Citation Impact
Citing Papers
Genome-wide CRISPR screens reveal a specific ligand for the glycan-binding immune checkpoint receptor Siglec-7
2021 StandoutNobel
The mucin-selective protease StcE enables molecular and functional analysis of human cancer-associated mucins
2019 StandoutNobel
Modulation of immune cell reactivity with cis -binding Siglec agonists
2021 StandoutNobel
A metabolic labeling approach toward proteomic analysis of mucin-type O-linked glycosylation
2003 StandoutNobel
Diagnosis and management of acute myeloid leukemia in adults: recommendations from an international expert panel, on behalf of the European LeukemiaNet
2009 Standout
Defining the in vivo function of Siglec-F, a CD33-related Siglec expressed on mouse eosinophils
2007
A Logic-Gated Nanorobot for Targeted Transport of Molecular Payloads
2012 StandoutScience
Cancer statistics, 2022
2022 Standout
A mechanosensory complex that mediates the endothelial cell response to fluid shear stress
2005 StandoutNature
Cancer statistics, 2023
2023 Standout
The ceramide moiety of disialoganglioside (GD3) is essential for GD3 recognition by the sialic acid–binding lectin SIGLEC7 on the cell surface
2019
Inverting family GH156 sialidases define an unusual catalytic motif for glycosidase action
2019 StandoutNobel
Siglecs: A journey through the evolution of sialic acid-binding immunoglobulin-type lectins
2018
Cancer statistics, 2020
2020 Standout
Cancer Statistics, 2021
2021 Standout
Siglec-8 antibody reduces eosinophils and mast cells in a transgenic mouse model of eosinophilic gastroenteritis
2019
Calicheamicin-conjugated humanized anti-CD33 monoclonal antibody (gemtuzumab zogamicin, CMA-676) shows cytocidal effect on CD33-positive leukemia cell lines, but is inactive on P-glycoprotein-expressing sublines
2000
Sialic Acids in Molecular and Cellular Interactions
1997
Cryptic sialic acid binding lectins on human blood leukocytes can be unmasked by sialidase treatment or cellular activation
1999
Targeting of the CD33-calicheamicin immunoconjugate Mylotarg (CMA-676) in acute myeloid leukemia: in vivo and in vitro saturation and internalization by leukemic and normal myeloid cells
2001
Siglecs and their roles in the immune system
2007 Standout
Molecular diversity and evolution of the Siglec family of cell-surface lectins
2006
Constitutively unmasked CD22 on B cells of ST6Gal I knockout mice: novel sialoside probe for murine CD22
2002
The inhibitory effect of anti-CD33 monoclonal antibodies on AML cell growth correlates with Syk and/or ZAP-70 expression
2003
Characterization of the Sialic Acid-binding Site in Sialoadhesin by Site-directed Mutagenesis
1996
Robo4 Cooperates with Cxcr4 to Specify Hematopoietic Stem Cell Localization to Bone Marrow Niches
2011
Associations of genetic polymorphisms of Siglecs with human diseases
2014
A Small Region of the Natural Killer Cell Receptor, Siglec-7, Is Responsible for Its Preferred Binding to α2,8-Disialyl and Branched α2,6-Sialyl Residues
2002
I-type lectins
2002
Sialic Acid Specificity of Myelin-associated Glycoprotein Binding
1997
Expression of CD33-related siglecs on human mononuclear phagocytes, monocyte-derived dendritic cells and plasmacytoid dendritic cells
2004
Glycosylation in Cellular Mechanisms of Health and Disease
2006 Standout
The potential role of sialoadhesin as a macrophage recognition molecule in health and disease
1997
Siglec-8 as a drugable target to treat eosinophil and mast cell-associated conditions
2012
PD‐1 signaling in primary T cells
2009
Sialoside Specificity of the Siglec Family Assessed Using Novel Multivalent Probes
2003
The bone marrow niche for haematopoietic stem cells
2014 StandoutNature
mSiglec-E, a novel mouse CD33-related siglec (sialic acid-binding immunoglobulin-like lectin) that recruits Src homology 2 (SH2)-domain-containing protein tyrosine phosphatases SHP-1 and SHP-2
2001
Cloning, Characterization, and Phylogenetic Analysis of Siglec-9, a New Member of the CD33-related Group of Siglecs
2000
Glycans in cancer and inflammation — potential for therapeutics and diagnostics
2005 StandoutNobel
Siglecs in the immune system
2001
Functional groups of sialic acids involved in binding to siglecs (sialoadhesins) deduced from interactions with synthetic analogues
1998
Mouse Siglec-F and human Siglec-8 are functionally convergent paralogs that are selectively expressed on eosinophils and recognize 6′-sulfo-sialyl Lewis X as a preferred glycan ligand
2005
Potent Glycan Inhibitors of Myelin-associated Glycoprotein Enhance Axon Outgrowth in Vitro
2005
Loss of N-Glycolylneuraminic Acid in Human Evolution
2000
Siglecs: sialic-acid-binding immunoglobulin-like lectins in cell–cell interactions and signalling
2002
Initial sequence of the chimpanzee genome and comparison with the human genome
2005 StandoutNature
Siglecs, sialic acids and innate immunity
2001
GlcNAc 2-Epimerase Can Serve a Catabolic Role in Sialic Acid Metabolism
2003 StandoutNobel
Proteomic analysis of high‐density lipoprotein
2006
Negative Regulation of Toll-like Receptor-4 Signaling through the Binding of Glycosylphosphatidylinositol-anchored Glycoprotein, CD14, with the Sialic Acid-binding Lectin, CD33
2014
Genomic and Epigenomic Landscapes of Adult De Novo Acute Myeloid Leukemia
2013 Standout
A uniquely human consequence of domain-specific functional adaptation in a sialic acid-binding receptor
2003
Reduced effect of gemtuzumab ozogamicin (CMA-676) on P-glycoprotein and/or CD34-positive leukemia cells and its restoration by multidrug resistance modifiers
2002
Survey of the year 2003 commercial optical biosensor literature
2004
BTLA is a lymphocyte inhibitory receptor with similarities to CTLA-4 and PD-1
2003 StandoutNobel
The murine inhibitory receptor mSiglec‐E is expressed broadly on cells of the innate immune system whereas mSiglec‐F is restricted to eosinophils
2004
OB-BP1/Siglec-6
1999
The Sialoadhesins ? A family of sialic acid-dependent cellular recognition molecules within the immunoglobulin superfamily
1996
Siglec-9, a Novel Sialic Acid Binding Member of the Immunoglobulin Superfamily Expressed Broadly on Human Blood Leukocytes
2000
Negative Regulation of T Cell Receptor Signaling by Siglec-7 (p70/AIRM) and Siglec-9
2004
Synthesis and Microcontact Printing of Dual End‐Functionalized Mucin‐like Glycopolymers for Microarray Applications
2009 StandoutNobel
Constitutive repressor activity of CD33 on human monocytes requires sialic acid recognition and phosphoinositide 3‐kinase‐mediated intracellular signaling
2004
Analysis of the CD33-related siglec family reveals that Siglec-9 is an endocytic receptor expressed on subsets of acute myeloid leukemia cells and absent from normal hematopoietic progenitors
2006
Glycan Array Screening Reveals a Candidate Ligand for Siglec-8*
2004
Siglecs in innate immunity
2005
Molecular Cloning of MIS, a Myeloid Inhibitory Siglec, That Binds Protein-tyrosine Phosphatases SHP-1 and SHP-2
2001
Carbohydrate recognition systems: functional triads in cell—cell interactions
1996
Aggregation-induced emission
2011 Standout
Multifarious roles of sialic acids in immunity
2012
The Amino-terminal Immunoglobulin-like Domain of Sialoadhesin Contains the Sialic Acid Binding Site
1995
Lectin Domains of Polypeptide GalNAc Transferases Exhibit Glycopeptide Binding Specificity
2011 StandoutNobel
Differential Effects of Unnatural Sialic Acids on the Polysialylation of the Neural Cell Adhesion Molecule and Neuronal Behavior
2002 StandoutNobel
Siglec-7: a sialic acid-binding lectin of the immunoglobulin superfamily
2000
Crystal Structure of the N-Terminal Domain of Sialoadhesin in Complex with 3′ Sialyllactose at 1.85 Å Resolution
1998
Obesity is associated with macrophage accumulation in adipose tissue
2003 Standout
The Human Condition—A Molecular Approach
2014 StandoutNobel
Ganglioside GD3 expression on target cells can modulate NK cell cytotoxicity via siglec‐7‐dependent and ‐independent mechanisms
2003
I-type Lectins
1995
Multiple changes in sialic acid biology during human evolution
2008
Small RNAs are modified with N-glycans and displayed on the surface of living cells
2021 StandoutNobel
The role of the macrophage in immune regulation
1998
Siglecs—the major subfamily of I-type lectins
2005
Internalization and cell cycle-dependent killing of leukemic cells by Gemtuzumab Ozogamicin: rationale for efficacy in CD33-negative malignancies with endocytic capacity
2003
Macrophage–tumour cell interactions: identification of MUC1 on breast cancer cells as a potential counter‐receptor for the macrophage‐restricted receptor, sialoadhesin
1999
Signal Transduction Pathways Mediated by PECAM-1
2003
Siglec-9 transduces apoptotic and nonapoptotic death signals into neutrophils depending on the proinflammatory cytokine environment
2005
The Membrane-Proximal Immunoreceptor Tyrosine-Based Inhibitory Motif Is Critical for the Inhibitory Signaling Mediated by Siglecs-7 and -9, CD33-Related Siglecs Expressed on Human Monocytes and NK Cells
2004
Localization of the Putative Sialic Acid-binding Site on the Immunoglobulin Superfamily Cell-surface Molecule CD22
1996
PD-1 Inhibits Antiviral Immunity at the Effector Phase in the Liver
2003 StandoutNobel
Recognition of sialylated meningococcal lipopolysaccharide by siglecs expressed on myeloid cells leads to enhanced bacterial uptake
2003
Natural Product Synthesis Using Multicomponent Reaction Strategies
2009 Standout
Differentiation of Monocytes into Dendritic Cells in a Model of Transendothelial Trafficking
1998 StandoutScienceNobel
CD33 responses are blocked by SOCS3 through accelerated proteasomal-mediated turnover
2006
Sialic Acid-Binding Immunoglobulin-Like Lectin 7 Mediates Selective Recognition of Sialylated Glycans Expressed on Campylobacter jejuni Lipooligosaccharides
2006
Intensified and protective CD4+ T cell immunity in mice with anti–dendritic cell HIV gag fusion antibody vaccine
2006 StandoutNobel
Acute Myeloid Leukemia
2015 Standout
Discovery of Siglec‐14, a novel sialic acid receptor undergoing concerted evolution with Siglec‐5 in primates
2006
Molecular analysis of sialoside binding to sialoadhesin by NMR and site-directed mutagenesis
1999
Antitumor Antibiotics: Bleomycin, Enediynes, and Mitomycin
2005 Standout
Surface expression and function of p75/AIRM-1 or CD33 in acute myeloid leukemias: Engagement of CD33 induces apoptosis of leukemic cells
2001
Siglec-8 and Siglec-9 binding specificities and endogenous airway ligand distributions and properties
2017
SQV-7, a protein involved in Caenorhabditis elegans epithelial invagination and early embryogenesis, transports UDP-glucuronic acid, UDP- N - acetylgalactosamine, and UDP-galactose
2001 StandoutNobel
CD150 Association with Either the SH2-Containing Inositol Phosphatase or the SH2-Containing Protein Tyrosine Phosphatase Is Regulated by the Adaptor Protein SH2D1A
2001
Myeloid specific human CD33 is an inhibitory receptor with differential ITIM function in recruiting the phosphatases SHP-1 and SHP-2
2000
Lectins: Carbohydrate-Specific Proteins That Mediate Cellular Recognition
1998 Standout
CD22, A B LYMPHOCYTE–SPECIFIC ADHESION MOLECULE THAT REGULATES ANTIGEN RECEPTOR SIGNALING*
1997
Trance, a Tumor Necrosis Factor Family Member, Enhances the Longevity and Adjuvant Properties of Dendritic Cells in Vivo
2000 StandoutNobel
Sialic acid binding receptors (siglecs) expressed by macrophages
1999
A Self-Assembled Multivalent Pseudopolyrotaxane for Binding Galectin-1
2004 StandoutNobel
Influence of CD33 expression levels and ITIM-dependent internalization on gemtuzumab ozogamicin–induced cytotoxicity
2004
Toward the potential cure of leukemias in the next decade
2018
The Formation of Immunogenic Major Histocompatibility Complex Class II–Peptide Ligands in Lysosomal Compartments of Dendritic Cells Is Regulated by Inflammatory Stimuli
2000 StandoutNobel
Cutting Edge: CD43 Functions as a T Cell Counterreceptor for the Macrophage Adhesion Receptor Sialoadhesin (Siglec-1)
2001
Characterization of Siglec-H as a novel endocytic receptor expressed on murine plasmacytoid dendritic cell precursors
2006
Siglec‐7 tetramers characterize B‐cell subpopulations and leukemic blasts
2012
Enhanced T Cell Function in a Mouse Model of Human Glycosylation
2013
Characterization of human sialoadhesin, a sialic acid binding receptor expressed by resident and inflammatory macrophage populations
2001
Nanoparticle size and surface properties determine the protein corona with possible implications for biological impacts
2008 Standout
Identification and Characterization of a Novel Siglec, Siglec-7, Expressed by Human Natural Killer Cells and Monocytes
1999
Management of acute promyelocytic leukemia: recommendations from an expert panel on behalf of the European LeukemiaNet
2008
T-Independent Immune Response: New Aspects of B Cell Biology
2000 StandoutScienceNobel
Precision glycocalyx editing as a strategy for cancer immunotherapy
2016 StandoutNobel
Myeloid precursors and acute myeloid leukemia cells express multiple CD33-related Siglecs
2006
Probing the cis interactions of the inhibitory receptor Siglec-7 with α2,8-disialylated ligands on natural killer cells and other leukocytes using glycan-specific antibodies and by analysis of α2,8-sialyltransferase gene expression
2006
Myeloid specific human CD33 is an inhibitory receptor with differential ITIM function in recruiting the phosphatases SHP-1 and SHP-2
2000
Decoding the Patterns of Self and Nonself by the Innate Immune System
2002 StandoutScience
Obesity is associated with macrophage accumulation in adipose tissue
2003 Standout
Surface Plasmon Resonance Sensors for Detection of Chemical and Biological Species
2008 Standout
Dendritic Cells: Unique Leukocyte Populations Which Control the Primary Immune Response
1997
Inactivation of CMP- N -acetylneuraminic acid hydroxylase occurred prior to brain expansion during human evolution
2002 StandoutNobel
Masking and unmasking of the sialic acid-binding lectin activity of CD22 (Siglec-2) on B lymphocytes
1998
Acute myeloid leukaemia
2016
Identification and Molecular Cloning of P75/Airm1, a Novel Member of the Sialoadhesin Family That Functions as an Inhibitory Receptor in Human Natural Killer Cells
1999
Engagement of p75/AIRM1 or CD33 inhibits the proliferation of normal or leukemic myeloid cells
1999
Ligation of Siglec-8: a selective mechanism for induction of human eosinophil apoptosis
2003
Chemically Defined Sialoside Scaffolds for Investigation of Multivalent Interactions with Sialic Acid Binding Proteins†
2003 StandoutNobel
Induction of Epstein-Barr Virus-Specific Cytotoxic T-Lymphocyte Responses Using Dendritic Cells Pulsed With EBNA-3A Peptides or UV-Inactivated, Recombinant EBNA-3A Vaccinia Virus
1999 StandoutNobel
Sialic acid binding immunoglobulin‐like lectins may regulate innate immune responses by modulating the life span of granulocytes
2006
Chemical Diversity in the Sialic Acids and Related α-Keto Acids: An Evolutionary Perspective
2002
Immune Inhibitory Receptors
2000 Science
Chemical Glycoproteomics
2016 StandoutNobel
Animal Lectins
1997
Induction of Epstein-Barr Virus-Specific Cytotoxic T-Lymphocyte Responses Using Dendritic Cells Pulsed With EBNA-3A Peptides or UV-Inactivated, Recombinant EBNA-3A Vaccinia Virus
1999 StandoutNobel
Works of Sylvie Freeman being referenced
Identification of the CD33‐related Siglec receptor, Siglec‐5 (CD170), as a useful marker in both normal myelopoiesis and acute myeloid leukaemias
2003
Identification of SAF-2, a novel siglec expressed on eosinophils, mast cells, and basophils
2000
Differential association of cytoplasmic signalling molecules SHP‐1, SHP‐2, SHIP and phospholipase C‐γ1 with PECAM‐1/CD31
1999
Characterization of Siglec-5 (CD170) expression and functional activity of anti–Siglec-5 antibodies on human phagocytes
2003
The Myeloid-specific Sialic Acid-binding Receptor, CD33, Associates with the Protein-tyrosine Phosphatases, SHP-1 and SHP-2
1999
Siglec-5 (CD170) Can Mediate Inhibitory Signaling in the Absence of Immunoreceptor Tyrosine-based Inhibitory Motif Phosphorylation
2005
A Novel Role for PECAM-1 (CD31) in Regulating Haematopoietic Progenitor Cell Compartmentalization between the Peripheral Blood and Bone Marrow
2008
A comparative study of the asparagine‐linked oligosaccharides on siglec‐5, siglec‐7 and siglec‐8, expressed in a CHO cell line, and their contribution to ligand recognition
2001
Sialoadhesin binds preferentially to cells of the granulocytic lineage.
1995
Characterization of CD33 as a new member of the sialoadhesin family of cellular interaction molecules
1995
Addition of Gemtuzumab Ozogamicin to Induction Chemotherapy Improves Survival in Older Patients With Acute Myeloid Leukemia
2012
Characterization of Siglec-5, a Novel Glycoprotein Expressed on Myeloid Cells Related to CD33
1998
Characterization of Siglec-5, a Novel Glycoprotein Expressed on Myeloid Cells Related to CD33
1998
Sialoadhesin and related cellular recognition molecules of the immunoglobulin superfamily
1996
Development of Minimal Residual Disease–Directed Therapy in Acute Myeloid Leukemia
2008
Defining minimal residual disease in acute myeloid leukemia: which platforms are ready for “prime time”?
2014