Standout Papers
- LRRC8 Proteins Form Volume-Regulated Anion Channels that Sense Ionic Strength (2016)
- OSCA/TMEM63 are an evolutionarily conserved family of mechanically activated ion channels (2018)
- Stretch-activated ion channels identified in the touch-sensitive structures of carnivorous Droseraceae plants (2021)
- Structure of the mechanically activated ion channel Piezo1 (2017)
- Dehydrated hereditary stomatocytosis linked to gain-of-function mutations in mechanically activated PIEZO1 ion channels (2013)
- Piezos thrive under pressure: mechanically activated ion channels in health and disease (2017)
- Endogenous Piezo1 Can Confound Mechanically Activated Channel Identification and Characterization (2017)
- Correction: Corrigendum: Dehydrated hereditary stomatocytosis linked to gain-of-function mutations in mechanically activated PIEZO1 ion channels (2013)
- Piezo1 ion channel pore properties are dictated by C-terminal region (2015)
- The Mechanosensitive Ion Channel Piezo Inhibits Axon Regeneration (2019)
- Cryo-EM structure of the mechanically activated ion channel OSCA1.2 (2018)
- Piezo1, a mechanically activated ion channel, is required for vascular development in mice (2014)
- The mechanosensitive ion channel Piezo2 mediates sensitivity to mechanical pain in mice (2018)
Citation Impact
Citing Papers
Interactions between the N- and C-termini of the mechanosensitive ion channel At MSL10 are consistent with a three-step mechanism for activation
2020
A common polymorphism in the mechanosensitive ion channel PIEZO1 is associated with protection from severe malaria in humans
2020
Cryo-EM structure of OSCA1.2 from Oryza sativa elucidates the mechanical basis of potential membrane hyperosmolality gating
2019
PIEZOs mediate neuronal sensing of blood pressure and the baroreceptor reflex
2018 StandoutScienceNobel
PIEZO ion channel is required for root mechanotransduction in Arabidopsis thaliana
2021 StandoutNobel
Spatiotemporal dynamics of PIEZO1 localization controls keratinocyte migration during wound healing
2021 StandoutNobel
Stimulation of Piezo1 by mechanical signals promotes bone anabolism
2019
Mechanical sensitivity of Piezo1 ion channels can be tuned by cellular membrane tension
2015
Piezo1 ion channels inherently function as independent mechanotransducers
2021
Modulation of non‐NMDA receptor gating by auxiliary subunits
2014
Myosin-II mediated traction forces evoke localized Piezo1-dependent Ca2+ flickers
2019
Genetic analysis of a Piezo-like protein suppressing systemic movement of plant viruses in Arabidopsis thaliana
2019
A lever-like transduction pathway for long-distance chemical- and mechano-gating of the mechanosensitive Piezo1 channel
2018
Removal of the mechanoprotective influence of the cytoskeleton reveals PIEZO1 is gated by bilayer tension
2016
Piezo1 channel activation mimics high glucose as a stimulator of insulin release
2019
Localized force application reveals mechanically sensitive domains of Piezo1
2016
Radial symmetry in a chimeric glutamate receptor pore
2014
DeepEMhancer: a deep learning solution for cryo-EM volume post-processing
2021 Standout
Piezo1 Channels Are Inherently Mechanosensitive
2016 StandoutNobel
Piezo1 in Smooth Muscle Cells Is Involved in Hypertension-Dependent Arterial Remodeling
2015
Enantiomeric Aβ peptides inhibit the fluid shear stress response of PIEZO1
2018
Investigation of associations between Piezo1 mechanoreceptor gain-of-function variants and glaucoma-related phenotypes in humans and mice
2020 StandoutNobel
Structural mechanism for gating of a eukaryotic mechanosensitive channel of small conductance
2020
Discoveries in structure and physiology of mechanically activated ion channels
2020 StandoutNatureNobel
Mechano-Gated Ion Channels in Sensory Systems
2013
Inactivation Kinetics and Mechanical Gating of Piezo1 Ion Channels Depend on Subdomains within the Cap
2020
Non-uniform refinement: adaptive regularization improves single-particle cryo-EM reconstruction
2020 Standout
Slower Piezo1 Inactivation in Dehydrated Hereditary Stomatocytosis (Xerocytosis)
2013
Channel opening and gating mechanism in AMPA-subtype glutamate receptors
2017 StandoutNatureNobel
Novel mutations in PIEZO1 cause an autosomal recessive generalized lymphatic dysplasia with non-immune hydrops fetalis
2015
Mechanosensory hair cells express two molecularly distinct mechanotransduction channels
2016 StandoutNobel
Piezo1 incorporates mechanical force signals into the genetic program that governs lymphatic valve development and maintenance
2019
Mechanosensation of cyclical force by PIEZO1 is essential for innate immunity
2019 Nature
Force-induced conformational changes in PIEZO1
2019 NatureNobel
Water transport, perception, and response in plants
2019
Mechanically activated ion channel Piezo1 modulates macrophage polarization and stiffness sensing
2021
A mechanosensitive Ca2+ channel activity is dependent on the developmental regulator DEK1
2017
Inactivation of Mechanically Activated Piezo1 Ion Channels Is Determined by the C-Terminal Extracellular Domain and the Inner Pore Helix
2017
Macrophages in immunoregulation and therapeutics
2023 Standout
Probing Intersubunit Interfaces in AMPA-subtype Ionotropic Glutamate Receptors
2016
Structure and mechanogating of the mammalian tactile channel PIEZO2
2019 Nature
Impaired PIEZO1 function in patients with a novel autosomal recessive congenital lymphatic dysplasia
2015 StandoutNobel
Uncovering the Cells and Circuits of Touch in Normal and Pathological Settings
2018
The Role of PIEZO2 in Human Mechanosensation
2016
Mechanically Activated Ion Channels
2015 StandoutNobel
Structural Designs and Mechanogating Mechanisms of the Mechanosensitive Piezo Channels
2021
Membrane protein structural biology in the era of single particle cryo-EM
2018
Piezo2 is the principal mechanotransduction channel for proprioception
2015 StandoutNobel
Biophysical Principles of Ion-Channel-Mediated Mechanosensory Transduction
2019
A role of PIEZO1 in iron metabolism in mice and humans
2021 StandoutNobel
A Plug-and-Latch Mechanism for Gating the Mechanosensitive Piezo Channel
2020
Piezo1 is required for outflow tract and aortic valve development.
2020
Mechanical stretch triggers rapid epithelial cell division through Piezo1
2017 Nature
Piezo2 is the major transducer of mechanical forces for touch sensation in mice
2014 StandoutNatureNobel
Molecular Structure of the Hair Cell Mechanoelectrical Transduction Complex
2018
Piezo1 forms mechanosensitive ion channels in the human MCF-7 breast cancer cell line
2015
The Piezo Mechanosensitive Ion Channels: May the Force Be with You!
2015
Mammalian Mechanoelectrical Transduction: Structure and Function of Force-Gated Ion Channels
2019
Probing the gating mechanism of the mechanosensitive channel Piezo1 with the small molecule Yoda1
2018
Tuning ion channel mechanosensitivity by asymmetry of the transbilayer pressure profile
2018
Atherosclerosis
2019 Standout
Piezo1 plays a role in erythrocyte volume homeostasis
2013
Structure and mechanogating mechanism of the Piezo1 channel
2018 Nature
PIEZO2 in sensory neurons and urothelial cells coordinates urination
2020 StandoutNatureNobel
Architecture of the mammalian mechanosensitive Piezo1 channel
2015 Nature
Structural Bases of Desensitization in AMPA Receptor-Auxiliary Subunit Complexes
2017 StandoutNobel
Piezo2 senses airway stretch and mediates lung inflation-induced apnoea
2016 StandoutNatureNobel
Structure of the hyperosmolality-gated calcium-permeable channel OSCA1.2
2018
Piezo1-Mediated Ca2+ Activities Regulate Brain Vascular Pathfinding during Development
2020
TLR4 signalling via Piezo1 engages and enhances the macrophage mediated host response during bacterial infection
2021
Crowding-induced opening of the mechanosensitive Piezo1 channel in silico
2021
A Molecular Determinant of Subtype-Specific Desensitization in Ionotropic Glutamate Receptors
2016
Merkel cells and neurons keep in touch
2014 StandoutNobel
Novel mechanisms of PIEZO1 dysfunction in hereditary xerocytosis
2017
TMEM87a/Elkin1, a component of a novel mechanoelectrical transduction pathway, modulates melanoma adhesion and migration
2020
Elucidation of AMPA receptor–stargazin complexes by cryo–electron microscopy
2016 StandoutScienceNobel
The mechanosensitive Piezo1 channel is required for bone formation
2019
Piezo1 links mechanical forces to red blood cell volume
2015 StandoutNobel
Activation of TRPV1 channels inhibits mechanosensitive Piezo channel activity by depleting membrane phosphoinositides
2015
Structure of the human volume regulated anion channel
2018 StandoutNobel
Mechanosensitive Ion Channels: Structural Features Relevant to Mechanotransduction Mechanisms
2020
Quantifying the Dynamics of Protein Self-Organization Using Deep Learning Analysis of Atomic Force Microscopy Data
2020 StandoutNobel
Piezo1 mediates angiogenesis through activation of MT1-MMP signaling
2018
Direct measurement of TRPV4 and PIEZO1 activity reveals multiple mechanotransduction pathways in chondrocytes
2017
Auxiliary proteins promote modal gating ofAMPA ‐ and kainate‐type glutamate receptors
2014
Glutamate receptor pores
2014
How cells channel their stress: Interplay between Piezo1 and the cytoskeleton
2017
Bacterial Mechanosensors
2017
Neuropathic Pain: From Mechanisms to Treatment
2020 Standout
Recent insights into the cellular biology of atherosclerosis
2015
Yoda1 analogue (D ooku1) which antagonizes Y oda1‐evoked activation of P iezo1 and aortic relaxation
2018
Structure-guided examination of the mechanogating mechanism of PIEZO2
2019
Piezo1 channels restrain regulatory T cells but are dispensable for effector CD4 + T cell responses
2021 Standout
Targeting Piezo1 unleashes innate immunity against cancer and infectious disease
2020
Mechanically activated piezo channels modulate outflow tract valve development through the Yap1 and Klf2-Notch signaling axis
2019
The effects of Tmc1 Beethoven mutation on mechanotransducer channel function in cochlear hair cells
2015
Endothelial cation channel PIEZO1 controls blood pressure by mediating flow-induced ATP release
2016
Functional Insights from Glutamate Receptor Ion Channel Structures
2012
Mechanically activated ion channel PIEZO1 is required for lymphatic valve formation
2018 StandoutNobel
Disorders of erythrocyte volume homeostasis
2015
Cryo-EM structures and functional characterization of murine Slc26a9 reveal mechanism of uncoupled chloride transport
2019
Structure and gating of tetrameric glutamate receptors
2013
Vascular Smooth Muscle Cells in Atherosclerosis
2016 Standout
Reactive Oxygen Species in Metabolic and Inflammatory Signaling
2018 Standout
Mechanosensitive ion channel Piezo2 is inhibited by D-GsMTx4
2017
Mammalian TRP ion channels are insensitive to membrane stretch
2019
Molecular basis of force-from-lipids gating in the mechanosensitive channel MscS
2019
Identification of novel PIEZO1 variants using prenatal exome sequencing and correlation to ultrasound and autopsy findings of recurrent hydrops fetalis
2018
Endothelial Cell Dysfunction and the Pathobiology of Atherosclerosis
2016 Standout
Stretch-activated ion channel Piezo1 directs lineage choice in human neural stem cells
2014
PIEZO2 mediates injury-induced tactile pain in mice and humans
2018
The physiology of plant responses to drought
2020 StandoutScience
Myeloid Piezo1 Deletion Protects Renal Fibrosis by Restraining Macrophage Infiltration and Activation
2022
Piezo’s membrane footprint and its contribution to mechanosensitivity
2018 Nobel
Chemical activation of the mechanotransduction channel Piezo1
2015 StandoutNobel
Astrocytes in the optic nerve head express putative mechanosensitive channels.
2015
Works of Swetha E. Murthy being referenced
Piezo1 ion channel pore properties are dictated by C-terminal region
2015 StandoutNobel
The Mechanosensitive Ion Channel Piezo Inhibits Axon Regeneration
2019 StandoutNobel
Dehydrated hereditary stomatocytosis linked to gain-of-function mutations in mechanically activated PIEZO1 ion channels
2013 StandoutNobel
Piezos thrive under pressure: mechanically activated ion channels in health and disease
2017 StandoutNobel
Structure of the mechanically activated ion channel Piezo1
2017 StandoutNatureNobel
NMDA receptor activation requires remodelling of intersubunit contacts within ligand-binding heterodimers
2011
Endogenous Piezo1 Can Confound Mechanically Activated Channel Identification and Characterization
2017 StandoutNobel
LRRC8 Proteins Form Volume-Regulated Anion Channels that Sense Ionic Strength
2016 StandoutNobel
Cryo-EM structure of the mechanically activated ion channel OSCA1.2
2018 StandoutNobel
The mechanosensitive ion channel Piezo2 mediates sensitivity to mechanical pain in mice
2018 StandoutNobel
Piezo1, a mechanically activated ion channel, is required for vascular development in mice
2014 StandoutNobel
Probing the activation sequence of NMDA receptors with lurcher mutations
2012
OSCA/TMEM63 are an evolutionarily conserved family of mechanically activated ion channels
2018 StandoutNobel