Citation Impact
Citing Papers
Targeted cell killing by reconstituted caspases
2007 StandoutNobel
Mediation of Poly(ADP-Ribose) Polymerase-1-Dependent Cell Death by Apoptosis-Inducing Factor
2002 StandoutScience
Identification of the MDM2 Oncoprotein as a Substrate for CPP32-like Apoptotic Proteases
1997
Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase
2005 StandoutNature
Processing of the Nedd2 precursor by ICE‐like proteases and granzyme B
1996
Apoptosis in the nervous system
2000 StandoutNature
Dynamic O-Glycosylation of Nuclear and Cytosolic Proteins
2001
A Combinatorial Approach Defines Specificities of Members of the Caspase Family and Granzyme B
1997 Standout
Cleavage of CPP32 by Granzyme B Represents a Critical Role for Granzyme B in the Induction of Target Cell DNA Fragmentation
1996
Essential role of active nuclear transport in apoptosis
1997
Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-β
2000 StandoutNature
Release of chromatin protein HMGB1 by necrotic cells triggers inflammation
2002 StandoutNature
A Sequential Two-Step Mechanism for the Production of the Mature p17:p12 Form of Caspase-3 in Vitro
1997
Role of HIF-1α in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis
1998 StandoutNatureNobel
Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy
2005 StandoutNature
Proteolytic Cleavage of the mdm2 Oncoprotein during Apoptosis
1997
Control of Apoptosis by Proteases
1997
Phosphorylation of IκB-α Inhibits Its Cleavage by Caspase CPP32 in Vitro
1997 StandoutNobel
The Large Subunit of the DNA Replication Complex C (DSEB/RF-C140) Cleaved and Inactivated by Caspase-3 (CPP32/YAMA) during Fas-induced Apoptosis
1997
Poly(ADP-Ribose) Polymerase Inhibition in Oxidant-Stressed Endothelial Cells Prevents Oncosis and Permits Caspase Activation and Apoptosis
1999
Cleavage of Focal Adhesion Kinase by Caspases during Apoptosis
1997
Structure of Recombinant Human CPP32 in Complex with the Tetrapeptide Acetyl-Asp-Val-Ala-Asp Fluoromethyl Ketone
1997
Proteolytic cleavage of HsRad51 during apoptosis
1998
Loss of cyclophilin D reveals a critical role for mitochondrial permeability transition in cell death
2005 StandoutNature
The large subunit of replication factor C is a substrate for caspase-3 invitro and is cleaved by a caspase-3-like protease during Fas-mediated apoptosis
1997
The biochemistry of apoptosis
2000 StandoutNature
Cleavage of p21Cip1/Waf1 and p27Kip1 Mediates Apoptosis in Endothelial Cells through Activation of Cdk2: Role of a Caspase Cascade
1998
Sequential activation of three distinct ICE‐like activities in Fas‐ligated Jurkat cells
1996
Caspases: Preparation and Characterization
1999
PARP is important for genomic stability but dispensable in apoptosis
1997
Nitric Oxide Inhibits Apoptosis by Preventing Increases in Caspase-3-like Activity via Two Distinct Mechanisms
1997
Generation of Anti-apoptotic Presenilin-2 Polypeptides by Alternative Transcription, Proteolysis, and Caspase-3 Cleavage
1997
Papillomaviruses and cancer: from basic studies to clinical application
2002 StandoutNobel
Caspase-Mediated Fragmentation of Calpain Inhibitor Protein Calpastatin during Apoptosis
1998
Control of apoptosis and mitotic spindle checkpoint by survivin
1998 StandoutNature
The C. elegans Protein EGL-1 Is Required for Programmed Cell Death and Interacts with the Bcl-2–like Protein CED-9
1998 StandoutNobel
Presence of a pre-apoptotic complex of pro-caspase-3, Hsp60 and Hsp10 in the mitochondrial fraction of Jurkat cells
1999
Mitochondrial cytochrome c release in apoptosis occurs upstream of DEVD-specific caspase activation and independently of mitochondrial transmembrane depolarization
1998
Death substrates come alive
1997
Caspase structure, proteolytic substrates, and function during apoptotic cell death
1999
Macromolecular substrates for the ICE-like proteases during apoptosis
1997
Cytochrome c and dATP-Dependent Formation of Apaf-1/Caspase-9 Complex Initiates an Apoptotic Protease Cascade
1997 Standout
Impaired phagocytosis of apoptotic cell material by monocyte-derived macrophages from patients with systemic lupus erythematosus
1998
Proteases to die for
1998
Caenorhabditis elegans CED-9 protein is a bifunctional cell-death inhibitor
1997 StandoutNatureNobel
Granzyme B Directly and Efficiently Cleaves Several Downstream Caspase Substrates: Implications for CTL-Induced Apoptosis
1998
Functional Activation of Nedd2/ICH-1 (Caspase-2) Is an Early Process in Apoptosis
1997
Caspases: killer proteases
1997 Standout
Molecular Pathogenesis of Cancer of the Cervix and Its Causation by Specific Human Papillomavirus Types
1994 StandoutNobel
A model for p53-induced apoptosis
1997 StandoutNature
Essential contribution of caspase 3/CPP32 to apoptosis and its associated nuclear changes
1998
ICE/CED3-like Proteases as Therapeutic Targets for the Control of Inappropriate Apoptosis
1996
Heteronuclear Ribonucleoproteins C1 and C2, Components of the Spliceosome, Are Specific Targets of Interleukin 1β-converting Enzyme-like Proteases in Apoptosis
1996
Cleavage of Automodified Poly(ADP-ribose) Polymerase during Apoptosis
1999
Cytochrome c-dependent and -independent Induction of Apoptosis in Multiple Myeloma Cells
1997
Disrupted dichotomous intracellular control of human papillomavirus infection in cancer of the cervix
1994 StandoutNobel
Tumor Necrosis Factor-induced Apoptosis Stimulates p53 Accumulation and p21WAF1 Proteolysis in ME-180 Cells
1998
DFF, a Heterodimeric Protein That Functions Downstream of Caspase-3 to Trigger DNA Fragmentation during Apoptosis
1997 Standout
Molecular characterization of mitochondrial apoptosis-inducing factor
1999 StandoutNature
Direct Inhibition of Type 5 Adenylyl Cyclase Prevents Myocardial Apoptosis without Functional Deterioration
2004
A caspase-activated DNase that degrades DNA during apoptosis, and its inhibitor ICAD
1998 StandoutNature
Calcium/Calmodulin-dependent Protein Kinase IV Is Cleaved by Caspase-3 and Calpain in SH-SY5Y Human Neuroblastoma Cells Undergoing Apoptosis
1998
Purification and catalytic properties of human caspase family members
1999
The c-IAP-1 and c-IAP-2 proteins are direct inhibitors of specific caspases
1997
Caspase-3-mediated Cleavage of Protein Kinase C θ in Induction of Apoptosis
1997
The role of the bcl-2/ced-9 gene family in cancer and general implications of defects in cell death control for tumourigenesis and resistance to chemotherapy
1997
The TRA-1A Sex Determination Protein of C. elegans Regulates Sexually Dimorphic Cell Deaths by Repressing the egl-1 Cell Death Activator Gene
1999 StandoutNobel
Protease Involvement in Fodrin Cleavage and Phosphatidylserine Exposure in Apoptosis
1996
Up-regulation of Apoptosis Inhibitory Protein IAP-2 by Hypoxia
2001 StandoutNobel
Phosphatidylserine Externalization during CD95-induced Apoptosis of Cells and Cytoplasts Requires ICE/CED-3 Protease Activity
1996
Regulation of Protein Phosphatase 2A Activity by Caspase-3 during Apoptosis
1998
Proapoptotic BAX and BAK: A Requisite Gateway to Mitochondrial Dysfunction and Death
2001 StandoutScience
Metabolic cross-talk allows labeling of O-linked β- N -acetylglucosamine-modified proteins via the N -acetylgalactosamine salvage pathway
2011 StandoutNobel
The Bcl-2 Protein Family: Arbiters of Cell Survival
1998 StandoutScience
The Caspase-3 Precursor Has a Cytosolic and Mitochondrial Distribution: Implications for Apoptotic Signaling
1998
Selective cleavage of nuclear autoantigens during CD95 (Fas/APO-1)-mediated T cell apoptosis.
1996
Requirement of JNK for Stress- Induced Activation of the Cytochrome c-Mediated Death Pathway
2000 StandoutScience
Epidermal growth factor (EGF) elicits down-regulation of human papillomavirus type 16 (HPV-16) E6/E7 mRNA at the transcriptional level in an EGF-stimulated human keratinocyte cell line: functional role of EGF-responsive silencer in the HPV-16 long control region
1991
Repression of the human papillomavirus type 18 enhancer by the cellular transcription factor Oct-1
1991 StandoutNobel
Prevention of Apoptosis by Bcl-2: Release of Cytochrome c from Mitochondria Blocked
1997 StandoutScience
Cleavage of β-Catenin and Plakoglobin and Shedding of VE-Cadherin during Endothelial Apoptosis: Evidence for a Role for Caspases and Metalloproteinases
1998
Kinase cascades regulating entry into apoptosis
1997
Resistance of actin to cleavage during apoptosis
1997
Systems analysis of PKA-mediated phosphorylation gradients in live cardiac myocytes
2006 StandoutNobel
Internally quenched fluorescent peptide substrates disclose the subsite preferences of human caspases 1, 3, 6, 7 and 8
2000 StandoutNobel
Processing/Activation of At Least Four Interleukin-1β Converting Enzyme–like Proteases Occurs during the Execution Phase of Apoptosis in Human Monocytic Tumor Cells
1997
NF-κB Antiapoptosis: Induction of TRAF1 and TRAF2 and c-IAP1 and c-IAP2 to Suppress Caspase-8 Activation
1998 StandoutScience
A chemical approach for identifying O -GlcNAc-modified proteins in cells
2003 StandoutNobel
Fas Preassociation Required for Apoptosis Signaling and Dominant Inhibition by Pathogenic Mutations
2000 StandoutScienceNobel
Requirement of poly(ADP-ribose) polymerase in recovery from DNA damage in mice and in cells
1997
Noxa, a BH3-Only Member of the Bcl-2 Family and Candidate Mediator of p53-Induced Apoptosis
2000 StandoutScience
Viruses in Human Cancers
1991 StandoutScienceNobel
Proteolytic Activation of Protein Kinase C δ by an ICE/CED 3-like Protease Induces Characteristics of Apoptosis
1996
Caspases: the executioners of apoptosis
1997 Standout
Mutational analysis of cis elements involved in E2 modulation of human papillomavirus type 16 P97 and type 18 P105 promoters
1990
Mitochondria and Apoptosis
1998 StandoutScience
Retinoic acid-mediated repression of human papillomavirus 18 transcription and different ligand regulation of the retinoic acid receptor beta gene in non-tumorigenic and tumorigenic HeLa hybrid cells.
1992 StandoutNobel
Mammalian Caspases: Structure, Activation, Substrates, and Functions During Apoptosis
1999 Standout
Influence of chromosomal integration on glucocorticoid-regulated transcription of growth-stimulating papillomavirus genes E6 and E7 in cervical carcinoma cells.
1991 StandoutNobel
Induction and Evasion of Host Defenses by Type 1-Piliated Uropathogenic Escherichia coli
1998 StandoutScience
Progesterone and glucocorticoid response elements occur in the long control regions of several human papillomaviruses involved in anogenital neoplasia
1989
LBR, a chromatin and lamin binding protein from the inner nuclear membrane, is proteolyzed at late stages of apoptosis
1998
Translocation of C. elegans CED-4 to Nuclear Membranes During Programmed Cell Death
2000 StandoutScienceNobel
Commitment and Effector Phases of the Physiological Cell Death Pathway Elucidated with Respect to Bcl-2, Caspase, and Cyclin-Dependent Kinase Activities
1998
Conversion of Bcl-2 to a Bax-like Death Effector by Caspases
1997 Science
Internally quenched fluorescent peptide substrates disclose the subsite preferences of human caspases 1, 3, 6, 7 and 8
2000 StandoutNobel
Caspases: Enemies Within
1998 StandoutScience
Metabolic labeling enables selective photocrosslinking of O-GlcNAc-modified proteins to their binding partners
2012 StandoutNobel
Regulation of Cell Death Protease Caspase-9 by Phosphorylation
1998 StandoutScience
Works of T Chong being referenced
The enhancer of human papillomavirus type 16: binding sites for the ubiquitous transcription factors oct-1, NFA, TEF-2, NF1, and AP-1 participate in epithelial cell-specific transcription
1991
Numerous nuclear proteins bind the long control region of human papillomavirus type 16: a subset of 6 of 23 DNase I-protected segments coincides with the location of the cell-type-specific enhancer
1989
Apopain/CPP32 cleaves proteins that are essential for cellular repair: a fundamental principle of apoptotic death.
1996