Citation Impact
Citing Papers
Elevated CRAF as a Potential Mechanism of Acquired Resistance to BRAF Inhibition in Melanoma
2008
A Phase I clinical and pharmacological study of cis-diamminedichloro(2-methylpyridine) platinum II (AMD473)
2003
Development of a Purine-Scaffold Novel Class of Hsp90 Binders that Inhibit the Proliferation of Cancer Cells and Induce the Degradation of Her2 Tyrosine Kinase
2002
A Phase I clinical study of cisplatin-incorporated polymeric micelles (NC-6004) in patients with solid tumours
2011
Design and synthesis of ansamycin antibiotics
2008
Pharmacokinetics and pharmacodynamics of 17-demethoxy 17-[[(2-dimethylamino)ethyl]amino]geldanamycin (17DMAG, NSC 707545) in C.B-17 SCID mice bearing MDA-MB-231 human breast cancer xenografts
2004
Bim Protein Degradation Contributes to Cisplatin Resistance
2011
The role of copper transporters in the development of resistance to Pt drugs
2004
Modulation of the cellular pharmacology of JM118, the major metabolite of satraplatin, by copper influx and efflux transporters
2005
Mesoporous silica nanoparticles in biomedical applications
2012 StandoutNobel
Cisplatin: mode of cytotoxic action and molecular basis of resistance
2003 Standout
AKT/PKB Signaling: Navigating Downstream
2007 Standout
Firefly luciferase mutants as sensors of proteome stress
2011
Sirtuin-7 Inhibits the Activity of Hypoxia-inducible Factors
2013 StandoutNobel
Unravelling the pathogenesis of inflammatory bowel disease
2007 StandoutNature
Molecular mechanisms of drug resistance
2005
Spermidine/Spermine-N1-Acetyltransferase 2 Is an Essential Component of the Ubiquitin Ligase Complex That Regulates Hypoxia-inducible Factor 1α
2007 StandoutNobel
Akt-regulated pathways in prostate cancer
2005
Copper‐Catalyzed Arylative Meyer–Schuster Rearrangement of Propargylic Alcohols to Complex Enones Using Diaryliodonium Salts
2013
Automated ligand fitting by core-fragment fitting and extension into density
2006
Altered states: selectively drugging the Hsp90 cancer chaperone
2004
The resurgence of platinum-based cancer chemotherapy
2007 Standout
Calcineurin Promotes Hypoxia-inducible Factor 1α Expression by Dephosphorylating RACK1 and Blocking RACK1 Dimerization
2007 StandoutNobel
The Hsp90 Chaperone Machinery
2008
New approaches to molecular cancer therapeutics
2006
Heat shock protein 90: The cancer chaperone
2007
HSP90 and the chaperoning of cancer
2005 Standout
Melanomas acquire resistance to B-RAF(V600E) inhibition by RTK or N-RAS upregulation
2010 StandoutNature
Metal N-heterocyclic carbene complexes as potential antitumor metallodrugs
2012
A crucial function of SGT1 and HSP90 in inflammasome activity links mammalian and plant innate immune responses
2007
Crystal structure of an Hsp90–nucleotide–p23/Sba1 closed chaperone complex
2006 Nature
MAP kinase signalling pathways in cancer
2007 Standout
A phase II trial of ZD0473 in platinum-pretreated ovarian cancer
2002
An update on satraplatin: the first orally available platinum anticancer drug
2000
Intracellular metabolism of the orally active platinum drug JM216: influence of glutathione levels
1996
Sequence-dependent synergism between the new generation platinum agent ZD0473 and paclitaxel in cisplatin-sensitive and -resistant human ovarian carcinoma cell lines
2002
The endoplasmic reticulum stress response in immunity and autoimmunity
2008
Four-and-a-Half LIM Domain Proteins Inhibit Transactivation by Hypoxia-inducible Factor 1
2012 StandoutNobel
Cellular processing of platinum anticancer drugs
2005 Standout
Identification of genes associated with platinum drug sensitivity and resistance in human ovarian cancer cells
2005
NOD1 and NOD2 signalling links ER stress with inflammation
2016 StandoutNature
Molecular chaperones in protein folding and proteostasis
2011 StandoutNature
Engineering CAR-T cells: Design concepts
2015
RACK1 Competes with HSP90 for Binding to HIF-1α and Is Required for O2-Independent and HSP90 Inhibitor-Induced Degradation of HIF-1α
2007 StandoutNobel
Proteotoxic stress and inducible chaperone networks in neurodegenerative disease and aging
2008
Targeting the Raf-MEK-ERK mitogen-activated protein kinase cascade for the treatment of cancer
2007 Standout
Transforming fragments into candidates: small becomes big in medicinal chemistry
2009
Interpretation of ensembles created by multiple iterative rebuilding of macromolecular models
2007
Platinum‐based anticancer agents: Innovative design strategies and biological perspectives
2003
Features and development of Coot
2010 Standout
The Inflammasomes
2010 Standout
Hsp70 and CHIP Selectively Mediate Ubiquitination and Degradation of Hypoxia-inducible Factor (HIF)-1α but Not HIF-2α
2009 StandoutNobel
ZD0473 treatment in lung cancer: an overview of the clinical trial results
2002
PHENIX: a comprehensive Python-based system for macromolecular structure solution
2010 Standout
Is Cisplatin-Induced Cell Death Always Produced by Apoptosis?
2001
Platinum drugs in the treatment of non-small-cell lung cancer
2002
Pyruvate Kinase M2 Is a PHD3-Stimulated Coactivator for Hypoxia-Inducible Factor 1
2011 StandoutNobel
High-throughput screening assay for inhibitors of heat-shock protein 90 ATPase activity
2004
Amine‐Responsive Adaptable Nanospaces: Fluorescent Porous Coordination Polymer for Molecular Recognition
2014 StandoutNobel
Effect of p53 Status on Sensitivity to Platinum Complexes in a Human Ovarian Cancer Cell Line
2000
Spermidine/Spermine N1-Acetyltransferase-1 Binds to Hypoxia-inducible Factor-1α (HIF-1α) and RACK1 and Promotes Ubiquitination and Degradation of HIF-1α
2007 StandoutNobel
Chaperone-mediated Autophagy Targets Hypoxia-inducible Factor-1α (HIF-1α) for Lysosomal Degradation
2013 StandoutNobel
Identification of an Ire1alpha endonuclease specific inhibitor with cytotoxic activity against human multiple myeloma
2010
Click Chemistry for Drug Development and Diverse Chemical–Biology Applications
2013 Standout
Basis for Design and Development of Platinum(IV) Anticancer Complexes
2007
SuFEx Click Chemistry Enabled Late-Stage Drug Functionalization
2018 StandoutNobel
Biochemical Modulation of Cisplatin Mechanisms of Action: Enhancement of Antitumor Activity and Circumvention of Drug Resistance
2003 Standout
Circadian clock disruption improves the efficacy of chemotherapy through p73-mediated apoptosis
2011 StandoutNobel
Life with Oxygen
2007 StandoutScienceNobel
Digoxin and other cardiac glycosides inhibit HIF-1α synthesis and block tumor growth
2008 StandoutNobel
Photoexpulsion of Surface-Grafted Ruthenium Complexes and Subsequent Release of Cytotoxic Cargos to Cancer Cells from Mesoporous Silica Nanoparticles
2013 StandoutNobel
Multidimensional SuFEx Click Chemistry: Sequential Sulfur(VI) Fluoride Exchange Connections of Diverse Modules Launched From An SOF4 Hub
2017 StandoutNobel
Phase I Pharmacokinetic and Pharmacodynamic Study of 17-Allylamino, 17-Demethoxygeldanamycin in Patients With Advanced Malignancies
2005
The Role of Cellular Accumulation in Determining Sensitivity to Platinum-Based Chemotherapy
2007
Cooperative capture synthesis: yet another playground for copper-free click chemistry
2016 StandoutNobel
Structure of the Ire1 autophosphorylation complex and implications for the unfolded protein response
2011
Cyclin-dependent kinases regulate lysosomal degradation of hypoxia-inducible factor 1α to promote cell-cycle progression
2014 StandoutNobel
Current Status of Platinum-Based Antitumor Drugs
1999 Standout
Inhibition of signal transduction by the Hsp90 inhibitor 17-allylamino-17-demethoxygeldanamycin results in cytostasis and apoptosis.
2001
Inhibitors of HSP90 and other chaperones for the treatment of cancer
2004
Asymmetric Catalysis by Architectural and Functional Molecular Engineering: Practical Chemo- and Stereoselective Hydrogenation of Ketones
2001 StandoutNobel
Altered Hsp90 function in cancer: A unique therapeutic opportunity
2004
DNA Mismatch Repair: Functions and Mechanisms
2005 StandoutNobel
EglN3 hydroxylase stabilizes BIM-EL linking VHL type 2C mutations to pheochromocytoma pathogenesis and chemotherapy resistance
2019 StandoutNobel
The Unfolded Protein Response: From Stress Pathway to Homeostatic Regulation
2011 StandoutScience
Copper-Catalyzed Synthesis of Mixed Alkyl Aryl Phosphonates
2014 StandoutNobel
Relationship of Solution and Protein-Bound Structures of DNA Duplexes with the Major Intrastrand Cross-Link Lesions Formed on Cisplatin Binding to DNA
2001
Small molecule probes to quantify the functional fraction of a specific protein in a cell with minimal folding equilibrium shifts
2014 StandoutNobel
Why Does Cisplatin Reach Guanine-N7 with Competing S-Donor Ligands Available in the Cell?
1999
cis -Diammine(pyridine)chloroplatinum(II), a monofunctional platinum(II) antitumor agent: Uptake, structure, function, and prospects
2008 StandoutNobel
Combining cytotoxics and 17-allylamino, 17-demethoxygeldanamycin: sequence and tumor biology matters. Commentary re: P. Münster et al., Modulation of Hsp90 function by ansamycins sensitizes breast cancer cells to chemotherapy-induced apoptosis in an RB- and schedule-dependent manner. Clin. Cancer Res., 7: 2228-2236, 2001.
2001
Phase I Trial of 17-Allylamino-17-Demethoxygeldanamycin in Patients With Advanced Cancer
2005
Structure of P-Glycoprotein Reveals a Molecular Basis for Poly-Specific Drug Binding
2009 StandoutScience
Diversity Oriented Clicking (DOC): Divergent Synthesis of SuFExable Pharmacophores from 2‐Substituted‐Alkynyl‐1‐Sulfonyl Fluoride (SASF) Hubs
2020 StandoutNobel
Enhanced sensitivity to DSS colitis caused by a hypomorphic Mbtps1 mutation disrupting the ATF6-driven unfolded protein response
2009 StandoutNobel
Coadministration of the heat shock protein 90 antagonist 17-allylamino- 17-demethoxygeldanamycin with suberoylanilide hydroxamic acid or sodium butyrate synergistically induces apoptosis in human leukemia cells.
2003
Geldanamycin and its 17-allylamino-17-demethoxy analogue antagonize the action of Cisplatin in human colon adenocarcinoma cells: differential caspase activation as a basis for interaction.
2003
Direct Cellular Responses to Platinum-Induced DNA Damage
2007
Circadian control of XPA and excision repair of cisplatin-DNA damage by cryptochrome and HERC2 ubiquitin ligase
2010 StandoutNobel
CAR T cell immunotherapy for human cancer
2018 StandoutScience
Photopharmacology: Beyond Proof of Principle
2014 StandoutNobel
Confinement-Controlled, Either syn- or anti-Selective Catalytic Asymmetric Mukaiyama Aldolizations of Propionaldehyde Enolsilanes
2021 StandoutNobel
Gene expression profiling of human colon cancer cells following inhibition of signal transduction by 17-allylamino-17-demethoxygeldanamycin, an inhibitor of the hsp90 molecular chaperone
2000
Works of Swee Y. Sharp being referenced
EGFRvIII Deletion Mutations in Pediatric High-Grade Glioma and Response to Targeted Therapy in Pediatric Glioma Cell Lines
2009
BCL-2 family protein expression and platinum drug resistance in ovarian carcinoma
2000
DT-Diaphorase Expression and Tumor Cell Sensitivity to 17-Allylamino,17-demethoxygeldanamycin, an Inhibitor of Heat Shock Protein 90
1999
Mechanisms of drug resistance to the platinum complex ZD0473 in ovarian cancer cell lines
2000
Structure-Activity Relationships in Purine-Based Inhibitor Binding to HSP90 Isoforms
2004
In vitro circumvention of cisplatin resistance by the novel sterically hindered platinum complex AMD473
1998
The identification, synthesis, protein crystal structure and in vitro biochemical evaluation of a new 3,4-diarylpyrazole class of Hsp90 inhibitors
2005
Synthetic ansamycins prepared by a ring-expanding Claisen rearrangement. Synthesis and biological evaluation of ring and conformational analogues of the Hsp90 molecular chaperone inhibitor geldanamycin
2007
Targeting the Hsp90 Chaperone: Synthesis of Novel Resorcylic Acid Macrolactone Inhibitors of Hsp90
2010
Retention of activity by the new generation platinum agent AMD0473 in four human tumour cell lines possessing acquired resistance to oxaliplatin
2002
Inhibitors of the HSP90 Molecular Chaperone: Current Status
2006
Transport of cisplatin and bis-acetato-ammine-dichlorocyclohexylamine Platinum(IV) (JM216) in human ovarian carcinoma cell lines: identification of a plasma membrane protein associated with cisplatin resistance.
1995
Mini-review: discovery and development of platinum complexes designed to circumvent cisplatin resistance
1999
Selective potentiation of platinum drug cytotoxicity in cisplatin-sensitive and-resistant human ovarian carcinoma cell lines by amphotericin B
1994
Heat shock protein inhibition is associated with activation of the unfolded protein response pathway in myeloma plasma cells
2007