Citation Impact
Citing Papers
A Diverse Array of Cancer-Associated MTOR Mutations Are Hyperactivating and Can Predict Rapamycin Sensitivity
2014
The GAP arginine finger movement into the catalytic site of Ras increases the activation entropy
2008
Wild-Type KRAS Is Required for Panitumumab Efficacy in Patients With Metastatic Colorectal Cancer
2008 Standout
Reciprocal Regulation of DUSP9 and DUSP16 Expression by HIF1 Controls ERK and p38 MAP Kinase Activity and Mediates Chemotherapy-Induced Breast Cancer Stem Cell Enrichment
2018 StandoutNobel
Proteomic Analysis of Exosomes from Mutant KRAS Colon Cancer Cells Identifies Intercellular Transfer of Mutant KRAS
2012
Hallmarks of Cancer: The Next Generation
2011 Standout
Inference and analysis of cell-cell communication using CellChat
2021 Standout
Computationally designed sensors detect endogenous Ras activity and signaling effectors at subcellular resolution
2024 StandoutNobel
Adults with genetic syndromes and cardiovascular abnormalities: clinical history and management
2008
EGFR Antagonists in Cancer Treatment
2008 Standout
Regulation and function of mTOR signalling in T cell fate decisions
2012
K-ras Mutations and Benefit from Cetuximab in Advanced Colorectal Cancer
2008 Standout
A view on drug resistance in cancer
2019 StandoutNature
K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions
2013 StandoutNature
Oncogene addiction: setting the stage for molecularly targeted cancer therapy
2007
Pathological roles of MAPK signaling pathways in human diseases
2010 Standout
Rheb Inhibits C-Raf Activity and B-Raf/C-Raf Heterodimerization
2006
Cell Signaling by Receptor Tyrosine Kinases
2010 Standout
Obesity-induced gut microbial metabolite promotes liver cancer through senescence secretome
2013 StandoutNature
Therapeutic Strategies for Targeting Ras Proteins
2011
Single-Cell Profiling Identifies Aberrant STAT5 Activation in Myeloid Malignancies with Specific Clinical and Biologic Correlates
2008
RAS oncogenes: weaving a tumorigenic web
2011
The RAS/MAPK syndromes: novel roles of the RAS pathway in human genetic disorders
2008
Mutations and Treatment Outcome in Cytogenetically Normal Acute Myeloid Leukemia
2008
Activating K-Ras mutations outwith ‘hotspot’ codons in sporadic colorectal tumours – implications for personalised cancer medicine
2010
TRIBE: Hijacking an RNA-Editing Enzyme to Identify Cell-Specific Targets of RNA-Binding Proteins
2016 StandoutNobel
RNA-binding proteins in human genetic disease
2008
Cetuximab and Chemotherapy as Initial Treatment for Metastatic Colorectal Cancer
2009 Standout
Ras history
2010
Colorectal cancer
2013 Standout
Melanomas acquire resistance to B-RAF(V600E) inhibition by RTK or N-RAS upregulation
2010 StandoutNature
Protein tyrosine phosphatases: from genes, to function, to disease
2006
ROS Function in Redox Signaling and Oxidative Stress
2014 Standout
Activation of MEK1 or MEK2 isoform is sufficient to fully transform intestinal epithelial cells and induce the formation of metastatic tumors
2008
Lung cancer: current therapies and new targeted treatments
2016 Standout
Mammalian display screening of diverse cystine-dense peptides for difficult to drug targets
2017 StandoutNobel
Colorectal cancer
2019 Standout
mTOR Signaling in Growth, Metabolism, and Disease
2017 Standout
Noonan syndrome and related disorders: dysregulated RAS-mitogen activated protein kinase signal transduction
2006
Translational implications of somatic genomics in acute myeloid leukaemia
2014
Recurring HRAS mutation G12S in Dutch patients with Costello syndrome
2006
Cancer-associated IDH2 mutants drive an acute myeloid leukemia that is susceptible to Brd4 inhibition
2013
Genetic Basis for Congenital Heart Defects: Current Knowledge
2007
Regulating the regulator: post-translational modification of RAS
2011
Targeting the Raf-MEK-ERK mitogen-activated protein kinase cascade for the treatment of cancer
2007 Standout
Programmed Cell Senescence during Mammalian Embryonic Development
2013 Standout
EMT: 2016
2016 Standout
Insights into RNA Biology from an Atlas of Mammalian mRNA-Binding Proteins
2012 Standout
Negative regulation of Shh levels by Kras and Fgfr2 during hair follicle development
2012
Genomic and Epigenomic Landscapes of Adult De Novo Acute Myeloid Leukemia
2013 Standout
RNA-binding proteins in human genetic disease
2020
Mitogen-Activated Protein (MAP) Kinase/MAP Kinase Phosphatase Regulation: Roles in Cell Growth, Death, and Cancer
2008
Molecular mechanisms of cancer development in obesity
2011
Understanding the Intersections between Metabolism and Cancer Biology
2017 Standout
Exosomes facilitate therapeutic targeting of oncogenic KRAS in pancreatic cancer
2017 StandoutNature
What We Talk About When We Talk About Fat
2014 Standout
Role of Matrix Metalloproteinase-9 in the Development of Diabetic Retinopathy and Its Regulation by H-Ras
2010
Genotype differences in cognitive functioning in Noonan syndrome
2008
Glypican-1 identifies cancer exosomes and detects early pancreatic cancer
2015 StandoutNature
Inhibition of mTORC1 leads to MAPK pathway activation through a PI3K-dependent feedback loop in human cancer
2008 Standout
Dynamics and control of the ERK signaling pathway: Sensitivity, bistability, and oscillations
2018
Computation of Conformational Coupling in Allosteric Proteins
2009 StandoutNobel
The PI3K Pathway in Human Disease
2017 Standout
cPLA2 Regulates the Expression of Type I Interferons and Intracellular Immunity to Chlamydia trachomatis
2010
Does the PI3K pathway promote or antagonize regulatory T cell development and function?
2012
Senescence in tumours: evidence from mice and humans
2009
Feedback and redundancy in receptor tyrosine kinase signaling: relevance to cancer therapies
2014
Beyond EGFR and ALK inhibition: Unravelling and exploiting novel genetic alterations in advanced non small-cell lung cancer
2015
The cancer genome
2009 StandoutNature
Germline Missense Mutations Affecting KRAS Isoform B Are Associated with a Severe Noonan Syndrome Phenotype
2006
Principles of Cancer Therapy: Oncogene and Non-oncogene Addiction
2009 Standout
Synthetic Lethal Interaction between Oncogenic KRAS Dependency and STK33 Suppression in Human Cancer Cells
2009
Biomarker-driven and molecular targeted therapies for colorectal cancers
2017
Photoremovable Protecting Groups in Chemistry and Biology: Reaction Mechanisms and Efficacy
2012 Standout
Oncogenic transformation and experimental models of human cancer
2007
Acute Myeloid Leukemia
2015 Standout
The Spectrum of Cardiac Anomalies in Noonan Syndrome as a Result of Mutations in the PTPN11 Gene
2007
2011 ACCF/AHA Guideline for the Diagnosis and Treatment of Hypertrophic Cardiomyopathy
2011 Standout
VEGF Secreted by Hypoxic Müller Cells Induces MMP-2 Expression and Activity in Endothelial Cells to Promote Retinal Neovascularization in Proliferative Diabetic Retinopathy
2013 StandoutNobel
The 2008 revision of the World Health Organization (WHO) classification of myeloid neoplasms and acute leukemia: rationale and important changes
2009 Standout
Small-molecule ligands bind to a distinct pocket in Ras and inhibit SOS-mediated nucleotide exchange activity
2012
ACC/AHA 2008 Guidelines for the Management of Adults With Congenital Heart Disease: Executive Summary
2008 Standout
A Novel Role for Copper in Ras/Mitogen-Activated Protein Kinase Signaling
2012
How I treat juvenile myelomonocytic leukemia
2015
Click-Chemistry Based High Throughput Screening Platform for Modulators of Ras Palmitoylation
2017 StandoutNobel
Gene mutation patterns and their prognostic impact in a cohort of 1185 patients with acute myeloid leukemia
2011
Nf1 limits epicardial derivative expansion by regulating epithelial to mesenchymal transition and proliferation
2012
Single-Cell Mass Cytometry of Differential Immune and Drug Responses Across a Human Hematopoietic Continuum
2011 StandoutScience
Use and Abuse of RNAi to Study Mammalian Gene Function
2012 StandoutScienceNobel
Phospholipase A2Enzymes: Physical Structure, Biological Function, Disease Implication, Chemical Inhibition, and Therapeutic Intervention
2011 Standout
Chemotherapy triggers HIF-1–dependent glutathione synthesis and copper chelation that induces the breast cancer stem cell phenotype
2015 StandoutNobel
WebGestalt 2019: gene set analysis toolkit with revamped UIs and APIs
2019 Standout
Prognostic Role of KRAS and BRAF in Stage II and III Resected Colon Cancer: Results of the Translational Study on the PETACC-3, EORTC 40993, SAKK 60-00 Trial
2009
The 2016 revision to the World Health Organization classification of myeloid neoplasms and acute leukemia
2016 Standout
Mitochondrial activation chemicals synergize with surface receptor PD-1 blockade for T cell-dependent antitumor activity
2017 StandoutNobel
Neurodevelopmental Outcomes in Children With Congenital Heart Disease: Evaluation and Management
2012 Standout
Oncogene-specific activation of tyrosine kinase networks during prostate cancer progression
2012
Works of Suzanne Schubbert being referenced
Mutation analysis in Costello syndrome: functional and structural characterization of theHRASp.Lys117Arg mutation
2007
Deregulated Ras signaling in developmental disorders: new tricks for an old dog
2007
Germline KRAS mutations cause Noonan syndrome
2006
Hyperactive Ras in developmental disorders and cancer
2007
Germline Mutations in Components of the Ras Signaling Pathway in Noonan Syndrome and Related Disorders
2006
Biochemical and Functional Characterization of Germ Line KRAS Mutations
2007
Suppression of leukemia development caused by PTEN loss
2011
Functional analysis of leukemia-associated PTPN11 mutations in primary hematopoietic cells
2005