolution and Structural Conservation in Chimeric Cytochromes P450
2004 StandoutNobel
Regulation of Ferroptotic Cancer Cell Death by GPX4
2014 Standout
The Mechanism of Microsomal Azoreduction: Predictions Based on Electronic Aspects of Structure-Activity Relationships
1995
A redox-based mechanism for the neuroprotective and neurodestructive effects of nitric oxide and related nitroso-compounds
1993 StandoutNature
The catalytic pathway of horseradish peroxidase at high resolution
2002 StandoutNature
The L-Arginine-Nitric Oxide Pathway
1993 Standout
On the mechanism of amine oxidations by P450
1995
X-ray Absorption Near Edge Studies of Cytochrome P-450-CAM, Chloroperoxidase, and Myoglobin
1995
From endoplasmic-reticulum stress to the inflammatory response
2008 StandoutNature
Isoprenylation in regulation of signal transduction by G-protein-coupled receptor kinases
1992 StandoutNatureNobel
Enzymatic functionalization of carbon–hydrogen bonds
2010 StandoutNobel
Long-term potentiation in the hippocampus is blocked by tyrosine kinase inhibitors
1991 StandoutNatureNobel
Replacement of active-site cysteine-436 by serine converts cytochrome P450 2B4 into an NADPH oxidase with negligible monooxygenase activity
2002
Microarray Analysis and Organization of Circadian Gene Expression in Drosophila
2001 StandoutNobel
Escherichia coliFlavodoxin Sepharose as an Affinity Resin for Cytochromes P450 and Use to Identify a Putative Cytochrome P450c17/3β-Hydroxysteroid Dehydrogenase Interaction
1997
Crystal Structures of a Complexed and Peptide-Free Membrane Protein–Binding Domain: Molecular Basis of Peptide Recognition by PDZ
1996 StandoutNobel
Predicting the orientation of eukaryotic membrane-spanning proteins.
1989
Biochemistry of Nitric Oxide and Its Redox-Activated Forms
1992 StandoutScience
The mouse and human genes encoding the recognition component of the N-end rule pathway
1998 StandoutNobel
Cloning, structure, and expression of the mitochondrial cytochrome P-450 sterol 26-hydroxylase, a bile acid biosynthetic enzyme
1989
Flavodoxin and NADPH-flavodoxin reductase from Escherichia coli support bovine cytochrome P450c17 hydroxylase activities.
1994
Characterization of human sterol 27-hydroxylase. A mitochondrial cytochrome P-450 that catalyzes multiple oxidation reaction in bile acid biosynthesis.
1991
Enantioselective α-Hydroxylation of 2-Arylacetic Acid Derivatives and Buspirone Catalyzed by Engineered Cytochrome P450 BM-3
2006 StandoutNobel
Nitric Oxide: A Physiologic Mediator of Penile Erection
1992 StandoutScience
Mutagenesis at a Highly Conserved Phenylalanine in Cytochrome P450 2E1 Affects Heme Incorporation and Catalytic Activity
1994
A new paradigm for electrostatic catalysis of radical reactions in vitamin B 12 enzymes
2007 StandoutNobel
NADPH-cytochrome P-450 oxidoreductase: flavin mononucleotide and flavin adenine dinucleotide domains evolved from different flavoproteins
1986
NADPH-initiated cytochrome P450-mediated free metal ion-independent oxidative damage of microsomal proteins. Exclusive prevention by ascorbic acid.
1994
Adenylyl Cyclase Amino Acid Sequence: Possible Channel- or Transporter-Like Structure
1989 StandoutScienceNobel
G-protein alpha-subunit expression, myristoylation, and membrane association in COS cells.
1990 StandoutNobel
Cloning and Characterization of Inducible Nitric Oxide Synthase from Mouse Macrophages
1992 StandoutScience
Isolation of the cDNA for erythrocyte integral membrane protein of 28 kilodaltons: member of an ancient channel family.
1991 StandoutNobel
Tests of the roles of two diffusible substances in long-term potentiation: evidence for nitric oxide as a possible early retrograde messenger.
1991 StandoutNobel
Characterization of the Flavoprotein Moieties of NADPH-Sulfite Reductase from Salmonella typhimurium and Escherichia coli
1989
PKD2 , a Gene for Polycystic Kidney Disease That Encodes an Integral Membrane Protein
1996 StandoutScience
Single-molecule height measurements on microsomal cytochrome P450 in nanometer-scale phospholipid bilayer disks
2002
Functions of Ceramide in Coordinating Cellular Responses to Stress
1996 StandoutScience
General approach to reversing ketol-acid reductoisomerase cofactor dependence from NADPH to NADH
2013 StandoutNobel
Expression and enzymatic activity of recombinant cytochrome P450 17 alpha-hydroxylase in Escherichia coli.
1991
Prostaglandin H synthase kinetics. The effect of substituted phenols on cyclooxygenase activity and the substituent effect on phenolic peroxidatic activity.
1992
A mixed quantum mechanics/molecular mechanics (QM/MM) method for large-scale modeling of chemistry in protein environments
2000
Mice lacking inducible nitric oxide synthase are not resistant to lipopolysaccharide-induced death.
1995 StandoutNobel
Identification of Mechanism-Based Inactivation in P450-Catalyzed Cyclopropanation Facilitates Engineering of Improved Enzymes
2016 StandoutNobel
Chimeric tumor necrosis factor receptors with constitutive signaling activity.
1995 StandoutNobel
Carbon Monoxide: a Putative Neural Messenger
1993 StandoutScience
Pentalenolactone Biosynthesis. Molecular Cloning and Assignment of Biochemical Function to PtlI, a Cytochrome P450 of Streptomyces avermitilis
2006 StandoutNobel
Chemomimetic Biocatalysis: Exploiting the Synthetic Potential of Cofactor-Dependent Enzymes To Create New Catalysts
2015 StandoutNobel
On the conservative nature of intragenic recombination
2005 StandoutNobel
Structure of a cytochrome P450–redox partner electron-transfer complex
1999
The receptor kinase family: primary structure of rhodopsin kinase reveals similarities to the beta-adrenergic receptor kinase.
1991 StandoutNobel
The amino acid composition is different between the cytoplasmic and extracellular sides in membrane proteins
1992
Crystal Structure of Hemoprotein Domain of P450BM-3, a Prototype for Microsomal P450's
1993 ScienceNobel
Regio- and Enantioselective Alkane Hydroxylation with Engineered Cytochromes P450 BM-3
2003 StandoutNobel
Heme-Containing Oxygenases
1996 Standout
Two closely linked but separable promoters for human neuronal nitric oxide synthase gene transcription.
1995 StandoutNobel
The Catalytic Pathway of Cytochrome P450cam at Atomic Resolution
2000 Science
Raman Evidence for a Weakened O−O Bond in Mononuclear Low-Spin Iron(III)−Hydroperoxides
1998 StandoutNobel
Photopharmacology: Beyond Proof of Principle
2014 StandoutNobel
A receptor guanylyl cyclase expressed specifically in olfactory sensory neurons.
1995 StandoutNobel
Elevated blood pressures in mice lacking endothelial nitric oxide synthase
1996 StandoutNobel
Enzyme-Controlled Nitrogen-Atom Transfer Enables Regiodivergent C–H Amination
2014 StandoutNobel
Receptor regulation of G-protein palmitoylation.
1994 StandoutNobel
Structural Adaptability Facilitates Histidine Heme Ligation in a Cytochrome P450
2015 StandoutNobel
Works of T D Porter being referenced
Coding nucleotide sequence of rat NADPH-cytochrome P-450 oxidoreductase cDNA and identification of flavin-binding domains.
1985
Purification and properties of a shortened form of cytochrome P-450 2E1: deletion of the NH2-terminal membrane-insertion signal peptide does not alter the catalytic activities.
1991
Alcohol-inducible cytochrome P-450IIE1 lacking the hydrophobic NH2-terminal segment retains catalytic activity and is membrane-bound when expressed in Escherichia coli
1991
cDNA and derived amino acid sequence of ethanol-inducible rabbit liver cytochrome P-450 isozyme 3a (P-450ALC).
1987
Organization and differential expression of two highly similar genes in the rabbit alcohol-inducible cytochrome P-450 subfamily.
1988
Structural analysis of the FMN binding domain of NADPH-cytochrome P-450 oxidoreductase by site-directed mutagenesis
1989
Cytochrome P-450. Multiplicity of isoforms, substrates, and catalytic and regulatory mechanisms
1991